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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

RIR1

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176SubstrateUniRule annotation1
Sitei192Important for hydrogen atom transferUniRule annotation1
Binding sitei222Substrate; via amide nitrogenUniRule annotation1
Active sitei392Proton acceptorUniRule annotation1
Active sitei394Cysteine radical intermediateUniRule annotation1
Active sitei396Proton acceptorUniRule annotation1
Sitei408Important for hydrogen atom transferUniRule annotation1
Sitei709Important for electron transferUniRule annotation1
Sitei710Important for electron transferUniRule annotation1
Sitei763Interacts with thioredoxin/glutaredoxinUniRule annotation1
Sitei766Interacts with thioredoxin/glutaredoxinUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunitUniRule annotation (EC:1.17.4.1UniRule annotation)
Short name:
R1UniRule annotation
Alternative name(s):
Ribonucleotide reductase large subunitUniRule annotation
Gene namesi
Name:RIR1UniRule annotation
Ordered Locus Names:61, EELF2
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
Proteomesi
  • UP000000587 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872431 – 767Ribonucleoside-diphosphate reductase large subunitAdd BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi192 ↔ 408Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ01037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 192Substrate bindingUniRule annotation2
Regioni392 – 396Substrate bindingUniRule annotation5
Regioni578 – 582Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

KOiK10807.

Family and domain databases

HAMAPiMF_04026. HSV_RIR1. 1 hit.
InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQETIISNL IDMLKVSAGW DREANEISGR LFHKLMDMSS TETISQYMSL
60 70 80 90 100
FGPLLEPHIL EFIQNYEQEI DEVCLEYRAS YDFMCLRNCG ILPAKRFYDT
110 120 130 140 150
YVLPPRTEMN GKYESIPHFF ARIAAYCAWN CIMCEPLKDT LVYVQKRDWN
160 170 180 190 200
VEIKTDMQIF KYFYKVISSQ LVCCATPVMR SAGVAGENLS SCFIIAPTLD
210 220 230 240 250
TEKSTISSIF GELAPLLASR SGVGVDVTKF SFGGKNIHSC LKLINAQVEF
260 270 280 290 300
FNDKSVRPVS VATYIEVWHC QIHEFLSAKL PENPDRCNSI FQGVCVPSLF
310 320 330 340 350
FKMYESDPNG LWYLFDPQDA PNLTRLYGLE FEEEYLRLVS EKKYKQSVTL
360 370 380 390 400
KSLMFSLINT IIKTGSPYVI SKEAMNKHHW YETQGEAINC SNLCAEIVQQ
410 420 430 440 450
PKQFTSTCNL ANVCLPKCLN SSNFPYTCSN TAQFDFSKLE YAVQAAVFII
460 470 480 490 500
NACILSPSPT SSATVGQRER SMGIGCHGLA DVFSEMGYGY LDLESECLDR
510 520 530 540 550
DIFETMYYTA VKTSSEICSV GKGQPFAGFR KSKLAHGVFH WATWDAMPQR
560 570 580 590 600
VPMKQWIHLQ DNIKKFGVFN SQFIALMPTA GTSQLTGYTD SFYPYFANMS
610 620 630 640 650
SKVSNKEEIM KPNITFLKNV KPQDLCTVRF YGGDVSMMPE DVSTRYKHFL
660 670 680 690 700
TAFDYCPEAQ MRRASIRAPY VDQSQSLTLF LTEENVQSAK YLKDLLLLGF
710 720 730 740 750
RLGLKTIMYY CRVKKTTKLL QLECLKLDEH TKKDAQIVLA DLARELPDSH
760
KTEDACPLDQ SECIACQ
Length:767
Mass (Da):87,216
Last modified:April 1, 1993 - v1
Checksum:iFE5922B11FFCA6DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA. Translation: CAA45684.1.
M86409 Genomic DNA. Translation: AAA46137.1.
RefSeqiNP_040263.1. NC_001350.1.

Genome annotation databases

GeneIDi1682460.
KEGGivg:1682460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA. Translation: CAA45684.1.
M86409 Genomic DNA. Translation: AAA46137.1.
RefSeqiNP_040263.1. NC_001350.1.

3D structure databases

ProteinModelPortaliQ01037.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1682460.
KEGGivg:1682460.

Phylogenomic databases

KOiK10807.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

HAMAPiMF_04026. HSV_RIR1. 1 hit.
InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR1_SHV21
AccessioniPrimary (citable) accession number: Q01037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.