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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-3001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:rrnAC3339
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Chaperone protein DnaKPRO_0000078594Add
BLAST

Proteomic databases

PRIDEiQ01100.

Interactioni

Protein-protein interaction databases

STRINGi272569.rrnAC3339.

Structurei

3D structure databases

ProteinModelPortaliQ01100.
SMRiQ01100. Positions 4-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiarCOG03060. Archaea.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiDLTGDRM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNKILGID LGTTNSAFAV MEGGDPEIIV NGEGERTTPS VVAFDDGERL
60 70 80 90 100
VGKPAKNQAV KNPDETIQSI KRHMGEDDYS VELDGEEYTP EQVSAMILQK
110 120 130 140 150
IKHDAEEYLG DEIEKAVITV PAYFNDRQRQ ATKDAGEIAG FEVERIVNEP
160 170 180 190 200
TAAAMAYGLD DESDQTVLVY DLGGGTFDVS ILDLGGGVYE VVATNGDNDL
210 220 230 240 250
GGDDWDHAII DYLADEFEAE HGIDLRDDRQ ALQRLTEAAE EAKIELSSRK
260 270 280 290 300
ETRINLPFIA TTDDGPLDLE QKITRAKFES LTEDLIERTV GPTEQALADA
310 320 330 340 350
DYTKSDIDEV ILVGGSTRMP QVQDQVEEMT GQEPKKNVNP DEAVALGAAI
360 370 380 390 400
QAGVLSGDVD DIVLLDVTPL SLGVEVKGGL FERLIDKNTT IPTEESKIFT
410 420 430 440 450
TAQDNQTQVQ IRVFQGEREI AEENELLGAF ALSGIPPAPA GTPQIEVSFN
460 470 480 490 500
IDENGIVNVE AEDKGSGNKE DITIEGGAGL SDDQIEEMQQ EAEQHAEEDE
510 520 530 540 550
QRRERIEARN EAEASVRRAE TLLDENEEEI DEDLQSDIEA KIEDVEEVLE
560 570 580 590 600
DEDATKEDYE AVTETLSEEL QEIGKQMYQD QAQQAAGGAA GAGPGGAAGP
610 620 630
GGAAGPGGAA GGAAEQGEEY VDADFEDVEE SDEDE
Length:635
Mass (Da):68,531
Last modified:January 4, 2005 - v2
Checksum:iDD6877DB18495E6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761E → Q in AAA73181 (PubMed:1624448).Curated
Sequence conflicti137 – 1371E → K in AAA73181 (PubMed:1624448).Curated
Sequence conflicti290 – 2901V → L in AAA73181 (PubMed:1624448).Curated
Sequence conflicti336 – 3383KNV → RTS in AAA73181 (PubMed:1624448).Curated
Sequence conflicti429 – 4291A → R in AAA73181 (PubMed:1624448).Curated
Sequence conflicti504 – 5052ER → DG in AAA73181 (PubMed:1624448).Curated
Sequence conflicti586 – 61732AGGAA…AAEQG → QAVPRALVRVARPAPGALPD RAAQQAAAEQGA in AAA73181 (PubMed:1624448).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84006 Genomic DNA. Translation: AAA73181.1.
AY596297 Genomic DNA. Translation: AAV48029.1.
PIRiA42988.
RefSeqiWP_011224743.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV48029; AAV48029; rrnAC3339.
GeneIDi3127719.
KEGGihma:rrnAC3339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84006 Genomic DNA. Translation: AAA73181.1.
AY596297 Genomic DNA. Translation: AAV48029.1.
PIRiA42988.
RefSeqiWP_011224743.1. NC_006396.1.

3D structure databases

ProteinModelPortaliQ01100.
SMRiQ01100. Positions 4-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC3339.

Proteomic databases

PRIDEiQ01100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV48029; AAV48029; rrnAC3339.
GeneIDi3127719.
KEGGihma:rrnAC3339.

Phylogenomic databases

eggNOGiarCOG03060. Archaea.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiDLTGDRM.

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-3001-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_HALMA
AccessioniPrimary (citable) accession number: Q01100
Secondary accession number(s): Q5UXH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.