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Q01319

- RIR2_BHV1C

UniProt

Q01319 - RIR2_BHV1C

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

UL40

Organism
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Iron 1PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron 1PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron 2By similarity
Metal bindingi106 – 1061Iron 1PROSITE-ProRule annotation
Active sitei110 – 1101PROSITE-ProRule annotation
Metal bindingi166 – 1661Iron 2By similarity
Metal bindingi200 – 2001Iron 2By similarity
Metal bindingi203 – 2031Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:UL40
OrganismiBovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifieri10323 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Ribonucleoside-diphosphate reductase small chainPRO_0000190507Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliQ01319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01319-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAADAATL TRKYKYFYET ECPDLDHLRS LSVANRWLET EFPLADDAKD
60 70 80 90 100
VARLSGAELE FYRFLFAFLS AADDLVNVNL GDLSELFTQK DILHYYIEQE
110 120 130 140 150
SIEVVHSRVY SAIQLLLFRN DAVARAGYVE GALGDPAVRR KVDWLERRVA
160 170 180 190 200
AAESVAEKYV LMILIEGIFF SSSFAAIAYL RTHNLFVVTC QTNDLISRDE
210 220 230 240 250
AVHTAASCCI FDNYLGGERP PPARIYELFR EAWKLSASLF GCAPRGSHIL
260 270 280 290 300
DVEAISAYVE YSADRLLAAI QLPPLFGTPP PGTDFPLALM TAEKHTNFFE
310
RRSTNYTGTV INDL
Length:314
Mass (Da):35,251
Last modified:April 1, 1993 - v1
Checksum:i257FB0E91111632E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54206 Genomic DNA. Translation: CAA90928.1.
M84470 Genomic DNA. Translation: AAA46063.1.
Z49078 Genomic DNA. Translation: CAA88899.1.
AJ004801 Genomic DNA. Translation: CAA06093.1.
PIRiA43367. WMBEB4.
RefSeqiNP_045318.1. NC_001847.1.

Genome annotation databases

GeneIDi4783423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54206 Genomic DNA. Translation: CAA90928.1 .
M84470 Genomic DNA. Translation: AAA46063.1 .
Z49078 Genomic DNA. Translation: CAA88899.1 .
AJ004801 Genomic DNA. Translation: CAA06093.1 .
PIRi A43367. WMBEB4.
RefSeqi NP_045318.1. NC_001847.1.

3D structure databases

ProteinModelPortali Q01319.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4783423.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and 5'- and 3'-end transcript mapping of the gene encoding the small subunit of ribonucleotide reductase from bovine herpesvirus type-1."
    Simard C., Bastien N., Trudel M.
    Virology 190:689-701(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Cooper / 34.
  2. "Sequence analysis of the UL39, UL38, and UL37 homologues of bovine herpesvirus 1 and expression studies of UL40 and UL39, the subunits of ribonucleotide reductase."
    Simard C., Langlois I., Styger D., Vogt B., Vlcek C., Chalifour A., Trudel M., Schwyzer M.
    Virology 212:734-740(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1."
    Schwyzer M., Styger D., Vogt B., Lowery D.E., Simard C., LaBoissiere S., Misra V., Vlcek C., Paces V.
    Vet. Microbiol. 53:67-77(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR2_BHV1C
AccessioniPrimary (citable) accession number: Q01319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3