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Q00IB6

- CPL4_ARATH

UniProt

Q00IB6 - CPL4_ARATH

Protein

RNA polymerase II C-terminal domain phosphatase-like 4

Gene

CPL4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates 'Ser-2' and/or 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II By similarity. Required for normal plant growth.By similarity1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds magnesium, cobalt or manganese ions.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-EC
    3. protein C-terminus binding Source: UniProtKB
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. response to salt stress Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G58003-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II C-terminal domain phosphatase-like 4 (EC:3.1.3.16)
    Short name:
    FCP-like 4
    Alternative name(s):
    Carboxyl-terminal phosphatase-like 4
    Short name:
    AtCPL4
    Short name:
    CTD phosphatase-like 4
    Gene namesi
    Name:CPL4
    Ordered Locus Names:At5g58003
    ORF Names:MTI20
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G58003.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440RNA polymerase II C-terminal domain phosphatase-like 4PRO_0000376086Add
    BLAST

    Proteomic databases

    PaxDbiQ00IB6.
    PRIDEiQ00IB6.

    Expressioni

    Inductioni

    By NaCl.1 Publication

    Gene expression databases

    GenevestigatoriQ00IB6.

    Interactioni

    Subunit structurei

    Interacts with RAP74.1 Publication

    Protein-protein interaction databases

    BioGridi624522. 1 interaction.
    STRINGi3702.AT5G58003.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00IB6.
    SMRiQ00IB6. Positions 97-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini118 – 292175FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST
    Domaini337 – 42993BRCTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The BRCT domain is required for interaction with RAP74.

    Sequence similaritiesi

    Contains 1 BRCT domain.PROSITE-ProRule annotation
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5190.
    HOGENOMiHOG000239575.
    OMAiQEEDFPV.
    PhylomeDBiQ00IB6.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF00533. BRCT. 1 hit.
    PF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02250. FCP1_euk. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00IB6-1 [UniParc]FASTAAdd to Basket

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    MSVASDSPVH SSSSSDDLAA FLDAELDSAS DASSGPSEEE EAEDDVESGL    50
    KRQKLEHLEE ASSSKGECEH PGSFGNMCFV CGQKLEETGV SFRYIHKEMR 100
    LNEDEISRLR DSDSRFLQRQ RKLYLVLDLD HTLLNTTILR DLKPEEEYLK 150
    SHTHSLQDGC NVSGGSLFLL EFMQMMTKLR PFVHSFLKEA SEMFVMYIYT 200
    MGDRNYARQM AKLLDPKGEY FGDRVISRDD GTVRHEKSLD VVLGQESAVL 250
    ILDDTENAWP KHKDNLIVIE RYHFFSSSCR QFDHRYKSLS ELKSDESEPD 300
    GALATVLKVL KQAHALFFEN VDEGISNRDV RLMLKQVRKE ILKGCKIVFS 350
    RVFPTKAKPE DHPLWKMAEE LGATCATEVD ASVTHVVAMD VGTEKARWAV 400
    REKKYVVHRG WIDAANYLWM KQPEENFGLE QLKKQLTEEE 440
    Length:440
    Mass (Da):50,264
    Last modified:November 14, 2006 - v1
    Checksum:i7712641DC888B82B
    GO

    Sequence cautioni

    The sequence BAB08870.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At5g58000 and At5g58003.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ503426 mRNA. Translation: ABF55959.1.
    AB013396 Genomic DNA. Translation: BAB08870.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED96984.1.
    RefSeqiNP_001078764.1. NM_001085295.1.
    UniGeneiAt.71283.

    Genome annotation databases

    EnsemblPlantsiAT5G58003.1; AT5G58003.1; AT5G58003.
    GeneIDi5008312.
    KEGGiath:AT5G58003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ503426 mRNA. Translation: ABF55959.1 .
    AB013396 Genomic DNA. Translation: BAB08870.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED96984.1 .
    RefSeqi NP_001078764.1. NM_001085295.1.
    UniGenei At.71283.

    3D structure databases

    ProteinModelPortali Q00IB6.
    SMRi Q00IB6. Positions 97-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 624522. 1 interaction.
    STRINGi 3702.AT5G58003.1-P.

    Proteomic databases

    PaxDbi Q00IB6.
    PRIDEi Q00IB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G58003.1 ; AT5G58003.1 ; AT5G58003 .
    GeneIDi 5008312.
    KEGGi ath:AT5G58003.

    Organism-specific databases

    TAIRi AT5G58003.

    Phylogenomic databases

    eggNOGi COG5190.
    HOGENOMi HOG000239575.
    OMAi QEEDFPV.
    PhylomeDBi Q00IB6.

    Enzyme and pathway databases

    BioCyci ARA:AT5G58003-MONOMER.

    Miscellaneous databases

    PROi Q00IB6.

    Gene expression databases

    Genevestigatori Q00IB6.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF00533. BRCT. 1 hit.
    PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02250. FCP1_euk. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis carboxyl-terminal domain phosphatase-like isoforms share common catalytic and interaction domains but have distinct in planta functions."
      Bang W., Kim S., Ueda A., Vikram M., Yun D., Bressan R.A., Hasegawa P.M., Bahk J., Koiwa H.
      Plant Physiol. 142:586-594(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAP74, INDUCTION BY NACL, BRCT DOMAIN, SUBCELLULAR LOCATION.
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
      Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
      DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Evolutionary radiation pattern of novel protein phosphatases revealed by analysis of protein data from the completely sequenced genomes of humans, green algae, and higher plants."
      Kerk D., Templeton G., Moorhead G.B.G.
      Plant Physiol. 146:351-367(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiCPL4_ARATH
    AccessioniPrimary (citable) accession number: Q00IB6
    Secondary accession number(s): Q9FJL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3