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Reviewed, UniProtKB/Swiss-Prot Q01299 (POLG_TBEVH)

Last modified February 9, 2010. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Genome polyprotein
Cleaved into the following 10 chains:
    1- Recommended name:
            Protein C
        Alternative name(s):
            Core protein
            Capsid protein
    2- Recommended name:
            Small envelope protein M
        Alternative name(s):
            Matrix protein
    3- Recommended name:
            Envelope protein E
    4- Recommended name:
            Non-structural protein 1
                Short name=NS1
    5- Recommended name:
            Non-structural protein 2A
                Short name=NS2A
    6- Recommended name:
            Serine protease subunit NS2B
        Alternative name(s):
            Non-structural protein 2B
            Flavivirin protease NS2B regulatory subunit
    7- Recommended name:
            Serine protease/NTPase/helicase NS3
              EC=3.4.21.91
              EC=3.6.1.15
              EC=3.6.1.-
        Alternative name(s):
            Flavivirin protease NS3 catalytic subunit
            Non-structural protein 3
    8- Recommended name:
            Non-structural protein 4A
                Short name=NS4A
    9- Recommended name:
            Non-structural protein 4B
                Short name=NS4B
    10- Recommended name:
            Methyltransferase/RNA-directed RNA polymerase NS5
              EC=2.7.7.48
              EC=2.1.1.56
              EC=2.1.1.57
        Alternative name(s):
            Non-structural protein 5
OrganismTick-borne encephalitis virus (strain Hypr) (TBEV) [Complete proteome]
Taxonomic identifier70733 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › tick-borne encephalitis virus group
Virus hostIxodes ricinus (Sheep tick) [TaxID: 34613]
Ixodes persulcatus (Taiga tick) [TaxID: 34615]

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Protein attributes

Sequence length3414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function By similarity.

Non-structural protein 2B is a required cofactor for the serine protease function of NS3 By similarity.

Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, cleaves the polyprotein By similarity.

RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions By similarity.

Catalytic activity

Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

NTP + H2O = NDP + phosphate.

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA.

Subunit structure

NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter By similarity.

Subcellular location

Protein C: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Small envelope protein M: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Envelope protein E: Virion Potential. Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4A: Host membrane; Single-pass membrane protein Potential.

Non-structural protein 4B: Host membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins By similarity.

Miscellaneous

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity.

The nonstructural protein NS1 presents two alternative cleavage sites for its C-terminus (either at position 1128 or at 1190), which may define a soluble or a membrane-bound form of NS1.

Sequence similarities

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 peptidase S7 domain.

Contains 1 RdRp catalytic domain.

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Ontologies

Keywords
   Biological processRNA replication
   Cellular componentCapsid protein
Core protein
Envelope protein
Host membrane
Membrane
Virion
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
Methyltransferase
Nucleotidyltransferase
RNA-directed RNA polymerase
Transferase
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processRNA metabolic process

Inferred from electronic annotation. Source: InterPro

methylation

Inferred from electronic annotation. Source: InterPro

transcription, RNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

viral genome replication

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host Potential
Chain2 – 112111Protein C
PRO_0000037793
Propeptide113 – 20593
PRO_0000037794
Chain206 – 28075Small envelope protein M
PRO_0000037795
Chain281 – 776496Envelope protein E
PRO_0000037796
Chain777 – ?1128352Non-structural protein 1
PRO_0000037797
Chain?1129 – 1358230Non-structural protein 2A
PRO_0000037798
Chain1359 – 1489131Serine protease subunit NS2B
PRO_0000037799
Chain1490 – 2110621Serine protease/NTPase/helicase NS3
PRO_0000037800
Chain2111 – 2259149Non-structural protein 4A
PRO_0000037801
Chain2260 – 2511252Non-structural protein 4B
PRO_0000037802
Chain2512 – 3414903Methyltransferase/RNA-directed RNA polymerase NS5
PRO_0000037803

Regions

Transmembrane33 – 5321 Potential
Transmembrane99 – 11921 Potential
Transmembrane254 – 27421 Potential
Transmembrane728 – 74821 Potential
Transmembrane760 – 78021 Potential
Transmembrane1133 – 115321 Potential
Transmembrane1159 – 117921 Potential
Transmembrane1203 – 122523 Potential
Transmembrane1233 – 125321 Potential
Transmembrane1294 – 131421 Potential
Transmembrane1383 – 140321 Potential
Transmembrane1455 – 147521 Potential
Transmembrane2161 – 218121 Potential
Transmembrane2190 – 221021 Potential
Transmembrane2212 – 223221 Potential
Transmembrane2245 – 226521 Potential
Transmembrane2344 – 236421 Potential
Transmembrane2369 – 238921 Potential
Transmembrane2433 – 245321 Potential
Domain1496 – 1672177Peptidase S7
Domain1675 – 1831157Helicase ATP-binding
Domain1841 – 2000160Helicase C-terminal
Domain3040 – 3189150RdRp catalytic
Nucleotide binding1688 – 16958ATP Potential
Motif1779 – 17824DEAH box

