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Q00982 (BLO5_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-5

EC=3.5.2.6
Gene names
Name:bla
Synonyms:oxa5
Encoded onPlasmid pMG54
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes both oxacillin and methicillin.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by clavulanic acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 267248Beta-lactamase OXA-5
PRO_0000017028

Regions

Region205 – 2073Substrate binding By similarity

Sites

Active site671Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue701N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00982 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: BAFB61380DB7D536

FASTA26729,432
        10         20         30         40         50         60 
MKTIAAYLVL VFYASTALSE SISENLAWNK EFSSESVHGV FVLCKSSSNS CTTNNAARAS 

        70         80         90        100        110        120 
TAYIPASTFK IPNALIGLET GAIKDERQVF KWDGKPRAMK QWEKDLKLRG AIQVSAVPVF 

       130        140        150        160        170        180 
QQIAREVGEI RMQKYLNLFS YGNANIGGGI DKFWLEGQLR ISAFNQVKFL ESLYLNNLPA 

       190        200        210        220        230        240 
SKANQLIVKE AIVTEATPEY IVHSKTGYSG VGTESSPGVA WWVGWVEKGT EVYFFAFNMD 

       250        260 
IDNESKLPSR KSISTKIMAS EGIIIGG 

« Hide

References

[1]"Phylogeny of LCR-1 and OXA-5 with class A and class D beta-lactamases."
Couture F., Lachapelle J., Levesque R.C.
Mol. Microbiol. 6:1693-1705(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 76072601.
Transposon: Tn1406.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58272 Genomic DNA. Translation: CAA41211.1.
PIRS22684.

3D structure databases

ProteinModelPortalQ00982.
SMRQ00982. Positions 21-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO5_PSEAI
AccessionPrimary (citable) accession number: Q00982
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families