Q01101 (INSM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 108.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Insulinoma-associated protein 1 Alternative name(s): Zinc finger protein IA-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 510 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May be associated with the transformation of neuroendocrine cells. |
| Subcellular location | Nucleus Potential. |
| Tissue specificity | Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal tissues tested. |
| Sequence similarities | Contains 5 C2H2-type zinc fingers. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | endocrine pancreas development Traceable author statement. Source: Reactome regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW type B pancreatic cell developmentInferred from electronic annotation. Source: Compara |
| Cellular_component | nucleoplasm Traceable author statement. Source: Reactome |
| Molecular_function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||
Molecule processing | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 510 | 510 | Insulinoma-associated protein 1 | PRO_0000047268 | |||||||||||||
Regions | |||||||||||||||||
| Zinc finger | 267 – 287 | 21 | C2H2-type 1; atypical | ||||||||||||||
| Zinc finger | 295 – 317 | 23 | C2H2-type 2 | ||||||||||||||
| Zinc finger | 367 – 389 | 23 | C2H2-type 3 | ||||||||||||||
| Zinc finger | 441 – 464 | 24 | C2H2-type 4 | ||||||||||||||
| Zinc finger | 469 – 492 | 24 | C2H2-type 5 | ||||||||||||||
| Region | 1 – 20 | 20 | SNAG domain By similarity | ||||||||||||||
| Compositional bias | 1 – 250 | 250 | Ala/Gly/Pro-rich | ||||||||||||||
Secondary structure | |||||||||||||||||
Helix Strand Turn | |||||||||||||||||
| Beta strand | 449 – 452 | 4 | |||||||||||||||
| Helix | 453 – 461 | 9 | |||||||||||||||
| Beta strand | 466 – 470 | 5 | |||||||||||||||
| Beta strand | 477 – 480 | 4 | |||||||||||||||
| Helix | 481 – 489 | 9 | |||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs." Goto Y., de Silva M.G., Toscani A., Prabhakar B.S., Notkins A.L., Lan M.S. J. Biol. Chem. 267:15252-15257(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1." Lan M.S., Li Q., Lu J., Modi W.S., Notkins A.L. J. Biol. Chem. 269:14170-14174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M93119 mRNA. Translation: AAA58680.1. AL161658 Genomic DNA. Translation: CAC36065.1. U07172 Genomic DNA. Translation: AAA20938.1. | ||||||||||||
| IPI | IPI00005944. | ||||||||||||
| PIR | A42750. | ||||||||||||
| RefSeq | NP_002187.1. NM_002196.2. | ||||||||||||
| UniGene | Hs.89584. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q01101. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q01101. 3 interactions. | ||||||||||||
| MINT | MINT-1395936. | ||||||||||||
| STRING | 9606.ENSP00000312631. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q01101. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 547700. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | Q01101. | ||||||||||||
| PRIDE | Q01101. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000310227; ENSP00000312631; ENSG00000173404. | ||||||||||||
| GeneID | 3642. | ||||||||||||
| KEGG | hsa:3642. | ||||||||||||
| UCSC | uc002wrx.3. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 3642. | ||||||||||||
| GeneCards | GC20P020348. | ||||||||||||
| HGNC | HGNC:6090. INSM1. | ||||||||||||
| MIM | 600010. gene. | ||||||||||||
| neXtProt | NX_Q01101. | ||||||||||||
| Orphanet | 877. Endocrine tumor. | ||||||||||||
| PharmGKB | PA29897. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | NOG308747. | ||||||||||||
| HOGENOM | HOG000113079. | ||||||||||||
| HOVERGEN | HBG052137. | ||||||||||||
| InParanoid | Q01101. | ||||||||||||
| OMA | ELKMGTA. | ||||||||||||
| OrthoDB | EOG4M0F1T. | ||||||||||||
| PhylomeDB | Q01101. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_111045. Developmental Biology. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | Q01101. | ||||||||||||
| CleanEx | HS_INSM1. | ||||||||||||
| Genevestigator | Q01101. | ||||||||||||
| GermOnline | ENSG00000173404. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| Gene3D | 3.30.160.60. 1 hit. | ||||||||||||
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] | ||||||||||||
| Pfam | PF00096. zf-C2H2. 4 hits. [Graphical view] | ||||||||||||
| SMART | SM00355. ZnF_C2H2. 5 hits. [Graphical view] | ||||||||||||
| PROSITE | PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| GenomeRNAi | 3642. | ||||||||||||
| NextBio | 14255. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | INSM1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q01101 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