Sites

Active site15431Charge relay system By similarity
Active site15671Charge relay system By similarity
Active site16271Charge relay system By similarity
Active site25721For 2'-O-methyltransferase activity By similarity
Active site26571For 2'-O-methyltransferase and N-7 methyltransferase activity By similarity
Active site26941For 2'-O-methyltransferase activity By similarity
Active site27301For 2'-O-methyltransferase activity By similarity

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...); by host Potential
Glycosylation4341N-linked (GlcNAc...); by host Potential
Glycosylation8611N-linked (GlcNAc...); by host Potential
Glycosylation9831N-linked (GlcNAc...); by host Potential
Glycosylation9991N-linked (GlcNAc...); by host Potential
Glycosylation16491N-linked (GlcNAc...); by host Potential
Glycosylation19881N-linked (GlcNAc...); by host Potential
Glycosylation20441N-linked (GlcNAc...); by host Potential
Glycosylation25291N-linked (GlcNAc...); by host Potential
Glycosylation27261N-linked (GlcNAc...); by host Potential
Disulfide bond283 ↔ 310 By similarity
Disulfide bond340 ↔ 396 By similarity
Disulfide bond354 ↔ 385 By similarity
Disulfide bond372 ↔ 401 By similarity
Disulfide bond466 ↔ 570 By similarity
Disulfide bond587 ↔ 618 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q01299-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EC0B1A5325A08C19

FASTA3,414378,545
        10         20         30         40         50         60 
MVKKAILKGK GGGPPRRVSK ETATKTRQPR VQMPNGLVLM RMMGILWHAV AGTARNPVLK 

        70         80         90        100        110        120 
AFWNSVPLKQ ATAALRKIKR TVSALMVGLQ KRGKRRSATD WMSWLLVITL LGMTIAATVR 

       130        140        150        160        170        180 
KERDGSTVIR AEGKDAATQV RVENGTCVIL ATDMGSWCDD SLSYECVTID QGEEPVDVDC 

       190        200        210        220        230        240 
FCRNVDGVYL EYGRCGKQEG SRTRRSVLIP SHAQGELTGR GHKWLEGDSL RTHLTRVEGW 

       250        260        270        280        290        300 
VWKNRLLALA MVTVVWLTLE SVVTRVAVLV VLLCLAPVYA SRCTHLENRD FVTGTQGTTR 

       310        320        330        340        350        360 
VTLVLELGGC VTITAEGKPS MDVWLDAIYQ ENPAQTREYC LHAKLSDTKV AARCPTMGPA 

       370        380        390        400        410        420 
TLAEEHQGGT VCKRDQSDRG WGNHCGLFGK GSIVACVKAA CEAKKKATGH VYDANKIVYT 

       430        440        450        460        470        480 
VKVEPHTGDY VAANETHSGR KTASFTVSSE KTILTMGEYG DVSLLCRVAS GVDLAQTVIL 

       490        500        510        520        530        540 
ELDKTVEHLP TAWQVHRDWF NDLALPWKHE GARNWNNAER LVEFGAPHAV KMDVYNLGDQ 

       550        560        570        580        590        600 
TGVLLKALAG VPVAHIEGTK YHLKSGHVTC EVGLEKLKMK GLTYTMCDKT KFTWKRAPTD 

       610        620        630        640        650        660 
SGHDTVVMEV TFSGTKPCRI PVRAVAHGSP DVNVAMLITP NPTIENNGGG FIEMQLPPGD 

       670        680        690        700        710        720 
NIIYVGELSY QWFQKGSSIG RVFQKTKKGI ERLTVIGEHA WDFGSAGGFL SSIGKALHTV 

       730        740        750        760        770        780 
LGGAFNSIFG GVGFLPKLLL GVALAWLGLN MRNPTMSMSF LLAGVLVLAM TLGVGADVGC 

       790        800        810        820        830        840 
AVDTERMELR CGEGLVVWRE VSEWYDNYAY YPETPGALAS AIKETFEEGS CGVVPQNRLE 

       850        860        870        880        890        900 
MAMWRSSVTE LNLALAEGEA NLTVMVDKFD PTDYRGGVPG LLKKGKDIKV SWKSWGHSMI 

       910        920        930        940        950        960 
WSIPEAPRRF MVGTEGQSEC PLERRKTGVF TVAEFGVGLR TKVFLDFRQE PTHECDTGVM 

