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Q00983

- BLL1_PSEAI

UniProt

Q00983 - BLL1_PSEAI

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Protein

Beta-lactamase LCR-1

Gene

lcr1

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This oxacillinase hydrolyzes methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by cloxacillin and clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase LCR-1 (EC:3.5.2.6)
Gene namesi
Name:lcr1
Encoded oniPlasmid pMG760 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 260241Beta-lactamase LCR-1PRO_0000017023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-carboxylysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ00983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2033Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00983-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKSTLLAFG LFIALSARAE NQAIAKLFLR AGVDGTIVIE SLTTGQRLVH
60 70 80 90 100
NDPRAQQRYP AASTFKVLNT LIALEEGAIS GENQIFHWNG TQYSIANWNQ
110 120 130 140 150
DQTLDSAFKV SCVWCYQQIA LRVGALKYPA YIQQTNYGHL LEPFNGTEFW
160 170 180 190 200
LDGSLTISAE EQVAFLRQVV ERKLPFKASS YDSLKKVMFA DENAQYRLYA
210 220 230 240 250
KTGWATRMTP SVGWYVGYVE AKDDVWLFAL NLATRDANDL PLRTQIAKDA
260
LKAIGAFPTK
Length:260
Mass (Da):29,144
Last modified:June 1, 1994 - v1
Checksum:i9948E6BCD8E3D8BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56809 Genomic DNA. Translation: CAA40146.1.
PIRiS22683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56809 Genomic DNA. Translation: CAA40146.1 .
PIRi S22683.

3D structure databases

ProteinModelPortali Q00983.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
    Couture F., Lachapelle J., Levesque R.C.
    Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2293E.
    Transposon: Tn1412.

Entry informationi

Entry nameiBLL1_PSEAI
AccessioniPrimary (citable) accession number: Q00983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3