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Q00G26 (PLIN5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Perilipin-5
Alternative name(s):
Lipid storage droplet protein 5
Gene names
Name:PLIN5
Synonyms:LSDP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to lipid droplets and protects them from lipolytic degradation. Ref.1

Subcellular location

Lipid droplet. Note: Lipid droplet surface-associated. Ref.1

Tissue specificity

Expressed in skeletal muscle, liver, heart and kidney. Ref.1

Sequence similarities

Belongs to the perilipin family.

Sequence caution

The sequence BAC87086.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
   Cellular componentLipid droplet
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentlipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Perilipin-5
PRO_0000338982

Amino acid modifications

Modified residue1481Phosphoserine By similarity

Natural variations

Natural variant61A → V.
Corresponds to variant rs10407239 [ dbSNP | Ensembl ].
VAR_043850
Natural variant2551C → R. Ref.1 Ref.3
Corresponds to variant rs1610090 [ dbSNP | Ensembl ].
VAR_043851
Natural variant3061R → W. Ref.1
Corresponds to variant rs1062223 [ dbSNP | Ensembl ].
VAR_043852

Sequences

Sequence LengthMass (Da)Tools
Q00G26 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: B9747E905DFB56E2

FASTA46350,791
        10         20         30         40         50         60 
MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH PLLGSACRLA 

        70         80         90        100        110        120 
ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL EEKLPFLQQP SETVVTSAKD 

       130        140        150        160        170        180 
VVASSVTGVV DLARRGRRWS VELKRSVSHA VDVVLEKSEE LVDHFLPMTE EELAALAAEA 

       190        200        210        220        230        240 
EGPEVGSVED QRRQQGYFVR LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL 

       250        260        270        280        290        300 
IDHMQCGVTP TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA 

       310        320        330        340        350        360 
LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR VAHAHACVDE 

       370        380        390        400        410        420 
LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI GGPDPRWAHL DWPAQQRAWE 

       430        440        450        460 
AEHRDGSGNG DGDRMGVAGD ICEQEPETPS CPVKHTLMPE LDF 

« Hide

References

« Hide 'large scale' references
[1]"LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues."
Dalen K.T., Dahl T., Holter E., Arntsen B., Londos C., Sztalryd C., Nebb H.I.
Biochim. Biophys. Acta 1771:210-227(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANTS ARG-255 AND TRP-306.
Tissue: Heart.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-255.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ839131 mRNA. Translation: ABH07519.1.
AC011498 mRNA. No translation available.
BC131524 mRNA. Translation: AAI31525.1.
AK127689 mRNA. Translation: BAC87086.1. Sequence problems.
RefSeqNP_001013728.2. NM_001013706.2.
UniGeneHs.131034.

3D structure databases

ProteinModelPortalQ00G26.
SMRQ00G26. Positions 166-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371272.

Chemistry

BindingDBQ00G26.

PTM databases

PhosphoSiteQ00G26.

Polymorphism databases

DMDM292495026.

Proteomic databases

PaxDbQ00G26.
PRIDEQ00G26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381848; ENSP00000371272; ENSG00000214456.
GeneID440503.
KEGGhsa:440503.
UCSCuc002mas.3. human.

Organism-specific databases

CTD440503.
GeneCardsGC19M004522.
HGNCHGNC:33196. PLIN5.
MIM613248. gene.
neXtProtNX_Q00G26.
PharmGKBPA165394043.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68472.
HOGENOMHOG000033816.
HOVERGENHBG002935.
InParanoidQ00G26.
OMACRLAEHC.
OrthoDBEOG7SN8CD.
PhylomeDBQ00G26.
TreeFamTF328397.

Gene expression databases

ArrayExpressQ00G26.
BgeeQ00G26.
GenevestigatorQ00G26.

Family and domain databases

InterProIPR004279. Perilipin.
[Graphical view]
PANTHERPTHR14024. PTHR14024. 1 hit.
PfamPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFPIRSF036881. PAT. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPLIN5. human.
NextBio109299.
PROQ00G26.
SOURCESearch...

Entry information

Entry namePLIN5_HUMAN
AccessionPrimary (citable) accession number: Q00G26
Secondary accession number(s): A2RRC1, Q6ZS68
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM