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Q00983

- BLL1_PSEAI

UniProt

Q00983 - BLL1_PSEAI

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Protein
Beta-lactamase LCR-1
Gene
lcr1
Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This oxacillinase hydrolyzes methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by cloxacillin and clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase LCR-1 (EC:3.5.2.6)
Gene namesi
Name:lcr1
Encoded oniPlasmid pMG760 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 260241Beta-lactamase LCR-1
PRO_0000017023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-carboxylysine By similarity

Structurei

3D structure databases

ProteinModelPortaliQ00983.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2033Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00983-1 [UniParc]FASTAAdd to Basket

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MLKSTLLAFG LFIALSARAE NQAIAKLFLR AGVDGTIVIE SLTTGQRLVH    50
NDPRAQQRYP AASTFKVLNT LIALEEGAIS GENQIFHWNG TQYSIANWNQ 100
DQTLDSAFKV SCVWCYQQIA LRVGALKYPA YIQQTNYGHL LEPFNGTEFW 150
LDGSLTISAE EQVAFLRQVV ERKLPFKASS YDSLKKVMFA DENAQYRLYA 200
KTGWATRMTP SVGWYVGYVE AKDDVWLFAL NLATRDANDL PLRTQIAKDA 250
LKAIGAFPTK 260
Length:260
Mass (Da):29,144
Last modified:June 1, 1994 - v1
Checksum:i9948E6BCD8E3D8BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56809 Genomic DNA. Translation: CAA40146.1.
PIRiS22683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56809 Genomic DNA. Translation: CAA40146.1 .
PIRi S22683.

3D structure databases

ProteinModelPortali Q00983.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
    Couture F., Lachapelle J., Levesque R.C.
    Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2293E.
    Transposon: Tn1412.

Entry informationi

Entry nameiBLL1_PSEAI
AccessioniPrimary (citable) accession number: Q00983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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