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Q00982

- BLO5_PSEAI

UniProt

Q00982 - BLO5_PSEAI

Protein

Beta-lactamase OXA-5

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes both oxacillin and methicillin.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by clavulanic acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-5 (EC:3.5.2.6)
    Gene namesi
    Name:bla
    Synonyms:oxa5
    Encoded oniPlasmid pMG540 Publication
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 267248Beta-lactamase OXA-5PRO_0000017028Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ00982.
    SMRiQ00982. Positions 21-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 2073Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00982-1 [UniParc]FASTAAdd to Basket

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    MKTIAAYLVL VFYASTALSE SISENLAWNK EFSSESVHGV FVLCKSSSNS    50
    CTTNNAARAS TAYIPASTFK IPNALIGLET GAIKDERQVF KWDGKPRAMK 100
    QWEKDLKLRG AIQVSAVPVF QQIAREVGEI RMQKYLNLFS YGNANIGGGI 150
    DKFWLEGQLR ISAFNQVKFL ESLYLNNLPA SKANQLIVKE AIVTEATPEY 200
    IVHSKTGYSG VGTESSPGVA WWVGWVEKGT EVYFFAFNMD IDNESKLPSR 250
    KSISTKIMAS EGIIIGG 267
    Length:267
    Mass (Da):29,432
    Last modified:April 1, 1993 - v1
    Checksum:iBAFB61380DB7D536
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58272 Genomic DNA. Translation: CAA41211.1.
    PIRiS22684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58272 Genomic DNA. Translation: CAA41211.1 .
    PIRi S22684.

    3D structure databases

    ProteinModelPortali Q00982.
    SMRi Q00982. Positions 21-266.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
      Couture F., Lachapelle J., Levesque R.C.
      Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 76072601.
      Transposon: Tn1406.

    Entry informationi

    Entry nameiBLO5_PSEAI
    AccessioniPrimary (citable) accession number: Q00982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3