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Q00982

- BLO5_PSEAI

UniProt

Q00982 - BLO5_PSEAI

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Protein

Beta-lactamase OXA-5

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes both oxacillin and methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-5 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa5
Encoded oniPlasmid pMG540 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 267248Beta-lactamase OXA-5PRO_0000017028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-carboxylysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ00982.
SMRiQ00982. Positions 21-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2073Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00982-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTIAAYLVL VFYASTALSE SISENLAWNK EFSSESVHGV FVLCKSSSNS
60 70 80 90 100
CTTNNAARAS TAYIPASTFK IPNALIGLET GAIKDERQVF KWDGKPRAMK
110 120 130 140 150
QWEKDLKLRG AIQVSAVPVF QQIAREVGEI RMQKYLNLFS YGNANIGGGI
160 170 180 190 200
DKFWLEGQLR ISAFNQVKFL ESLYLNNLPA SKANQLIVKE AIVTEATPEY
210 220 230 240 250
IVHSKTGYSG VGTESSPGVA WWVGWVEKGT EVYFFAFNMD IDNESKLPSR
260
KSISTKIMAS EGIIIGG
Length:267
Mass (Da):29,432
Last modified:April 1, 1993 - v1
Checksum:iBAFB61380DB7D536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1.
PIRiS22684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1 .
PIRi S22684.

3D structure databases

ProteinModelPortali Q00982.
SMRi Q00982. Positions 21-266.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
    Couture F., Lachapelle J., Levesque R.C.
    Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 76072601.
    Transposon: Tn1406.

Entry informationi

Entry nameiBLO5_PSEAI
AccessioniPrimary (citable) accession number: Q00982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3