Reviewed,
UniProtKB/Swiss-Prot Q01066 (PDE1B_RAT)
Last modified
November 3, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Short name=Cam-PDE 1B EC=3.1.4.17 Alternative name(s): 63 kDa Cam-PDE | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 535 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. |
| Enzyme regulation | Type I PDE are activated by the binding of calmodulin in the presence of Ca2+. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Sequence similarities | Belongs to the cyclic nucleotide phosphodiesterase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Calmodulin-binding cAMP cGMP |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cAMP catabolic process Inferred from direct assay. Source: RGD cGMP catabolic processInferred from direct assay. Source: RGD |
| Cellular component | cell soma Inferred from direct assay. Source: RGD cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3',5'-cyclic-AMP phosphodiesterase activity Inferred from direct assay. Source: RGD calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activityInferred from direct assay. Source: RGD calmodulin bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 535 | 535 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | PRO_0000198791 | |||||
Regions | |||||||||
| Region | 27 – 47 | 21 | Calmodulin-binding Potential | ||||||
| Region | 196 – 495 | 300 | Catalytic By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 465 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase." Repaske D.R., Swinnen J.V., Jin S.-L.C., van Wyk J.J., Conti M. J. Biol. Chem. 267:18683-18688(1992) [PubMed: 1326532] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Phosphodiesterase 1B (PDE1B) in rat brain." Prime G.R., Sutor B. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M94537 mRNA. Translation: AAA16530.1. AF327906 mRNA. Translation: AAK15740.1. | |
| IPI | IPI00199077. |
| PIR | A44161. |
| RefSeq | NP_073201.1. |
| UniGene | Rn.53489 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OYN based on UniProtKB Q08499. |
| SMR | Q01066. Positions 145-474. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q01066. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000055272; ENSRNOP00000052147; ENSRNOG00000036828; Rattus norvegicus. [Genome view] |
| GeneID | 29691. |
| KEGG | rno:29691. |
| UCSC | NM_022710. rat. |
Organism-specific databases | |
| CTD | 29691. |
| RGD | 3278. Pde1b. |
Phylogenomic databases | |
| HOVERGEN | Q01066. |
| OMA | DVDVGDP. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.17. 248. |
Gene expression databases | |
| ArrayExpress | Q01066. |
| Genevestigator | Q01066. |
| GermOnline | ENSRNOG00000036828. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. IPR013706. PDEase_N. [Graphical view] |
| Pfam | PF00233. PDEase_I. 1 hit. PF08499. PDEase_I_N. 1 hit. [Graphical view] |
| PRINTS | PR00387. PDIESTERASE1. |
| SMART | SM00471. HDc. 1 hit. [Graphical view] |
| PROSITE | PS00126. PDEASE_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 610076. |
Entry information
| Entry name | PDE1B_RAT | ||||||||
| Accession | Primary (citable) accession number: Q01066 Secondary accession number(s): Q548L3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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