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Protein

CD83 antigen

Gene

CD83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
hCD83
Alternative name(s):
B-cell activation protein
Cell surface protein HB15
CD_antigen: CD83
Gene namesi
Name:CD83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112149.9.
HGNCiHGNC:1703. CD83.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 144ExtracellularSequence analysisAdd BLAST125
Transmembranei145 – 166HelicalSequence analysisAdd BLAST22
Topological domaini167 – 205CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9308.
OpenTargetsiENSG00000112149.
PharmGKBiPA26241.

Polymorphism and mutation databases

BioMutaiCD83.
DMDMi232223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001465720 – 205CD83 antigenAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 107PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi86N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ01151.
PaxDbiQ01151.
PeptideAtlasiQ01151.
PRIDEiQ01151.

PTM databases

iPTMnetiQ01151.
PhosphoSitePlusiQ01151.
SwissPalmiQ01151.

Expressioni

Tissue specificityi

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

Gene expression databases

BgeeiENSG00000112149.
CleanExiHS_CD83.
ExpressionAtlasiQ01151. baseline and differential.
GenevisibleiQ01151. HS.

Organism-specific databases

HPAiCAB002509.
HPA041454.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi114721. 50 interactors.
IntActiQ01151. 4 interactors.
STRINGi9606.ENSP00000368450.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi31 – 33Combined sources3
Beta strandi46 – 52Combined sources7
Beta strandi92 – 94Combined sources3
Helixi99 – 101Combined sources3
Beta strandi103 – 110Combined sources8
Beta strandi112 – 115Combined sources4
Beta strandi117 – 126Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MIXX-ray1.70A20-131[»]
5MJ0X-ray3.20A/B20-131[»]
5MJ1X-ray1.80A20-131[»]
5MJ2X-ray1.98A20-131[»]
ProteinModelPortaliQ01151.
SMRiQ01151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 114Ig-like V-typeAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX7. Eukaryota.
ENOG410ZACF. LUCA.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
HOVERGENiHBG005291.
InParanoidiQ01151.
KOiK06510.
OMAiIFTCKFA.
OrthoDBiEOG091G0OEV.
PhylomeDBiQ01151.
TreeFamiTF337861.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV
60 70 80 90 100
KLLEGGEERM ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC
110 120 130 140 150
NSGTYRCTLQ DPDGQRNLSG KVILRVTGCP AQRKEETFKK YRAEIVLLLA
160 170 180 190 200
LVIFYLTLII FTCKFARLQS IFPDFSKAGM ERAFLPVTSP NKHLGLVTPH

KTELV
Length:205
Mass (Da):23,042
Last modified:April 1, 1993 - v1
Checksum:i1D77133595F2B852
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033609182R → Q. Corresponds to variant dbSNP:rs2230193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11697 mRNA. Translation: CAA77755.1.
S53354 mRNA. Translation: AAB25085.1.
CR457019 mRNA. Translation: CAG33300.1.
AL133259, AL022396 Genomic DNA. Translation: CAB96723.2.
AL022396, AL133259 Genomic DNA. Translation: CAI20374.1.
BC030830 mRNA. Translation: AAH30830.1.
CCDSiCCDS4532.1.
PIRiA48929.
RefSeqiNP_001035370.1. NM_001040280.1.
NP_001238830.1. NM_001251901.1.
NP_004224.1. NM_004233.3.
UniGeneiHs.595133.

Genome annotation databases

EnsembliENST00000379153; ENSP00000368450; ENSG00000112149.
GeneIDi9308.
KEGGihsa:9308.
UCSCiuc003nbi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD83_HUMAN
AccessioniPrimary (citable) accession number: Q01151
Secondary accession number(s): Q5THX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 27, 2017
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references