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Q00994 (BEX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein BEX3
Alternative name(s):
Brain-expressed X-linked protein 3
Nerve growth factor receptor-associated protein 1
Ovarian granulosa cell 13.0 kDa protein HGR74
p75NTR-associated cell death executor
Gene names
Name:NGFRAP1
Synonyms:BEX3, DXS6984E, NADE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death By similarity. May play an important role in the pathogenesis of neurogenetic diseases.

Subunit structure

Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC By similarity. Binds to the DEATH domain of p75NTR/NGFR.

Subcellular location

Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria By similarity.

Tissue specificity

Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. Ref.3

Domain

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR By similarity.

Post-translational modification

Ubiquitinated. Degraded by the proteasome By similarity.

Miscellaneous

Binds transition metals By similarity.

Sequence similarities

Belongs to the BEX family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TSC1Q925745EBI-741753,EBI-1047085

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q00994-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q00994-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 111111Protein BEX3
PRO_0000096688

Regions

Region68 – 11144Interaction with 14-3-3 epsilon By similarity
Region68 – 9326Interaction with p75NTR/NGFR By similarity
Motif77 – 8711Nuclear export signal By similarity

Natural variations

Alternative sequence1 – 1010Missing in isoform 2.
VSP_046343

Secondary structure

......... 111
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 29AA0573282C933E

FASTA11112,959
        10         20         30         40         50         60 
MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA IPNRQINDGM 

        70         80         90        100        110 
GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH HDHHDEFCLM P 

« Hide

Isoform 2 [UniParc].

Checksum: ED263FF37D8E838F
Show »

FASTA10111,762

References

« Hide 'large scale' references
[1]"Characterization of three abundant mRNAs from human ovarian granulosa cells."
Rapp G., Freudenstein J., Klaudiny J., Mucha J., Wempe F., Zimmer M., Scheit K.H.
DNA Cell Biol. 9:479-485(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Ovary.
[2]"NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR."
Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M.T., Nadano D., Suvanto P., Hanaoka T., Li Y., Irie S., Greene L.A., Sato T.-A.
J. Biol. Chem. 275:17566-17570(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
[3]"Characterization of the Bex gene family in humans, mice, and rats."
Alvarez E., Zhou W., Witta S.E., Freed C.R.
Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cerebellum.
[5]"A comparative gene expression profile of the whole eye from human, mouse, and guinea pig."
Zhou X., Wang W., Lu F., Hu S., Jiang L., Yan D., Zhang X., Yu X., Yu J., Qu J.
Mol. Vis. 13:2214-2221(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
[6]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[9]"Theoretical model for p75NTR-associated cell death executor."
Arunkumar S.
Submitted (JAN-2005) to the PDB data bank
Cited for: 3D-STRUCTURE MODELING OF 1-111.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M38188 mRNA. Translation: AAA63232.1.
AF187064 mRNA. Translation: AAF75129.1.
AY833562 mRNA. Translation: AAX40680.1.
AK315371 mRNA. Translation: BAG37764.1.
EL953547 Genomic DNA. No translation available.
AL606763 Genomic DNA. No translation available.
CH471190 Genomic DNA. Translation: EAW54710.1.
CH471190 Genomic DNA. Translation: EAW54712.1.
BC003190 mRNA. Translation: AAH03190.1.
CCDSCCDS14508.1. [Q00994-1]
CCDS14509.1. [Q00994-2]
PIRC35826.
RefSeqNP_055195.1. NM_014380.2. [Q00994-1]
NP_996798.1. NM_206915.2. [Q00994-1]
NP_996800.1. NM_206917.2. [Q00994-2]
UniGeneHs.448588.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SA6model-A1-111[»]
ProteinModelPortalQ00994.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117956. 11 interactions.
IntActQ00994. 13 interactions.
MINTMINT-1471079.
STRING9606.ENSP00000361718.

Polymorphism databases

DMDM547642.

Proteomic databases

PaxDbQ00994.
PRIDEQ00994.

Protocols and materials databases

DNASU27018.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299872; ENSP00000299872; ENSG00000166681. [Q00994-1]
ENST00000361298; ENSP00000354843; ENSG00000166681. [Q00994-2]
ENST00000372634; ENSP00000361717; ENSG00000166681. [Q00994-2]
ENST00000372635; ENSP00000361718; ENSG00000166681. [Q00994-1]
ENST00000372645; ENSP00000361728; ENSG00000166681. [Q00994-1]
GeneID27018.
KEGGhsa:27018.
UCSCuc004ekh.3. human. [Q00994-1]

Organism-specific databases

CTD27018.
GeneCardsGC0XP102631.
HGNCHGNC:13388. NGFRAP1.
HPAHPA018886.
MIM300361. gene.
neXtProtNX_Q00994.
PharmGKBPA31616.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG48134.
HOGENOMHOG000236300.
HOVERGENHBG080240.
InParanoidQ00994.
KOK12465.
OMALMANIHQ.
OrthoDBEOG7T1RF2.
PhylomeDBQ00994.
TreeFamTF337909.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ00994.
CleanExHS_NGFRAP1.
GenevestigatorQ00994.

Family and domain databases

InterProIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamPF04538. BEX. 1 hit.
[Graphical view]
PIRSFPIRSF008633. BEX. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNGFRAP1. human.
GeneWikiNGFRAP1.
GenomeRNAi27018.
NextBio49532.
PROQ00994.
SOURCESearch...

Entry information

Entry nameBEX3_HUMAN
AccessionPrimary (citable) accession number: Q00994
Secondary accession number(s): B2RD17 expand/collapse secondary AC list , D3DXA3, Q5JQT4, Q5JQT5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM