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Q01114

- IL9R_MOUSE

UniProt

Q01114 - IL9R_MOUSE

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Protein

Interleukin-9 receptor

Gene
Il9r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for interleukin-9.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9 receptor
Short name:
IL-9 receptor
Short name:
IL-9R
Alternative name(s):
CD_antigen: CD129
Gene namesi
Name:Il9r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96564. Il9r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 270233Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Reviewed predictionAdd
BLAST
Topological domaini292 – 468177Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed predictionAdd
BLAST
Chaini38 – 468431Interleukin-9 receptorPRO_0000010912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ01114.

PTM databases

PhosphoSiteiQ01114.

Expressioni

Gene expression databases

BgeeiQ01114.
CleanExiMM_IL9R.
GenevestigatoriQ01114.

Structurei

3D structure databases

ProteinModelPortaliQ01114.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 256109Fibronectin type-IIIAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi244 – 2485WSXWS motif
Motifi301 – 3099Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Gly
Compositional biasi419 – 4224Poly-Pro

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45141.
HOVERGENiHBG005032.
InParanoidiQ01114.
KOiK05073.
OrthoDBiEOG7TQV0Z.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01114-1 [UniParc]FASTAAdd to Basket

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MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA    50
GAFTCLSNSI YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM 100
CTLVLPKEEV FLPFDNFTIT LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS 150
DLQSNVSSGR CVLTWGINLA LEPLITSLSY ELAFKRQEEA WEARHKDRIV 200
GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY KSHWSEWSQP 250
VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI 300
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES 350
SIWEAVATLT YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG 400
QPSAYLPQED WAPLGSARPP PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE 450
SPELTLAQPV ALPVSSRA 468
Length:468
Mass (Da):52,261
Last modified:April 1, 1993 - v1
Checksum:iBBE7179FD72E29A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84746 mRNA. Translation: AAA37871.1.
CCDSiCCDS24517.1.
PIRiA45268.
RefSeqiNP_032400.1. NM_008374.2.
UniGeneiMm.384.

Genome annotation databases

EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
GeneIDi16199.
KEGGimmu:16199.
UCSCiuc007iix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84746 mRNA. Translation: AAA37871.1 .
CCDSi CCDS24517.1.
PIRi A45268.
RefSeqi NP_032400.1. NM_008374.2.
UniGenei Mm.384.

3D structure databases

ProteinModelPortali Q01114.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q01114.

Proteomic databases

PRIDEi Q01114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000145401 ; ENSMUSP00000118204 ; ENSMUSG00000020279 .
GeneIDi 16199.
KEGGi mmu:16199.
UCSCi uc007iix.2. mouse.

Organism-specific databases

CTDi 3581.
MGIi MGI:96564. Il9r.

Phylogenomic databases

eggNOGi NOG45141.
HOVERGENi HBG005032.
InParanoidi Q01114.
KOi K05073.
OrthoDBi EOG7TQV0Z.

Miscellaneous databases

NextBioi 289133.
PROi Q01114.
SOURCEi Search...

Gene expression databases

Bgeei Q01114.
CleanExi MM_IL9R.
Genevestigatori Q01114.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.

Entry informationi

Entry nameiIL9R_MOUSE
AccessioniPrimary (citable) accession number: Q01114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi