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Q01166 (BLAC_YEREN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:blaA
OrganismYersinia enterocolitica
Taxonomic identifier630 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 294264Beta-lactamase
PRO_0000017022

Regions

Region239 – 2413Substrate binding By similarity

Sites

Active site751Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01166 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 45E5B721A98B98C5

FASTA29431,931
        10         20         30         40         50         60 
MKHSSLRRSL LLAGITLPLV SFALPAWANA LPASVDKQLA ELERNANGRL GVAMINTGNG 

        70         80         90        100        110        120 
TKILYRAAQR FPFCSTFKFM LAAAVLDQSQ SQPNLLNKHI NYHESDLLSY APITRKNLAH 

       130        140        150        160        170        180 
GMTVSELCAA TIQYSDNTAA NLLIKELGGL AAVNQFARSI GDQMFRLDRW EPDLNTARPN 

       190        200        210        220        230        240 
DPRDTTTPAA MAASMNKLVL GDALRPAQRS QLAVWLKGNT TGDATIRAGA PTDWIVGDKT 

       250        260        270        280        290 
GSGDYGTTND IAVLWPTKGA PIVLVVYFTQ REKDAKPRRD VLASVTKIIL SQIS 

« Hide

References

[1]"Nucleotide sequence of a new class A beta-lactamase gene from the chromosome of Yersinia enterocolitica: implications for the evolution of class A beta-lactamases."
Seoane A., Garcia Lobo J.M.
Mol. Gen. Genet. 228:215-220(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Y-56 / Serotype O:3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57074 Genomic DNA. Translation: CAA40357.1.
PIRS16553.

3D structure databases

ProteinModelPortalQ01166.
SMRQ01166. Positions 34-289.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_YEREN
AccessionPrimary (citable) accession number: Q01166
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families