Reviewed, UniProtKB/Swiss-Prot Q01101 (INSM1_HUMAN)

Names and origin

Protein names

Recommended name:
    Insulinoma-associated protein 1
Alternative name(s):
    Zinc finger protein IA-1

Gene names

Name:	INSM1
Synonyms:	IA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be associated with the transformation of neuroendocrine cells.
Subcellular location	Nucleus Potential.
Tissue specificity	Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal tissues tested.
Sequence similarities	Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	Insulinoma-associated protein 1		PRO_0000047268
Regions
	Zinc finger	267 – 287	21	C2H2-type 1; atypical
	Zinc finger	295 – 317	23	C2H2-type 2
	Zinc finger	367 – 389	23	C2H2-type 3
	Zinc finger	441 – 464	24	C2H2-type 4
	Zinc finger	469 – 492	24	C2H2-type 5
	Compositional bias	1 – 250	250	Ala/Gly/Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q01101-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 22D4E97696397365	FASTA	510	52,923
	10 20 30 40 50 60 MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE 70 80 90 100 110 120 RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF 130 140 150 160 170 180 NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA 190 200 210 220 230 240 RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV 250 260 270 280 290 300 LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 310 320 330 340 350 360 AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES 370 380 390 400 410 420 GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ 430 440 450 460 470 480 EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS 490 500 510 SPGLTRHINK CHPSENRQVI LLQVPVRPAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs." Goto Y., de Silva M.G., Toscani A., Prabhakar B.S., Notkins A.L., Lan M.S. J. Biol. Chem. 267:15252-15257(1992) [PubMed: 1634555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1." Lan M.S., Li Q., Lu J., Modi W.S., Notkins A.L. J. Biol. Chem. 269:14170-14174(1994) [PubMed: 8188699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M93119 mRNA. Translation: AAA58680.1. AL161658 Genomic DNA. Translation: CAC36065.1. U07172 Genomic DNA. Translation: AAA20938.1.
IPI	IPI00005944.
PIR	A42750.
RefSeq	NP_002187.1.
UniGene	Hs.89584
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01101. 2 interactions.
Proteomic databases
PRIDE	Q01101.
Genome annotation databases
Ensembl	ENSG00000173404. Homo sapiens. [Contig view]
GeneID	3642.
KEGG	hsa:3642.
Organism-specific databases
GeneCards	GC20P020296.
HGNC	HGNC:6090. INSM1.
MIM	600010. gene.
Orphanet	877. Endocrine tumor.
PharmGKB	PA29897.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q01101.
HOVERGEN	Q01101.
OMA	Q01101. TPVSYRV.
Enzyme and pathway databases
Reactome	REACT_13698. Regulation of beta-cell development.
Gene expression databases
ArrayExpress	Q01101.
Bgee	Q01101.
CleanEx	HS_INSM1.
GermOnline	ENSG00000173404. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14255.
SOURCE	Search...

Entry information

Entry name

INSM1_HUMAN

Accession

Primary (citable) accession number: Q01101

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)