Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

4-dihydromethyl-trisporate dehydrogenase

Gene

tdh

Organism
Mucor mucedo (Common pinmould)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.1 Publication

Pathwayi: trisporate biosynthesis

This protein is involved in the pathway trisporate biosynthesis, which is part of Pheromone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway trisporate biosynthesis and in Pheromone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton donorBy similarity1
Sitei80Lowers pKa of active site TyrBy similarity1
Binding sitei113SubstrateBy similarity1

GO - Molecular functioni

  • oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor Source: UniProtKB

GO - Biological processi

  • trisporic acid biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00170

Names & Taxonomyi

Protein namesi
Recommended name:
4-dihydromethyl-trisporate dehydrogenase (EC:1.1.1.-)
Short name:
4-dihydromethyl-TA dehydrogenase
Gene namesi
Name:tdh
OrganismiMucor mucedo (Common pinmould)Imported
Taxonomic identifieri29922 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246771 – 3214-dihydromethyl-trisporate dehydrogenaseAdd BLAST321

Structurei

3D structure databases

ProteinModelPortaliQ01213
SMRiQ01213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q01213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDYLTLNR TGDKMPIRGF GCWKIDTKDC EETVYQAIKT GYRLFDGACD
60 70 80 90 100
YGNEVEVGRG INKAINEGLV KREDLFIVTK LWNTFHSKKH VRALFDRQLK
110 120 130 140 150
DTGLEYFDLY LIHFPVPLQY VDPATVYPPG WYVGDAKSLQ FEQSPIHECW
160 170 180 190 200
AELEKIVDAG LARNIGVANF NCQAILDLLT YARIKPAVLQ IELHPYLPQE
210 220 230 240 250
RLVKWVKEQG IQITAYSSFG PTSYVDLTES GKTYTSLLEH ASVKSVADKH
260 270 280 290 300
NVSTGQVLLR WALDREFAVI PKSVNAGRMK ANLEILDIKL DAEDNKTLDS
310 320
LKTNQRFNDP MTYGFGLPLF D
Length:321
Mass (Da):36,484
Last modified:November 1, 1996 - v1
Checksum:iAA64AED8DC95EC37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40T → M AA sequence (PubMed:8828234).Curated1
Sequence conflicti49C → E AA sequence (PubMed:8828234).Curated1
Sequence conflicti255G → N AA sequence (PubMed:8828234).Curated1
Sequence conflicti271P → I AA sequence (PubMed:8828234).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73640 Genomic DNA Translation: CAA98021.1
AJ831376 Genomic DNA Translation: CAH40839.1

Similar proteinsi

Entry informationi

Entry nameiDTDH_MUCMU
AccessioniPrimary (citable) accession number: Q01213
Secondary accession number(s): Q659V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health