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Q01043

- CGH2_SHV21

UniProt

Q01043 - CGH2_SHV21

Protein

Cyclin homolog

Gene

72

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. modulation by virus of host cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Host-virus interaction, Modulation of host cell cycle by viral cyclin-like protein, Modulation of host cell cycle by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin homolog
    Alternative name(s):
    V-cyclin
    Gene namesi
    Name:72
    Synonyms:ECLF2
    OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
    Taxonomic identifieri10383 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
    Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
    ProteomesiUP000000587: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Cyclin homologPRO_0000080509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-232038.

    Structurei

    Secondary structure

    1
    254
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 184
    Helixi21 – 3111
    Turni40 – 434
    Beta strandi45 – 473
    Helixi49 – 6517
    Helixi72 – 8312
    Turni84 – 863
    Turni91 – 933
    Helixi94 – 10916
    Helixi116 – 1194
    Turni122 – 1254
    Helixi129 – 14214
    Turni143 – 1453
    Helixi152 – 1543
    Helixi156 – 1627
    Helixi167 – 1693
    Helixi170 – 18415
    Helixi188 – 1903
    Beta strandi191 – 1933
    Helixi195 – 20814
    Helixi218 – 22811
    Helixi232 – 24716
    Helixi251 – 2533

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BU2X-ray3.00A22-250[»]
    1JOWX-ray3.10A1-254[»]
    1XO2X-ray2.90A1-254[»]
    2EUFX-ray3.00A1-254[»]
    2F2CX-ray2.80A1-254[»]
    4P41X-ray2.90A1-254[»]
    ProteinModelPortaliQ01043.
    SMRiQ01043. Positions 22-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ01043.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin D subfamily.Curated

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR015322. Cyclin_dom_herpesvir.
    IPR017285. Cyclin_herpesvir.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    PF09241. Herp-Cyclin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037816. Viral_cyclin. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01043-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD    50
    NRTILLTWMH LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA 100
    CVLIGSKIRT VKPMTVSKLT YLSCDCFTNL ELINQEKDIL EALKWDTEAV 150
    LATDFLIPLC NALKIPEDLW PQLYEAASTT ICKALIQPNI ALLSPGLICA 200
    GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD QVSEAFSLYD 250
    LEIL 254
    Length:254
    Mass (Da):28,637
    Last modified:April 1, 1993 - v1
    Checksum:iB682EB10111207F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76368 Genomic DNA. Translation: AAB21115.1.
    X64346 Genomic DNA. Translation: CAA45695.1.
    M86409 Genomic DNA. Translation: AAA46148.1.
    RefSeqiNP_040274.1. NC_001350.1.

    Genome annotation databases

    GeneIDi1682479.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76368 Genomic DNA. Translation: AAB21115.1 .
    X64346 Genomic DNA. Translation: CAA45695.1 .
    M86409 Genomic DNA. Translation: AAA46148.1 .
    RefSeqi NP_040274.1. NC_001350.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BU2 X-ray 3.00 A 22-250 [» ]
    1JOW X-ray 3.10 A 1-254 [» ]
    1XO2 X-ray 2.90 A 1-254 [» ]
    2EUF X-ray 3.00 A 1-254 [» ]
    2F2C X-ray 2.80 A 1-254 [» ]
    4P41 X-ray 2.90 A 1-254 [» ]
    ProteinModelPortali Q01043.
    SMRi Q01043. Positions 22-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-232038.

    Chemistry

    BindingDBi Q01043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1682479.

    Miscellaneous databases

    EvolutionaryTracei Q01043.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR015322. Cyclin_dom_herpesvir.
    IPR017285. Cyclin_herpesvir.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    PF09241. Herp-Cyclin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037816. Viral_cyclin. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the herpesvirus saimiri genome."
      Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
      J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
      Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
      Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins."
      Nicholas J., Cameron K.R., Honess R.W.
      Nature 355:362-365(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIMILARITY TO G-PROTEIN COUPLED RECEPTORS.
    4. "Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6."
      Schulze-Gahmen U., Jung J.U., Kim S.-H.
      Structure 7:245-254(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-250.

    Entry informationi

    Entry nameiCGH2_SHV21
    AccessioniPrimary (citable) accession number: Q01043
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3