Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q01319

- RIR2_BHV1C

UniProt

Q01319 - RIR2_BHV1C

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

UL40

Organism
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731Iron 1PROSITE-ProRule annotation
    Metal bindingi103 – 1031Iron 1PROSITE-ProRule annotation
    Metal bindingi103 – 1031Iron 2By similarity
    Metal bindingi106 – 1061Iron 1PROSITE-ProRule annotation
    Active sitei110 – 1101PROSITE-ProRule annotation
    Metal bindingi166 – 1661Iron 2By similarity
    Metal bindingi200 – 2001Iron 2By similarity
    Metal bindingi203 – 2031Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:UL40
    OrganismiBovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
    Taxonomic identifieri10323 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Ribonucleoside-diphosphate reductase small chainPRO_0000190507Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAADAATL TRKYKYFYET ECPDLDHLRS LSVANRWLET EFPLADDAKD    50
    VARLSGAELE FYRFLFAFLS AADDLVNVNL GDLSELFTQK DILHYYIEQE 100
    SIEVVHSRVY SAIQLLLFRN DAVARAGYVE GALGDPAVRR KVDWLERRVA 150
    AAESVAEKYV LMILIEGIFF SSSFAAIAYL RTHNLFVVTC QTNDLISRDE 200
    AVHTAASCCI FDNYLGGERP PPARIYELFR EAWKLSASLF GCAPRGSHIL 250
    DVEAISAYVE YSADRLLAAI QLPPLFGTPP PGTDFPLALM TAEKHTNFFE 300
    RRSTNYTGTV INDL 314
    Length:314
    Mass (Da):35,251
    Last modified:April 1, 1993 - v1
    Checksum:i257FB0E91111632E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54206 Genomic DNA. Translation: CAA90928.1.
    M84470 Genomic DNA. Translation: AAA46063.1.
    Z49078 Genomic DNA. Translation: CAA88899.1.
    AJ004801 Genomic DNA. Translation: CAA06093.1.
    PIRiA43367. WMBEB4.
    RefSeqiNP_045318.1. NC_001847.1.

    Genome annotation databases

    GeneIDi4783423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54206 Genomic DNA. Translation: CAA90928.1 .
    M84470 Genomic DNA. Translation: AAA46063.1 .
    Z49078 Genomic DNA. Translation: CAA88899.1 .
    AJ004801 Genomic DNA. Translation: CAA06093.1 .
    PIRi A43367. WMBEB4.
    RefSeqi NP_045318.1. NC_001847.1.

    3D structure databases

    ProteinModelPortali Q01319.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4783423.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and 5'- and 3'-end transcript mapping of the gene encoding the small subunit of ribonucleotide reductase from bovine herpesvirus type-1."
      Simard C., Bastien N., Trudel M.
      Virology 190:689-701(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Cooper / 34.
    2. "Sequence analysis of the UL39, UL38, and UL37 homologues of bovine herpesvirus 1 and expression studies of UL40 and UL39, the subunits of ribonucleotide reductase."
      Simard C., Langlois I., Styger D., Vogt B., Vlcek C., Chalifour A., Trudel M., Schwyzer M.
      Virology 212:734-740(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1."
      Schwyzer M., Styger D., Vogt B., Lowery D.E., Simard C., LaBoissiere S., Misra V., Vlcek C., Paces V.
      Vet. Microbiol. 53:67-77(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Tinkering with a viral ribonucleotide reductase."
      Lembo D., Brune W.
      Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiRIR2_BHV1C
    AccessioniPrimary (citable) accession number: Q01319
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3