Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q01114

- IL9R_MOUSE

UniProt

Q01114 - IL9R_MOUSE

Protein

Interleukin-9 receptor

Gene

Il9r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is a receptor for interleukin-9.

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-9 receptor
    Short name:
    IL-9 receptor
    Short name:
    IL-9R
    Alternative name(s):
    CD_antigen: CD129
    Gene namesi
    Name:Il9r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96564. Il9r.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 468431Interleukin-9 receptorPRO_0000010912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ01114.

    PTM databases

    PhosphoSiteiQ01114.

    Expressioni

    Gene expression databases

    BgeeiQ01114.
    CleanExiMM_IL9R.
    GenevestigatoriQ01114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01114.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 270233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 468177CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini148 – 256109Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi244 – 2485WSXWS motif
    Motifi301 – 3099Box 1 motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 474Poly-Gly
    Compositional biasi419 – 4224Poly-Pro

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45141.
    HOVERGENiHBG005032.
    InParanoidiQ01114.
    KOiK05073.
    OrthoDBiEOG7TQV0Z.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01114-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA    50
    GAFTCLSNSI YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM 100
    CTLVLPKEEV FLPFDNFTIT LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS 150
    DLQSNVSSGR CVLTWGINLA LEPLITSLSY ELAFKRQEEA WEARHKDRIV 200
    GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY KSHWSEWSQP 250
    VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI 300
    FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES 350
    SIWEAVATLT YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG 400
    QPSAYLPQED WAPLGSARPP PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE 450
    SPELTLAQPV ALPVSSRA 468
    Length:468
    Mass (Da):52,261
    Last modified:April 1, 1993 - v1
    Checksum:iBBE7179FD72E29A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84746 mRNA. Translation: AAA37871.1.
    CCDSiCCDS24517.1.
    PIRiA45268.
    RefSeqiNP_032400.1. NM_008374.2.
    UniGeneiMm.384.

    Genome annotation databases

    EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
    GeneIDi16199.
    KEGGimmu:16199.
    UCSCiuc007iix.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84746 mRNA. Translation: AAA37871.1 .
    CCDSi CCDS24517.1.
    PIRi A45268.
    RefSeqi NP_032400.1. NM_008374.2.
    UniGenei Mm.384.

    3D structure databases

    ProteinModelPortali Q01114.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q01114.

    Proteomic databases

    PRIDEi Q01114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000145401 ; ENSMUSP00000118204 ; ENSMUSG00000020279 .
    GeneIDi 16199.
    KEGGi mmu:16199.
    UCSCi uc007iix.2. mouse.

    Organism-specific databases

    CTDi 3581.
    MGIi MGI:96564. Il9r.

    Phylogenomic databases

    eggNOGi NOG45141.
    HOVERGENi HBG005032.
    InParanoidi Q01114.
    KOi K05073.
    OrthoDBi EOG7TQV0Z.

    Miscellaneous databases

    NextBioi 289133.
    PROi Q01114.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01114.
    CleanExi MM_IL9R.
    Genevestigatori Q01114.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.

    Entry informationi

    Entry nameiIL9R_MOUSE
    AccessioniPrimary (citable) accession number: Q01114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3