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Protein

Decorin

Gene

Dcn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.By similarity

GO - Molecular functioni

  • collagen binding Source: RGD
  • extracellular matrix binding Source: Ensembl
  • glycosaminoglycan binding Source: Ensembl
  • protein kinase inhibitor activity Source: GO_Central
  • protein N-terminus binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1474228 Degradation of the extracellular matrix
R-RNO-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-RNO-2022870 Chondroitin sulfate biosynthesis
R-RNO-2022923 Dermatan sulfate biosynthesis
R-RNO-2024101 CS/DS degradation
R-RNO-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
Dermatan sulfate proteoglycan-II
Short name:
DSPG
PG-S2
PG40
Gene namesi
Name:Dcn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi61895 Dcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
PropeptideiPRO_000003271917 – 302 PublicationsAdd BLAST14
ChainiPRO_000003272031 – 354DecorinAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Disulfide bondi49 ↔ 55By similarity
Disulfide bondi53 ↔ 62By similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 341By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ01129
PRIDEiQ01129

PTM databases

iPTMnetiQ01129
PhosphoSitePlusiQ01129

Expressioni

Developmental stagei

The amount of DSPG per cervix increases 4-fold during pregnancy, then falls precipitously within 1 day post partum.

Gene expression databases

BgeeiENSRNOG00000004554
GenevisibleiQ01129 RN

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

GO - Molecular functioni

  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi247822, 4 interactors
STRINGi10116.ENSRNOP00000006070

Structurei

3D structure databases

ProteinModelPortaliQ01129
SMRiQ01129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 88LRR 1Add BLAST21
Repeati89 – 112LRR 2Add BLAST24
Repeati113 – 136LRR 3Add BLAST24
Repeati137 – 157LRR 4Add BLAST21
Repeati158 – 181LRR 5Add BLAST24
Repeati182 – 207LRR 6Add BLAST26
Repeati208 – 228LRR 7Add BLAST21
Repeati229 – 252LRR 8Add BLAST24
Repeati253 – 276LRR 9Add BLAST24
Repeati277 – 299LRR 10Add BLAST23
Repeati300 – 329LRR 11Add BLAST30
Repeati330 – 354LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 62Cys-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiQ01129
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B
PhylomeDBiQ01129
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATLVLFLL AQVSWAGPFE QRGLFDFMLE DEASGIIPYD PDNPLISMCP
60 70 80 90 100
YRCQCHLRVV QCSDLGLDKV PWEFPPDTTL LDLQNNKITE IKEGAFKNLK
110 120 130 140 150
DLHTLILVNN KISKISPEAF KPLVKLERLY LSKNHLKELP EKLPKTLQEL
160 170 180 190 200
RLHDNEITKL KKSVFNGLNR MIVIELGGNP LKNSGIENGA LQGMKGLGYI
210 220 230 240 250
RISDTNITAI PQGLPTSISE LHLDGNKIAK VDAASLKGMS NLSKLGLSFN
260 270 280 290 300
SITVVENGSL ANVPHLRELH LDNNKLLRVP AGLAQHKYVQ VVYLHNNNIS
310 320 330 340 350
EVGQHDFCLP SYQTRKTSYT AVSLYSNPVR YWQIHPHTFR CVFGRSTIQL

GNYK
Length:354
Mass (Da):39,805
Last modified:April 1, 1993 - v1
Checksum:i152D92F42D9F5A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12298 mRNA Translation: CAA78170.1
BC083750 mRNA Translation: AAH83750.1
X59859 mRNA Translation: CAA42519.1
PIRiS29145
RefSeqiNP_077043.1, NM_024129.1
XP_006241347.1, XM_006241285.1
UniGeneiRn.106103

Genome annotation databases

EnsembliENSRNOT00000006070; ENSRNOP00000006070; ENSRNOG00000004554
GeneIDi29139
KEGGirno:29139
UCSCiRGD:61895 rat

Similar proteinsi

Entry informationi

Entry nameiPGS2_RAT
AccessioniPrimary (citable) accession number: Q01129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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