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Q01231

- CXA5_MOUSE

UniProt

Q01231 - CXA5_MOUSE

Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: Ensembl
    2. gap junction hemi-channel activity Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. artery morphogenesis Source: BHF-UCL
    3. atrial cardiac muscle cell action potential Source: Ensembl
    4. atrial septum morphogenesis Source: MGI
    5. atrial ventricular junction remodeling Source: MGI
    6. AV node cell to bundle of His cell communication Source: MGI
    7. blood vessel development Source: MGI
    8. bundle of His cell to Purkinje myocyte communication Source: Ensembl
    9. cardiac conduction Source: MGI
    10. cardiac conduction system development Source: MGI
    11. cell communication by chemical coupling Source: Ensembl
    12. cell communication by electrical coupling involved in cardiac conduction Source: MGI
    13. cell communication involved in cardiac conduction Source: MGI
    14. embryonic heart tube development Source: MGI
    15. embryonic limb morphogenesis Source: MGI
    16. endothelium development Source: Ensembl
    17. foramen ovale closure Source: MGI
    18. gap junction assembly Source: Ensembl
    19. mitral valve development Source: Ensembl
    20. negative regulation of blood pressure Source: Ensembl
    21. negative regulation of glomerular filtration Source: Ensembl
    22. outflow tract morphogenesis Source: Ensembl
    23. positive regulation of cell communication by chemical coupling Source: Ensembl
    24. positive regulation of vasoconstriction Source: Ensembl
    25. positive regulation of vasodilation Source: Ensembl
    26. potassium ion transport Source: Ensembl
    27. protein oligomerization Source: Ensembl
    28. pulmonary valve formation Source: Ensembl
    29. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
    30. regulation of heart rate by cardiac conduction Source: MGI
    31. regulation of membrane depolarization during cardiac muscle cell action potential Source: MGI
    32. regulation of renin secretion into blood stream Source: MGI
    33. regulation of systemic arterial blood pressure Source: MGI
    34. regulation of vasodilation Source: MGI
    35. regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
    36. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
    37. renal system process involved in regulation of systemic arterial blood pressure Source: MGI
    38. SA node cell action potential Source: MGI
    39. septum primum development Source: MGI
    40. skeletal system development Source: MGI
    41. vasomotion Source: Ensembl
    42. ventricular cardiac muscle cell action potential Source: MGI
    43. ventricular septum morphogenesis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-5 protein
    Alternative name(s):
    Connexin-40
    Short name:
    Cx40
    Gene namesi
    Name:Gja5
    Synonyms:Cxn-40
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:95716. Gja5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. connexon complex Source: Ensembl
    3. gap junction Source: MGI
    4. integral component of plasma membrane Source: Ensembl
    5. intercalated disc Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Gap junction alpha-5 proteinPRO_0000057820Add
    BLAST

    Proteomic databases

    PRIDEiQ01231.

    PTM databases

    PhosphoSiteiQ01231.

    Expressioni

    Tissue specificityi

    Kidney, heart and skin, but most abundant in lung.

    Gene expression databases

    ArrayExpressiQ01231.
    BgeeiQ01231.
    CleanExiMM_GJA5.
    GenevestigatoriQ01231.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    3D structure databases

    DisProtiDP00646.
    ProteinModelPortaliQ01231.
    SMRiQ01231. Positions 3-229, 251-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 16467CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 20520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 358132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45265.
    GeneTreeiENSGT00740000115285.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    KOiK07614.
    OMAiDWSFLGE.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002264. Connexin40.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF13. PTHR11984:SF13. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01135. CONNEXINA5.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA    50
    DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV 100
    RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL 150
    NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR 200
    PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL 250
    PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE 300
    VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK 350
    ARSDDLSV 358
    Length:358
    Mass (Da):40,413
    Last modified:January 23, 2007 - v2
    Checksum:iC5418F657142896A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61675 Genomic DNA. Translation: CAA43850.1.
    BC053054 mRNA. Translation: AAH53054.1.
    CCDSiCCDS17652.1.
    PIRiS23111.
    RefSeqiNP_001258557.1. NM_001271628.1.
    NP_032147.1. NM_008121.3.
    UniGeneiMm.281816.

    Genome annotation databases

    EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123.
    GeneIDi14613.
    KEGGimmu:14613.
    UCSCiuc008qoo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61675 Genomic DNA. Translation: CAA43850.1 .
    BC053054 mRNA. Translation: AAH53054.1 .
    CCDSi CCDS17652.1.
    PIRi S23111.
    RefSeqi NP_001258557.1. NM_001271628.1.
    NP_032147.1. NM_008121.3.
    UniGenei Mm.281816.

    3D structure databases

    DisProti DP00646.
    ProteinModelPortali Q01231.
    SMRi Q01231. Positions 3-229, 251-358.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q01231.

    Proteomic databases

    PRIDEi Q01231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072600 ; ENSMUSP00000088264 ; ENSMUSG00000057123 .
    GeneIDi 14613.
    KEGGi mmu:14613.
    UCSCi uc008qoo.1. mouse.

    Organism-specific databases

    CTDi 2702.
    MGIi MGI:95716. Gja5.

    Phylogenomic databases

    eggNOGi NOG45265.
    GeneTreei ENSGT00740000115285.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    KOi K07614.
    OMAi DWSFLGE.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286420.
    PROi Q01231.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01231.
    Bgeei Q01231.
    CleanExi MM_GJA5.
    Genevestigatori Q01231.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002264. Connexin40.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF13. PTHR11984:SF13. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01135. CONNEXINA5.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
      Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
      J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCXA5_MOUSE
    AccessioniPrimary (citable) accession number: Q01231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3