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Q00986

- MCPA_CAUCR

UniProt

Q00986 - MCPA_CAUCR

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Protein

Chemoreceptor McpA

Gene

mcpA

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation.

GO - Molecular functioni

  1. signal transducer activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciCAULO:CC0430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemoreceptor McpA
Alternative name(s):
Methyl-accepting chemotaxis protein
Gene namesi
Name:mcpA
Ordered Locus Names:CC_0430
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Localized at the flagellum-bearing pole of the swarmer cell.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence Analysis
Transmembranei6 – 2924HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 188159PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei189 – 21224HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 657445CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Chemoreceptor McpAPRO_0000110545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei378 – 3781Glutamate methyl ester (Gln)By similarity
Modified residuei385 – 3851Glutamate methyl ester (Glu)By similarity
Modified residuei392 – 3921Glutamate methyl ester (Glu)By similarity
Modified residuei574 – 5741Glutamate methyl ester (Gln)By similarity

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliQ00986.
SMRiQ00986. Positions 217-264, 299-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 26954HAMP 1PROSITE-ProRule annotationAdd
BLAST
Domaini297 – 34953HAMP 2PROSITE-ProRule annotationAdd
BLAST
Domaini354 – 583230Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HAMP domains.PROSITE-ProRule annotation
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
HOGENOMiHOG000148074.
KOiK03406.
OMAiTHKAGNI.
OrthoDBiEOG6G4VQG.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER
60 70 80 90 100
DMRQNLEIQR ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD
110 120 130 140 150
AVKKDLLALK SKLPAEEQPK IAELIKSLEE CRSAIDTVSG MISVDFNMAA
160 170 180 190 200
GFIAPFEEQY VKMTGQLDQV VAAANQRIES ESAKRQAQAT AAMSVTIIMS
210 220 230 240 250
LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID LEKMTRGDEL
260 270 280 290 300
GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS
310 320 330 340 350
LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV
360 370 380 390 400
IAASTDGLST GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT
410 420 430 440 450
AAGARQASDV VSTTRGEATH SGQVVHQAVS AMGEIEKSSG QISQIIGVID
460 470 480 490 500
EIAFQTNLLA LNAGVEAARA GEAGRGFAVV AQEVRALAQR SAEAAKEIKA
510 520 530 540 550
LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI AASAAEQATG
560 570 580 590 600
LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS
610 620 630 640 650
GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA

SDGWEEF
Length:657
Mass (Da):69,346
Last modified:February 1, 1994 - v1
Checksum:i2D5CC51CA43D7250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66502 Genomic DNA. Translation: CAA47122.1.
AE005673 Genomic DNA. Translation: AAK22417.1.
PIRiS23064.
RefSeqiNP_419249.1. NC_002696.2.
WP_010918318.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22417; AAK22417; CC_0430.
GeneIDi942024.
KEGGiccr:CC_0430.
PATRICi21297794. VBICauCre124313_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66502 Genomic DNA. Translation: CAA47122.1 .
AE005673 Genomic DNA. Translation: AAK22417.1 .
PIRi S23064.
RefSeqi NP_419249.1. NC_002696.2.
WP_010918318.1. NC_002696.2.

3D structure databases

ProteinModelPortali Q00986.
SMRi Q00986. Positions 217-264, 299-599.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK22417 ; AAK22417 ; CC_0430 .
GeneIDi 942024.
KEGGi ccr:CC_0430.
PATRICi 21297794. VBICauCre124313_0435.

Phylogenomic databases

eggNOGi COG0840.
HOGENOMi HOG000148074.
KOi K03406.
OMAi THKAGNI.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci CAULO:CC0430-MONOMER.

Family and domain databases

InterProi IPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view ]
PRINTSi PR00260. CHEMTRNSDUCR.
SMARTi SM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view ]
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polar localization of a bacterial chemoreceptor."
    Alley M.R.K., Maddock J.R., Shapiro L.
    Genes Dev. 6:825-836(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 19089 / CB15.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiMCPA_CAUCR
AccessioniPrimary (citable) accession number: Q00986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3