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Q01081

- U2AF1_HUMAN

UniProt

Q01081 - U2AF1_HUMAN

Protein

Splicing factor U2AF 35 kDa subunit

Gene

U2AF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 4029C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri149 – 17628C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA 3'-end processing Source: Reactome
    3. mRNA export from nucleus Source: Reactome
    4. mRNA processing Source: ProtInc
    5. mRNA splicing, via spliceosome Source: UniProtKB
    6. RNA splicing Source: Reactome
    7. termination of RNA polymerase II transcription Source: Reactome
    8. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Splicing factor U2AF 35 kDa subunit
    Alternative name(s):
    U2 auxiliary factor 35 kDa subunit
    U2 small nuclear RNA auxiliary factor 1
    U2 snRNP auxiliary factor small subunit
    Gene namesi
    Name:U2AF1
    Synonyms:U2AF35, U2AFBP
    ORF Names:FP793
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:12453. U2AF1.

    Subcellular locationi

    Nucleus 1 Publication. Nucleus speckle 1 Publication

    GO - Cellular componenti

    1. Cajal body Source: ProtInc
    2. catalytic step 2 spliceosome Source: UniProtKB
    3. nuclear speck Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: HPA
    6. spliceosomal complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi134 – 1341W → A: Decreases affinity for UAF2 by 3 orders of magnitude. 1 Publication

    Organism-specific databases

    PharmGKBiPA37103.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 240239Splicing factor U2AF 35 kDa subunitPRO_0000081994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei61 – 611Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ01081.
    PaxDbiQ01081.
    PeptideAtlasiQ01081.
    PRIDEiQ01081.

    PTM databases

    PhosphoSiteiQ01081.

    Expressioni

    Gene expression databases

    ArrayExpressiQ01081.
    BgeeiQ01081.
    CleanExiHS_U2AF1.
    GenevestigatoriQ01081.

    Organism-specific databases

    HPAiHPA044833.

    Interactioni

    Subunit structurei

    Interacts (via RS domain) with PHF5A (via N-terminus) By similarity. Identified in the spliceosome C complex. Heterodimer with U2AF2. Interacts with ZRANB2.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CIR1Q86X954EBI-632461,EBI-627102
    JMJD6Q6NYC12EBI-632461,EBI-8464037
    NKAPQ8N5F72EBI-632461,EBI-721539
    SF3B2Q134352EBI-632461,EBI-749111
    SRPK2P783624EBI-632461,EBI-593303
    SUV39H1O434632EBI-632461,EBI-349968
    U2AF2P263688EBI-632461,EBI-742339

    Protein-protein interaction databases

    BioGridi113157. 106 interactions.
    DIPiDIP-1108N.
    IntActiQ01081. 34 interactions.
    MINTiMINT-1468226.
    STRINGi9606.ENSP00000291552.

    Structurei

    Secondary structure

    1
    240
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi45 – 539
    Helixi64 – 9229
    Beta strandi96 – 1016
    Beta strandi104 – 11815
    Helixi120 – 13011
    Beta strandi142 – 1443

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JMTX-ray2.20A43-146[»]
    ProteinModelPortaliQ01081.
    SMRiQ01081. Positions 43-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ01081.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 14783RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi178 – 24063Arg/Gly/Ser-rich (RS domain)Add
    BLAST
    Compositional biasi210 – 22314Poly-GlyAdd
    BLAST

    Domaini

    The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer.

    Sequence similaritiesi

    Belongs to the splicing factor SR family.Curated
    Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 4029C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri149 – 17628C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG323920.
    HOGENOMiHOG000178619.
    HOVERGENiHBG054605.
    KOiK12836.
    OMAiYGSIEEM.
    OrthoDBiEOG70089G.
    PhylomeDBiQ01081.
    TreeFamiTF300143.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR009145. U2_small.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PANTHERiPTHR12620. PTHR12620. 1 hit.
    PfamiPF00642. zf-CCCH. 2 hits.
    [Graphical view]
    PRINTSiPR01848. U2AUXFACTOR.
    SMARTiSM00360. RRM. 1 hit.
    SM00356. ZnF_C3H1. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01081-1) [UniParc]FASTAAdd to Basket

    Also known as: U2AF35a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN    50
    IYRNPQNSSQ SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN 100
    VCDNLGDHLV GNVYVKFRRE EDAEKAVIDL NNRWFNGQPI HAELSPVTDF 150
    REACCRQYEM GECTRGGFCN FMHLKPISRE LRRELYGRRR KKHRSRSRSR 200
    ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF 240
    Length:240
    Mass (Da):27,872
    Last modified:January 23, 2007 - v3
    Checksum:i3DA130DCE0B953F6
    GO
    Isoform 2 (identifier: Q01081-2) [UniParc]FASTAAdd to Basket

    Also known as: U2AF35b

    The sequence of this isoform differs from the canonical sequence as follows:
         47-66: ALLNIYRNPQNSSQSADGLR → LIQNIYRNPQNSAQTADGSH

    Note: Interacts with U2AF2 and stimulates U2AF splicing activity in vitro. Less efficient than isoform 1.

