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Protein

Perilipin-5

Gene

PLIN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-5
Alternative name(s):
Lipid storage droplet protein 5
Gene namesi
Name:PLIN5
Synonyms:LSDP5, OXPAT, PAT-1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000214456.8
HGNCiHGNC:33196 PLIN5
MIMi613248 gene
neXtProtiNX_Q00G26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi440503
OpenTargetsiENSG00000214456
PharmGKBiPA165394043

Polymorphism and mutation databases

BioMutaiPLIN5
DMDMi292495026

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003389821 – 463Perilipin-5Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei322PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00G26
PaxDbiQ00G26
PeptideAtlasiQ00G26
PRIDEiQ00G26

PTM databases

iPTMnetiQ00G26
PhosphoSitePlusiQ00G26

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, heart and kidney.1 Publication

Inductioni

Increased by endurance and sprint interval training.1 Publication

Gene expression databases

BgeeiENSG00000214456
ExpressionAtlasiQ00G26 baseline and differential
GenevisibleiQ00G26 HS

Interactioni

Subunit structurei

Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1366356 interactors.
STRINGi9606.ENSP00000371272

Chemistry databases

BindingDBiQ00G26

Structurei

3D structure databases

ProteinModelPortaliQ00G26
SMRiQ00G26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 173Essential for lipid droplet targetingBy similarityAdd BLAST173
Regioni1 – 108Interaction with LIPEBy similarityAdd BLAST108
Regioni185 – 463Interaction with PNPLA2 and ABHD5By similarityAdd BLAST279
Regioni444 – 463Recruits mitochondria at the lipid droplet surfaceBy similarityAdd BLAST20

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiENOG410IM0T Eukaryota
ENOG410XS97 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiQ00G26
KOiK20255
OMAiIHVLIYA
OrthoDBiEOG091G0D6Q
PhylomeDBiQ00G26
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q00G26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH
60 70 80 90 100
PLLGSACRLA ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL
110 120 130 140 150
EEKLPFLQQP SETVVTSAKD VVASSVTGVV DLARRGRRWS VELKRSVSHA
160 170 180 190 200
VDVVLEKSEE LVDHFLPMTE EELAALAAEA EGPEVGSVED QRRQQGYFVR
210 220 230 240 250
LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL IDHMQCGVTP
260 270 280 290 300
TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA
310 320 330 340 350
LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR
360 370 380 390 400
VAHAHACVDE LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI
410 420 430 440 450
GGPDPRWAHL DWPAQQRAWE AEHRDGSGNG DGDRMGVAGD ICEQEPETPS
460
CPVKHTLMPE LDF
Length:463
Mass (Da):50,791
Last modified:March 23, 2010 - v2
Checksum:iB9747E905DFB56E2
GO

Sequence cautioni

The sequence BAC87086 differs from that shown. Probable cloning artifact.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0438506A → V. Corresponds to variant dbSNP:rs10407239Ensembl.1
Natural variantiVAR_043851255C → R2 PublicationsCorresponds to variant dbSNP:rs1610090Ensembl.1
Natural variantiVAR_043852306R → W1 PublicationCorresponds to variant dbSNP:rs1062223Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ839131 mRNA Translation: ABH07519.1
AC011498 mRNA No translation available.
BC131524 mRNA Translation: AAI31525.1
AK127689 mRNA Translation: BAC87086.1 Sequence problems.
CCDSiCCDS42473.1
RefSeqiNP_001013728.2, NM_001013706.2
UniGeneiHs.131034

Genome annotation databases

EnsembliENST00000381848; ENSP00000371272; ENSG00000214456
GeneIDi440503
KEGGihsa:440503
UCSCiuc002mas.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLIN5_HUMAN
AccessioniPrimary (citable) accession number: Q00G26
Secondary accession number(s): A2RRC1, Q6ZS68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome