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Protein

Interleukin-9 receptor

Gene

Il9r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for interleukin-9.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9 receptor
Short name:
IL-9 receptor
Short name:
IL-9R
Alternative name(s):
CD_antigen: CD129
Gene namesi
Name:Il9r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96564. Il9r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 270233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 468177CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 468431Interleukin-9 receptorPRO_0000010912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ01114.

PTM databases

PhosphoSiteiQ01114.

Expressioni

Gene expression databases

BgeeiQ01114.
CleanExiMM_IL9R.
ExpressionAtlasiQ01114. baseline and differential.
GenevestigatoriQ01114.

Structurei

3D structure databases

ProteinModelPortaliQ01114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 256109Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi244 – 2485WSXWS motif
Motifi301 – 3099Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Gly
Compositional biasi419 – 4224Poly-Pro

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45141.
HOVERGENiHBG005032.
InParanoidiQ01114.
KOiK05073.
OrthoDBiEOG7TQV0Z.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA
60 70 80 90 100
GAFTCLSNSI YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM
110 120 130 140 150
CTLVLPKEEV FLPFDNFTIT LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS
160 170 180 190 200
DLQSNVSSGR CVLTWGINLA LEPLITSLSY ELAFKRQEEA WEARHKDRIV
210 220 230 240 250
GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY KSHWSEWSQP
260 270 280 290 300
VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI
310 320 330 340 350
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES
360 370 380 390 400
SIWEAVATLT YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG
410 420 430 440 450
QPSAYLPQED WAPLGSARPP PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE
460
SPELTLAQPV ALPVSSRA
Length:468
Mass (Da):52,261
Last modified:April 1, 1993 - v1
Checksum:iBBE7179FD72E29A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84746 mRNA. Translation: AAA37871.1.
CCDSiCCDS24517.1.
PIRiA45268.
RefSeqiNP_032400.1. NM_008374.2.
UniGeneiMm.384.

Genome annotation databases

EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
GeneIDi16199.
KEGGimmu:16199.
UCSCiuc007iix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84746 mRNA. Translation: AAA37871.1.
CCDSiCCDS24517.1.
PIRiA45268.
RefSeqiNP_032400.1. NM_008374.2.
UniGeneiMm.384.

3D structure databases

ProteinModelPortaliQ01114.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ01114.

Proteomic databases

PRIDEiQ01114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
GeneIDi16199.
KEGGimmu:16199.
UCSCiuc007iix.2. mouse.

Organism-specific databases

CTDi3581.
MGIiMGI:96564. Il9r.

Phylogenomic databases

eggNOGiNOG45141.
HOVERGENiHBG005032.
InParanoidiQ01114.
KOiK05073.
OrthoDBiEOG7TQV0Z.

Miscellaneous databases

NextBioi289133.
PROiQ01114.
SOURCEiSearch...

Gene expression databases

BgeeiQ01114.
CleanExiMM_IL9R.
ExpressionAtlasiQ01114. baseline and differential.
GenevestigatoriQ01114.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.

Entry informationi

Entry nameiIL9R_MOUSE
AccessioniPrimary (citable) accession number: Q01114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 7, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.