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Q01043 (CGH2_SHV21) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin homolog
Alternative name(s):
V-cyclin
Gene names
Name:72
Synonyms:ECLF2
OrganismSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]
Taxonomic identifier10383 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

Sequence similarities

Belongs to the cyclin family. Cyclin D subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Cyclin homolog
PRO_0000080509

Secondary structure

.......................................... 254
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q01043 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: B682EB10111207F4

FASTA25428,637
        10         20         30         40         50         60 
MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD NRTILLTWMH 

        70         80         90        100        110        120 
LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA CVLIGSKIRT VKPMTVSKLT 

       130        140        150        160        170        180 
YLSCDCFTNL ELINQEKDIL EALKWDTEAV LATDFLIPLC NALKIPEDLW PQLYEAASTT 

       190        200        210        220        230        240 
ICKALIQPNI ALLSPGLICA GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD 

       250 
QVSEAFSLYD LEIL 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of the herpesvirus saimiri genome."
Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins."
Nicholas J., Cameron K.R., Honess R.W.
Nature 355:362-365(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: SIMILARITY TO G-PROTEIN COUPLED RECEPTORS.
[4]"Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6."
Schulze-Gahmen U., Jung J.U., Kim S.-H.
Structure 7:245-254(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-250.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.
RefSeqNP_040274.1. NC_001350.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BU2X-ray3.00A22-250[»]
1JOWX-ray3.10A1-254[»]
1XO2X-ray2.90A1-254[»]
2EUFX-ray3.00A1-254[»]
2F2CX-ray2.80A1-254[»]
4P41X-ray2.90A1-254[»]
ProteinModelPortalQ01043.
SMRQ01043. Positions 22-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-232038.

Chemistry

BindingDBQ01043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1682479.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view]
PIRSFPIRSF037816. Viral_cyclin. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ01043.

Entry information

Entry nameCGH2_SHV21
AccessionPrimary (citable) accession number: Q01043
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references