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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Lipomyces starkeyi (Oleaginous yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiLipomyces starkeyi (Oleaginous yeast)
Taxonomic identifieri29829 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesLipomycetaceaeLipomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154334Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.

Sequencei

Sequence statusi: Complete.

Q01128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSTTSLCT PIVKICGLTV EAAHCAISSG ADLIGMILVP DLKRTVQQTK
60 70 80 90 100
LKAISRAVTR IPGVPTSPSR GIDRPSHGLV RGTFSADYTS WPLVVGVFRN
110 120 130 140 150
QSLDEVLRML RNYDLDIVQL HGSEPLHQWT REIPVPVIKK FGLGEDDLMA
160 170 180 190 200
PGLHAVTLLD GGAGGEGQKI SWEGLPGSGA FMLAGGLTVD NVAVAVKIPN
210 220 230
VAGVDVSSGV ATDGMQDLEK NCRCLFRNAK GW
Length:232
Mass (Da):24,625
Last modified:November 1, 1996 - v1
Checksum:iE6FF1B4EA7D7A9E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68292 Genomic DNA. Translation: CAA92584.1.
PIRiS70355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68292 Genomic DNA. Translation: CAA92584.1.
PIRiS70355.

3D structure databases

ProteinModelPortaliQ01128.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Electrophoretic karyotype of the amylolytic yeast Lipomyces starkeyi and cloning, sequencing and chromosomal localization of its TRP1 gene."
    Bignell G.R., Bruce I.J., Evans I.H.
    Curr. Genet. 30:83-88(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCYC 1436.

Entry informationi

Entry nameiTRPF_LIPST
AccessioniPrimary (citable) accession number: Q01128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.