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Q01231 (CXA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name=Cx40
Gene names
Name:Gja5
Synonyms:Cxn-40
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Kidney, heart and skin, but most abundant in lung.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Gap junction
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processAV node cell to bundle of His cell communication

Inferred from mutant phenotype PubMed 10515563. Source: MGI

SA node cell action potential

Inferred from mutant phenotype PubMed 11046183. Source: MGI

angiogenesis

Inferred from electronic annotation. Source: Ensembl

artery morphogenesis

Inferred from mutant phenotype PubMed 20530546. Source: BHF-UCL

atrial cardiac muscle cell action potential

Inferred from electronic annotation. Source: Ensembl

atrial septum morphogenesis

Inferred from mutant phenotype PubMed 10969038. Source: MGI

atrial ventricular junction remodeling

Inferred from mutant phenotype PubMed 10969038. Source: MGI

blood vessel development

Inferred from mutant phenotype PubMed 12435353. Source: MGI

bundle of His cell to Purkinje myocyte communication

Inferred from electronic annotation. Source: Ensembl

cardiac conduction

Inferred from mutant phenotype PubMed 10515563PubMed 10969038PubMed 18599871PubMed 9501069PubMed 9501070. Source: MGI

cardiac conduction system development

Inferred from mutant phenotype PubMed 18599871PubMed 22203979. Source: MGI

cell communication by chemical coupling

Inferred from electronic annotation. Source: Ensembl

cell communication by electrical coupling involved in cardiac conduction

Inferred from mutant phenotype PubMed 11046183. Source: MGI

cell communication involved in cardiac conduction

Inferred from mutant phenotype PubMed 10747000. Source: MGI

embryonic heart tube development

Inferred from mutant phenotype PubMed 14732399PubMed 22203979. Source: MGI

embryonic limb morphogenesis

Inferred from mutant phenotype PubMed 15923624. Source: MGI

endothelium development

Inferred from electronic annotation. Source: Ensembl

foramen ovale closure

Inferred from mutant phenotype PubMed 10969038. Source: MGI

gap junction assembly

Inferred from electronic annotation. Source: Ensembl

mitral valve development

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of glomerular filtration

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell communication by chemical coupling

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

potassium ion transport

Inferred from electronic annotation. Source: Ensembl

protein oligomerization

Inferred from electronic annotation. Source: Ensembl

pulmonary valve formation

Inferred from electronic annotation. Source: Ensembl

regulation of atrial cardiac muscle cell membrane depolarization

Inferred from mutant phenotype PubMed 10515563PubMed 10969038PubMed 9501070. Source: MGI

regulation of heart rate by cardiac conduction

Inferred from mutant phenotype PubMed 11046183. Source: MGI

regulation of membrane depolarization during cardiac muscle cell action potential

Inferred from mutant phenotype PubMed 9501070. Source: MGI

regulation of renin secretion into blood stream

Inferred from mutant phenotype PubMed 17255527. Source: MGI

regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 10747000. Source: MGI

regulation of vasodilation

Inferred from mutant phenotype PubMed 10747000. Source: MGI

regulation of ventricular cardiac muscle cell membrane depolarization

Inferred from mutant phenotype PubMed 10515563PubMed 9501070. Source: MGI

regulation of ventricular cardiac muscle cell membrane repolarization

Inferred from mutant phenotype PubMed 10969038. Source: MGI

renal system process involved in regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 17255527. Source: MGI

septum primum development

Inferred from mutant phenotype PubMed 10969038. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 15923624. Source: MGI

vasomotion

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle cell action potential

Inferred from mutant phenotype PubMed 9501070. Source: MGI

ventricular septum morphogenesis

Inferred from mutant phenotype PubMed 10969038. Source: MGI

   Cellular_componentcell projection

Inferred from electronic annotation. Source: Ensembl

connexon complex

Inferred from electronic annotation. Source: Ensembl

gap junction

Inferred from direct assay PubMed 9501070. Source: MGI

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

intercalated disc

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling

Inferred from electronic annotation. Source: Ensembl

gap junction hemi-channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Gap junction alpha-5 protein
PRO_0000057820

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 7636Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 16467Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 20520Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 358132Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q01231 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: C5418F657142896A

FASTA35840,413
        10         20         30         40         50         60 
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFRCDTIQPG 

        70         80         90        100        110        120 
CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKQKLRD AEKAKEAHRT 

       130        140        150        160        170        180 
GAYEYPVAEK AELSCWKEVD GKIVLQGTLL NTYVCTILIR TTMEVAFIVG QYLLYGIFLD 

       190        200        210        220        230        240 
TLHVCRRSPC PHPVNCYVSR PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK 

       250        260        270        280        290        300 
SRQGVDKHQL PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE 

       310        320        330        340        350 
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK ARSDDLSV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61675 Genomic DNA. Translation: CAA43850.1.
BC053054 mRNA. Translation: AAH53054.1.
PIRS23111.
RefSeqNP_001258557.1. NM_001271628.1.
NP_032147.1. NM_008121.3.
UniGeneMm.281816.

3D structure databases

DisProtDP00646.
ProteinModelPortalQ01231.
SMRQ01231. Positions 3-229, 251-358.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ01231.

Proteomic databases

PRIDEQ01231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123.
GeneID14613.
KEGGmmu:14613.
UCSCuc008qoo.1. mouse.

Organism-specific databases

CTD2702.
MGIMGI:95716. Gja5.

Phylogenomic databases

eggNOGNOG45265.
GeneTreeENSGT00740000115285.
HOGENOMHOG000231127.
HOVERGENHBG009576.
KOK07614.
OMADWSFLGE.
TreeFamTF329606.

Gene expression databases

ArrayExpressQ01231.
BgeeQ01231.
CleanExMM_GJA5.
GenevestigatorQ01231.

Family and domain databases

InterProIPR000500. Connexin.
IPR002264. Connexin40.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286420.
PROQ01231.
SOURCESearch...

Entry information

Entry nameCXA5_MOUSE
AccessionPrimary (citable) accession number: Q01231
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot