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Protein

Cyclin homolog

Gene

72

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Host-virus interaction, Modulation of host cell cycle by viral cyclin-like protein, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin homolog
Alternative name(s):
V-cyclin
Gene namesi
Name:72
Synonyms:ECLF2
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
Proteomesi
  • UP000000587 Componenti: Genome

Pathology & Biotechi

Chemistry databases

DrugBankiDB07379. (2S)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805091 – 254Cyclin homologAdd BLAST254

Interactioni

Protein-protein interaction databases

MINTiMINT-232038.

Chemistry databases

BindingDBiQ01043.

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 18Combined sources4
Helixi21 – 31Combined sources11
Turni40 – 43Combined sources4
Beta strandi45 – 47Combined sources3
Helixi49 – 65Combined sources17
Helixi72 – 83Combined sources12
Turni84 – 86Combined sources3
Turni91 – 93Combined sources3
Helixi94 – 109Combined sources16
Helixi116 – 119Combined sources4
Turni122 – 125Combined sources4
Helixi129 – 142Combined sources14
Turni143 – 145Combined sources3
Helixi152 – 154Combined sources3
Helixi156 – 162Combined sources7
Helixi167 – 169Combined sources3
Helixi170 – 184Combined sources15
Helixi188 – 190Combined sources3
Beta strandi191 – 193Combined sources3
Helixi195 – 208Combined sources14
Helixi218 – 228Combined sources11
Helixi232 – 247Combined sources16
Helixi251 – 253Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BU2X-ray3.00A22-250[»]
1JOWX-ray3.10A1-254[»]
1XO2X-ray2.90A1-254[»]
2EUFX-ray3.00A1-254[»]
2F2CX-ray2.80A1-254[»]
4TTHX-ray2.90A1-254[»]
ProteinModelPortaliQ01043.
SMRiQ01043.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01043.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

OrthoDBiVOG090000TF.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
PIRSFiPIRSF037816. Viral_cyclin. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD
60 70 80 90 100
NRTILLTWMH LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA
110 120 130 140 150
CVLIGSKIRT VKPMTVSKLT YLSCDCFTNL ELINQEKDIL EALKWDTEAV
160 170 180 190 200
LATDFLIPLC NALKIPEDLW PQLYEAASTT ICKALIQPNI ALLSPGLICA
210 220 230 240 250
GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD QVSEAFSLYD

LEIL
Length:254
Mass (Da):28,637
Last modified:April 1, 1993 - v1
Checksum:iB682EB10111207F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.
RefSeqiNP_040274.1. NC_001350.1.

Genome annotation databases

GeneIDi1682479.
KEGGivg:1682479.

Similar proteinsi

Entry informationi

Entry nameiCGH2_SHV21
AccessioniPrimary (citable) accession number: Q01043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families