Reviewed, UniProtKB/Swiss-Prot Q01166 (BLAC_YEREN)

Names and origin

Protein names

Recommended name:
    Beta-lactamase
    EC=3.5.2.6
Alternative name(s):
    Penicillinase

Gene names

Name:

blaA

Organism

Yersinia enterocolitica

Taxonomic identifier

630 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Sequence similarities	Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 294	264	Beta-lactamase		PRO_0000017022
Regions
	Region	239 – 241	3	Substrate binding By similarity
Sites
	Active site	75	1	Acyl-ester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q01166-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 45E5B721A98B98C5	FASTA	294	31,931
	10 20 30 40 50 60 MKHSSLRRSL LLAGITLPLV SFALPAWANA LPASVDKQLA ELERNANGRL GVAMINTGNG 70 80 90 100 110 120 TKILYRAAQR FPFCSTFKFM LAAAVLDQSQ SQPNLLNKHI NYHESDLLSY APITRKNLAH 130 140 150 160 170 180 GMTVSELCAA TIQYSDNTAA NLLIKELGGL AAVNQFARSI GDQMFRLDRW EPDLNTARPN 190 200 210 220 230 240 DPRDTTTPAA MAASMNKLVL GDALRPAQRS QLAVWLKGNT TGDATIRAGA PTDWIVGDKT 250 260 270 280 290 GSGDYGTTND IAVLWPTKGA PIVLVVYFTQ REKDAKPRRD VLASVTKIIL SQIS

References

[1]

"Nucleotide sequence of a new class A beta-lactamase gene from the chromosome of Yersinia enterocolitica: implications for the evolution of class A beta-lactamases." Seoane A., Garcia Lobo J.M. Mol. Gen. Genet. 228:215-220(1991) [PubMed: 1886608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Y-56 / Serotype O:3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X57074 Genomic DNA. Translation: CAA40357.1.
PIR	S16553.
3D structure databases
HSSP	HSSP built from PDB template 1BZA based on UniProtKB Q47066.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.5.2.6. 74505.
Family and domain databases
InterPro	IPR001466. Beta_lactamase-related. IPR000871. Beta_lactamase_A/D. [Graphical view]
Pfam	PF00144. Beta-lactamase. 1 hit. [Graphical view]
PRINTS	PR00118. BLACTAMASEA.
PROSITE	PS00146. BETA_LACTAMASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BLAC_YEREN

Accession

Primary (citable) accession number: Q01166

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)