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Q00993

- UFO_MOUSE

UniProt

Q00993 - UFO_MOUSE

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Protein

Tyrosine-protein kinase receptor UFO

Gene
Axl, Ark, Ufo
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Activated by GAS6-binding and subsequent autophosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei561 – 5611ATP By similarity
Active sitei666 – 6661Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi536 – 5449ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatidylserine binding Source: Ensembl
  3. protein heterodimerization activity Source: MGI
  4. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic cell clearance Source: UniProtKB
  2. blood vessel remodeling Source: MGI
  3. cell maturation Source: Ensembl
  4. cellular response to extracellular stimulus Source: MGI
  5. cellular response to hydrogen peroxide Source: Ensembl
  6. cellular response to interferon-alpha Source: Ensembl
  7. cellular response to lipopolysaccharide Source: Ensembl
  8. dendritic cell differentiation Source: Ensembl
  9. enzyme linked receptor protein signaling pathway Source: MGI
  10. erythrocyte homeostasis Source: MGI
  11. forebrain cell migration Source: MGI
  12. inflammatory response Source: MGI
  13. innate immune response Source: UniProtKB-KW
  14. natural killer cell differentiation Source: MGI
  15. negative regulation of apoptotic process Source: UniProtKB
  16. negative regulation of dendritic cell apoptotic process Source: Ensembl
  17. negative regulation of interferon-gamma production Source: Ensembl
  18. negative regulation of lymphocyte activation Source: MGI
  19. negative regulation of neuron apoptotic process Source: MGI
  20. negative regulation of tumor necrosis factor production Source: MGI
  21. neuron migration Source: MGI
  22. organ regeneration Source: Ensembl
  23. ovulation cycle Source: MGI
  24. phagocytosis Source: MGI
  25. platelet activation Source: MGI
  26. positive regulation of cytokine-mediated signaling pathway Source: Ensembl
  27. positive regulation of natural killer cell differentiation Source: Ensembl
  28. positive regulation of protein kinase B signaling Source: UniProtKB
  29. protein kinase B signaling Source: MGI
  30. secretion by cell Source: MGI
  31. spermatogenesis Source: MGI
  32. substrate adhesion-dependent cell spreading Source: MGI
  33. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptor UFO (EC:2.7.10.1)
Alternative name(s):
Adhesion-related kinase
Gene namesi
Name:Axl
Synonyms:Ark, Ufo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1347244. Axl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 445427Extracellular Reviewed predictionAdd
BLAST
Transmembranei446 – 46621Helical; Reviewed predictionAdd
BLAST
Topological domaini467 – 888422Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 888870Tyrosine-protein kinase receptor UFOPRO_0000024482Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi50 ↔ 111 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi154 ↔ 199 By similarity
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Modified residuei697 – 6971Phosphotyrosine; by autocatalysis By similarity
Modified residuei773 – 7731Phosphotyrosine; by autocatalysis By similarity
Modified residuei815 – 8151Phosphotyrosine; by autocatalysis By similarity
Modified residuei860 – 8601Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion By similarity.
Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ00993.
PRIDEiQ00993.

PTM databases

PhosphoSiteiQ00993.

Miscellaneous databases

PMAP-CutDBQ80YQ3.

Expressioni

Tissue specificityi

In distinct substructures of a broad spectrum of developing tissues (in the late embryogenesis). In cells forming organ capsules as well as in connective tissue structures (in adult).

Gene expression databases

ArrayExpressiQ00993.
BgeeiQ00993.
CleanExiMM_AXL.
GenevestigatoriQ00993.

Interactioni

Subunit structurei

Heterodimer and heterotetramer with ligand GAS6 By similarity. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2 By similarity.1 Publication

Protein-protein interaction databases

BioGridi204922. 1 interaction.
IntActiQ00993. 2 interactions.
STRINGi10090.ENSMUSP00000002677.

Structurei

3D structure databases

ProteinModelPortaliQ00993.
SMRiQ00993. Positions 29-417, 485-836.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12293Ig-like C2-type 1Add
BLAST
Domaini133 – 21684Ig-like C2-type 2Add
BLAST
Domaini221 – 325105Fibronectin type-III 1Add
BLAST
Domaini330 – 42293Fibronectin type-III 2Add
BLAST
Domaini530 – 801272Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 8668Interaction with GAS6 By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108377.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
InParanoidiQ80YQ3.
KOiK05115.
OMAiQVQGEPP.
OrthoDBiEOG77DJ5C.
TreeFamiTF317402.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00993-1 [UniParc]FASTAAdd to Basket

