ID   LUCI_LUCLA              Reviewed;         548 AA.
AC   Q01158;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=Luciferin 4-monooxygenase;
DE            Short=Luciferase;
DE            EC=1.13.12.7;
OS   Luciola lateralis (Firefly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Elateroidea; Lampyridae; Luciolinae; Luciola.
OX   NCBI_TaxID=7052;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92305054; PubMed=1610896; DOI=10.1016/0167-4781(92)90071-7;
RA   Tatsumi H., Kajiyama N., Nakano E.;
RT   "Molecular cloning and expression in Escherichia coli of a cDNA clone
RT   encoding luciferase of a firefly, Luciola lateralis.";
RL   Biochim. Biophys. Acta 1131:161-165(1992).
CC   -!- FUNCTION: Produces green light.
CC   -!- CATALYTIC ACTIVITY: Photinus luciferin + O(2) + ATP = oxidized
CC       Photinus luciferin + CO(2) + AMP + diphosphate + light.
CC   -!- COFACTOR: Magnesium.
CC   -!- SUBCELLULAR LOCATION: Peroxisome (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family.
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DR   EMBL; X66919; CAA47358.1; -; mRNA.
DR   PIR; S23437; S23437.
DR   HSSP; P08659; 1LCI.
DR   SMR; Q01158; 7-545.
DR   BRENDA; 1.13.12.7; 262202.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0047077; F:Photinus-luciferin 4-monooxygenase (ATP-hyd...; IEA:EC.
DR   GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Luminescence; Magnesium; Metal-binding; Monooxygenase;
KW   Nucleotide-binding; Oxidoreductase; Peroxisome; Photoprotein.
FT   CHAIN         1    548       Luciferin 4-monooxygenase.
FT                                /FTId=PRO_0000193144.
FT   MOTIF       546    548       Microbody targeting signal (Potential).
SQ   SEQUENCE   548 AA;  60125 MW;  AC62F9320BB6D4A6 CRC64;
     MENMENDENI VYGPEPFYPI EEGSAGAQLR KYMDRYAKLG AIAFTNALTG VDYTYAEYLE
     KSCCLGEALK NYGLVVDGRI ALCSENCEEF FIPVLAGLFI GVGVAPTNEI YTLRELVHSL
     GISKPTIVFS SKKGLDKVIT VQKTVTAIKT IVILDSKVDY RGYQSMDNFI KKNTPQGFKG
     SSFKTVEVNR KEQVALIMNS SGSTGLPKGV QLTHENAVTR FSHARDPIYG NQVSPGTAIL
     TVVPFHHGFG MFTTLGYLTC GFRIVMLTKF DEETFLKTLQ DYKCSSVILV PTLFAILNRS
     ELLDKYDLSN LVEIASGGAP LSKEIGEAVA RRFNLPGVRQ GYGLTETTSA IIITPEGDDK
     PGASGKVVPL FKAKVIDLDT KKTLGPNRRG EVCVKGPMLM KGYVDNPEAT REIIDEEGWL
     HTGDIGYYDE EKHFFIVDRL KSLIKYKGYQ VPPAELESVL LQHPNIFDAG VAGVPDPIAG
     ELPGAVVVLE KGKSMTEKEV MDYVASQVSN AKRLRGGVRF VDEVPKGLTG KIDGKAIREI
     LKKPVAKM
//