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Q01257 (ARSC_STAXY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase
EC=1.20.4.-
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase
EC=3.1.3.48
Gene names
Name:arsC
Encoded onPlasmid pSX267
OrganismStaphylococcus xylosus
Taxonomic identifier1288 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP-Rule MF_01624

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP-Rule MF_01624

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP-Rule MF_01624

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01624

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Keywords
   Biological processArsenical resistance
   DomainRedox-active center
   Molecular functionHydrolase
Oxidoreductase
   PTMDisulfide bond
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processresponse to arsenic-containing substance

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionarsenate reductase (thioredoxin) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Protein ArsC HAMAP-Rule MF_01624
PRO_0000162534

Sites

Active site101Nucleophile; for reductase activity and phosphatase activity By similarity
Active site821Nucleophile; for reductase activity By similarity
Active site891Nucleophile; for reductase activity By similarity

Amino acid modifications

Disulfide bond10 ↔ 82Redox-active; alternate By similarity
Disulfide bond82 ↔ 89Redox-active; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01257 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 99C84FA73896D094

FASTA13114,888
        10         20         30         40         50         60 
MDKKTIYFIC TGNSCRSQMA EGWGREILGE DWNVYSAGIE THGVNPKAIE AMKEVDIDIS 

        70         80         90        100        110        120 
NHTSDLIDNH ILKQSDLVVT LCSDADDNCP ILPPNVKKEH WGLEDPAGKE WSEFQRVRDE 

       130 
IKLAIENFKL R 

« Hide

References

[1]"Expression and regulation of the antimonite, arsenite, and arsenate resistance operon of Staphylococcus xylosus plasmid pSX267."
Rosenstein R., Peschel A., Wieland B., Goetz F.
J. Bacteriol. 174:3676-3683(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 20267 / Isolate C2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80565 Genomic DNA. Translation: AAA27589.1.
PIRC41902.

3D structure databases

ProteinModelPortalQ01257.
SMRQ01257. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_01624. Arsenate_reduct.
InterProIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
TIGRFAMsTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARSC_STAXY
AccessionPrimary (citable) accession number: Q01257
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families