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Protein

Protein A52

Gene

VACWR178

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Associates also with host IRAK2 to inhibit NF-kappa-B signaling.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A52
Gene namesi
Ordered Locus Names:VACWR178
ORF Names:A52R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Protein A52PRO_0000099350Add
BLAST

Interactioni

Subunit structurei

Interacts with host TRAF6 and IRAK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF6Q9Y4K32EBI-3863691,EBI-359276From a different organism.

Protein-protein interaction databases

IntActiQ01220. 21 interactions.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi56 – 7015Combined sources
Beta strandi72 – 743Combined sources
Helixi78 – 847Combined sources
Helixi86 – 949Combined sources
Helixi97 – 1037Combined sources
Turni104 – 1074Combined sources
Helixi111 – 12515Combined sources
Helixi131 – 15020Combined sources
Helixi154 – 1574Combined sources
Helixi158 – 16710Combined sources
Helixi170 – 18819Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VVWX-ray1.90A/B37-190[»]
2VVXX-ray2.75A/B37-190[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01220.

Family & Domainsi

Sequence similaritiesi

Belongs to the orthopoxvirus A52R protein family.Curated

Family and domain databases

InterProiIPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKIDISIS GDKFTVTTRR ENEERKKYLP LQKEKTTDVI KPDYLEYDDL
60 70 80 90 100
LDRDEMFTIL EEYFMYRGLL GLRIKYGRLF NEIKKFDNDA EEQFGTIEEL
110 120 130 140 150
KQKLRLNSEE GADNFIDYIK VQKQDIVKLT VYDCISMIGL CACVVDVWRN
160 170 180 190
EKLFSRWKYC LRAIKLFIND HMLDKIKSIL QNRLVYVEMS
Length:190
Mass (Da):22,770
Last modified:April 1, 1993 - v1
Checksum:i747CCF0DC8FB7926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01826.1.
AY243312 Genomic DNA. Translation: AAO89457.1.
PIRiJQ1790.
RefSeqiYP_233060.1. NC_006998.1.

Genome annotation databases

GeneIDi3707707.
KEGGivg:3707707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01826.1.
AY243312 Genomic DNA. Translation: AAO89457.1.
PIRiJQ1790.
RefSeqiYP_233060.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VVWX-ray1.90A/B37-190[»]
2VVXX-ray2.75A/B37-190[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01220. 21 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707707.
KEGGivg:3707707.

Miscellaneous databases

EvolutionaryTraceiQ01220.

Family and domain databases

InterProiIPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat."
    Smith G.L., Chan Y.S., Howard S.T.
    J. Gen. Virol. 72:1349-1376(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb."
    Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense."
    Harte M.T., Haga I.R., Maloney G., Gray P., Reading P.C., Bartlett N.W., Smith G.L., Bowie A., O'Neill L.A.
    J. Exp. Med. 197:343-351(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10."
    Maloney G., Schroder M., Bowie A.G.
    J. Biol. Chem. 280:30838-30844(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST TRAF6 AND IRAK2.
  5. "Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis."
    Graham S.C., Bahar M.W., Cooray S., Chen R.A., Whalen D.M., Abrescia N.G., Alderton D., Owens R.J., Stuart D.I., Smith G.L., Grimes J.M.
    PLoS Pathog. 4:E1000128-E1000128(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 37-190.

Entry informationi

Entry nameiA52_VACCW
AccessioniPrimary (citable) accession number: Q01220
Secondary accession number(s): Q76ZM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 11, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.