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Q01231

- CXA5_MOUSE

UniProt

Q01231 - CXA5_MOUSE

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Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: Ensembl
  2. gap junction hemi-channel activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. artery morphogenesis Source: BHF-UCL
  3. atrial cardiac muscle cell action potential Source: Ensembl
  4. atrial septum morphogenesis Source: MGI
  5. atrial ventricular junction remodeling Source: MGI
  6. AV node cell to bundle of His cell communication Source: MGI
  7. blood vessel development Source: MGI
  8. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  9. cardiac conduction Source: MGI
  10. cardiac conduction system development Source: MGI
  11. cell communication by chemical coupling Source: Ensembl
  12. cell communication by electrical coupling involved in cardiac conduction Source: MGI
  13. cell communication involved in cardiac conduction Source: MGI
  14. embryonic heart tube development Source: MGI
  15. embryonic limb morphogenesis Source: MGI
  16. endothelium development Source: Ensembl
  17. foramen ovale closure Source: MGI
  18. gap junction assembly Source: Ensembl
  19. mitral valve development Source: Ensembl
  20. negative regulation of blood pressure Source: Ensembl
  21. negative regulation of glomerular filtration Source: Ensembl
  22. outflow tract morphogenesis Source: Ensembl
  23. positive regulation of cell communication by chemical coupling Source: Ensembl
  24. positive regulation of vasoconstriction Source: Ensembl
  25. positive regulation of vasodilation Source: Ensembl
  26. potassium ion transport Source: Ensembl
  27. protein oligomerization Source: Ensembl
  28. pulmonary valve formation Source: Ensembl
  29. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  30. regulation of heart rate by cardiac conduction Source: MGI
  31. regulation of membrane depolarization during cardiac muscle cell action potential Source: MGI
  32. regulation of renin secretion into blood stream Source: MGI
  33. regulation of systemic arterial blood pressure Source: MGI
  34. regulation of vasodilation Source: MGI
  35. regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
  36. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  37. renal system process involved in regulation of systemic arterial blood pressure Source: MGI
  38. SA node cell action potential Source: MGI
  39. septum primum development Source: MGI
  40. skeletal system development Source: MGI
  41. vasomotion Source: Ensembl
  42. ventricular cardiac muscle cell action potential Source: MGI
  43. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:Gja5
Synonyms:Cxn-40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95716. Gja5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 16467CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 20520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 358132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. connexon complex Source: Ensembl
  3. gap junction Source: MGI
  4. integral component of plasma membrane Source: Ensembl
  5. intercalated disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Gap junction alpha-5 proteinPRO_0000057820Add
BLAST

Proteomic databases

PRIDEiQ01231.

PTM databases

PhosphoSiteiQ01231.

Expressioni

Tissue specificityi

Kidney, heart and skin, but most abundant in lung.

Gene expression databases

BgeeiQ01231.
CleanExiMM_GJA5.
ExpressionAtlasiQ01231. baseline and differential.
GenevestigatoriQ01231.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

DisProtiDP00646.
ProteinModelPortaliQ01231.
SMRiQ01231. Positions 3-229, 251-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45265.
GeneTreeiENSGT00760000118780.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ01231.
KOiK07614.
OMAiDWSFLGE.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL
160 170 180 190 200
NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL
260 270 280 290 300
PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE
310 320 330 340 350
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK

ARSDDLSV
Length:358
Mass (Da):40,413
Last modified:January 23, 2007 - v2
Checksum:iC5418F657142896A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA. Translation: CAA43850.1.
BC053054 mRNA. Translation: AAH53054.1.
CCDSiCCDS17652.1.
PIRiS23111.
RefSeqiNP_001258557.1. NM_001271628.1.
NP_032147.1. NM_008121.3.
UniGeneiMm.281816.

Genome annotation databases

EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123.
GeneIDi14613.
KEGGimmu:14613.
UCSCiuc008qoo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA. Translation: CAA43850.1 .
BC053054 mRNA. Translation: AAH53054.1 .
CCDSi CCDS17652.1.
PIRi S23111.
RefSeqi NP_001258557.1. NM_001271628.1.
NP_032147.1. NM_008121.3.
UniGenei Mm.281816.

3D structure databases

DisProti DP00646.
ProteinModelPortali Q01231.
SMRi Q01231. Positions 3-229, 251-358.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q01231.

Proteomic databases

PRIDEi Q01231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072600 ; ENSMUSP00000088264 ; ENSMUSG00000057123 .
GeneIDi 14613.
KEGGi mmu:14613.
UCSCi uc008qoo.1. mouse.

Organism-specific databases

CTDi 2702.
MGIi MGI:95716. Gja5.

Phylogenomic databases

eggNOGi NOG45265.
GeneTreei ENSGT00760000118780.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi Q01231.
KOi K07614.
OMAi DWSFLGE.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286420.
PROi Q01231.
SOURCEi Search...

Gene expression databases

Bgeei Q01231.
CleanExi MM_GJA5.
ExpressionAtlasi Q01231. baseline and differential.
Genevestigatori Q01231.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
    Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
    J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCXA5_MOUSE
AccessioniPrimary (citable) accession number: Q01231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3