       970        980        990       1000       1010       1020 
GAAVKNGMAI HTDQSLWMRS MKNDTGTYIV ELLVTDLRNC SWPASHTIDN ADVVDSELFL 

      1030       1040       1050       1060       1070       1080 
PASLAGPRSW YNRIPGYSEQ VKGPWKHTPI RVIREECPGT TVTINAKCDK RGASVRSTTE 

      1090       1100       1110       1120       1130       1140 
SGKVIPEWCC RACTMPPVTF RTGTDCWYAM EIRPVHDQGG LVRSMVVADN GELLSEGGVP 

      1150       1160       1170       1180       1190       1200 
GIVALFVVLE YIIRRRPSTG STVVWGGIVV LALLVTGMVR MESLVRYVVA VGITFHLELG 

      1210       1220       1230       1240       1250       1260 
PEIVALMLLQ AVFELRVGLL SAFALRRSLT VREMVTTYFL LLVLELGLPS ANLEDFWKWG 

      1270       1280       1290       1300       1310       1320 
DALAMGALIF RACTAEGKTG AGLLLMALMT QQDVVTVHHG LVCFLSAASA CSIWRLLRGH 

      1330       1340       1350       1360       1370       1380 
REQKGLTWIV PLARLLGGEG SGIRLLAFWE LSAHRGRRSF SEPLTVVGVM LTLASGMMRH 

      1390       1400       1410       1420       1430       1440 
TSQEALCALA VASFLLLMLV LGTRKMQLVA EWSGCVEWHP ELVNEGGEVS LRVRQDAMGN 

      1450       1460       1470       1480       1490       1500 
FHLTELEKEE RMMAFWLIAG LAASAIHWSG IIGVMGLWTL TKMLRSSRRS DLVFSGQGGR 

      1510       1520       1530       1540       1550       1560 
ERGDRPFEVK DGVYRIFSPG LFWGQNQVGV GYGSKGVLHT MWHVTRGAAL SIDDAVAGPY 

      1570       1580       1590       1600       1610       1620 
WADVREDVVC YGGAWSLEEK WKGETVQVHA FPPGKAHEVH QCQPGELILD TGRKLGAIPI 

      1630       1640       1650       1660       1670       1680 
DLVKGTSGSP ILNAQGVVVG LYGNGLKTNE TYVSSIAQGE AEKSRPNLPQ AVVGTGWTSK 

      1690       1700       1710       1720       1730       1740 
GQITVLDMHP GSGKTHRVLP ELIRQCIDRR LRTLVLAPTR VVLKEMERAL NGKRVRFHSP 

      1750       1760       1770       1780       1790       1800 
AVSDQQAGGA IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYTLAK 

      1810       1820       1830       1840       1850       1860 
ENKCALVLMT ATPPGKSEPF PESNGAITSE ERQIPNGEWR DGFDWITEYE GRTAWFVPSI 

      1870       1880       1890       1900       1910       1920 
AKGGAIARTL RQKGKSVICL NSKTFEKDYS RVRDEKPDFV VTTDISEMGA NLDVSRVIDG 

      1930       1940       1950       1960       1970       1980 
RTNIKPEEVD GKVELTGTRR VTTASAAQRR GRVGRQDGRT DEYIYSGQCD DDDSGLVQWK 

      1990       2000       2010       2020       2030       2040 
EAQILLDNIT TLRGPVATFY GPEQDKMPEV AGHFRLTEEK RKHFRHLLTH CDFTPWLAWH 

      2050       2060       2070       2080       2090       2100 
VAANVSSVTD RSWTWEGPEA NAVDEASGGL VTFRSPNGAE RTLRPVWKDA RMFKEGRDIK 

      2110       2120       2130       2140       2150       2160 
EFVAYASGRR SFGDVLTGMS GVPELLRHRC VSALDVFYTL MHEKPDSRAM RMAERDAPEA 

      2170       2180       2190       2200       2210       2220 
FLTMVEMMVL GLATLGVIWC FVVRTSISRM MLGTLVLLAS LLLLWAGGVG YGNMAGVALI 

      2230       2240       2250       2260       2270       2280 
FYTLLTVLQP EAGKQRSSDD NKLAYFLLTL CSLAGLVAAN EMGFLEKTKA DLSTVLWSER 

      2290       2300       2310       2320       2330       2340 
EEPRPWSEWT NVDIQPARSW GTYVLVVSLF TPYIIHQLQT KIQQLVNSAV ASGAQAMRDL 

      2350       2360       2370       2380       2390       2400 
GGGAPFFGVA GHVMTLGVVS LIGATPTSLM VGVGLAALHL AIVVSGLEAE LTQRAHKVFF 

