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Q01034

- DUT_SHV21

UniProt

Q01034 - DUT_SHV21

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

54

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:54
    Synonyms:EDRF3
    OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
    Taxonomic identifieri10383 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
    Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
    ProteomesiUP000000587: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182957Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ01034.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 3 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 2 hits.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q01034-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYKVPEIYY RFEPQTFYIT SPARASNLQL INHNNILVKA GQVTIVSTGI    50
    IFPKETSFAF ILYGKSAKSI FCHTGLIDPG FQGELKLIVL NKTEDDITLF 100
    ENDLRVSVTA FVYGVPKLHD YSDLCPPRYS KDAGFDLYLP TDVTVKPRVP 150
    NRYSVNICCP AQLKSYKPVL FGRSGLAAKG LTIKVSRWQN QLQIIFYNYT 200
    KSQITYTART RIAQVVFMHK KHLPTTLTRL KPTMHLSENI KYSWARVSFQ 250
    DIKTFPVQDE KLYSSSKDTS DSQMSRGDAG LGSSGLM 287
    Length:287
    Mass (Da):32,508
    Last modified:April 1, 1993 - v1
    Checksum:i598D495D74274A11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64346 Genomic DNA. Translation: CAA45677.1.
    M86409 Genomic DNA. Translation: AAA46131.1.
    RefSeqiNP_040256.1. NC_001350.1.

    Genome annotation databases

    GeneIDi1682515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64346 Genomic DNA. Translation: CAA45677.1 .
    M86409 Genomic DNA. Translation: AAA46131.1 .
    RefSeqi NP_040256.1. NC_001350.1.

    3D structure databases

    ProteinModelPortali Q01034.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1682515.

    Family and domain databases

    Gene3Di 2.70.40.10. 3 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the herpesvirus saimiri genome."
      Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
      J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
      Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
      Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_SHV21
    AccessioniPrimary (citable) accession number: Q01034
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3