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Protein

Protein Vpr

Gene

vpr

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.UniRule annotation
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotationSAAS annotation
Biological processCell cycleUniRule annotationSAAS annotation, Host-virus interactionUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation, Viral penetration into host nucleusUniRule annotationSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VprUniRule annotationSAAS annotation
Alternative name(s):
Viral protein RUniRule annotation
Gene namesi
Name:vprUniRule annotationImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000109925 Componenti: Genome
  • UP000169170 Componenti: Genome

Subcellular locationi

  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR000012. RetroV_VpR/X.
PfamiView protein in Pfam
PF00522. VPR. 1 hit.
PRINTSiPR00444. HIVVPRVPX.

Sequencei

Sequence statusi: Complete.

Q00C63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAPEDQGP QREPYNEWAL ELLEELKSEA VRHFPRLWLH GLGQHIYETY
60 70 80 90
GDTWTGVEAI IRMLQQLLFI HFRIGCRHSR IGITPQRRAR NGASRS
Length:96
Mass (Da):11,295
Last modified:November 14, 2006 - v1
Checksum:iDAB147836A71665B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ853441 Genomic RNA. Translation: ABI79828.1.
DQ853454 Genomic RNA. Translation: ABI79942.1.
DQ854074 Genomic RNA. Translation: ABI80102.1.
DQ854076 Genomic RNA. Translation: ABI80106.1.
DQ854077 Genomic RNA. Translation: ABI80108.1.
DQ854081 Genomic RNA. Translation: ABI80116.1.
DQ854083 Genomic RNA. Translation: ABI80120.1.
DQ854090 Genomic RNA. Translation: ABI80134.1.
DQ854099 Genomic RNA. Translation: ABI80152.1.
DQ854100 Genomic RNA. Translation: ABI80154.1.
DQ854102 Genomic RNA. Translation: ABI80158.1.
DQ854105 Genomic RNA. Translation: ABI80164.1.
DQ854107 Genomic RNA. Translation: ABI80168.1.
DQ854112 Genomic RNA. Translation: ABI80177.1.
DQ854122 Genomic RNA. Translation: ABI80197.1.
DQ854125 Genomic RNA. Translation: ABI80203.1.
DQ854127 Genomic RNA. Translation: ABI80206.1.
DQ854132 Genomic RNA. Translation: ABI80216.1.
DQ854134 Genomic RNA. Translation: ABI80220.1.
DQ854146 Genomic RNA. Translation: ABI80243.1.
DQ854147 Genomic RNA. Translation: ABI80245.1.
DQ854150 Genomic RNA. Translation: ABI80251.1.
DQ854151 Genomic RNA. Translation: ABI80253.1.
DQ854156 Genomic RNA. Translation: ABI80263.1.
DQ854166 Genomic RNA. Translation: ABI80283.1.

Similar proteinsi

Entry informationi

Entry nameiQ00C63_9HIV1
AccessioniPrimary (citable) accession number: Q00C63
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported