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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:54, EDRF3
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
Proteomesi
  • UP000000587 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829571 – 287Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST287

Proteomic databases

PRIDEiQ01034

Structurei

3D structure databases

ProteinModelPortaliQ01034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 175Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 3 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 2 hits
SUPFAMiSSF51283 SSF51283, 3 hits

Sequencei

Sequence statusi: Complete.

Q01034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYKVPEIYY RFEPQTFYIT SPARASNLQL INHNNILVKA GQVTIVSTGI
60 70 80 90 100
IFPKETSFAF ILYGKSAKSI FCHTGLIDPG FQGELKLIVL NKTEDDITLF
110 120 130 140 150
ENDLRVSVTA FVYGVPKLHD YSDLCPPRYS KDAGFDLYLP TDVTVKPRVP
160 170 180 190 200
NRYSVNICCP AQLKSYKPVL FGRSGLAAKG LTIKVSRWQN QLQIIFYNYT
210 220 230 240 250
KSQITYTART RIAQVVFMHK KHLPTTLTRL KPTMHLSENI KYSWARVSFQ
260 270 280
DIKTFPVQDE KLYSSSKDTS DSQMSRGDAG LGSSGLM
Length:287
Mass (Da):32,508
Last modified:April 1, 1993 - v1
Checksum:i598D495D74274A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA Translation: CAA45677.1
M86409 Genomic DNA Translation: AAA46131.1
RefSeqiNP_040256.1, NC_001350.1

Genome annotation databases

GeneIDi1682515
KEGGivg:1682515

Similar proteinsi

Entry informationi

Entry nameiDUT_SHV21
AccessioniPrimary (citable) accession number: Q01034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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