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Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • artery morphogenesis Source: BHF-UCL
  • atrial septum development Source: MGI
  • atrial septum morphogenesis Source: MGI
  • atrial ventricular junction remodeling Source: MGI
  • AV node cell to bundle of His cell communication Source: MGI
  • AV node cell to bundle of His cell communication by electrical coupling Source: BHF-UCL
  • blood vessel development Source: MGI
  • bundle of His cell to Purkinje myocyte communication by electrical coupling Source: MGI
  • cardiac conduction Source: MGI
  • cardiac conduction system development Source: MGI
  • cell communication by chemical coupling Source: Ensembl
  • cell communication by electrical coupling involved in cardiac conduction Source: MGI
  • cell communication involved in cardiac conduction Source: MGI
  • embryonic heart tube development Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • endothelium development Source: Ensembl
  • foramen ovale closure Source: MGI
  • gap junction assembly Source: MGI
  • mitral valve development Source: MGI
  • negative regulation of blood pressure Source: Ensembl
  • negative regulation of glomerular filtration Source: Ensembl
  • outflow tract morphogenesis Source: MGI
  • positive regulation of cell communication by chemical coupling Source: Ensembl
  • positive regulation of vasoconstriction Source: Ensembl
  • positive regulation of vasodilation Source: Ensembl
  • potassium ion transport Source: Ensembl
  • protein oligomerization Source: Ensembl
  • pulmonary valve formation Source: MGI
  • regulation of atrial cardiac muscle cell action potential Source: MGI
  • regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  • regulation of AV node cell action potential Source: BHF-UCL
  • regulation of bundle of His cell action potential Source: BHF-UCL
  • regulation of cardiac muscle contraction Source: MGI
  • regulation of heart rate by cardiac conduction Source: MGI
  • regulation of membrane depolarization during cardiac muscle cell action potential Source: MGI
  • regulation of Purkinje myocyte action potential Source: MGI
  • regulation of renin secretion into blood stream Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • regulation of vasodilation Source: MGI
  • regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  • renal system process involved in regulation of systemic arterial blood pressure Source: MGI
  • SA node cell action potential Source: MGI
  • septum primum development Source: MGI
  • skeletal system development Source: MGI
  • vasomotion Source: Ensembl
  • ventricular cardiac muscle cell action potential Source: MGI
  • ventricular septum development Source: MGI
  • ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:Gja5
Synonyms:Cxn-40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95716. Gja5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 16467CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 20520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 358132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Gap junction alpha-5 proteinPRO_0000057820Add
BLAST

Proteomic databases

PRIDEiQ01231.

PTM databases

PhosphoSiteiQ01231.

Expressioni

Tissue specificityi

Kidney, heart and skin, but most abundant in lung.

Gene expression databases

BgeeiQ01231.
CleanExiMM_GJA5.
ExpressionAtlasiQ01231. baseline and differential.
GenevisibleiQ01231. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088264.

Structurei

3D structure databases

DisProtiDP00646.
ProteinModelPortaliQ01231.
SMRiQ01231. Positions 3-229, 251-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45265.
GeneTreeiENSGT00800000124029.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ01231.
KOiK07614.
OMAiHKHSTVI.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL
160 170 180 190 200
NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL
260 270 280 290 300
PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE
310 320 330 340 350
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK

ARSDDLSV
Length:358
Mass (Da):40,413
Last modified:January 23, 2007 - v2
Checksum:iC5418F657142896A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA. Translation: CAA43850.1.
BC053054 mRNA. Translation: AAH53054.1.
CCDSiCCDS17652.1.
PIRiS23111.
RefSeqiNP_001258557.1. NM_001271628.1.
NP_032147.1. NM_008121.3.
UniGeneiMm.281816.

Genome annotation databases

EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123.
GeneIDi14613.
KEGGimmu:14613.
UCSCiuc008qoo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA. Translation: CAA43850.1.
BC053054 mRNA. Translation: AAH53054.1.
CCDSiCCDS17652.1.
PIRiS23111.
RefSeqiNP_001258557.1. NM_001271628.1.
NP_032147.1. NM_008121.3.
UniGeneiMm.281816.

3D structure databases

DisProtiDP00646.
ProteinModelPortaliQ01231.
SMRiQ01231. Positions 3-229, 251-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088264.

PTM databases

PhosphoSiteiQ01231.

Proteomic databases

PRIDEiQ01231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123.
GeneIDi14613.
KEGGimmu:14613.
UCSCiuc008qoo.2. mouse.

Organism-specific databases

CTDi2702.
MGIiMGI:95716. Gja5.

Phylogenomic databases

eggNOGiNOG45265.
GeneTreeiENSGT00800000124029.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ01231.
KOiK07614.
OMAiHKHSTVI.
TreeFamiTF329606.

Miscellaneous databases

NextBioi286420.
PROiQ01231.
SOURCEiSearch...

Gene expression databases

BgeeiQ01231.
CleanExiMM_GJA5.
ExpressionAtlasiQ01231. baseline and differential.
GenevisibleiQ01231. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
    Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
    J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCXA5_MOUSE
AccessioniPrimary (citable) accession number: Q01231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.