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Protein

Beta-lactamase OXA-5

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes both oxacillin and methicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-5 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa5
Encoded oniPlasmid pMG540 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001702820 – 267Beta-lactamase OXA-5Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-carboxylysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ00982.
SMRiQ00982.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 207Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18792.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
PfamiView protein in Pfam
PF00905. Transpeptidase. 1 hit.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00337. BETA_LACTAMASE_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIAAYLVL VFYASTALSE SISENLAWNK EFSSESVHGV FVLCKSSSNS
60 70 80 90 100
CTTNNAARAS TAYIPASTFK IPNALIGLET GAIKDERQVF KWDGKPRAMK
110 120 130 140 150
QWEKDLKLRG AIQVSAVPVF QQIAREVGEI RMQKYLNLFS YGNANIGGGI
160 170 180 190 200
DKFWLEGQLR ISAFNQVKFL ESLYLNNLPA SKANQLIVKE AIVTEATPEY
210 220 230 240 250
IVHSKTGYSG VGTESSPGVA WWVGWVEKGT EVYFFAFNMD IDNESKLPSR
260
KSISTKIMAS EGIIIGG
Length:267
Mass (Da):29,432
Last modified:April 1, 1993 - v1
Checksum:iBAFB61380DB7D536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1.
PIRiS22684.
RefSeqiWP_032488483.1. NG_049776.1.

Genome annotation databases

KEGGiag:CAA41211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58272 Genomic DNA. Translation: CAA41211.1.
PIRiS22684.
RefSeqiWP_032488483.1. NG_049776.1.

3D structure databases

ProteinModelPortaliQ00982.
SMRiQ00982.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA41211.

Phylogenomic databases

KOiK18792.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
PfamiView protein in Pfam
PF00905. Transpeptidase. 1 hit.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00337. BETA_LACTAMASE_D. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLO5_PSEAI
AccessioniPrimary (citable) accession number: Q00982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 15, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.