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Protein

Beta-lactamase LCR-1

Gene

lcr1

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This oxacillinase hydrolyzes methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by cloxacillin and clavulanic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase LCR-1 (EC:3.5.2.6)
Gene namesi
Name:lcr1
Encoded oniPlasmid pMG760 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001702320 – 260Beta-lactamase LCR-1Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66N6-carboxylysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ00983
SMRiQ00983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 203Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSTLLAFG LFIALSARAE NQAIAKLFLR AGVDGTIVIE SLTTGQRLVH
60 70 80 90 100
NDPRAQQRYP AASTFKVLNT LIALEEGAIS GENQIFHWNG TQYSIANWNQ
110 120 130 140 150
DQTLDSAFKV SCVWCYQQIA LRVGALKYPA YIQQTNYGHL LEPFNGTEFW
160 170 180 190 200
LDGSLTISAE EQVAFLRQVV ERKLPFKASS YDSLKKVMFA DENAQYRLYA
210 220 230 240 250
KTGWATRMTP SVGWYVGYVE AKDDVWLFAL NLATRDANDL PLRTQIAKDA
260
LKAIGAFPTK
Length:260
Mass (Da):29,144
Last modified:June 1, 1994 - v1
Checksum:i9948E6BCD8E3D8BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56809 Genomic DNA Translation: CAA40146.1
PIRiS22683
RefSeqiWP_032488481.1, NZ_NIZR01000073.1

Similar proteinsi

Entry informationi

Entry nameiBLL1_PSEAI
AccessioniPrimary (citable) accession number: Q00983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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