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Protein

4-dihydromethyl-trisporate dehydrogenase

Gene

tdh

Organism
Mucor mucedo (Common pinmould)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.1 Publication

Pathwayi: trisporate biosynthesis

This protein is involved in the pathway trisporate biosynthesis, which is part of Pheromone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway trisporate biosynthesis and in Pheromone biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton donorBy similarity
Sitei80 – 801Lowers pKa of active site TyrBy similarity
Binding sitei113 – 1131SubstrateBy similarity

GO - Molecular functioni

  • oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor Source: UniProtKB

GO - Biological processi

  • trisporic acid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00170.

Names & Taxonomyi

Protein namesi
Recommended name:
4-dihydromethyl-trisporate dehydrogenase (EC:1.1.1.-)
Short name:
4-dihydromethyl-TA dehydrogenase
Gene namesi
Name:tdh
OrganismiMucor mucedo (Common pinmould)Imported
Taxonomic identifieri29922 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3213214-dihydromethyl-trisporate dehydrogenasePRO_0000124677Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDYLTLNR TGDKMPIRGF GCWKIDTKDC EETVYQAIKT GYRLFDGACD
60 70 80 90 100
YGNEVEVGRG INKAINEGLV KREDLFIVTK LWNTFHSKKH VRALFDRQLK
110 120 130 140 150
DTGLEYFDLY LIHFPVPLQY VDPATVYPPG WYVGDAKSLQ FEQSPIHECW
160 170 180 190 200
AELEKIVDAG LARNIGVANF NCQAILDLLT YARIKPAVLQ IELHPYLPQE
210 220 230 240 250
RLVKWVKEQG IQITAYSSFG PTSYVDLTES GKTYTSLLEH ASVKSVADKH
260 270 280 290 300
NVSTGQVLLR WALDREFAVI PKSVNAGRMK ANLEILDIKL DAEDNKTLDS
310 320
LKTNQRFNDP MTYGFGLPLF D
Length:321
Mass (Da):36,484
Last modified:November 1, 1996 - v1
Checksum:iAA64AED8DC95EC37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401T → M AA sequence (PubMed:8828234).Curated
Sequence conflicti49 – 491C → E AA sequence (PubMed:8828234).Curated
Sequence conflicti255 – 2551G → N AA sequence (PubMed:8828234).Curated
Sequence conflicti271 – 2711P → I AA sequence (PubMed:8828234).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73640 Genomic DNA. Translation: CAA98021.1.
AJ831376 Genomic DNA. Translation: CAH40839.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73640 Genomic DNA. Translation: CAA98021.1.
AJ831376 Genomic DNA. Translation: CAH40839.1.

3D structure databases

ProteinModelPortaliQ01213.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00170.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTDH_MUCMU
AccessioniPrimary (citable) accession number: Q01213
Secondary accession number(s): Q659V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.