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Q01098 (NMDE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate [NMDA] receptor subunit epsilon-3
Alternative name(s):
N-methyl D-aspartate receptor subtype 2C
Short name=NMDAR2C
Short name=NR2C
Gene names
Name:Grin2c
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subunit structure

Interacts with PDZ domains of INADL and DLG4 By similarity. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainSignal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
   Molecular functionIonic channel
Ligand-gated ion channel
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdirectional locomotion

Inferred from genetic interaction. Source: MGI

negative regulation of protein catabolic process

Inferred from genetic interaction. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype. Source: MGI

protein localization

Inferred from mutant phenotype. Source: MGI

regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype. Source: MGI

response to wounding

Inferred from genetic interaction. Source: MGI

   Cellular componentN-methyl-D-aspartate selective glutamate receptor complex

Inferred from physical interaction. Source: MGI

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

postsynaptic density

Inferred from direct assay. Source: MGI

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-methyl-D-aspartate selective glutamate receptor activity

Inferred from mutant phenotype. Source: MGI

cation channel activity

Inferred from mutant phenotype. Source: MGI

extracellular-glutamate-gated ion channel activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 12391220Glutamate [NMDA] receptor subunit epsilon-3
PRO_0000011581

Regions

Topological domain20 – 553534Extracellular Potential
Transmembrane554 – 57421Helical; Potential
Topological domain575 – 62652Cytoplasmic Potential
Transmembrane627 – 64721Helical; Potential
Topological domain648 – 814167Extracellular Potential
Transmembrane815 – 83521Helical; Potential
Topological domain836 – 1239404Cytoplasmic Potential
Motif1237 – 12393PDZ-binding By similarity

Sites

Site6121Functional determinant of NMDA receptors By similarity

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation5391N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q01098 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 793E8E731E20C3C9

FASTA1,239135,420
        10         20         30         40         50         60 
MGGALGPALL LTSLLGAWAG LGAGQGEQAV TVAVVFGSSG PLQAQARTRL TPQNFLDLPL 

        70         80         90        100        110        120 
EIQPLTIGVN NTNPSSILTQ ICGLLGAARV HGIVFEDNVD TEAVAQLLDF VSSQTHVPIL 

       130        140        150        160        170        180 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 

       190        200        210        220        230        240 
GVRAVADASY LSWRLLDVLT LELGPGGPRA RTQRLLRQVD APVLVAYCSR EEAEVLFAEA 

       250        260        270        280        290        300 
AQAGLVGPGH VWLVPNLALG STDAPPAAFP VGLISVVTES WRLSLRQKVR DGVAILALGA 

       310        320        330        340        350        360 
HSYRRQYGTL PAPAGDCRSH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 

       370        380        390        400        410        420 
IALNRHRLWE MVGRWDHGVL YMKYPVWPRY STSLQPVVDS RHLTVATLEE RPFVIVESPD 

       430        440        450        460        470        480 
PGTGGCVPNT VPCRRQSNHT FSSGDITPYT KLCCKGFCID ILKKLAKVVK FSYDLYLVTN 

       490        500        510        520        530        540 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEII DFSVPFVETG ISVMVARSNG 

       550        560        570        580        590        600 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTKGK KSGGPSFTIG 

       610        620        630        640        650        660 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 

       670        680        690        700        710        720 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 

       730        740        750        760        770        780 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 

       790        800        810        820        830        840 
LGDGETQKLE TVWLSGICHN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 

       850        860        870        880        890        900 
WKLRHSVPSS SQLDFLLAFS RGIYSCFNGV QSLPSPARPP SPDLTAGSAQ ANVLKMLQAA 

       910        920        930        940        950        960 
RDMVSTADVS GSLDRATRTI ENWGNNRRAP APTTSGPRSC TPGPPGQPSP SGWRPPGGGR 

       970        980        990       1000       1010       1020 
TPLARRAPQP PARPATCAGS PQPDVSRASC RHAWDARWPV RVGHQGSHLS ASERRALPER 

      1030       1040       1050       1060       1070       1080 
SLLHAHCHYS SFPRAERSGR PFLPLFPEPP EPDDLPLLGP EQLARREALL RAAWARGPRP 

      1090       1100       1110       1120       1130       1140 
RHASLPSSVA EAFTRSNPLP ARCTGHACAC PCPQSRPSCR HVAQTQSLRL PSYREACVEG 

      1150       1160       1170       1180       1190       1200 
VPAGVAATWQ PRQHVCLHTH THLPFCWGTV CRHPPPCSSH SPWLIGTWEP PSHRGRTLGL 

      1210       1220       1230 
GTGYRDSGVL EEVSREACGT QGFPRSCTWR RISSLESEV

« Hide

References

[1]"Molecular diversity of the NMDA receptor channel."
Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., Mishina M.
Nature 358:36-41(1992) [PubMed: 1377365] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Kashiwabuchi N.
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10694 mRNA. Translation: BAA01536.1.
IPIIPI00321321.
PIRI49705.
RefSeqNP_034480.2. NM_010350.2.
UniGeneMm.39090.

3D structure databases

ProteinModelPortalQ01098.
SMRQ01098. Positions 27-390, 400-799.
ModBaseSearch...

Protein-protein interaction databases

IntActQ01098. 1 interaction.
MINTMINT-104161.
STRINGQ01098.

PTM databases

PhosphoSiteQ01098.

Proteomic databases

PRIDEQ01098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003351; ENSMUSP00000003351; ENSMUSG00000020734.
ENSMUST00000106554; ENSMUSP00000102164; ENSMUSG00000020734.
GeneID14813.
KEGGmmu:14813.

Organism-specific databases

CTD2905.
MGIMGI:95822. Grin2c.

Phylogenomic databases

GeneTreeENSGT00540000070221.
HOGENOMHBG443877.
HOVERGENHBG052636.
InParanoidQ01098.
OMAARDMVTT.
OrthoDBEOG42RD6M.
PhylomeDBQ01098.

Gene expression databases

ArrayExpressQ01098.
BgeeQ01098.
GenevestigatorQ01098.
GermOnlineENSMUSG00000020734. Mus musculus.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
[Graphical view]
KOK05211.
PfamPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287007.
SOURCESearch...

Entry information

Entry nameNMDE3_MOUSE
AccessionPrimary (citable) accession number: Q01098
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: November 16, 2011
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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