    Show »
    Length:240
    Mass (Da):27,882
    Checksum:iDDBE62F36F0CDF52
    GO
    Isoform 3 (identifier: Q01081-3) [UniParc]FASTAAdd to Basket

    Also known as: U2AF35c

    The sequence of this isoform differs from the canonical sequence as follows:
         47-66: ALLNIYRNPQNSSQSADGLR → LIQNIYRNPQNSAQTADGSH
         67-75: CAVSDVEMQ → YHCPLEHLP
         76-240: Missing.

    Note: Produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:75
    Mass (Da):8,572
    Checksum:i30BF651C83599A9D
    GO
    Isoform 4 (identifier: Q01081-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Show »
    Length:167
    Mass (Da):19,715
    Checksum:i3EBB13A8234C736B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373Missing in isoform 4. 1 PublicationVSP_042664Add
    BLAST
    Alternative sequencei47 – 6620ALLNI…ADGLR → LIQNIYRNPQNSAQTADGSH in isoform 2 and isoform 3. 1 PublicationVSP_042665Add
    BLAST
    Alternative sequencei67 – 759CAVSDVEMQ → YHCPLEHLP in isoform 3. CuratedVSP_042666
    Alternative sequencei76 – 240165Missing in isoform 3. CuratedVSP_042667Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96982 mRNA. Translation: AAA36619.1.
    AJ627978 mRNA. Translation: CAF29556.1.
    AF370386 mRNA. Translation: AAQ15222.1.
    AP001631 Genomic DNA. No translation available.
    AP001748 Genomic DNA. Translation: BAA95534.1.
    CH471079 Genomic DNA. Translation: EAX09501.1.
    CH471079 Genomic DNA. Translation: EAX09502.1.
    CH471079 Genomic DNA. Translation: EAX09504.1.
    CH471079 Genomic DNA. Translation: EAX09505.1.
    BC001177 mRNA. Translation: AAH01177.1.
    BC001923 mRNA. Translation: AAH01923.1.
    CCDSiCCDS13694.1. [Q01081-1]
    CCDS33574.1. [Q01081-2]
    CCDS42948.1. [Q01081-4]
    PIRiA46179.
    RefSeqiNP_001020374.1. NM_001025203.1. [Q01081-2]
    NP_001020375.1. NM_001025204.1. [Q01081-4]
    NP_006749.1. NM_006758.2. [Q01081-1]
    XP_006723990.1. XM_006723927.1. [Q01081-2]
    XP_006723991.1. XM_006723928.1. [Q01081-1]
    XP_006723992.1. XM_006723929.1. [Q01081-4]
    XP_006726861.1. XM_006726798.1. [Q01081-2]
    XP_006726862.1. XM_006726799.1. [Q01081-1]
    XP_006726863.1. XM_006726800.1. [Q01081-4]
    UniGeneiHs.365116.

    Genome annotation databases

    EnsembliENST00000291552; ENSP00000291552; ENSG00000160201. [Q01081-1]
    ENST00000380276; ENSP00000369629; ENSG00000160201. [Q01081-2]
    ENST00000398137; ENSP00000381205; ENSG00000160201. [Q01081-4]
    ENST00000459639; ENSP00000418705; ENSG00000160201. [Q01081-4]
    ENST00000464750; ENSP00000420672; ENSG00000160201. [Q01081-3]
    GeneIDi102724594.
    7307.
    KEGGihsa:102724594.
    hsa:7307.
    UCSCiuc002zcy.1. human. [Q01081-1]
    uc002zda.1. human. [Q01081-2]

    Polymorphism databases

    DMDMi267187.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96982 mRNA. Translation: AAA36619.1 .
    AJ627978 mRNA. Translation: CAF29556.1 .
    AF370386 mRNA. Translation: AAQ15222.1 .
    AP001631 Genomic DNA. No translation available.
    AP001748 Genomic DNA. Translation: BAA95534.1 .
    CH471079 Genomic DNA. Translation: EAX09501.1 .
    CH471079 Genomic DNA. Translation: EAX09502.1 .
    CH471079 Genomic DNA. Translation: EAX09504.1 .
    CH471079 Genomic DNA. Translation: EAX09505.1 .
    BC001177 mRNA. Translation: AAH01177.1 .
    BC001923 mRNA. Translation: AAH01923.1 .
    CCDSi CCDS13694.1. [Q01081-1 ]
    CCDS33574.1. [Q01081-2 ]
    CCDS42948.1. [Q01081-4 ]
    PIRi A46179.
    RefSeqi NP_001020374.1. NM_001025203.1. [Q01081-2 ]
    NP_001020375.1. NM_001025204.1. [Q01081-4 ]
    NP_006749.1. NM_006758.2. [Q01081-1 ]
    XP_006723990.1. XM_006723927.1. [Q01081-2 ]
    XP_006723991.1. XM_006723928.1. [Q01081-1 ]
    XP_006723992.1. XM_006723929.1. [Q01081-4 ]
    XP_006726861.1. XM_006726798.1. [Q01081-2 ]
    XP_006726862.1. XM_006726799.1. [Q01081-1 ]
    XP_006726863.1. XM_006726800.1. [Q01081-4 ]
    UniGenei Hs.365116.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JMT X-ray 2.20 A 43-146 [» ]
    ProteinModelPortali Q01081.
    SMRi Q01081. Positions 43-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113157. 106 interactions.
    DIPi DIP-1108N.
    IntActi Q01081. 34 interactions.
    MINTi MINT-1468226.
    STRINGi 9606.ENSP00000291552.

    PTM databases

    PhosphoSitei Q01081.

    Polymorphism databases

    DMDMi 267187.

    Proteomic databases

    MaxQBi Q01081.
    PaxDbi Q01081.
    PeptideAtlasi Q01081.
    PRIDEi Q01081.

    Protocols and materials databases

    DNASUi 7307.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291552 ; ENSP00000291552 ; ENSG00000160201 . [Q01081-1 ]
    ENST00000380276 ; ENSP00000369629 ; ENSG00000160201 . [Q01081-2 ]
    ENST00000398137 ; ENSP00000381205 ; ENSG00000160201 . [Q01081-4 ]
    ENST00000459639 ; ENSP00000418705 ; ENSG00000160201 . [Q01081-4 ]
    ENST00000464750 ; ENSP00000420672 ; ENSG00000160201 . [Q01081-3 ]
    GeneIDi 102724594.
    7307.
    KEGGi hsa:102724594.
    hsa:7307.
    UCSCi uc002zcy.1. human. [Q01081-1 ]
    uc002zda.1. human. [Q01081-2 ]

    Organism-specific databases

    CTDi 7307.
    GeneCardsi GC21M044513.
    HGNCi HGNC:12453. U2AF1.
    HPAi HPA044833.
    MIMi 191317. gene.
    neXtProti NX_Q01081.
    PharmGKBi PA37103.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323920.
    HOGENOMi HOG000178619.
    HOVERGENi HBG054605.
    KOi K12836.
    OMAi YGSIEEM.
    OrthoDBi EOG70089G.
    PhylomeDBi Q01081.
    TreeFami TF300143.

    Enzyme and pathway databases

    Reactomei REACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi U2AF1. human.
    EvolutionaryTracei Q01081.
    GeneWikii U2_small_nuclear_RNA_auxiliary_factor_1.
    GenomeRNAii 7307.
    NextBioi 28572.
    PROi Q01081.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01081.
    Bgeei Q01081.
    CleanExi HS_U2AF1.
    Genevestigatori Q01081.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR009145. U2_small.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    PANTHERi PTHR12620. PTHR12620. 1 hit.
    Pfami PF00642. zf-CCCH. 2 hits.
    [Graphical view ]
    PRINTSi PR01848. U2AUXFACTOR.
    SMARTi SM00360. RRM. 1 hit.
    SM00356. ZnF_C3H1. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit."
      Zhang M., Zamore P.D., Carmo-Fonseca M., Lamond A.I., Green M.R.
      Proc. Natl. Acad. Sci. U.S.A. 89:8769-8773(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 68-89 AND 126-151.
      Tissue: Fetal brain.
    2. "Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAs."
      Pacheco T.R.D., Gomes N.L., Benes V., Ansorge W., Wollerton M., Smith C.W., Valcarcel J., Carmo-Fonseca M.
      J. Biol. Chem. 279:27039-27049(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION.
      Tissue: Spleen.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    7. Bienvenut W.V.
      Submitted (JUL-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    8. "The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing."
      Zuo P., Maniatis T.
      Genes Dev. 10:1356-1368(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."
      Adams D.J., van der Weyden L., Mayeda A., Stamm S., Morris B.J., Rasko J.E.J.
      J. Cell Biol. 154:25-32(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZRANB2.
    10. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer."
      Kielkopf C.L., Rodionova N.A., Green M.R., Burley S.K.
      Cell 106:595-605(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 43-146 IN COMPLEX WITH U2AF2, MUTAGENESIS OF TRP-134.

    Entry informationi

    Entry nameiU2AF1_HUMAN
    AccessioniPrimary (citable) accession number: Q01081
    Secondary accession number(s): Q701P4, Q71RF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 167 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3