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Q01034

- DUT_SHV21

UniProt

Q01034 - DUT_SHV21

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
54, EDRF3
Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:54
Synonyms:EDRF3
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
ProteomesiUP000000587: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182957Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01034.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 3 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 2 hits.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

Q01034-1 [UniParc]FASTAAdd to Basket

« Hide

MPYKVPEIYY RFEPQTFYIT SPARASNLQL INHNNILVKA GQVTIVSTGI    50
IFPKETSFAF ILYGKSAKSI FCHTGLIDPG FQGELKLIVL NKTEDDITLF 100
ENDLRVSVTA FVYGVPKLHD YSDLCPPRYS KDAGFDLYLP TDVTVKPRVP 150
NRYSVNICCP AQLKSYKPVL FGRSGLAAKG LTIKVSRWQN QLQIIFYNYT 200
KSQITYTART RIAQVVFMHK KHLPTTLTRL KPTMHLSENI KYSWARVSFQ 250
DIKTFPVQDE KLYSSSKDTS DSQMSRGDAG LGSSGLM 287
Length:287
Mass (Da):32,508
Last modified:April 1, 1993 - v1
Checksum:i598D495D74274A11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64346 Genomic DNA. Translation: CAA45677.1.
M86409 Genomic DNA. Translation: AAA46131.1.
RefSeqiNP_040256.1. NC_001350.1.

Genome annotation databases

GeneIDi1682515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64346 Genomic DNA. Translation: CAA45677.1 .
M86409 Genomic DNA. Translation: AAA46131.1 .
RefSeqi NP_040256.1. NC_001350.1.

3D structure databases

ProteinModelPortali Q01034.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1682515.

Family and domain databases

Gene3Di 2.70.40.10. 3 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 2 hits.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the herpesvirus saimiri genome."
    Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
    J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
    Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
    Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_SHV21
AccessioniPrimary (citable) accession number: Q01034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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