Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetolactate synthase

Gene

OT_ostta16g02080

Organism
Ostreococcus tauri
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathway: L-isoleucine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (OT_ostta16g02080)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathway: L-valine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (OT_ostta16g02080)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
Gene namesi
ORF Names:OT_ostta16g02080Imported
OrganismiOstreococcus tauriImported
Taxonomic identifieri70448 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaprasinophytesMamiellophyceaeMamiellalesBathycoccaceaeOstreococcus
ProteomesiUP000009170 Componenti: Chromosome 16

PTM / Processingi

Proteomic databases

PRIDEiQ00U23.

Interactioni

Protein-protein interaction databases

STRINGi70448.Q00U23.

Structurei

3D structure databases

ProteinModelPortaliQ00U23.
SMRiQ00U23. Positions 81-669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258448.
InParanoidiQ00U23.
KOiK01652.
OMAiHSWVVRD.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00U23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHANARAQRT PTTALSVQNA RVSRRAAIRA RSQIRRVLSL KSPAVREPGA
60 70 80 90 100
SEYVDPSQFT ELELTTSQMT AYASRRPIGH FQSRFADDEP RKGADILVEA
110 120 130 140 150
LEREGVDCVF AYPGGASMEI HQSLTKSVTG IRNVLCRHEQ GEVFAAEGYA
160 170 180 190 200
KSTGKVGVCI ATSGPGATNL VTGLADALLD SVPMVAITGQ VPRPMIGTDA
210 220 230 240 250
FQETPIVEIT RQITKHNYLV MNVEEIPRIV REAFFLASSG RPGPVLIDIP
260 270 280 290 300
KDVQQQLAVP YWEPKVSLHG YLSRLPGPPT NPQIQQVVDL IKKSKKPIVY
310 320 330 340 350
AGGGCLDASK ELVEFCRATG IPVTNTLMGL GTFPQSDDLS LSMLGMHGAV
360 370 380 390 400
YANYAIDSAD LLLAFGVRFD DRVTGKLAEF AKRAAIVHID IDPAELGKNK
410 420 430 440 450
KPFCSIFSNI KPALRSLNKL IALDAANLPD FSDWRAEIEV KRKEFPFPIP
460 470 480 490 500
KQQGDVIAPQ AAIELLCKLT EGKAIISTGV GQHQMWAAQH YKFDEPRNWL
510 520 530 540 550
SSGGLGSMGF GLPAAIGAQA ARPDELVIDI DGDGSFVMNI QELATLHAEE
560 570 580 590 600
LPVKCFILNN QYLGMVVQWE DRFYKANRGH TYLGSPNDDY QVSKEEAHIF
610 620 630 640 650
PDFVTISNGF RVPAERVTRM SELEGAIKRM IETPGPYLLD VMVPHVEHVL
660 670
PMVPGGGTFA DTIVTGDGRT PEEKDMKTL
Length:679
Mass (Da):74,211
Last modified:November 14, 2006 - v1
Checksum:i48CFA490D4655C0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAID01000016 Genomic DNA. Translation: CAL58226.1.
RefSeqiXP_003083677.1. XM_003083629.1.

Genome annotation databases

GeneIDi9831116.
KEGGiota:Ot16g02270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAID01000016 Genomic DNA. Translation: CAL58226.1.
RefSeqiXP_003083677.1. XM_003083629.1.

3D structure databases

ProteinModelPortaliQ00U23.
SMRiQ00U23. Positions 81-669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70448.Q00U23.

Proteomic databases

PRIDEiQ00U23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9831116.
KEGGiota:Ot16g02270.

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258448.
InParanoidiQ00U23.
KOiK01652.
OMAiHSWVVRD.

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OTTH0595Imported.

Entry informationi

Entry nameiQ00U23_OSTTA
AccessioniPrimary (citable) accession number: Q00U23
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.