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Q01114 (IL9R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-9 receptor

Short name=IL-9 receptor
Short name=IL-9R
Alternative name(s):
CD_antigen=CD129
Gene names
Name:Il9r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for interleukin-9.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Secreted.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 1 fibronectin type-III domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 468431Interleukin-9 receptor
PRO_0000010912

Regions

Topological domain38 – 270233Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 468177Cytoplasmic Potential
Domain148 – 256109Fibronectin type-III
Motif244 – 2485WSXWS motif
Motif301 – 3099Box 1 motif
Compositional bias44 – 474Poly-Gly
Compositional bias419 – 4224Poly-Pro

Amino acid modifications

Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q01114 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: BBE7179FD72E29A5

FASTA46852,261
        10         20         30         40         50         60 
MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA GAFTCLSNSI 

        70         80         90        100        110        120 
YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM CTLVLPKEEV FLPFDNFTIT 

       130        140        150        160        170        180 
LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS DLQSNVSSGR CVLTWGINLA LEPLITSLSY 

       190        200        210        220        230        240 
ELAFKRQEEA WEARHKDRIV GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY 

       250        260        270        280        290        300 
KSHWSEWSQP VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI 

       310        320        330        340        350        360 
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES SIWEAVATLT 

       370        380        390        400        410        420 
YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG QPSAYLPQED WAPLGSARPP 

       430        440        450        460 
PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE SPELTLAQPV ALPVSSRA 

« Hide

References

[1]"Expression cloning of the murine and human interleukin 9 receptor cDNAs."
Renauld J.-C., Druez C., Kermouni A., Houssiau F., Uyttenhove C., van Roost E., van Snick J.
Proc. Natl. Acad. Sci. U.S.A. 89:5690-5694(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84746 mRNA. Translation: AAA37871.1.
PIRA45268.
RefSeqNP_032400.1. NM_008374.2.
UniGeneMm.384.

3D structure databases

ProteinModelPortalQ01114.
SMRQ01114. Positions 52-257.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ01114.

Proteomic databases

PRIDEQ01114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
GeneID16199.
KEGGmmu:16199.
UCSCuc007iix.2. mouse.

Organism-specific databases

CTD3581.
MGIMGI:96564. Il9r.

Phylogenomic databases

eggNOGNOG45141.
HOVERGENHBG005032.
InParanoidQ01114.
KOK05073.
OrthoDBEOG7TQV0Z.

Gene expression databases

BgeeQ01114.
CleanExMM_IL9R.
GenevestigatorQ01114.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289133.
PROQ01114.
SOURCESearch...

Entry information

Entry nameIL9R_MOUSE
AccessionPrimary (citable) accession number: Q01114
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot