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Reviewed, UniProtKB/Swiss-Prot Q00IB6 (CPL4_ARATH)

Last modified October 13, 2009. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    RNA polymerase II C-terminal domain phosphatase-like 4
      Short name=FCP-like 4
    EC=3.1.3.16
Alternative name(s):
    Carboxyl-terminal phosphatase-like 4
      Short name=CTD phosphatase-like 4
      Short name=AtCPL4
Gene names
Name: CPL4
Ordered Locus Names: At5g58003
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidseurosids IIBrassicalesBrassicaceaeArabidopsis

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Processively dephosphorylates 'Ser-2' and/or 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II By similarity. Required for normal plant growth.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds magnesium, cobalt or manganese ions By similarity.

Subunit structure

Interacts with RAP74. Ref.1

Subcellular location

Nucleus. Ref.1

Induction

By NaCl. Ref.1

Domain

The BRCT domain is required for interaction with RAP74. Ref.1

Sequence similarities

Contains 1 BRCT domain.

Contains 1 FCP1 homology domain.

Sequence caution

The sequence BAB08870.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At5g58000 and At5g58003.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440RNA polymerase II C-terminal domain phosphatase-like 4
PRO_0000376086

Regions

Domain118 – 292175FCP1 homology
Domain337 – 42993BRCT

Sequences

Sequence LengthMass (Da)Tools
Q00IB6-1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 7712641DC888B82B

FASTA44050,264
        10         20         30         40         50         60 
MSVASDSPVH SSSSSDDLAA FLDAELDSAS DASSGPSEEE EAEDDVESGL KRQKLEHLEE 

        70         80         90        100        110        120 
ASSSKGECEH PGSFGNMCFV CGQKLEETGV SFRYIHKEMR LNEDEISRLR DSDSRFLQRQ 

       130        140        150        160        170        180 
RKLYLVLDLD HTLLNTTILR DLKPEEEYLK SHTHSLQDGC NVSGGSLFLL EFMQMMTKLR 

       190        200        210        220        230        240 
PFVHSFLKEA SEMFVMYIYT MGDRNYARQM AKLLDPKGEY FGDRVISRDD GTVRHEKSLD 

       250        260        270        280        290        300 
VVLGQESAVL ILDDTENAWP KHKDNLIVIE RYHFFSSSCR QFDHRYKSLS ELKSDESEPD 

       310        320        330        340        350        360 
GALATVLKVL KQAHALFFEN VDEGISNRDV RLMLKQVRKE ILKGCKIVFS RVFPTKAKPE 

       370        380        390        400        410        420 
DHPLWKMAEE LGATCATEVD ASVTHVVAMD VGTEKARWAV REKKYVVHRG WIDAANYLWM 

       430        440 
KQPEENFGLE QLKKQLTEEE 

« Hide

References

« Hide 'large scale' references
[1]"Arabidopsis carboxyl-terminal domain phosphatase-like isoforms share common catalytic and interaction domains but have distinct in planta functions."
Bang W., Kim S., Ueda A., Vikram M., Yun D., Bressan R.A., Hasegawa P.M., Bahk J., Koiwa H.
Plant Physiol. 142:586-594(2006) [PubMed: 16905668] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAP74, INDUCTION BY NACL, BRCT DOMAIN, SUBCELLULAR LOCATION.
Strain: cv. Columbia.
[2]"Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
DNA Res. 5:203-216(1998) [PubMed: 9734815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]"Evolutionary radiation pattern of novel protein phosphatases revealed by analysis of protein data from the completely sequenced genomes of humans, green algae, and higher plants."
Kerk D., Templeton G., Moorhead G.B.G.
Plant Physiol. 146:351-367(2008) [PubMed: 18156295] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

DQ503426 mRNA. Translation: ABF55959.1.
AB013396 Genomic DNA. Translation: BAB08870.1. Sequence problems.
IPIIPI00570463.
RefSeqNP_001078764.1.
UniGeneAt.71283

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ00IB6.

Genome annotation databases

GeneID5008312.
GenomeReviewsGene locus AT5G58003 in contig BA000015_GR.
KEGGath:AT5G58003.

Organism-specific databases

TAIRAt5g58003.

Gene expression databases

GenevestigatorQ00IB6.

Family and domain databases

InterProIPR001357. BRCT.
IPR011947. FCP1_euk.
IPR004274. NIF.
[Graphical view]
PfamPF00533. BRCT. 1 hit.
PF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 1 hit.
SM00577. CPDc. 1 hit.
[Graphical view]
TIGRFAMsTIGR02250. FCP1_euk. 1 hit.
PROSITEPS50172. BRCT. 1 hit.
PS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPL4_ARATH
AccessionPrimary (citable) accession number: Q00IB6
Secondary accession number(s): Q9FJL6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: November 14, 2006
Last modified: October 13, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents