Q01128 (TRPF_LIPST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:

TRP1

Organism

Lipomyces starkeyi (Oleaginous yeast)

Taxonomic identifier

29829 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Lipomycetaceae › Lipomyces

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	N-(5'-phosphoribosyl)anthranilate isomerase		PRO_0000154334

Sequences

	Sequence		Length	Mass (Da)
	Q01128 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E6FF1B4EA7D7A9E0	FASTA	232	24,625
	10 20 30 40 50 60 MTVSTTSLCT PIVKICGLTV EAAHCAISSG ADLIGMILVP DLKRTVQQTK LKAISRAVTR 70 80 90 100 110 120 IPGVPTSPSR GIDRPSHGLV RGTFSADYTS WPLVVGVFRN QSLDEVLRML RNYDLDIVQL 130 140 150 160 170 180 HGSEPLHQWT REIPVPVIKK FGLGEDDLMA PGLHAVTLLD GGAGGEGQKI SWEGLPGSGA 190 200 210 220 230 FMLAGGLTVD NVAVAVKIPN VAGVDVSSGV ATDGMQDLEK NCRCLFRNAK GW

References

[1]

"Electrophoretic karyotype of the amylolytic yeast Lipomyces starkeyi and cloning, sequencing and chromosomal localization of its TRP1 gene." Bignell G.R., Bruce I.J., Evans I.H. Curr. Genet. 30:83-88(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCYC 1436.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68292 Genomic DNA. Translation: CAA92584.1.
PIR	S70355.
3D structure databases
ProteinModelPortal	Q01128.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_LIPST

Accession

Primary (citable) accession number: Q01128

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program