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Q00986

- MCPA_CAUCR

UniProt

Q00986 - MCPA_CAUCR

Protein

Chemoreceptor McpA

Gene

mcpA

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation.

    GO - Molecular functioni

    1. signal transducer activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    BioCyciCAULO:CC0430-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chemoreceptor McpA
    Alternative name(s):
    Methyl-accepting chemotaxis protein
    Gene namesi
    Name:mcpA
    Ordered Locus Names:CC_0430
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: Localized at the flagellum-bearing pole of the swarmer cell.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Chemoreceptor McpAPRO_0000110545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei378 – 3781Glutamate methyl ester (Gln)By similarity
    Modified residuei385 – 3851Glutamate methyl ester (Glu)By similarity
    Modified residuei392 – 3921Glutamate methyl ester (Glu)By similarity
    Modified residuei574 – 5741Glutamate methyl ester (Gln)By similarity

    Keywords - PTMi

    Methylation

    Structurei

    3D structure databases

    ProteinModelPortaliQ00986.
    SMRiQ00986. Positions 217-264, 299-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55CytoplasmicSequence Analysis
    Topological domaini30 – 188159PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini213 – 657445CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2924HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 21224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini216 – 26954HAMP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini297 – 34953HAMP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini354 – 583230Methyl-accepting transducerPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 HAMP domains.PROSITE-ProRule annotation
    Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    HOGENOMiHOG000148074.
    KOiK03406.
    OMAiTHKAGNI.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    InterProiIPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view]
    PRINTSiPR00260. CHEMTRNSDUCR.
    SMARTiSM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    [Graphical view]
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00986-1 [UniParc]FASTAAdd to Basket

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    MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER    50
    DMRQNLEIQR ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD 100
    AVKKDLLALK SKLPAEEQPK IAELIKSLEE CRSAIDTVSG MISVDFNMAA 150
    GFIAPFEEQY VKMTGQLDQV VAAANQRIES ESAKRQAQAT AAMSVTIIMS 200
    LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID LEKMTRGDEL 250
    GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS 300
    LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV 350
    IAASTDGLST GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT 400
    AAGARQASDV VSTTRGEATH SGQVVHQAVS AMGEIEKSSG QISQIIGVID 450
    EIAFQTNLLA LNAGVEAARA GEAGRGFAVV AQEVRALAQR SAEAAKEIKA 500
    LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI AASAAEQATG 550
    LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS 600
    GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA 650
    SDGWEEF 657
    Length:657
    Mass (Da):69,346
    Last modified:February 1, 1994 - v1
    Checksum:i2D5CC51CA43D7250
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66502 Genomic DNA. Translation: CAA47122.1.
    AE005673 Genomic DNA. Translation: AAK22417.1.
    PIRiS23064.
    RefSeqiNP_419249.1. NC_002696.2.
    WP_010918318.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK22417; AAK22417; CC_0430.
    GeneIDi942024.
    KEGGiccr:CC_0430.
    PATRICi21297794. VBICauCre124313_0435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66502 Genomic DNA. Translation: CAA47122.1 .
    AE005673 Genomic DNA. Translation: AAK22417.1 .
    PIRi S23064.
    RefSeqi NP_419249.1. NC_002696.2.
    WP_010918318.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali Q00986.
    SMRi Q00986. Positions 217-264, 299-599.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK22417 ; AAK22417 ; CC_0430 .
    GeneIDi 942024.
    KEGGi ccr:CC_0430.
    PATRICi 21297794. VBICauCre124313_0435.

    Phylogenomic databases

    eggNOGi COG0840.
    HOGENOMi HOG000148074.
    KOi K03406.
    OMAi THKAGNI.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci CAULO:CC0430-MONOMER.

    Family and domain databases

    InterProi IPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view ]
    PRINTSi PR00260. CHEMTRNSDUCR.
    SMARTi SM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    [Graphical view ]
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polar localization of a bacterial chemoreceptor."
      Alley M.R.K., Maddock J.R., Shapiro L.
      Genes Dev. 6:825-836(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 19089 / CB15.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiMCPA_CAUCR
    AccessioniPrimary (citable) accession number: Q00986
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3