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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation
Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Viral release from host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000118991 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ00EX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 411CCHC-typeInterPro annotationAdd BLAST16
Domaini418 – 433CCHC-typeInterPro annotationAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 121Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.301 hit
1.10.150.901 hit
1.10.375.101 hit
InterProiView protein in InterPro
IPR000721 Gag_p24
IPR014817 Gag_p6
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF08705 Gag_p6, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits

Sequencei

Sequence statusi: Complete.

Q00EX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASILSG GELGRWEKIR LRPGGKKKYK LKHLVWASRE LERFAVNPGL
60 70 80 90 100
LETSEGCRQI LAQLQPALQT GSEELKSVYN TVATLYCVHQ RIDVKDTKEA
110 120 130 140 150
LDKIEEEQNK SKEKAQQAAA DTGNSSQVRN SSQVSQNYPI VQNLQGQMVH
160 170 180 190 200
QAISPRTLNA WVKVVEEKAF SPEVIPMFSA LSEGATPQDL NTMLNTVGGH
210 220 230 240 250
QAAMQMLKET INEEAAEWDR LHPVHAGPVA PGQMREPRGS DIAGTTSTLQ
260 270 280 290 300
EQIGWMTNNP PIPVGEIYKR WIIMGLNKIV RMYSPTSILD IRQGPKEPFR
310 320 330 340 350
DYVDRFYKTL RAEQASQDVK NWMTETLLVQ NANPDCKTIL KALGPGATLE
360 370 380 390 400
EMMTACQGVG GPSHKARVLA EAMSQANSTT IMMQKGNFRN QRKTVKCFNC
410 420 430 440 450
GKEGHIARNC RAPRKKGCWK CGREGHQMKD CTERQANFLG KIWPSHKGRP
460 470 480 490 500
GNFLQSRPEP TAPPAPPEES FRFGEGTTTP SQKQEPIDKE LYPLASLKSL

FGSDPSSQ
Length:508
Mass (Da):56,519
Last modified:November 14, 2006 - v1
Checksum:i28E47DCD3C2CE994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ853447 Genomic RNA Translation: ABI79878.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiQ00EX2_9HIV1
AccessioniPrimary (citable) accession number: Q00EX2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported