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Protein

Protein A52

Gene

VACWR178

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Associates also with host IRAK2 to inhibit NF-kappa-B signaling.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A52
Gene namesi
Ordered Locus Names:VACWR178
ORF Names:A52R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000993501 – 190Protein A52Add BLAST190

Interactioni

Subunit structurei

Interacts with host TRAF6 and IRAK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF6Q9Y4K32EBI-3863691,EBI-359276From a different organism.

Protein-protein interaction databases

IntActiQ01220. 21 interactors.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 70Combined sources15
Beta strandi72 – 74Combined sources3
Helixi78 – 84Combined sources7
Helixi86 – 94Combined sources9
Helixi97 – 103Combined sources7
Turni104 – 107Combined sources4
Helixi111 – 125Combined sources15
Helixi131 – 150Combined sources20
Helixi154 – 157Combined sources4
Helixi158 – 167Combined sources10
Helixi170 – 188Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VVWX-ray1.90A/B37-190[»]
2VVXX-ray2.75A/B37-190[»]
SMRiQ01220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01220.

Family & Domainsi

Sequence similaritiesi

Belongs to the orthopoxvirus A52R protein family.Curated

Family and domain databases

InterProiIPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKIDISIS GDKFTVTTRR ENEERKKYLP LQKEKTTDVI KPDYLEYDDL
60 70 80 90 100
LDRDEMFTIL EEYFMYRGLL GLRIKYGRLF NEIKKFDNDA EEQFGTIEEL
110 120 130 140 150
KQKLRLNSEE GADNFIDYIK VQKQDIVKLT VYDCISMIGL CACVVDVWRN
160 170 180 190
EKLFSRWKYC LRAIKLFIND HMLDKIKSIL QNRLVYVEMS
Length:190
Mass (Da):22,770
Last modified:April 1, 1993 - v1
Checksum:i747CCF0DC8FB7926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01826.1.
AY243312 Genomic DNA. Translation: AAO89457.1.
PIRiJQ1790.
RefSeqiYP_233060.1. NC_006998.1.

Genome annotation databases

GeneIDi3707707.
KEGGivg:3707707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01826.1.
AY243312 Genomic DNA. Translation: AAO89457.1.
PIRiJQ1790.
RefSeqiYP_233060.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VVWX-ray1.90A/B37-190[»]
2VVXX-ray2.75A/B37-190[»]
SMRiQ01220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01220. 21 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707707.
KEGGivg:3707707.

Miscellaneous databases

EvolutionaryTraceiQ01220.

Family and domain databases

InterProiIPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA52_VACCW
AccessioniPrimary (citable) accession number: Q01220
Secondary accession number(s): Q76ZM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.