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Reviewed, UniProtKB/Swiss-Prot Q01151 (CD83_HUMAN)

Last modified January 19, 2010. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CD83 antigen
      Short name=hCD83
Alternative name(s):
    Cell surface protein HB15
    B-cell activation protein
    CD_antigen=CD83
Gene names
Name: CD83
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Subunit structure

Monomer.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processdefense response Ref.1

Traceable author statement. Source: ProtInc

humoral immune response Ref.2

Traceable author statement. Source: ProtInc

signal transduction

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 205186CD83 antigen
PRO_0000014657

Regions

Topological domain20 – 144125Extracellular Potential
Transmembrane145 – 16622 Potential
Topological domain167 – 20539Cytoplasmic Potential
Domain20 – 11495Ig-like V-type

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Ref.7
Glycosylation861N-linked (GlcNAc...) Ref.7
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 107 Potential

Natural variations

Natural variant1821R → Q: dbSNP rs2230193.
VAR_033609

Sequences

Sequence LengthMass (Da)Tools
Q01151-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 1D77133595F2B852

FASTA20523,042
        10         20         30         40         50         60 
MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV KLLEGGEERM 

        70         80         90        100        110        120 
ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC NSGTYRCTLQ DPDGQRNLSG 

       130        140        150        160        170        180 
KVILRVTGCP AQRKEETFKK YRAEIVLLLA LVIFYLTLII FTCKFARLQS IFPDFSKAGM 

       190        200 
ERAFLPVTSP NKHLGLVTPH KTELV 

« Hide

References

« Hide 'large scale' references
[1]"A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily."
Zhou L.-J., Schwarting R., Smith H.M., Tedder T.F.
J. Immunol. 149:735-742(1992) [PubMed: 1378080] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tonsil.
[2]"Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes."
Kozlow E.J., Wilson G.L., Fox C.H., Kehrl J.H.
Blood 81:454-461(1993) [PubMed: 8422464] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-86, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11697 mRNA. Translation: CAA77755.1.
S53354 mRNA. Translation: AAB25085.1.
CR457019 mRNA. Translation: CAG33300.1.
AL133259, AL022396 Genomic DNA. Translation: CAB96723.2.
AL022396, AL133259 Genomic DNA. Translation: CAI20374.1.
BC030830 mRNA. Translation: AAH30830.1.
IPIIPI00006003.
PIRA48929.
RefSeqNP_001035370.1.
NP_004224.1.
UniGeneHs.595133
Hs.654558

3D structure databases

SMRQ01151. Positions 19-131.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ01151.

PTM databases

PhosphoSiteQ01151.

Proteomic databases

PRIDEQ01151.

Genome annotation databases

EnsemblENST00000379153; ENSP00000368450; ENSG00000112149; Homo sapiens. [Genome view]
GeneID9308.
KEGGhsa:9308.
UCSCuc003nbh.1. human.
uc003nbi.1. human.

Organism-specific databases

CTD9308.
GeneCardsGC06P014225.
H-InvDBHIX0005593.
HGNCHGNC:1703. CD83.
HPACAB002509.
MIM604534. gene.
PharmGKBPA26241.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11350.
HOGENOMHBG125262.
HOVERGENQ01151.
InParanoidQ01151.
OMAEVKVACS.
OrthoDBEOG9J9QK6.
PhylomeDBQ01151.

Gene expression databases

ArrayExpressQ01151.
BgeeQ01151.
CleanExHS_CD83.
GenevestigatorQ01151.
GermOnlineENSG00000112149. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio34865.
SOURCESearch...

Entry information

Entry nameCD83_HUMAN
AccessionPrimary (citable) accession number: Q01151
Secondary accession number(s): Q5THX9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 19, 2010
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents