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Protein

Interleukin-9 receptor

Gene

Il9r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for interleukin-9.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9 receptor
Short name:
IL-9 receptor
Short name:
IL-9R
Alternative name(s):
CD_antigen: CD129
Gene namesi
Name:Il9r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96564. Il9r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 270ExtracellularSequence analysisAdd BLAST233
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 468CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001091238 – 468Interleukin-9 receptorAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01114.
PRIDEiQ01114.

PTM databases

PhosphoSitePlusiQ01114.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020279.
CleanExiMM_IL9R.
ExpressionAtlasiQ01114. baseline and differential.
GenevisibleiQ01114. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119557.

Structurei

3D structure databases

ProteinModelPortaliQ01114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 256Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi244 – 248WSXWS motif5
Motifi301 – 309Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Gly4
Compositional biasi419 – 422Poly-Pro4

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ2W. Eukaryota.
ENOG41116AC. LUCA.
GeneTreeiENSGT00510000049125.
HOVERGENiHBG005032.
InParanoidiQ01114.
KOiK05073.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA
60 70 80 90 100
GAFTCLSNSI YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM
110 120 130 140 150
CTLVLPKEEV FLPFDNFTIT LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS
160 170 180 190 200
DLQSNVSSGR CVLTWGINLA LEPLITSLSY ELAFKRQEEA WEARHKDRIV
210 220 230 240 250
GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY KSHWSEWSQP
260 270 280 290 300
VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI
310 320 330 340 350
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES
360 370 380 390 400
SIWEAVATLT YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG
410 420 430 440 450
QPSAYLPQED WAPLGSARPP PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE
460
SPELTLAQPV ALPVSSRA
Length:468
Mass (Da):52,261
Last modified:April 1, 1993 - v1
Checksum:iBBE7179FD72E29A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84746 mRNA. Translation: AAA37871.1.
CCDSiCCDS24517.1.
PIRiA45268.
RefSeqiNP_032400.1. NM_008374.2.
UniGeneiMm.384.

Genome annotation databases

EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279.
GeneIDi16199.
KEGGimmu:16199.
UCSCiuc007iix.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIL9R_MOUSE
AccessioniPrimary (citable) accession number: Q01114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 7, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families