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Q01151 (CD83_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD83 antigen

Short name=hCD83
Alternative name(s):
B-cell activation protein
Cell surface protein HB15
CD_antigen=CD83
Gene names
Name:CD83
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Subunit structure

Monomer.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 205186CD83 antigen
PRO_0000014657

Regions

Topological domain20 – 144125Extracellular Potential
Transmembrane145 – 16622Helical; Potential
Topological domain167 – 20539Cytoplasmic Potential
Domain20 – 11495Ig-like V-type

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Ref.8
Glycosylation861N-linked (GlcNAc...); atypical Ref.8
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 107 Potential

Natural variations

Natural variant1821R → Q.
Corresponds to variant rs2230193 [ dbSNP | Ensembl ].
VAR_033609

Sequences

Sequence LengthMass (Da)Tools
Q01151 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 1D77133595F2B852

FASTA20523,042
        10         20         30         40         50         60 
MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV KLLEGGEERM 

        70         80         90        100        110        120 
ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC NSGTYRCTLQ DPDGQRNLSG 

       130        140        150        160        170        180 
KVILRVTGCP AQRKEETFKK YRAEIVLLLA LVIFYLTLII FTCKFARLQS IFPDFSKAGM 

       190        200 
ERAFLPVTSP NKHLGLVTPH KTELV 

« Hide

References

« Hide 'large scale' references
[1]"A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily."
Zhou L.-J., Schwarting R., Smith H.M., Tedder T.F.
J. Immunol. 149:735-742(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tonsil.
[2]"Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes."
Kozlow E.J., Wilson G.L., Fox C.H., Kehrl J.H.
Blood 81:454-461(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-86.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11697 mRNA. Translation: CAA77755.1.
S53354 mRNA. Translation: AAB25085.1.
CR457019 mRNA. Translation: CAG33300.1.
AL133259, AL022396 Genomic DNA. Translation: CAB96723.2.
AL022396, AL133259 Genomic DNA. Translation: CAI20374.1.
BC030830 mRNA. Translation: AAH30830.1.
PIRA48929.
RefSeqNP_001035370.1. NM_001040280.1.
NP_001238830.1. NM_001251901.1.
NP_004224.1. NM_004233.3.
UniGeneHs.595133.

3D structure databases

ProteinModelPortalQ01151.
SMRQ01151. Positions 20-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114721. 2 interactions.
IntActQ01151. 2 interactions.
STRING9606.ENSP00000368450.

PTM databases

PhosphoSiteQ01151.

Polymorphism databases

DMDM232223.

Proteomic databases

PaxDbQ01151.
PRIDEQ01151.

Protocols and materials databases

DNASU9308.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379153; ENSP00000368450; ENSG00000112149.
GeneID9308.
KEGGhsa:9308.
UCSCuc003nbh.3. human.

Organism-specific databases

CTD9308.
GeneCardsGC06P014063.
HGNCHGNC:1703. CD83.
HPACAB002509.
HPA043887.
MIM604534. gene.
neXtProtNX_Q01151.
PharmGKBPA26241.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44884.
HOGENOMHOG000057288.
HOVERGENHBG005291.
InParanoidQ01151.
KOK06510.
OMADLPCTAP.
OrthoDBEOG70GMH9.
PhylomeDBQ01151.
TreeFamTF337861.

Gene expression databases

BgeeQ01151.
CleanExHS_CD83.
GenevestigatorQ01151.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD83.
GenomeRNAi9308.
NextBio34865.
PROQ01151.
SOURCESearch...

Entry information

Entry nameCD83_HUMAN
AccessionPrimary (citable) accession number: Q01151
Secondary accession number(s): Q5THX9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries