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Protein

Nucleolysin TIAR

Gene

TIAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • defense response Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • germ cell development Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • regulation of transcription by RNA polymerase II Source: ProtInc
  • stem cell division Source: Ensembl

Keywordsi

Molecular functionRNA-binding
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
SIGNORiQ01085

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolysin TIAR
Alternative name(s):
TIA-1-related protein
Gene namesi
Name:TIAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151923.17
HGNCiHGNC:11804 TIAL1
MIMi603413 gene
neXtProtiNX_Q01085

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7073
OpenTargetsiENSG00000151923
PharmGKBiPA36513

Polymorphism and mutation databases

BioMutaiTIAL1
DMDMi267131

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819781 – 375Nucleolysin TIARAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei201PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01085
MaxQBiQ01085
PaxDbiQ01085
PeptideAtlasiQ01085
PRIDEiQ01085

PTM databases

iPTMnetiQ01085
PhosphoSitePlusiQ01085
SwissPalmiQ01085

Expressioni

Gene expression databases

BgeeiENSG00000151923
CleanExiHS_TIAL1
ExpressionAtlasiQ01085 baseline and differential
GenevisibleiQ01085 HS

Organism-specific databases

HPAiHPA060962

Interactioni

Protein-protein interaction databases

BioGridi112929, 70 interactors
DIPiDIP-42425N
IntActiQ01085, 24 interactors
MINTiQ01085
STRINGi9606.ENSP00000358089

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Helixi22 – 32Combined sources11
Beta strandi35 – 41Combined sources7
Beta strandi50 – 57Combined sources8
Helixi58 – 68Combined sources11
Beta strandi71 – 73Combined sources3
Beta strandi76 – 82Combined sources7
Beta strandi97 – 102Combined sources6
Helixi110 – 116Combined sources7
Turni118 – 120Combined sources3
Beta strandi123 – 130Combined sources8
Beta strandi132 – 134Combined sources3
Beta strandi136 – 147Combined sources12
Helixi148 – 157Combined sources10
Turni158 – 160Combined sources3
Beta strandi164 – 166Combined sources3
Helixi193 – 199Combined sources7
Beta strandi206 – 210Combined sources5
Helixi218 – 228Combined sources11
Beta strandi231 – 237Combined sources7
Turni238 – 241Combined sources4
Beta strandi242 – 249Combined sources8
Helixi250 – 260Combined sources11
Beta strandi271 – 273Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4GNMR-A187-282[»]
2CQINMR-A1-90[»]
2DH7NMR-A89-180[»]
ProteinModelPortaliQ01085
SMRiQ01085
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01085

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 85RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini97 – 175RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini205 – 277RRM 3PROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0148 Eukaryota
ENOG410XQ8U LUCA
GeneTreeiENSGT00910000144106
HOGENOMiHOG000206748
HOVERGENiHBG105006
InParanoidiQ01085
KOiK13201
OMAiSWGKDKT
OrthoDBiEOG091G0FH8
PhylomeDBiQ01085
TreeFamiTF312915

Family and domain databases

CDDicd12616 RRM1_TIAR, 1 hit
cd12617 RRM2_TIAR, 1 hit
cd12620 RRM3_TIAR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034492 TIAR_RRM1
IPR034494 TIAR_RRM2
IPR034496 TIAR_RRM3
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01085-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEHTSNDPY
60 70 80 90 100
CFVEFYEHRD AAAALAAMNG RKILGKEVKV NWATTPSSQK KDTSNHFHVF
110 120 130 140 150
VGDLSPEITT EDIKSAFAPF GKISDARVVK DMATGKSKGY GFVSFYNKLD
160 170 180 190 200
AENAIVHMGG QWLGGRQIRT NWATRKPPAP KSTQENNTKQ LRFEDVVNQS
210 220 230 240 250
SPKNCTVYCG GIASGLTDQL MRQTFSPFGQ IMEIRVFPEK GYSFVRFSTH
260 270 280 290 300
ESAAHAIVSV NGTTIEGHVV KCYWGKESPD MTKNFQQVDY SQWGQWSQVY
310 320 330 340 350
GNPQQYGQYM ANGWQVPPYG VYGQPWNQQG FGVDQSPSAA WMGGFGAQPP
360 370
QGQAPPPVIP PPNQAGYGMA SYQTQ
Length:375
Mass (Da):41,591
Last modified:April 1, 1993 - v1
Checksum:i2F8D1C7169A7817E
GO
Isoform 2 (identifier: Q01085-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: E → EQPDSRRVNSSVGFSVLQ

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):43,449
Checksum:iF81DA9563C041D75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04370043E → EQPDSRRVNSSVGFSVLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96954 mRNA Translation: AAA36384.1
AK290695 mRNA Translation: BAF83384.1
AK290984 mRNA Translation: BAF83673.1
CCDSiCCDS31295.1 [Q01085-2]
CCDS7613.1 [Q01085-1]
PIRiA46174
RefSeqiNP_001029097.1, NM_001033925.1 [Q01085-2]
NP_003243.1, NM_003252.3 [Q01085-1]
UniGeneiHs.501203

Genome annotation databases

EnsembliENST00000369093; ENSP00000358089; ENSG00000151923 [Q01085-2]
ENST00000436547; ENSP00000394902; ENSG00000151923 [Q01085-1]
GeneIDi7073
KEGGihsa:7073
UCSCiuc001lei.2 human [Q01085-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTIAR_HUMAN
AccessioniPrimary (citable) accession number: Q01085
Secondary accession number(s): A8K3T0, A8K4L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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