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Q01260

- GP_INSV

UniProt

Q01260 - GP_INSV

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Protein
Envelope glycoprotein
Gene
GP
Organism
Impatiens necrotic spot virus (INSV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei459 – 4602Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiImpatiens necrotic spot virus (INSV)
Taxonomic identifieri11612 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiImpatiens [TaxID: 35939]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Glycoprotein G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: Glycoprotein G2 is retained in the Golgi complex and probably contains a Golgi retention signal By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 321321Lumenal Reviewed prediction
Add
BLAST
Transmembranei322 – 34221Helical; Reviewed prediction
Add
BLAST
Topological domaini343 – 459117Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini460 – 1044585Lumenal Reviewed prediction
Add
BLAST
Transmembranei1045 – 106521Helical; Reviewed prediction
Add
BLAST
Topological domaini1066 – 111045Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 88 Reviewed prediction
PRO_0000036868
Chaini9 – 11101102Envelope glycoprotein
PRO_0000036869Add
BLAST
Chaini9 – 459451Glycoprotein G1 Reviewed prediction
PRO_0000036870Add
BLAST
Chaini460 – 1110651Glycoprotein G2 Reviewed prediction
PRO_0000036871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi566 – 5661N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi582 – 5821N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi957 – 9571N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2 By similarity.
Glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 163Cell attachment site Reviewed prediction

Domaini

The cell attachment site present in these glycoproteins may help in the adhesion of virus to cells.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR014414. M_poly_TospoV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
[Graphical view]
PIRSFiPIRSF003960. M_poly_TospoV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01260-1 [UniParc]FASTAAdd to Basket

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MALKETDAKI HVERGDHPEI YDEAYYDRSV DHKNEILDTL AEMLQNATGK     50
TLRPTRDTQT VLANNEVPQS SSGLSSTPTT ISIMDLPNPC LNASSLTCSI 100
KGVSTFNVYY QVESNGVIYS CISDTITKLG NCEGSSELPR SFETVPVVPI 150
TKIDNKRKLS IGTKFYIIES LENYNYPIMY NSRPTNGTVS LQSVKFSGDC 200
KISKTNIVNS YTVSLTTPEK IMGYVVKREG SDMSHSIISF SGSVSLTFTE 250
ENMDGKHNLL CGDKSSKVPL VDKRVRDCII KYSKNIYKQT ACINFSWFRL 300
IMIALIVYFP IRYLVNKTSK TLFYGYDLLG LITYPILLLI NYLWSYFPLK 350
CKVCGNLCLV THECSKLCIC NKNKASEEHS EECPIITRTA EKNKKYNWAS 400
IEWFHLIVNT KIGLSFLKAV TETLIGFLIL SQMPMSMAQT AQCLDSCYYV 450
PGCDRFVTNR YDKCPEKDQC FCAIKENSIV ESNFLTNVVT EGPMDCIPYQ 500
ECKGRITENA LVTFVKCRFG CEYASIFQSK PLDNGFLEYS GDTLGLNAVN 550
LHFMKRLRNG IIDFYNKTEK YGYISGDALK SNESDIPESI FPRKSLIFDS 600
VIDGKYRYMI EESLLSGGGT VFSLNDKSSS TAQKFVVYIK KVRIQYDVSE 650
QYTTAPIQST HTDFFSTCTG KCSDCRKEQP ITGYQDFCIT PTSYWGCEEV 700
WCLAINEGAT CGFCRNVYDM DQSFRIYSVI KSTIKSEVCI SGFVGAKCFT 750
VSEEVPSESG YFQADILADF HNDGLTIGQL IAHGPDSHVY AGNIARLNNP 800
SKMFGHPQLS HQGDPIFSKK TLDTNDLSWD CSAIGKKTIT IKSCGYDTYR 850
FKTGLNQISD IPVQFTDQNS FYMEKIFSLG KLKIVLDLPS ELFKTVPKKP 900
ILSSVSLSCK GCFLCSQGLR CAASFISDIT FSARLTMKQC SLSTYQIAVK 950
KGANKYNLTM FCTSNPEKQK MIIEPEGDKS YSVEALVDSV AVLEPENIID 1000
QNDQHAHEEQ QYNSDTSVWS FWDYVKSPFN FIASHFGSFF DTVRVVLLIL 1050
FVFALAYLCS IVATMCRGYV RNKSYKTKYI EDTNDYSLVS TSSGKDTITR 1100
RRPPLDFSGI 1110
Length:1,110
Mass (Da):124,868
Last modified:February 1, 1994 - v1
Checksum:iB0691F892BAC7F6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74904 Genomic RNA. Translation: AAA46242.1.
PIRiB42544.
RefSeqiNP_619691.1. NC_003616.1.

Genome annotation databases

GeneIDi956573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74904 Genomic RNA. Translation: AAA46242.1 .
PIRi B42544.
RefSeqi NP_619691.1. NC_003616.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956573.

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR014414. M_poly_TospoV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
[Graphical view ]
PIRSFi PIRSF003960. M_poly_TospoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The M RNA of impatiens necrotic spot Tospovirus (Bunyaviridae) has an ambisense genomic organization."
    Law M.D., Speck J., Moyer J.W.
    Virology 188:732-741(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_INSV
AccessioniPrimary (citable) accession number: Q01260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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