ID   MCPA_CAUVC              Reviewed;         657 AA.
AC   Q00986;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   27-MAR-2024, entry version 139.
DE   RecName: Full=Chemoreceptor McpA;
DE   AltName: Full=Methyl-accepting chemotaxis protein;
GN   Name=mcpA; OrderedLocusNames=CC_0430;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=1577276; DOI=10.1101/gad.6.5.825;
RA   Alley M.R.K., Maddock J.R., Shapiro L.;
RT   "Polar localization of a bacterial chemoreceptor.";
RL   Genes Dev. 6:825-836(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Chemotactic-signal transducers respond to changes in the
CC       concentration of attractants and repellents in the environment,
CC       transduce a signal from the outside to the inside of the cell, and
CC       facilitate sensory adaptation through the variation of the level of
CC       methylation. Attractants increase the level of methylation while
CC       repellents decrease the level of methylation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Note=Localized at the flagellum-bearing pole of the swarmer cell.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; X66502; CAA47122.1; -; Genomic_DNA.
DR   EMBL; AE005673; AAK22417.1; -; Genomic_DNA.
DR   PIR; S23064; S23064.
DR   RefSeq; NP_419249.1; NC_002696.2.
DR   AlphaFoldDB; Q00986; -.
DR   SMR; Q00986; -.
DR   STRING; 190650.CC_0430; -.
DR   EnsemblBacteria; AAK22417; AAK22417; CC_0430.
DR   KEGG; ccr:CC_0430; -.
DR   PATRIC; fig|190650.5.peg.435; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_20_5; -.
DR   BioCyc; CAULO:CC0430-MONOMER; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd11386; MCP_signal; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR43531:SF11; METHYL-ACCEPTING CHEMOTAXIS PROTEIN 3; 1.
DR   PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Receptor;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..657
FT                   /note="Chemoreceptor McpA"
FT                   /id="PRO_0000110545"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..188
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..657
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          216..269
FT                   /note="HAMP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          297..349
FT                   /note="HAMP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          354..583
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          634..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         378
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         385
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         392
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         574
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   657 AA;  69346 MW;  2D5CC51CA43D7250 CRC64;
     MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER DMRQNLEIQR
     ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD AVKKDLLALK SKLPAEEQPK
     IAELIKSLEE CRSAIDTVSG MISVDFNMAA GFIAPFEEQY VKMTGQLDQV VAAANQRIES
     ESAKRQAQAT AAMSVTIIMS LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID
     LEKMTRGDEL GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS
     LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV IAASTDGLST
     GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT AAGARQASDV VSTTRGEATH
     SGQVVHQAVS AMGEIEKSSG QISQIIGVID EIAFQTNLLA LNAGVEAARA GEAGRGFAVV
     AQEVRALAQR SAEAAKEIKA LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI
     AASAAEQATG LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS
     GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA SDGWEEF
//