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Protein

Nucleolysin TIAR

Gene

TIAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

GO - Molecular functioni

  • AU-rich element binding Source: Ensembl
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • defense response Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • germ cell development Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • stem cell division Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151923-MONOMER.
ReactomeiR-HSA-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolysin TIAR
Alternative name(s):
TIA-1-related protein
Gene namesi
Name:TIAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11804. TIAL1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasmic granule

  • Note: The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic stress granule Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • lysosome Source: ProtInc
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7073.
OpenTargetsiENSG00000151923.
PharmGKBiPA36513.

Polymorphism and mutation databases

BioMutaiTIAL1.
DMDMi267131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819781 – 375Nucleolysin TIARAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei201PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01085.
MaxQBiQ01085.
PaxDbiQ01085.
PeptideAtlasiQ01085.
PRIDEiQ01085.

PTM databases

iPTMnetiQ01085.
PhosphoSitePlusiQ01085.
SwissPalmiQ01085.

Expressioni

Gene expression databases

BgeeiENSG00000151923.
CleanExiHS_TIAL1.
ExpressionAtlasiQ01085. baseline and differential.
GenevisibleiQ01085. HS.

Organism-specific databases

HPAiHPA060962.

Interactioni

Protein-protein interaction databases

BioGridi112929. 65 interactors.
DIPiDIP-42425N.
IntActiQ01085. 23 interactors.
MINTiMINT-1203913.
STRINGi9606.ENSP00000358089.

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Helixi22 – 32Combined sources11
Beta strandi35 – 41Combined sources7
Beta strandi50 – 57Combined sources8
Helixi58 – 68Combined sources11
Beta strandi71 – 73Combined sources3
Beta strandi76 – 82Combined sources7
Beta strandi97 – 102Combined sources6
Helixi110 – 116Combined sources7
Turni118 – 120Combined sources3
Beta strandi123 – 130Combined sources8
Beta strandi132 – 134Combined sources3
Beta strandi136 – 147Combined sources12
Helixi148 – 157Combined sources10
Turni158 – 160Combined sources3
Beta strandi164 – 166Combined sources3
Helixi193 – 199Combined sources7
Beta strandi206 – 210Combined sources5
Helixi218 – 228Combined sources11
Beta strandi231 – 237Combined sources7
Turni238 – 241Combined sources4
Beta strandi242 – 249Combined sources8
Helixi250 – 260Combined sources11
Beta strandi271 – 273Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4GNMR-A187-282[»]
2CQINMR-A1-90[»]
2DH7NMR-A89-180[»]
ProteinModelPortaliQ01085.
SMRiQ01085.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01085.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 85RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini97 – 175RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini205 – 277RRM 3PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0148. Eukaryota.
ENOG410XQ8U. LUCA.
GeneTreeiENSGT00860000133749.
HOGENOMiHOG000206748.
HOVERGENiHBG105006.
InParanoidiQ01085.
KOiK13201.
OMAiCKMITEM.
OrthoDBiEOG091G0FH8.
PhylomeDBiQ01085.
TreeFamiTF312915.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01085-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEHTSNDPY
60 70 80 90 100
CFVEFYEHRD AAAALAAMNG RKILGKEVKV NWATTPSSQK KDTSNHFHVF
110 120 130 140 150
VGDLSPEITT EDIKSAFAPF GKISDARVVK DMATGKSKGY GFVSFYNKLD
160 170 180 190 200
AENAIVHMGG QWLGGRQIRT NWATRKPPAP KSTQENNTKQ LRFEDVVNQS
210 220 230 240 250
SPKNCTVYCG GIASGLTDQL MRQTFSPFGQ IMEIRVFPEK GYSFVRFSTH
260 270 280 290 300
ESAAHAIVSV NGTTIEGHVV KCYWGKESPD MTKNFQQVDY SQWGQWSQVY
310 320 330 340 350
GNPQQYGQYM ANGWQVPPYG VYGQPWNQQG FGVDQSPSAA WMGGFGAQPP
360 370
QGQAPPPVIP PPNQAGYGMA SYQTQ
Length:375
Mass (Da):41,591
Last modified:April 1, 1993 - v1
Checksum:i2F8D1C7169A7817E
GO
Isoform 2 (identifier: Q01085-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: E → EQPDSRRVNSSVGFSVLQ

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):43,449
Checksum:iF81DA9563C041D75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04370043E → EQPDSRRVNSSVGFSVLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96954 mRNA. Translation: AAA36384.1.
AK290695 mRNA. Translation: BAF83384.1.
AK290984 mRNA. Translation: BAF83673.1.
CCDSiCCDS31295.1. [Q01085-2]
CCDS7613.1. [Q01085-1]
PIRiA46174.
RefSeqiNP_001029097.1. NM_001033925.1. [Q01085-2]
NP_003243.1. NM_003252.3. [Q01085-1]
UniGeneiHs.501203.

Genome annotation databases

EnsembliENST00000369093; ENSP00000358089; ENSG00000151923. [Q01085-2]
ENST00000436547; ENSP00000394902; ENSG00000151923. [Q01085-1]
GeneIDi7073.
KEGGihsa:7073.
UCSCiuc001lei.2. human. [Q01085-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96954 mRNA. Translation: AAA36384.1.
AK290695 mRNA. Translation: BAF83384.1.
AK290984 mRNA. Translation: BAF83673.1.
CCDSiCCDS31295.1. [Q01085-2]
CCDS7613.1. [Q01085-1]
PIRiA46174.
RefSeqiNP_001029097.1. NM_001033925.1. [Q01085-2]
NP_003243.1. NM_003252.3. [Q01085-1]
UniGeneiHs.501203.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4GNMR-A187-282[»]
2CQINMR-A1-90[»]
2DH7NMR-A89-180[»]
ProteinModelPortaliQ01085.
SMRiQ01085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112929. 65 interactors.
DIPiDIP-42425N.
IntActiQ01085. 23 interactors.
MINTiMINT-1203913.
STRINGi9606.ENSP00000358089.

PTM databases

iPTMnetiQ01085.
PhosphoSitePlusiQ01085.
SwissPalmiQ01085.

Polymorphism and mutation databases

BioMutaiTIAL1.
DMDMi267131.

Proteomic databases

EPDiQ01085.
MaxQBiQ01085.
PaxDbiQ01085.
PeptideAtlasiQ01085.
PRIDEiQ01085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369093; ENSP00000358089; ENSG00000151923. [Q01085-2]
ENST00000436547; ENSP00000394902; ENSG00000151923. [Q01085-1]
GeneIDi7073.
KEGGihsa:7073.
UCSCiuc001lei.2. human. [Q01085-1]

Organism-specific databases

CTDi7073.
DisGeNETi7073.
GeneCardsiTIAL1.
HGNCiHGNC:11804. TIAL1.
HPAiHPA060962.
MIMi603413. gene.
neXtProtiNX_Q01085.
OpenTargetsiENSG00000151923.
PharmGKBiPA36513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0148. Eukaryota.
ENOG410XQ8U. LUCA.
GeneTreeiENSGT00860000133749.
HOGENOMiHOG000206748.
HOVERGENiHBG105006.
InParanoidiQ01085.
KOiK13201.
OMAiCKMITEM.
OrthoDBiEOG091G0FH8.
PhylomeDBiQ01085.
TreeFamiTF312915.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151923-MONOMER.
ReactomeiR-HSA-6803529. FGFR2 alternative splicing.

Miscellaneous databases

ChiTaRSiTIAL1. human.
EvolutionaryTraceiQ01085.
GeneWikiiTIAL1.
GenomeRNAii7073.
PROiQ01085.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151923.
CleanExiHS_TIAL1.
ExpressionAtlasiQ01085. baseline and differential.
GenevisibleiQ01085. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIAR_HUMAN
AccessioniPrimary (citable) accession number: Q01085
Secondary accession number(s): A8K3T0, A8K4L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.