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Q01151

- CD83_HUMAN

UniProt

Q01151 - CD83_HUMAN

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Protein

CD83 antigen

Gene

CD83

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

GO - Biological processi

  1. defense response Source: ProtInc
  2. humoral immune response Source: ProtInc
  3. negative regulation of interleukin-4 production Source: Ensembl
  4. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-2 production Source: Ensembl
  7. response to organic cyclic compound Source: Ensembl
  8. signal transduction Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
hCD83
Alternative name(s):
B-cell activation protein
Cell surface protein HB15
CD_antigen: CD83
Gene namesi
Name:CD83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1703. CD83.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 144125ExtracellularSequence AnalysisAdd
BLAST
Transmembranei145 – 16622HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 20539CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 205186CD83 antigenPRO_0000014657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 107PROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...)1 Publication
Glycosylationi86 – 861N-linked (GlcNAc...); atypical1 Publication
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ01151.
PaxDbiQ01151.
PRIDEiQ01151.

PTM databases

PhosphoSiteiQ01151.

Expressioni

Tissue specificityi

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

Gene expression databases

BgeeiQ01151.
CleanExiHS_CD83.
GenevestigatoriQ01151.

Organism-specific databases

HPAiCAB002509.
HPA043887.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi114721. 2 interactions.
IntActiQ01151. 2 interactions.
STRINGi9606.ENSP00000368450.

Structurei

3D structure databases

ProteinModelPortaliQ01151.
SMRiQ01151. Positions 16-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11495Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44884.
GeneTreeiENSGT00390000007302.
HOGENOMiHOG000057288.
HOVERGENiHBG005291.
InParanoidiQ01151.
KOiK06510.
OMAiDLPCTAP.
OrthoDBiEOG70GMH9.
PhylomeDBiQ01151.
TreeFamiTF337861.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01151-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV
60 70 80 90 100
KLLEGGEERM ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC
110 120 130 140 150
NSGTYRCTLQ DPDGQRNLSG KVILRVTGCP AQRKEETFKK YRAEIVLLLA
160 170 180 190 200
LVIFYLTLII FTCKFARLQS IFPDFSKAGM ERAFLPVTSP NKHLGLVTPH

KTELV
Length:205
Mass (Da):23,042
Last modified:April 1, 1993 - v1
Checksum:i1D77133595F2B852
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821R → Q.
Corresponds to variant rs2230193 [ dbSNP | Ensembl ].
VAR_033609

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11697 mRNA. Translation: CAA77755.1.
S53354 mRNA. Translation: AAB25085.1.
CR457019 mRNA. Translation: CAG33300.1.
AL133259, AL022396 Genomic DNA. Translation: CAB96723.2.
AL022396, AL133259 Genomic DNA. Translation: CAI20374.1.
BC030830 mRNA. Translation: AAH30830.1.
CCDSiCCDS4532.1.
PIRiA48929.
RefSeqiNP_001035370.1. NM_001040280.1.
NP_001238830.1. NM_001251901.1.
NP_004224.1. NM_004233.3.
UniGeneiHs.595133.

Genome annotation databases

EnsembliENST00000379153; ENSP00000368450; ENSG00000112149.
GeneIDi9308.
KEGGihsa:9308.
UCSCiuc003nbh.3. human.

Polymorphism databases

DMDMi232223.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD83 antigen

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11697 mRNA. Translation: CAA77755.1 .
S53354 mRNA. Translation: AAB25085.1 .
CR457019 mRNA. Translation: CAG33300.1 .
AL133259 , AL022396 Genomic DNA. Translation: CAB96723.2 .
AL022396 , AL133259 Genomic DNA. Translation: CAI20374.1 .
BC030830 mRNA. Translation: AAH30830.1 .
CCDSi CCDS4532.1.
PIRi A48929.
RefSeqi NP_001035370.1. NM_001040280.1.
NP_001238830.1. NM_001251901.1.
NP_004224.1. NM_004233.3.
UniGenei Hs.595133.

3D structure databases

ProteinModelPortali Q01151.
SMRi Q01151. Positions 16-115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114721. 2 interactions.
IntActi Q01151. 2 interactions.
STRINGi 9606.ENSP00000368450.

PTM databases

PhosphoSitei Q01151.

Polymorphism databases

DMDMi 232223.

Proteomic databases

MaxQBi Q01151.
PaxDbi Q01151.
PRIDEi Q01151.

Protocols and materials databases

DNASUi 9308.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379153 ; ENSP00000368450 ; ENSG00000112149 .
GeneIDi 9308.
KEGGi hsa:9308.
UCSCi uc003nbh.3. human.

Organism-specific databases

CTDi 9308.
GeneCardsi GC06P014117.
HGNCi HGNC:1703. CD83.
HPAi CAB002509.
HPA043887.
MIMi 604534. gene.
neXtProti NX_Q01151.
PharmGKBi PA26241.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44884.
GeneTreei ENSGT00390000007302.
HOGENOMi HOG000057288.
HOVERGENi HBG005291.
InParanoidi Q01151.
KOi K06510.
OMAi DLPCTAP.
OrthoDBi EOG70GMH9.
PhylomeDBi Q01151.
TreeFami TF337861.

Miscellaneous databases

ChiTaRSi CD83. human.
GeneWikii CD83.
GenomeRNAii 9308.
NextBioi 34865.
PROi Q01151.
SOURCEi Search...

Gene expression databases

Bgeei Q01151.
CleanExi HS_CD83.
Genevestigatori Q01151.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily."
    Zhou L.-J., Schwarting R., Smith H.M., Tedder T.F.
    J. Immunol. 149:735-742(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tonsil.
  2. "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes."
    Kozlow E.J., Wilson G.L., Fox C.H., Kehrl J.H.
    Blood 81:454-461(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: B-cell.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-86.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCD83_HUMAN
AccessioniPrimary (citable) accession number: Q01151
Secondary accession number(s): Q5THX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3