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Protein

Cyclin homolog

Gene

72

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Host-virus interaction, Modulation of host cell cycle by viral cyclin-like protein, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin homolog
Alternative name(s):
V-cyclin
Gene namesi
Name:72
Synonyms:ECLF2
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
ProteomesiUP000000587 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Cyclin homologPRO_0000080509Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-232038.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 184Combined sources
Helixi21 – 3111Combined sources
Turni40 – 434Combined sources
Beta strandi45 – 473Combined sources
Helixi49 – 6517Combined sources
Helixi72 – 8312Combined sources
Turni84 – 863Combined sources
Turni91 – 933Combined sources
Helixi94 – 10916Combined sources
Helixi116 – 1194Combined sources
Turni122 – 1254Combined sources
Helixi129 – 14214Combined sources
Turni143 – 1453Combined sources
Helixi152 – 1543Combined sources
Helixi156 – 1627Combined sources
Helixi167 – 1693Combined sources
Helixi170 – 18415Combined sources
Helixi188 – 1903Combined sources
Beta strandi191 – 1933Combined sources
Helixi195 – 20814Combined sources
Helixi218 – 22811Combined sources
Helixi232 – 24716Combined sources
Helixi251 – 2533Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BU2X-ray3.00A22-250[»]
1JOWX-ray3.10A1-254[»]
1XO2X-ray2.90A1-254[»]
2EUFX-ray3.00A1-254[»]
2F2CX-ray2.80A1-254[»]
4TTHX-ray2.90A1-254[»]
ProteinModelPortaliQ01043.
SMRiQ01043. Positions 22-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01043.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

KOiK10152.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view]
PIRSFiPIRSF037816. Viral_cyclin. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSPNRLNR AKIDSTTMKD PRVLNNLKLR ELLLPKFTSL WEIQTEVTVD
60 70 80 90 100
NRTILLTWMH LLCESFELDK SVFPLSVSIL DRYLCKKQGT KKTLQKIGAA
110 120 130 140 150
CVLIGSKIRT VKPMTVSKLT YLSCDCFTNL ELINQEKDIL EALKWDTEAV
160 170 180 190 200
LATDFLIPLC NALKIPEDLW PQLYEAASTT ICKALIQPNI ALLSPGLICA
210 220 230 240 250
GGLLTTIETD NTNCRPWTCY LEDLSSILNF STNTVRTVKD QVSEAFSLYD

LEIL
Length:254
Mass (Da):28,637
Last modified:April 1, 1993 - v1
Checksum:iB682EB10111207F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.
RefSeqiNP_040274.1. NC_001350.1.

Genome annotation databases

GeneIDi1682479.
KEGGivg:1682479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76368 Genomic DNA. Translation: AAB21115.1.
X64346 Genomic DNA. Translation: CAA45695.1.
M86409 Genomic DNA. Translation: AAA46148.1.
RefSeqiNP_040274.1. NC_001350.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BU2X-ray3.00A22-250[»]
1JOWX-ray3.10A1-254[»]
1XO2X-ray2.90A1-254[»]
2EUFX-ray3.00A1-254[»]
2F2CX-ray2.80A1-254[»]
4TTHX-ray2.90A1-254[»]
ProteinModelPortaliQ01043.
SMRiQ01043. Positions 22-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-232038.

Chemistry

BindingDBiQ01043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1682479.
KEGGivg:1682479.

Phylogenomic databases

KOiK10152.

Miscellaneous databases

EvolutionaryTraceiQ01043.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015322. Cyclin_dom_herpesvir.
IPR017285. Cyclin_herpesvir.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
PF09241. Herp-Cyclin. 1 hit.
[Graphical view]
PIRSFiPIRSF037816. Viral_cyclin. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the herpesvirus saimiri genome."
    Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
    J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
    Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
    Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins."
    Nicholas J., Cameron K.R., Honess R.W.
    Nature 355:362-365(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO G-PROTEIN COUPLED RECEPTORS.
  4. "Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6."
    Schulze-Gahmen U., Jung J.U., Kim S.-H.
    Structure 7:245-254(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-250.

Entry informationi

Entry nameiCGH2_SHV21
AccessioniPrimary (citable) accession number: Q01043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.