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Q01151

- CD83_HUMAN

UniProt

Q01151 - CD83_HUMAN

Protein

CD83 antigen

Gene

CD83

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

    GO - Biological processi

    1. defense response Source: ProtInc
    2. humoral immune response Source: ProtInc
    3. negative regulation of interleukin-4 production Source: Ensembl
    4. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
    5. positive regulation of interleukin-10 production Source: Ensembl
    6. positive regulation of interleukin-2 production Source: Ensembl
    7. response to organic cyclic compound Source: Ensembl
    8. signal transduction Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD83 antigen
    Short name:
    hCD83
    Alternative name(s):
    B-cell activation protein
    Cell surface protein HB15
    CD_antigen: CD83
    Gene namesi
    Name:CD83
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1703. CD83.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26241.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 205186CD83 antigenPRO_0000014657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 107PROSITE-ProRule annotation
    Glycosylationi79 – 791N-linked (GlcNAc...)1 Publication
    Glycosylationi86 – 861N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ01151.
    PaxDbiQ01151.
    PRIDEiQ01151.

    PTM databases

    PhosphoSiteiQ01151.

    Expressioni

    Tissue specificityi

    Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

    Gene expression databases

    BgeeiQ01151.
    CleanExiHS_CD83.
    GenevestigatoriQ01151.

    Organism-specific databases

    HPAiCAB002509.
    HPA043887.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi114721. 2 interactions.
    IntActiQ01151. 2 interactions.
    STRINGi9606.ENSP00000368450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01151.
    SMRiQ01151. Positions 16-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 144125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20539CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei145 – 16622HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11495Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44884.
    HOGENOMiHOG000057288.
    HOVERGENiHBG005291.
    InParanoidiQ01151.
    KOiK06510.
    OMAiDLPCTAP.
    OrthoDBiEOG70GMH9.
    PhylomeDBiQ01151.
    TreeFamiTF337861.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01151-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV    50
    KLLEGGEERM ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC 100
    NSGTYRCTLQ DPDGQRNLSG KVILRVTGCP AQRKEETFKK YRAEIVLLLA 150
    LVIFYLTLII FTCKFARLQS IFPDFSKAGM ERAFLPVTSP NKHLGLVTPH 200
    KTELV 205
    Length:205
    Mass (Da):23,042
    Last modified:April 1, 1993 - v1
    Checksum:i1D77133595F2B852
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821R → Q.
    Corresponds to variant rs2230193 [ dbSNP | Ensembl ].
    VAR_033609

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11697 mRNA. Translation: CAA77755.1.
    S53354 mRNA. Translation: AAB25085.1.
    CR457019 mRNA. Translation: CAG33300.1.
    AL133259, AL022396 Genomic DNA. Translation: CAB96723.2.
    AL022396, AL133259 Genomic DNA. Translation: CAI20374.1.
    BC030830 mRNA. Translation: AAH30830.1.
    CCDSiCCDS4532.1.
    PIRiA48929.
    RefSeqiNP_001035370.1. NM_001040280.1.
    NP_001238830.1. NM_001251901.1.
    NP_004224.1. NM_004233.3.
    UniGeneiHs.595133.

    Genome annotation databases

    EnsembliENST00000379153; ENSP00000368450; ENSG00000112149.
    GeneIDi9308.
    KEGGihsa:9308.
    UCSCiuc003nbh.3. human.

    Polymorphism databases

    DMDMi232223.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    CD83 antigen

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11697 mRNA. Translation: CAA77755.1 .
    S53354 mRNA. Translation: AAB25085.1 .
    CR457019 mRNA. Translation: CAG33300.1 .
    AL133259 , AL022396 Genomic DNA. Translation: CAB96723.2 .
    AL022396 , AL133259 Genomic DNA. Translation: CAI20374.1 .
    BC030830 mRNA. Translation: AAH30830.1 .
    CCDSi CCDS4532.1.
    PIRi A48929.
    RefSeqi NP_001035370.1. NM_001040280.1.
    NP_001238830.1. NM_001251901.1.
    NP_004224.1. NM_004233.3.
    UniGenei Hs.595133.

    3D structure databases

    ProteinModelPortali Q01151.
    SMRi Q01151. Positions 16-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114721. 2 interactions.
    IntActi Q01151. 2 interactions.
    STRINGi 9606.ENSP00000368450.

    PTM databases

    PhosphoSitei Q01151.

    Polymorphism databases

    DMDMi 232223.

    Proteomic databases

    MaxQBi Q01151.
    PaxDbi Q01151.
    PRIDEi Q01151.

    Protocols and materials databases

    DNASUi 9308.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379153 ; ENSP00000368450 ; ENSG00000112149 .
    GeneIDi 9308.
    KEGGi hsa:9308.
    UCSCi uc003nbh.3. human.

    Organism-specific databases

    CTDi 9308.
    GeneCardsi GC06P014063.
    HGNCi HGNC:1703. CD83.
    HPAi CAB002509.
    HPA043887.
    MIMi 604534. gene.
    neXtProti NX_Q01151.
    PharmGKBi PA26241.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44884.
    HOGENOMi HOG000057288.
    HOVERGENi HBG005291.
    InParanoidi Q01151.
    KOi K06510.
    OMAi DLPCTAP.
    OrthoDBi EOG70GMH9.
    PhylomeDBi Q01151.
    TreeFami TF337861.

    Miscellaneous databases

    GeneWikii CD83.
    GenomeRNAii 9308.
    NextBioi 34865.
    PROi Q01151.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01151.
    CleanExi HS_CD83.
    Genevestigatori Q01151.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily."
      Zhou L.-J., Schwarting R., Smith H.M., Tedder T.F.
      J. Immunol. 149:735-742(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Tonsil.
    2. "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes."
      Kozlow E.J., Wilson G.L., Fox C.H., Kehrl J.H.
      Blood 81:454-461(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: B-cell.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-86.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCD83_HUMAN
    AccessioniPrimary (citable) accession number: Q01151
    Secondary accession number(s): Q5THX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3