Reviewed,
UniProtKB/Swiss-Prot Q01101 (INSM1_HUMAN)
Last modified
November 25, 2008.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Insulinoma-associated protein 1 Alternative name(s): Zinc finger protein IA-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 510 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May be associated with the transformation of neuroendocrine cells. |
| Subcellular location | NucleusPotential. |
| Tissue specificity | Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal tissues tested. |
| Sequence similarities | Contains 5 C2H2-type zinc fingers. |
Ontologies
Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 510 | 510 | Insulinoma-associated protein 1 | PRO_0000047268 | |||||
Regions | |||||||||
| Zinc finger | 267 – 287 | 21 | C2H2-type 1; atypical | ||||||
| Zinc finger | 295 – 317 | 23 | C2H2-type 2 | ||||||
| Zinc finger | 367 – 389 | 23 | C2H2-type 3 | ||||||
| Zinc finger | 441 – 464 | 24 | C2H2-type 4 | ||||||
| Zinc finger | 469 – 492 | 24 | C2H2-type 5 | ||||||
| Compositional bias | 1 – 250 | 250 | Ala/Gly/Pro-rich | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs." Goto Y., de Silva M.G., Toscani A., Prabhakar B.S., Notkins A.L., Lan M.S. J. Biol. Chem. 267:15252-15257(1992) [PubMed: 1634555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1." Lan M.S., Li Q., Lu J., Modi W.S., Notkins A.L. J. Biol. Chem. 269:14170-14174(1994) [PubMed: 8188699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M93119 mRNA. Translation: AAA58680.1. AL161658 Genomic DNA. Translation: CAC36065.1. U07172 Genomic DNA. Translation: AAA20938.1. | |
| PIR | A42750. |
| RefSeq | NP_002187.1. |
| UniGene | Hs.89584 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q01101. |
PTM databases | |
| PhosphoSite | Q01101. |
Genome annotation databases | |
| Ensembl | ENSG00000173404. Homo sapiens. [Contig view] |
| GeneID | 3642. |
| KEGG | hsa:3642. |
Organism-specific databases | |
| HGNC | HGNC:6090. INSM1. |
| MIM | 600010. gene. |
| Orphanet | 877. Endocrine tumour. |
| PharmGKB | PA29897. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q01101. |
| HOVERGEN | Q01101. |
Gene expression databases | |
| ArrayExpress | Q01101. |
| CleanEx | HS_INSM1. |
| GermOnline | ENSG00000173404. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view] |
| Pfam | PF00096. zf-C2H2. 4 hits. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 5 hits. [Graphical view] |
| PROSITE | PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14255. |
| SOURCE | Search... |
Entry information
| Entry name | INSM1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q01101 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