« Hide

MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC    50
ELQVQGEPPE VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA 100
LQLSDAGEYQ CMVHLEGRTF VSQPGFVGLE GLPYFLEEPE DKAVPANTPF 150
NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH SSQHSLQTPG LNKTSSFSCE 200
AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT PGLSGIYPLT 250
HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH 300
IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP 350
RVPLQGTLLG YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV 400
TAYTSAGDGP WSLPVPLEPW RPGQGQPLHH LVSEPPPRAF SWPWWYVLLG 450
ALVAAACVLI LALFLVHRRK KETRYGEVFE PTVERGELVV RYRVRKSYSR 500
RTTEATLNSL GISEELKEKL RDVMVDRHKV ALGKTLGEGE FGAVMEGQLN 550
QDDSILKVAV KTMKIAICTR SELEDFLSEA VCMKEFDHPN VMRLIGVCFQ 600
GSDREGFPEP VVILPFMKHG DLHSFLLYSR LGDQPVFLPT QMLVKFMADI 650
ASGMEYLSTK RFIHRDLAAR NCMLNENMSV CVADFGLSKK IYNGDYYRQG 700
RIAKMPVKWI AIESLADRVY TSKSDVWSFG VTMWEIATRG QTPYPGVENS 750
EIYDYLRQGN RLKQPVDCLD GLYALMSRCW ELNPRDRPSF AELREDLENT 800
LKALPPAQEP DEILYVNMDE GGSHLEPRGA AGGADPPTQP DPKDSCSCLT 850
AADVHSAGRY VLCPSTAPGP TLSADRGCPA PPGQEDGA 888
Length:888
Mass (Da):98,191
Last modified:July 27, 2011 - v2
Checksum:iC5350E3A8995E975
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti394 – 3941A → R in CAA42158. 1 Publication
Sequence conflicti486 – 4861G → P in CAA42158. 1 Publication
Sequence conflicti566 – 5661A → V in CAA42158. 1 Publication
Sequence conflicti768 – 7681C → F in CAA45097. 1 Publication
Sequence conflicti774 – 7741A → S in CAA45097. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63535 mRNA. Translation: CAA45097.1.
X59560 Genomic DNA. Translation: CAA42158.1.
AK155567 mRNA. Translation: BAE33327.1.
CH466593 Genomic DNA. Translation: EDL24236.1.
BC046618 mRNA. Translation: AAH46618.1.
BC050914 mRNA. Translation: AAH50914.1.
CCDSiCCDS20996.1.
PIRiS23065.
S23251.
RefSeqiNP_033491.2. NM_009465.4.
XP_006540052.1. XM_006539989.1.
XP_006540053.1. XM_006539990.1.
UniGeneiMm.4128.

Genome annotation databases

EnsembliENSMUST00000002677; ENSMUSP00000002677; ENSMUSG00000002602.
GeneIDi26362.
KEGGimmu:26362.
UCSCiuc009ftx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63535 mRNA. Translation: CAA45097.1 .
X59560 Genomic DNA. Translation: CAA42158.1 .
AK155567 mRNA. Translation: BAE33327.1 .
CH466593 Genomic DNA. Translation: EDL24236.1 .
BC046618 mRNA. Translation: AAH46618.1 .
BC050914 mRNA. Translation: AAH50914.1 .
CCDSi CCDS20996.1.
PIRi S23065.
S23251.
RefSeqi NP_033491.2. NM_009465.4.
XP_006540052.1. XM_006539989.1.
XP_006540053.1. XM_006539990.1.
UniGenei Mm.4128.

3D structure databases

ProteinModelPortali Q00993.
SMRi Q00993. Positions 29-417, 485-836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204922. 1 interaction.
IntActi Q00993. 2 interactions.
STRINGi 10090.ENSMUSP00000002677.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q00993.

Proteomic databases

PaxDbi Q00993.
PRIDEi Q00993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002677 ; ENSMUSP00000002677 ; ENSMUSG00000002602 .
GeneIDi 26362.
KEGGi mmu:26362.
UCSCi uc009ftx.2. mouse.

Organism-specific databases

CTDi 558.
MGIi MGI:1347244. Axl.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108377.
HOGENOMi HOG000231685.
HOVERGENi HBG006346.
InParanoidi Q80YQ3.
KOi K05115.
OMAi QVQGEPP.
OrthoDBi EOG77DJ5C.
TreeFami TF317402.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 3474.

Miscellaneous databases

ChiTaRSi AXL. mouse.
NextBioi 304223.
PMAP-CutDB Q80YQ3.
PROi Q00993.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00993.
Bgeei Q00993.
CleanExi MM_AXL.
Genevestigatori Q00993.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis."
    Faust M., Ebensperger C., Schulz A.S., Schleithoff L., Hameister H., Bartram C.R., Janssen J.W.G.
    Oncogene 7:1287-1293(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Heart.
  2. "A putative receptor tyrosine kinase with unique structural topology."
    Rescigno J., Mansukhani A., Basilico C.
    Oncogene 6:1909-1913(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Dendritic cell.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  6. "The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases."
    Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., Masiakowski P., Ryan T.E., Tobkes N.J., Chen D.H., DiStefano P.S., Long G.L., Basilico C., Goldfarb M.P.
    , Lemke G., Glass D.J., Yancopoulos G.D.
    Cell 80:661-670(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LIGAND GAS6.
  7. "TAM receptors are pleiotropic inhibitors of the innate immune response."
    Rothlin C.V., Ghosh S., Zuniga E.I., Oldstone M.B., Lemke G.
    Cell 131:1124-1136(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INNATE IMMUNE RESPONSE INHIBITION.
  8. "Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors."
    Sun B., Qi N., Shang T., Wu H., Deng T., Han D.
    Endocrinology 151:2886-2897(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INNATE IMMUNE RESPONSE INHIBITION.

Entry informationi

Entry nameiUFO_MOUSE
AccessioniPrimary (citable) accession number: Q00993
Secondary accession number(s): Q80YQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi