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Q00983 (BLL1_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase LCR-1

EC=3.5.2.6
Gene names
Name:lcr1
Encoded onPlasmid pMG76
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This oxacillinase hydrolyzes methicillin.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by cloxacillin and clavulanic acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 260241Beta-lactamase LCR-1
PRO_0000017023

Regions

Region201 – 2033Substrate binding By similarity

Sites

Active site631Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue661N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00983 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 9948E6BCD8E3D8BE

FASTA26029,144
        10         20         30         40         50         60 
MLKSTLLAFG LFIALSARAE NQAIAKLFLR AGVDGTIVIE SLTTGQRLVH NDPRAQQRYP 

        70         80         90        100        110        120 
AASTFKVLNT LIALEEGAIS GENQIFHWNG TQYSIANWNQ DQTLDSAFKV SCVWCYQQIA 

       130        140        150        160        170        180 
LRVGALKYPA YIQQTNYGHL LEPFNGTEFW LDGSLTISAE EQVAFLRQVV ERKLPFKASS 

       190        200        210        220        230        240 
YDSLKKVMFA DENAQYRLYA KTGWATRMTP SVGWYVGYVE AKDDVWLFAL NLATRDANDL 

       250        260 
PLRTQIAKDA LKAIGAFPTK 

« Hide

References

[1]"Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
Couture F., Lachapelle J., Levesque R.C.
Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 2293E.
Transposon: Tn1412.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56809 Genomic DNA. Translation: CAA40146.1.
PIRS22683.

3D structure databases

ProteinModelPortalQ00983.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLL1_PSEAI
AccessionPrimary (citable) accession number: Q00983
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families