Q01101 (INSM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulinoma-associated protein 1

Alternative name(s):
Zinc finger protein IA-1

Gene names

Name:	INSM1
Synonyms:	IA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be associated with the transformation of neuroendocrine cells.
Subcellular location	Nucleus Potential.
Tissue specificity	Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal tissues tested.
Sequence similarities	Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocrine pancreas development Traceable author statement. Source: Reactome regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW type B pancreatic cell development Inferred from electronic annotation. Source: Compara
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 510

510

Insulinoma-associated protein 1

PRO_0000047268

Regions

Zinc finger

267 – 287

21

C2H2-type 1; atypical

Zinc finger

295 – 317

23

C2H2-type 2

Zinc finger

367 – 389

23

C2H2-type 3

Zinc finger

441 – 464

24

C2H2-type 4

Zinc finger

469 – 492

24

C2H2-type 5

Region

1 – 20

20

SNAG domain By similarity

Compositional bias

1 – 250

250

Ala/Gly/Pro-rich

Secondary structure

1

.

.

.

.

.

.

.

.

.

510

Helix Strand Turn

Details...

Beta strand

449 – 452

4

Helix

453 – 461

9

Beta strand

466 – 470

5

Beta strand

477 – 480

4

Helix

481 – 489

9

Sequences

	Sequence		Length	Mass (Da)
	Q01101 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 22D4E97696397365	FASTA	510	52,923
	10 20 30 40 50 60 MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE 70 80 90 100 110 120 RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF 130 140 150 160 170 180 NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA 190 200 210 220 230 240 RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV 250 260 270 280 290 300 LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 310 320 330 340 350 360 AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES 370 380 390 400 410 420 GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ 430 440 450 460 470 480 EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS 490 500 510 SPGLTRHINK CHPSENRQVI LLQVPVRPAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs." Goto Y., de Silva M.G., Toscani A., Prabhakar B.S., Notkins A.L., Lan M.S. J. Biol. Chem. 267:15252-15257(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1." Lan M.S., Li Q., Lu J., Modi W.S., Notkins A.L. J. Biol. Chem. 269:14170-14174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M93119 mRNA. Translation: AAA58680.1.
AL161658 Genomic DNA. Translation: CAC36065.1.
U07172 Genomic DNA. Translation: AAA20938.1.

IPI

IPI00005944.

PIR

A42750.

RefSeq

NP_002187.1. NM_002196.2.

UniGene

Hs.89584.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LV2	NMR	-	A	424-497	[»]

ProteinModelPortal

Q01101.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q01101. 3 interactions.

MINT

MINT-1395936.

STRING

9606.ENSP00000312631.

PTM databases

PhosphoSite

Q01101.

Polymorphism databases

DMDM

547700.

Proteomic databases

PaxDb

Q01101.

PRIDE

Q01101.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000310227; ENSP00000312631; ENSG00000173404.

GeneID

3642.

KEGG

hsa:3642.

UCSC

uc002wrx.3. human.

Organism-specific databases

CTD

3642.

GeneCards

GC20P020348.

HGNC

HGNC:6090. INSM1.

MIM

600010. gene.

neXtProt

NX_Q01101.

Orphanet

877. Endocrine tumor.

PharmGKB

PA29897.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG308747.

HOGENOM

HOG000113079.

HOVERGEN

HBG052137.

InParanoid

Q01101.

OMA

ELKMGTA.

OrthoDB

EOG4M0F1T.

PhylomeDB

Q01101.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

Bgee

Q01101.

CleanEx

HS_INSM1.

Genevestigator

Q01101.

GermOnline

ENSG00000173404. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 1 hit.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Pfam

PF00096. zf-C2H2. 4 hits.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 5 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

3642.

NextBio

14255.

SOURCE

Search...

Entry information

Entry name

INSM1_HUMAN

Accession

Primary (citable) accession number: Q01101

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.