Q00986 (MCPA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemoreceptor McpA

Alternative name(s):
Methyl-accepting chemotaxis protein

Gene names

Name:	mcpA
Ordered Locus Names:	CC_0430

Organism

Caulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]

Taxonomic identifier

190650 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter crescentus

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Localized at the flagellum-bearing pole of the swarmer cell.
Sequence similarities	Contains 2 HAMP domains. Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Chemoreceptor McpA		PRO_0000110545
Regions
	Topological domain	1 – 5	5	Cytoplasmic Potential
	Transmembrane	6 – 29	24	Helical; Potential
	Topological domain	30 – 188	159	Periplasmic Potential
	Transmembrane	189 – 212	24	Helical; Potential
	Topological domain	213 – 657	445	Cytoplasmic Potential
	Domain	216 – 269	54	HAMP 1
	Domain	297 – 349	53	HAMP 2
	Domain	354 – 583	230	Methyl-accepting transducer
Amino acid modifications
	Modified residue	378	1	Glutamate methyl ester (Gln) By similarity
	Modified residue	385	1	Glutamate methyl ester (Glu) By similarity
	Modified residue	392	1	Glutamate methyl ester (Glu) By similarity
	Modified residue	574	1	Glutamate methyl ester (Gln) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q00986 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 2D5CC51CA43D7250	FASTA	657	69,346
	10 20 30 40 50 60 MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER DMRQNLEIQR 70 80 90 100 110 120 ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD AVKKDLLALK SKLPAEEQPK 130 140 150 160 170 180 IAELIKSLEE CRSAIDTVSG MISVDFNMAA GFIAPFEEQY VKMTGQLDQV VAAANQRIES 190 200 210 220 230 240 ESAKRQAQAT AAMSVTIIMS LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID 250 260 270 280 290 300 LEKMTRGDEL GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS 310 320 330 340 350 360 LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV IAASTDGLST 370 380 390 400 410 420 GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT AAGARQASDV VSTTRGEATH 430 440 450 460 470 480 SGQVVHQAVS AMGEIEKSSG QISQIIGVID EIAFQTNLLA LNAGVEAARA GEAGRGFAVV 490 500 510 520 530 540 AQEVRALAQR SAEAAKEIKA LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI 550 560 570 580 590 600 AASAAEQATG LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS 610 620 630 640 650 GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA SDGWEEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polar localization of a bacterial chemoreceptor." Alley M.R.K., Maddock J.R., Shapiro L. Genes Dev. 6:825-836(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 19089 / CB15.
[2]	"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66502 Genomic DNA. Translation: CAA47122.1. AE005673 Genomic DNA. Translation: AAK22417.1.
PIR	S23064.
RefSeq	NP_419249.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q00986.
SMR	Q00986. Positions 343-598.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK22417; AAK22417; CC_0430.
GeneID	942024.
KEGG	ccr:CC_0430.
PATRIC	21297794. VBICauCre124313_0435.
Phylogenomic databases
eggNOG	COG0840.
HOGENOM	HOG000148074.
KO	K03406.
OMA	THKAGNI.
ProtClustDB	CLSK2301612.
Family and domain databases
InterPro	IPR004090. Chemotax_Me-accpt_rcpt. IPR003660. HAMP_linker_domain. IPR004089. MCPsignal_dom. [Graphical view]
Pfam	PF00672. HAMP. 1 hit. PF00015. MCPsignal. 1 hit. [Graphical view]
PRINTS	PR00260. CHEMTRNSDUCR.
SMART	SM00304. HAMP. 2 hits. SM00283. MA. 1 hit. [Graphical view]
PROSITE	PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MCPA_CAUCR

Accession

Primary (citable) accession number: Q00986

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program