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Protein
Submitted name:

Nik-1

Gene

nik-1

Organism
Neurospora crassa
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nik-1Imported
Gene namesi
Name:nik-1Imported
OrganismiNeurospora crassaImported
Taxonomic identifieri5141 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5141.EFNCRP00000002499.

Structurei

3D structure databases

ProteinModelPortaliQ01309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 23356HAMPInterPro annotationAdd
BLAST
Domaini273 – 32553HAMPInterPro annotationAdd
BLAST
Domaini365 – 41753HAMPInterPro annotationAdd
BLAST
Domaini457 – 50953HAMPInterPro annotationAdd
BLAST
Domaini549 – 60153HAMPInterPro annotationAdd
BLAST
Domaini641 – 69353HAMPInterPro annotationAdd
BLAST
Domaini715 – 939225Histidine kinaseInterPro annotationAdd
BLAST
Domaini1087 – 1206120Response regulatoryInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
COG2770. LUCA.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 6 hits.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 6 hits.
PS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGPTLAAI AALVKSLAVD PATTQTSGLR PSTHVRLPGP YTREKGDLER
60 70 80 90 100
ELSALVVRIE QLETAAIAAS PPAMPDTPNA PTDALFSNGT LSPSSETPDA
110 120 130 140 150
RYPAPLPRNG FIDEALEGLR EHVDDQSKLL DSQRQELAGV NAQLIEQKQL
160 170 180 190 200
QEKALAIIEQ ERVATLEREL WKHQKANEAF QKALREIGEI VTAVARGDLS
210 220 230 240 250
KKVRMNSVEM DPEITTFKRT INTMMDQLQV FSSEVSRVAR EVGTEGILGG
260 270 280 290 300
QAQIEGVDGT WKELTDNVNV MAQNLTDQVR EIASVTTAVA HGDLTKKIER
310 320 330 340 350
PAKGEILQLQ QTINTMVDQL RTFASEVTRV ARDVGTEGIL GGQADVEGVQ
360 370 380 390 400
GMWNELTVNV NAMANNLTTQ VRDIIKVTTA VAKGDLTQKV QAECRGEIFE
410 420 430 440 450
LKKTINSMVD QLQQFAREVT KIAREVGTEG RLGGQATVHD VQGTWRDLTE
460 470 480 490 500
NVNGMAMNLT TQVREIAKVT TAVAKGDLTK KIGVEVQGEI LDLKNTINTM
510 520 530 540 550
VDRLGTFAFE VSKVAREVGT DGTLGGQAQV DNVEGKWKDL TENVNTMASN
560 570 580 590 600
LTSQVRGIST VTQAIANGDM SRKIEVEAKG EILILKETIN NMVDRLSIFC
610 620 630 640 650
NEVQRVAKDV GVDGIMGGQA DVAGLKGRWK EITTDVNTMA NNLTAQVRAF
660 670 680 690 700
GDITNAATDG DFTKLVEVEA SGEMDELKKK INQMVYNLRD SIQRNTQARE
710 720 730 740 750
AAELANKTKS EFLANMSHEI RTPMNGIIGM TQLTLDTDLT QYQREMLNIV
760 770 780 790 800
NSLANSLLTI IDDILDLSKI EARRMVIEEI PYTLRGTVFN ALKTLAVKET
810 820 830 840 850
EKFLDLTYRV DHSVPDHVVG DSFRLRQIIL NLVGNAIKFT EHGEVSLTIQ
860 870 880 890 900
KASSVQCSTE EYAIEFVVSD TGIGIPADKL DLIFDTFQQA DGSMTRKFGG
910 920 930 940 950
TGLGLSISKR LVNLMGGDVW VKSEYGKGSK FFFTCVVRLA NDDISLIAKQ
960 970 980 990 1000
LNPYKSHQVL FIDKGRTGHG PEIAKMLHGL GLVPIVVDSE RNPALEKARA
1010 1020 1030 1040 1050
AGQAPYDVII VDSIEDARRL RSVDDFKYLP IVLLAPVVHV SLKSCLDLGI
1060 1070 1080 1090 1100
TSYMTTPCQL IDLGNGMVPA LENRATPSLA DNTKSFEILL AEDNTVNQRL
1110 1120 1130 1140 1150
AVKILEKYHH VVTVVGNGEE AVEAVKRKKF DVILMDVQMP IMGGFEATAK
1160 1170 1180 1190 1200
IREYERSLGS QRTPIIALTA HAMMGDREKC IQAQMDEYLS KPLQQNHLIQ
1210 1220 1230 1240 1250
TILKCATLGG QLLEKNRERE LTRAADAVTG GRRDNGMYSA SQAAQHAALR
1260 1270 1280 1290
PPLATRGLTA ADSLVSGLES PSIVTADKED PLSRARASLS EPNIHKAS
Length:1,298
Mass (Da):141,974
Last modified:November 1, 1996 - v1
Checksum:iD1ED08E19472F45A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50263 mRNA. Translation: AAB03698.1.
PIRiT18359.
T47214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50263 mRNA. Translation: AAB03698.1.
PIRiT18359.
T47214.

3D structure databases

ProteinModelPortaliQ01309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.EFNCRP00000002499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
COG2770. LUCA.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 6 hits.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 6 hits.
PS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase."
    Alex L.A., Borkovich K.A., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 93:3416-3421(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 74-OR23-1VAImported.

Entry informationi

Entry nameiQ01309_NEUCS
AccessioniPrimary (citable) accession number: Q01309
Secondary accession number(s): Q01313
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.