Q01043 (CGH2_SHV21) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin homolog

Alternative name(s):
V-cyclin

Gene names

Name:	72
Synonyms:	ECLF2

Organism

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]

Taxonomic identifier

10383 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Saimiriine herpesvirus 2

Virus host

Saimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
Sequence similarities	Belongs to the cyclin family. Cyclin D subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Host-virus interaction Modulation of host cell cycle by viral cyclin-like protein Modulation of host cell cycle by virus
Molecular function	Cyclin
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW modulation by virus of host cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 254

254

Cyclin homolog

PRO_0000080509

Secondary structure

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254

Helix Strand Turn

Details...

Helix

15 – 18

4

Helix

21 – 31

11

Turn

40 – 43

4

Beta strand

45 – 47

3

Helix

49 – 65

17

Helix

72 – 83

12

Turn

84 – 86

3

Turn

91 – 93

3

Helix

94 – 109

16

Helix

116 – 119

4

Turn

122 – 125

4

Helix

129 – 142

14

Turn

143 – 145

3

Helix

152 – 154

3

Helix

156 – 162

7

Helix

167 – 169

3

Helix

170 – 184

15

Helix

188 – 190

3

Beta strand

191 – 193

3

Helix

195 – 208

14

Helix

218 – 228

11

Helix

232 – 247

16

Helix

251 – 253

3

Sequences

	Sequence		Length	Mass (Da)
	Q01043 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: B682EB10111207F4	FASTA	254	28,637
	10 20 30 40 50 60 MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD NRTILLTWMH 70 80 90 100 110 120 LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA CVLIGSKIRT VKPMTVSKLT 130 140 150 160 170 180 YLSCDCFTNL ELINQEKDIL EALKWDTEAV LATDFLIPLC NALKIPEDLW PQLYEAASTT 190 200 210 220 230 240 ICKALIQPNI ALLSPGLICA GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD 250 QVSEAFSLYD LEIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of the herpesvirus saimiri genome." Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W. J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus." Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W. Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins." Nicholas J., Cameron K.R., Honess R.W. Nature 355:362-365(1992) [PubMed] [Europe PMC] [Abstract] Cited for: SIMILARITY TO G-PROTEIN COUPLED RECEPTORS.
[4]	"Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6." Schulze-Gahmen U., Jung J.U., Kim S.-H. Structure 7:245-254(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-250.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.

RefSeq

NP_040274.1. NC_001350.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BU2	X-ray	3.00	A	22-250	[»]
1JOW	X-ray	3.10	A	1-254	[»]
1XO2	X-ray	2.90	A	1-254	[»]
2EUF	X-ray	3.00	A	1-254	[»]
2F2C	X-ray	2.80	A	1-254	[»]

ProteinModelPortal

Q01043.

SMR

Q01043. Positions 22-250.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-232038.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1682479.

Phylogenomic databases

ProtClustDB

CLSP2509707.

Family and domain databases

Gene3D

1.10.472.10. 2 hits.

InterPro

IPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view]

Pfam

PF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view]

PIRSF

PIRSF037816. Viral_cyclin. 1 hit.

SMART

SM00385. CYCLIN. 1 hit.
[Graphical view]

SUPFAM

SSF47954. Cyclin_like. 2 hits.

PROSITE

PS00292. CYCLINS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q01043.

EvolutionaryTrace

Q01043.

Entry information

Entry name

CGH2_SHV21

Accession

Primary (citable) accession number: Q01043

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program