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Q00982

- BLO5_PSEAI

UniProt

Q00982 - BLO5_PSEAI

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Protein
Beta-lactamase OXA-5
Gene
bla, oxa5
Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes both oxacillin and methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-5 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa5
Encoded oniPlasmid pMG540 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 267248Beta-lactamase OXA-5
PRO_0000017028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-carboxylysine By similarity

Structurei

3D structure databases

ProteinModelPortaliQ00982.
SMRiQ00982. Positions 21-266.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2073Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00982-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIAAYLVL VFYASTALSE SISENLAWNK EFSSESVHGV FVLCKSSSNS    50
CTTNNAARAS TAYIPASTFK IPNALIGLET GAIKDERQVF KWDGKPRAMK 100
QWEKDLKLRG AIQVSAVPVF QQIAREVGEI RMQKYLNLFS YGNANIGGGI 150
DKFWLEGQLR ISAFNQVKFL ESLYLNNLPA SKANQLIVKE AIVTEATPEY 200
IVHSKTGYSG VGTESSPGVA WWVGWVEKGT EVYFFAFNMD IDNESKLPSR 250
KSISTKIMAS EGIIIGG 267
Length:267
Mass (Da):29,432
Last modified:April 1, 1993 - v1
Checksum:iBAFB61380DB7D536
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1.
PIRiS22684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1 .
PIRi S22684.

3D structure databases

ProteinModelPortali Q00982.
SMRi Q00982. Positions 21-266.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
    Couture F., Lachapelle J., Levesque R.C.
    Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 76072601.
    Transposon: Tn1406.

Entry informationi

Entry nameiBLO5_PSEAI
AccessioniPrimary (citable) accession number: Q00982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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