      2410       2420       2430       2440       2450       2460 
SAMVRNPMVD GDVINPFGEG EAKPALYERR MSLVLAIVLC LMSVVMNRTV ASITEASAVG 

      2470       2480       2490       2500       2510       2520 
LAAAGQLLRP EADTLWTMPV ACGMSGVVRG SLWGFLPLGH RLWLRASGGR RGGSEGDTLG 

      2530       2540       2550       2560       2570       2580 
DLWKRRLNNC TREEFFVYRR TGILETERDK ARELLRRGET NMGLAVSRGT AKLAWLEERG 

      2590       2600       2610       2620       2630       2640 
YATLKGEVVD LGCGRGGWSY YAASRPAVMS VRAYTIGGRG HEAPKMVTSL GWNLIKFRSG 

      2650       2660       2670       2680       2690       2700 
MDVFSMQPHR ADTVMCDIGE SSPDAAVEGE RTRKVILLME QWKNRNPTAA CVFKVLAPYR 

      2710       2720       2730       2740       2750       2760 
PEVIEALHRF QLQWGGGLVR TPFSRNSTHE MYYSTAVTGN IVNSVNVQSR KLLARFGDQR 

      2770       2780       2790       2800       2810       2820 
GPTRVPELDL GVGTRCVVLA EDKVKEQDVQ ERIKALREQY SETWHMDEEH PYRTWQYWGS 

      2830       2840       2850       2860       2870       2880 
YRTAPTGSAA SLINGVVKLL SWPWNAREDV VRMAMTDTTA FGQQRVFKDK VDTKAQEPQP 

      2890       2900       2910       2920       2930       2940 
GTRVIMRAVN DWILERLAQK SKPRMCSREE FIAKVKSNAA LGAWSDEQNR WASAREAVED 

      2950       2960       2970       2980       2990       3000 
PAFWHLVDEE RERHLMGRCA HCVYNMMGKR EKKLGEFGVA KGSRAIWYMW LGSRFLEFEA 

      3010       3020       3030       3040       3050       3060 
LGFLNEDHWA SRESSGAGVE GISLNYLGWH LKKLSTLNGG LFYADDTAGW DTKVTNADLE 

      3070       3080       3090       3100       3110       3120 
DEEQILRYME GEHKQLATTI MQKAYHAKVV KVARPSRDGG CIMDVITRRD QRGSGQVVTY 

      3130       3140       3150       3160       3170       3180 
ALNTLTNIKV QLIRMMEGEG VIEAADAHNP RLLRVERWLK EHGEERLGRM LVSGDDCVVR 

      3190       3200       3210       3220       3230       3240 
PLDDRFGKAL YFLNDMAKTR KDIGEWEHSA GLSSWEEVPF CSHHFHELVM KDGRTLVVPC 

      3250       3260       3270       3280       3290       3300 
RDQDELVGRA RISPGCGWSV RETACLSKAY GQMWLLSYFH RRDLRTLGLA INSAVPVDWV 

      3310       3320       3330       3340       3350       3360 
PTGRTTWSIH ASGAWMTTED MLDVWNRVWI LDNPFMQNKG KVMEWRDVPY LPKAQDMLCS 

      3370       3380       3390       3400       3410 
SLVGRKERAE WAKNIWGAVE KVRKMIGPEK FKDYLSCMDR HDLHWELRLE SSII

« Hide

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References

[1]Wallner G., Mandl C.W., Ecker M., Holzmann H., Stiasny K., Kunz C., Heinz F.X.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Presence of poly(A) in a flavivirus: significant differences between the 3' noncoding regions of the genomic RNAs of tick-borne encephalitis virus strains."
Mandl C.W., Kunz C., Heinz F.X.
J. Virol. 65:4070-4077(1991) [PubMed: 1712858] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 3357-3414.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U39292 Genomic RNA. Translation: AAB53095.1.
M76660 Genomic RNA. Translation: AAA47904.1.

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR014001. DEAD-like_N.
IPR001650. DNA/RNA_helicase_C.
IPR000069. Env_glycoprot_M_flavivir.
IPR013754. Flav_glyE_dim.
IPR001122. Flavi_capsidC.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flv_glyE_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011999. GlycoprotE_cen/dimer_Flavivir.
IPR011998. GlycoprotE_cen/dimer_vir.
IPR014021. Helicase_SF1/SF2_ATP-bd.
IPR014756. Ig_E-set.
IPR001850. Peptidase_S7.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_RrmJ/FtsJ.
IPR009003. Ser/Cys_Pept_Trypsin-like.
[Graphical view]
Gene3DG3DSA:2.60.98.10. Flav_glyE_dim. 1 hit.
G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.
PfamPF01003. Flavi_capsid. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePOLG_TBEVH
AccessionPrimary (citable) accession number: Q01299
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents