Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:54, EDRF3
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
Proteomesi
  • UP000000587 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182957Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 1753Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Family and domain databases

Gene3Di2.70.40.10. 3 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 2 hits.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

Q01034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYKVPEIYY RFEPQTFYIT SPARASNLQL INHNNILVKA GQVTIVSTGI
60 70 80 90 100
IFPKETSFAF ILYGKSAKSI FCHTGLIDPG FQGELKLIVL NKTEDDITLF
110 120 130 140 150
ENDLRVSVTA FVYGVPKLHD YSDLCPPRYS KDAGFDLYLP TDVTVKPRVP
160 170 180 190 200
NRYSVNICCP AQLKSYKPVL FGRSGLAAKG LTIKVSRWQN QLQIIFYNYT
210 220 230 240 250
KSQITYTART RIAQVVFMHK KHLPTTLTRL KPTMHLSENI KYSWARVSFQ
260 270 280
DIKTFPVQDE KLYSSSKDTS DSQMSRGDAG LGSSGLM
Length:287
Mass (Da):32,508
Last modified:April 1, 1993 - v1
Checksum:i598D495D74274A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA. Translation: CAA45677.1.
M86409 Genomic DNA. Translation: AAA46131.1.
RefSeqiNP_040256.1. NC_001350.1.

Genome annotation databases

GeneIDi1682515.
KEGGivg:1682515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA. Translation: CAA45677.1.
M86409 Genomic DNA. Translation: AAA46131.1.
RefSeqiNP_040256.1. NC_001350.1.

3D structure databases

ProteinModelPortaliQ01034.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1682515.
KEGGivg:1682515.

Family and domain databases

Gene3Di2.70.40.10. 3 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 2 hits.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_SHV21
AccessioniPrimary (citable) accession number: Q01034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.