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Q00G26

- PLIN5_HUMAN

UniProt

Q00G26 - PLIN5_HUMAN

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Protein
Perilipin-5
Gene
PLIN5, LSDP5, OXPAT, PAT-1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE By similarity.1 Publication

GO - Biological processi

  1. lipid particle organization Source: UniProtKB
  2. negative regulation of fatty acid beta-oxidation Source: UniProtKB
  3. negative regulation of lipase activity Source: UniProtKB
  4. negative regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
  5. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  6. negative regulation of triglyceride catabolic process Source: UniProtKB
  7. positive regulation of fatty acid beta-oxidation Source: UniProtKB
  8. positive regulation of lipase activity Source: UniProtKB
  9. positive regulation of lipid storage Source: UniProtKB
  10. positive regulation of sequestering of triglyceride Source: UniProtKB
  11. positive regulation of triglyceride biosynthetic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-5
Alternative name(s):
Lipid storage droplet protein 5
Gene namesi
Name:PLIN5
Synonyms:LSDP5, OXPAT, PAT-1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:33196. PLIN5.

Subcellular locationi

Lipid droplet. Cytoplasm By similarity. Mitochondrion By similarity
Note: Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm By similarity.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. lipid particle Source: UniProtKB-SubCell
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Perilipin-5
PRO_0000338982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ00G26.
PRIDEiQ00G26.

PTM databases

PhosphoSiteiQ00G26.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, heart and kidney.1 Publication

Inductioni

Increased by endurance and sprint interval training.1 Publication

Gene expression databases

ArrayExpressiQ00G26.
BgeeiQ00G26.
GenevestigatoriQ00G26.

Interactioni

Subunit structurei

Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000371272.

Structurei

3D structure databases

ProteinModelPortaliQ00G26.
SMRiQ00G26. Positions 166-384.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 173173Essential for lipid droplet targeting By similarity
Add
BLAST
Regioni1 – 108108Interaction with LIPE By similarity
Add
BLAST
Regioni185 – 463279Interaction with PNPLA2 and ABHD5 By similarity
Add
BLAST
Regioni444 – 46320Recruits mitochondria at the lipid droplet surface By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the perilipin family.

Phylogenomic databases

eggNOGiNOG68472.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ00G26.
OMAiCRLAEHC.
OrthoDBiEOG7SN8CD.
PhylomeDBiQ00G26.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00G26-1 [UniParc]FASTAAdd to Basket

« Hide

MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH    50
PLLGSACRLA ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL 100
EEKLPFLQQP SETVVTSAKD VVASSVTGVV DLARRGRRWS VELKRSVSHA 150
VDVVLEKSEE LVDHFLPMTE EELAALAAEA EGPEVGSVED QRRQQGYFVR 200
LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL IDHMQCGVTP 250
TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA 300
LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR 350
VAHAHACVDE LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI 400
GGPDPRWAHL DWPAQQRAWE AEHRDGSGNG DGDRMGVAGD ICEQEPETPS 450
CPVKHTLMPE LDF 463
Length:463
Mass (Da):50,791
Last modified:March 23, 2010 - v2
Checksum:iB9747E905DFB56E2
GO

Sequence cautioni

The sequence BAC87086.1 differs from that shown. Reason: Probable cloning artifact.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → V.
Corresponds to variant rs10407239 [ dbSNP | Ensembl ].
VAR_043850
Natural varianti255 – 2551C → R.2 Publications
Corresponds to variant rs1610090 [ dbSNP | Ensembl ].
VAR_043851
Natural varianti306 – 3061R → W.1 Publication
Corresponds to variant rs1062223 [ dbSNP | Ensembl ].
VAR_043852

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ839131 mRNA. Translation: ABH07519.1.
AC011498 mRNA. No translation available.
BC131524 mRNA. Translation: AAI31525.1.
AK127689 mRNA. Translation: BAC87086.1. Sequence problems.
CCDSiCCDS42473.1.
RefSeqiNP_001013728.2. NM_001013706.2.
UniGeneiHs.131034.

Genome annotation databases

EnsembliENST00000381848; ENSP00000371272; ENSG00000214456.
GeneIDi440503.
KEGGihsa:440503.
UCSCiuc002mas.3. human.

Polymorphism databases

DMDMi292495026.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ839131 mRNA. Translation: ABH07519.1 .
AC011498 mRNA. No translation available.
BC131524 mRNA. Translation: AAI31525.1 .
AK127689 mRNA. Translation: BAC87086.1 . Sequence problems.
CCDSi CCDS42473.1.
RefSeqi NP_001013728.2. NM_001013706.2.
UniGenei Hs.131034.

3D structure databases

ProteinModelPortali Q00G26.
SMRi Q00G26. Positions 166-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371272.

Chemistry

BindingDBi Q00G26.

PTM databases

PhosphoSitei Q00G26.

Polymorphism databases

DMDMi 292495026.

Proteomic databases

PaxDbi Q00G26.
PRIDEi Q00G26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381848 ; ENSP00000371272 ; ENSG00000214456 .
GeneIDi 440503.
KEGGi hsa:440503.
UCSCi uc002mas.3. human.

Organism-specific databases

CTDi 440503.
GeneCardsi GC19M004522.
HGNCi HGNC:33196. PLIN5.
MIMi 613248. gene.
neXtProti NX_Q00G26.
PharmGKBi PA165394043.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68472.
HOGENOMi HOG000033816.
HOVERGENi HBG002935.
InParanoidi Q00G26.
OMAi CRLAEHC.
OrthoDBi EOG7SN8CD.
PhylomeDBi Q00G26.
TreeFami TF328397.

Miscellaneous databases

ChiTaRSi PLIN5. human.
NextBioi 109299.
PROi Q00G26.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00G26.
Bgeei Q00G26.
Genevestigatori Q00G26.

Family and domain databases

InterProi IPR004279. Perilipin.
[Graphical view ]
PANTHERi PTHR14024. PTHR14024. 1 hit.
Pfami PF03036. Perilipin. 1 hit.
[Graphical view ]
PIRSFi PIRSF036881. PAT. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues."
    Dalen K.T., Dahl T., Holter E., Arntsen B., Londos C., Sztalryd C., Nebb H.I.
    Biochim. Biophys. Acta 1771:210-227(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANTS ARG-255 AND TRP-306.
    Tissue: Heart.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-255.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114.
  5. "Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5."
    Shepherd S.O., Cocks M., Tipton K.D., Ranasinghe A.M., Barker T.A., Burniston J.G., Wagenmakers A.J., Shaw C.S.
    J. Physiol. (Lond.) 591:657-675(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPLIN5_HUMAN
AccessioniPrimary (citable) accession number: Q00G26
Secondary accession number(s): A2RRC1, Q6ZS68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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