Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q01043

- CGH2_SHV21

UniProt

Q01043 - CGH2_SHV21

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin homolog

Gene

72

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. modulation by virus of host cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Host-virus interaction, Modulation of host cell cycle by viral cyclin-like protein, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin homolog
Alternative name(s):
V-cyclin
Gene namesi
Name:72
Synonyms:ECLF2
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
ProteomesiUP000000587: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Cyclin homologPRO_0000080509Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-232038.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 184
Helixi21 – 3111
Turni40 – 434
Beta strandi45 – 473
Helixi49 – 6517
Helixi72 – 8312
Turni84 – 863
Turni91 – 933
Helixi94 – 10916
Helixi116 – 1194
Turni122 – 1254
Helixi129 – 14214
Turni143 – 1453
Helixi152 – 1543
Helixi156 – 1627
Helixi167 – 1693
Helixi170 – 18415
Helixi188 – 1903
Beta strandi191 – 1933
Helixi195 – 20814
Helixi218 – 22811
Helixi232 – 24716
Helixi251 – 2533

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BU2X-ray3.00A22-250[»]
1JOWX-ray3.10A1-254[»]
1XO2X-ray2.90A1-254[»]
2EUFX-ray3.00A1-254[»]
2F2CX-ray2.80A1-254[»]
4TTHX-ray2.90A1-254[»]
ProteinModelPortaliQ01043.
SMRiQ01043. Positions 22-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01043.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view]
PIRSFiPIRSF037816. Viral_cyclin. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD
60 70 80 90 100
NRTILLTWMH LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA
110 120 130 140 150
CVLIGSKIRT VKPMTVSKLT YLSCDCFTNL ELINQEKDIL EALKWDTEAV
160 170 180 190 200
LATDFLIPLC NALKIPEDLW PQLYEAASTT ICKALIQPNI ALLSPGLICA
210 220 230 240 250
GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD QVSEAFSLYD

LEIL
Length:254
Mass (Da):28,637
Last modified:April 1, 1993 - v1
Checksum:iB682EB10111207F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.
RefSeqiNP_040274.1. NC_001350.1.

Genome annotation databases

GeneIDi1682479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76368 Genomic DNA. Translation: AAB21115.1 .
X64346 Genomic DNA. Translation: CAA45695.1 .
M86409 Genomic DNA. Translation: AAA46148.1 .
RefSeqi NP_040274.1. NC_001350.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BU2 X-ray 3.00 A 22-250 [» ]
1JOW X-ray 3.10 A 1-254 [» ]
1XO2 X-ray 2.90 A 1-254 [» ]
2EUF X-ray 3.00 A 1-254 [» ]
2F2C X-ray 2.80 A 1-254 [» ]
4TTH X-ray 2.90 A 1-254 [» ]
ProteinModelPortali Q01043.
SMRi Q01043. Positions 22-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-232038.

Chemistry

BindingDBi Q01043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1682479.

Miscellaneous databases

EvolutionaryTracei Q01043.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037816. Viral_cyclin. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the herpesvirus saimiri genome."
    Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
    J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
    Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
    Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins."
    Nicholas J., Cameron K.R., Honess R.W.
    Nature 355:362-365(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO G-PROTEIN COUPLED RECEPTORS.
  4. "Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6."
    Schulze-Gahmen U., Jung J.U., Kim S.-H.
    Structure 7:245-254(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-250.

Entry informationi

Entry nameiCGH2_SHV21
AccessioniPrimary (citable) accession number: Q01043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3