Reviewed,
UniProtKB/Swiss-Prot Q00994 (BEX3_HUMAN)
Last modified
February 9, 2010.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein BEX3 Alternative name(s): Brain-expressed X-linked protein 3 p75NTR-associated cell death executor Nerve growth factor receptor-associated protein 1 Ovarian granulosa cell 13.0 kDa protein HGR74 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 111 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death By similarity. May play an important role in the pathogenesis of neurogenetic diseases. |
| Subunit structure | Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC By similarity. Binds to the DEATH domain of p75NTR/NGFR. |
| Subcellular location | Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria By similarity. |
| Tissue specificity | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. Ref.3 |
| Domain | The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR By similarity. |
| Post-translational modification | Ubiquitinated. Degraded by the proteasome By similarity. |
| Miscellaneous | Binds transition metals By similarity. |
| Sequence similarities | Belongs to the BEX family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Metal-binding |
| PTM | Ubl conjugation |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from Experiment. Source: Reactome multicellular organismal development Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytosol Ref.2 Inferred from Experiment. Source: Reactome nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | caspase regulator activity Inferred from Experiment. Source: Reactome metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||
Molecule processing | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 111 | 111 | Protein BEX3 | PRO_0000096688 | |||||||||||||
Regions | |||||||||||||||||
| Region | 68 – 111 | 44 | Interaction with 14-3-3 epsilon By similarity | ||||||||||||||
| Region | 68 – 93 | 26 | Interaction with p75NTR/NGFR By similarity | ||||||||||||||
| Motif | 77 – 87 | 11 | Nuclear export signal By similarity | ||||||||||||||
Secondary structure | |||||||||||||||||
Helix Strand Turn | |||||||||||||||||
| Beta strand | 2 – 4 | 3 | |||||||||||||||
| Turn | 22 – 26 | 5 | |||||||||||||||
| Beta strand | 28 – 30 | 3 | |||||||||||||||
| Beta strand | 39 – 43 | 5 | |||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Characterization of three abundant mRNAs from human ovarian granulosa cells." Rapp G., Freudenstein J., Klaudiny J., Mucha J., Wempe F., Zimmer M., Scheit K.H. DNA Cell Biol. 9:479-485(1990) [PubMed: 2171551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary. |
| [2] | "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M.T., Nadano D., Suvanto P., Hanaoka T., Li Y., Irie S., Greene L.A., Sato T.-A. J. Biol. Chem. 275:17566-17570(2000) [PubMed: 10764727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. |
| [3] | "Characterization of the Bex gene family in humans, mice, and rats." Alvarez E., Zhou W., Witta S.E., Freed C.R. Gene 357:18-28(2005) [PubMed: 15958283] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum. |
| [5] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
| [8] | "Theoretical model for p75NTR-associated cell death executor." Arunkumar S. Submitted (JAN-2005) to the PDB data bank Cited for: 3D-STRUCTURE MODELING OF 1-111. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M38188 mRNA. Translation: AAA63232.1. AF187064 mRNA. Translation: AAF75129.1. AY833562 mRNA. Translation: AAX40680.1. AK315371 mRNA. Translation: BAG37764.1. AL606763 Genomic DNA. Translation: CAI41522.1. AL606763 Genomic DNA. Translation: CAI41523.1. Different initiation. CH471190 Genomic DNA. Translation: EAW54710.1. BC003190 mRNA. Translation: AAH03190.1. | ||||||||||||
| IPI | IPI00025492. | ||||||||||||
| PIR | C35826. | ||||||||||||
| RefSeq | NP_055195.1. NP_996798.1. NP_996800.1. | ||||||||||||
| UniGene | Hs.448588 Hs.719133 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q00994. 3 interactions. | ||||||||||||
| STRING | Q00994. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q00994. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000372635; ENSP00000361718; ENSG00000166681; Homo sapiens. [Genome view] ENST00000372645; ENSP00000361728; ENSG00000166681; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 27018. | ||||||||||||
| KEGG | hsa:27018. | ||||||||||||
| UCSC | uc004eki.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 27018. | ||||||||||||
| GeneCards | GC0XP102437. | ||||||||||||
| H-InvDB | HIX0016948. | ||||||||||||
| HGNC | HGNC:13388. NGFRAP1. | ||||||||||||
| HPA | HPA018886. | ||||||||||||
| MIM | 300361. gene. | ||||||||||||
| PharmGKB | PA31616. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG21368. | ||||||||||||
| HOGENOM | HBG127440. | ||||||||||||
| HOVERGEN | Q00994. | ||||||||||||
| InParanoid | Q00994. | ||||||||||||
| OMA | EMEQPLQ. | ||||||||||||
| OrthoDB | EOG9SFCR4. | ||||||||||||
| PhylomeDB | Q00994. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | p75ntrpathway. p75(NTR)-mediated signaling. | ||||||||||||
| Reactome | REACT_11061. Signalling by NGF. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q00994. | ||||||||||||
| Bgee | Q00994. | ||||||||||||
| CleanEx | HS_NGFRAP1. | ||||||||||||
| Genevestigator | Q00994. | ||||||||||||
| GermOnline | ENSG00000166681. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR007623. BEX. [Graphical view] | ||||||||||||
| PIRSF | PIRSF008633. BEX. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 49532. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | BEX3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q00994 Secondary accession number(s): B2RD17, Q5JQT4, Q5JQT5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


