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Protein

Perilipin-5

Gene

PLIN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-5
Alternative name(s):
Lipid storage droplet protein 5
Gene namesi
Name:PLIN5
Synonyms:LSDP5, OXPAT, PAT-1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33196. PLIN5.

Subcellular locationi

  • Lipid droplet 1 Publication
  • Cytoplasm By similarity
  • Mitochondrion By similarity

  • Note: Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi440503.
OpenTargetsiENSG00000214456.
PharmGKBiPA165394043.

Polymorphism and mutation databases

BioMutaiPLIN5.
DMDMi292495026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003389821 – 463Perilipin-5Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei322PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00G26.
PaxDbiQ00G26.
PeptideAtlasiQ00G26.
PRIDEiQ00G26.

PTM databases

iPTMnetiQ00G26.
PhosphoSitePlusiQ00G26.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, heart and kidney.1 Publication

Inductioni

Increased by endurance and sprint interval training.1 Publication

Gene expression databases

BgeeiENSG00000214456.
ExpressionAtlasiQ00G26. baseline and differential.
GenevisibleiQ00G26. HS.

Organism-specific databases

HPAiHPA067913.

Interactioni

Subunit structurei

Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE (By similarity).By similarity

Protein-protein interaction databases

BioGridi136635. 5 interactors.
STRINGi9606.ENSP00000371272.

Chemistry databases

BindingDBiQ00G26.

Structurei

3D structure databases

ProteinModelPortaliQ00G26.
SMRiQ00G26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 173Essential for lipid droplet targetingBy similarityAdd BLAST173
Regioni1 – 108Interaction with LIPEBy similarityAdd BLAST108
Regioni185 – 463Interaction with PNPLA2 and ABHD5By similarityAdd BLAST279
Regioni444 – 463Recruits mitochondria at the lipid droplet surfaceBy similarityAdd BLAST20

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiENOG410IM0T. Eukaryota.
ENOG410XS97. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ00G26.
KOiK20255.
OMAiSKHRAQD.
OrthoDBiEOG091G0D6Q.
PhylomeDBiQ00G26.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00G26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH
60 70 80 90 100
PLLGSACRLA ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL
110 120 130 140 150
EEKLPFLQQP SETVVTSAKD VVASSVTGVV DLARRGRRWS VELKRSVSHA
160 170 180 190 200
VDVVLEKSEE LVDHFLPMTE EELAALAAEA EGPEVGSVED QRRQQGYFVR
210 220 230 240 250
LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL IDHMQCGVTP
260 270 280 290 300
TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA
310 320 330 340 350
LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR
360 370 380 390 400
VAHAHACVDE LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI
410 420 430 440 450
GGPDPRWAHL DWPAQQRAWE AEHRDGSGNG DGDRMGVAGD ICEQEPETPS
460
CPVKHTLMPE LDF
Length:463
Mass (Da):50,791
Last modified:March 23, 2010 - v2
Checksum:iB9747E905DFB56E2
GO

Sequence cautioni

The sequence BAC87086 differs from that shown. Probable cloning artifact.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0438506A → V.Corresponds to variant rs10407239dbSNPEnsembl.1
Natural variantiVAR_043851255C → R.2 PublicationsCorresponds to variant rs1610090dbSNPEnsembl.1
Natural variantiVAR_043852306R → W.1 PublicationCorresponds to variant rs1062223dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ839131 mRNA. Translation: ABH07519.1.
AC011498 mRNA. No translation available.
BC131524 mRNA. Translation: AAI31525.1.
AK127689 mRNA. Translation: BAC87086.1. Sequence problems.
CCDSiCCDS42473.1.
RefSeqiNP_001013728.2. NM_001013706.2.
UniGeneiHs.131034.

Genome annotation databases

EnsembliENST00000381848; ENSP00000371272; ENSG00000214456.
GeneIDi440503.
KEGGihsa:440503.
UCSCiuc002mas.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ839131 mRNA. Translation: ABH07519.1.
AC011498 mRNA. No translation available.
BC131524 mRNA. Translation: AAI31525.1.
AK127689 mRNA. Translation: BAC87086.1. Sequence problems.
CCDSiCCDS42473.1.
RefSeqiNP_001013728.2. NM_001013706.2.
UniGeneiHs.131034.

3D structure databases

ProteinModelPortaliQ00G26.
SMRiQ00G26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136635. 5 interactors.
STRINGi9606.ENSP00000371272.

Chemistry databases

BindingDBiQ00G26.

PTM databases

iPTMnetiQ00G26.
PhosphoSitePlusiQ00G26.

Polymorphism and mutation databases

BioMutaiPLIN5.
DMDMi292495026.

Proteomic databases

EPDiQ00G26.
PaxDbiQ00G26.
PeptideAtlasiQ00G26.
PRIDEiQ00G26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381848; ENSP00000371272; ENSG00000214456.
GeneIDi440503.
KEGGihsa:440503.
UCSCiuc002mas.5. human.

Organism-specific databases

CTDi440503.
DisGeNETi440503.
GeneCardsiPLIN5.
HGNCiHGNC:33196. PLIN5.
HPAiHPA067913.
MIMi613248. gene.
neXtProtiNX_Q00G26.
OpenTargetsiENSG00000214456.
PharmGKBiPA165394043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM0T. Eukaryota.
ENOG410XS97. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ00G26.
KOiK20255.
OMAiSKHRAQD.
OrthoDBiEOG091G0D6Q.
PhylomeDBiQ00G26.
TreeFamiTF328397.

Enzyme and pathway databases

BioCyciZFISH:G66-32573-MONOMER.

Miscellaneous databases

ChiTaRSiPLIN5. human.
GenomeRNAii440503.
PROiQ00G26.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214456.
ExpressionAtlasiQ00G26. baseline and differential.
GenevisibleiQ00G26. HS.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN5_HUMAN
AccessioniPrimary (citable) accession number: Q00G26
Secondary accession number(s): A2RRC1, Q6ZS68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.