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Q00986 (MCPA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chemoreceptor McpA
Alternative name(s):
Methyl-accepting chemotaxis protein
Gene names
Name:mcpA
Ordered Locus Names:CC_0430
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localized at the flagellum-bearing pole of the swarmer cell.

Sequence similarities

Contains 2 HAMP domains.

Contains 1 methyl-accepting transducer domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsignal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Chemoreceptor McpA
PRO_0000110545

Regions

Topological domain1 – 55Cytoplasmic Potential
Transmembrane6 – 2924Helical; Potential
Topological domain30 – 188159Periplasmic Potential
Transmembrane189 – 21224Helical; Potential
Topological domain213 – 657445Cytoplasmic Potential
Domain216 – 26954HAMP 1
Domain297 – 34953HAMP 2
Domain354 – 583230Methyl-accepting transducer

Amino acid modifications

Modified residue3781Glutamate methyl ester (Gln) By similarity
Modified residue3851Glutamate methyl ester (Glu) By similarity
Modified residue3921Glutamate methyl ester (Glu) By similarity
Modified residue5741Glutamate methyl ester (Gln) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00986 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 2D5CC51CA43D7250

FASTA65769,346
        10         20         30         40         50         60 
MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER DMRQNLEIQR 

        70         80         90        100        110        120 
ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD AVKKDLLALK SKLPAEEQPK 

       130        140        150        160        170        180 
IAELIKSLEE CRSAIDTVSG MISVDFNMAA GFIAPFEEQY VKMTGQLDQV VAAANQRIES 

       190        200        210        220        230        240 
ESAKRQAQAT AAMSVTIIMS LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID 

       250        260        270        280        290        300 
LEKMTRGDEL GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS 

       310        320        330        340        350        360 
LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV IAASTDGLST 

       370        380        390        400        410        420 
GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT AAGARQASDV VSTTRGEATH 

       430        440        450        460        470        480 
SGQVVHQAVS AMGEIEKSSG QISQIIGVID EIAFQTNLLA LNAGVEAARA GEAGRGFAVV 

       490        500        510        520        530        540 
AQEVRALAQR SAEAAKEIKA LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI 

       550        560        570        580        590        600 
AASAAEQATG LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS 

       610        620        630        640        650 
GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA SDGWEEF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66502 Genomic DNA. Translation: CAA47122.1.
AE005673 Genomic DNA. Translation: AAK22417.1.
PIRS23064.
RefSeqNP_419249.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ00986.
SMRQ00986. Positions 217-264, 299-599.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK22417; AAK22417; CC_0430.
GeneID942024.
KEGGccr:CC_0430.
PATRIC21297794. VBICauCre124313_0435.

Phylogenomic databases

eggNOGCOG0840.
HOGENOMHOG000148074.
KOK03406.
OMATHKAGNI.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK2301612.

Enzyme and pathway databases

BioCycCAULO:CC0430-MONOMER.

Family and domain databases

InterProIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSPR00260. CHEMTRNSDUCR.
SMARTSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMCPA_CAUCR
AccessionPrimary (citable) accession number: Q00986
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families