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Q01166

- BLAC_YEREN

UniProt

Q01166 - BLAC_YEREN

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Protein
Beta-lactamase
Gene
blaA
Organism
Yersinia enterocolitica
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaA
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 294264Beta-lactamase
PRO_0000017022Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01166.
SMRiQ01166. Positions 34-289.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni239 – 2413Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01166-1 [UniParc]FASTAAdd to Basket

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MKHSSLRRSL LLAGITLPLV SFALPAWANA LPASVDKQLA ELERNANGRL    50
GVAMINTGNG TKILYRAAQR FPFCSTFKFM LAAAVLDQSQ SQPNLLNKHI 100
NYHESDLLSY APITRKNLAH GMTVSELCAA TIQYSDNTAA NLLIKELGGL 150
AAVNQFARSI GDQMFRLDRW EPDLNTARPN DPRDTTTPAA MAASMNKLVL 200
GDALRPAQRS QLAVWLKGNT TGDATIRAGA PTDWIVGDKT GSGDYGTTND 250
IAVLWPTKGA PIVLVVYFTQ REKDAKPRRD VLASVTKIIL SQIS 294
Length:294
Mass (Da):31,931
Last modified:April 1, 1993 - v1
Checksum:i45E5B721A98B98C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57074 Genomic DNA. Translation: CAA40357.1.
PIRiS16553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57074 Genomic DNA. Translation: CAA40357.1 .
PIRi S16553.

3D structure databases

ProteinModelPortali Q01166.
SMRi Q01166. Positions 34-289.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a new class A beta-lactamase gene from the chromosome of Yersinia enterocolitica: implications for the evolution of class A beta-lactamases."
    Seoane A., Garcia Lobo J.M.
    Mol. Gen. Genet. 228:215-220(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Y-56 / Serotype O:3.

Entry informationi

Entry nameiBLAC_YEREN
AccessioniPrimary (citable) accession number: Q01166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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