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Protein

Gap junction beta-2 protein

Gene

Gjb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: MGI

GO - Biological processi

  • cell-cell signaling Source: MGI
  • cellular response to oxidative stress Source: Ensembl
  • decidualization Source: Ensembl
  • gap junction assembly Source: MGI
  • male genitalia development Source: Ensembl
  • response to estradiol Source: Ensembl
  • response to human chorionic gonadotropin Source: Ensembl
  • response to progesterone Source: Ensembl
  • sensory perception of sound Source: UniProtKB-KW
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Hearing

Enzyme and pathway databases

ReactomeiREACT_278834. Transport of connexins along the secretory pathway.
REACT_284891. Oligomerization of connexins into connexons.
REACT_295993. Gap junction assembly.
REACT_352700. Transport of connexons to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-2 protein
Alternative name(s):
Connexin-26
Short name:
Cx26
Gene namesi
Name:Gjb2
Synonyms:Cxn-26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95720. Gjb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 13941CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21523HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 22611CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Gap junction beta-2 proteinPRO_0000057858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 180By similarity
Disulfide bondi60 ↔ 174By similarity
Disulfide bondi64 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ00977.
PaxDbiQ00977.
PRIDEiQ00977.

PTM databases

PhosphoSiteiQ00977.

Expressioni

Tissue specificityi

Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

Gene expression databases

BgeeiQ00977.
CleanExiMM_GJB2.
ExpressionAtlasiQ00977. baseline and differential.
GenevisibleiQ00977. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Protein-protein interaction databases

IntActiQ00977. 1 interaction.
STRINGi10090.ENSMUSP00000054343.

Structurei

3D structure databases

ProteinModelPortaliQ00977.
SMRiQ00977. Positions 2-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39645.
GeneTreeiENSGT00800000124042.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ00977.
KOiK07621.
OMAiVMYDGFA.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ00977.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHHFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF
160 170 180 190 200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG
210 220
ICILLNITEL CYLFVRYCSG KSKRPV
Length:226
Mass (Da):26,411
Last modified:April 1, 1993 - v1
Checksum:i0D8178F7A339E0B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81445 Genomic DNA. Translation: AAA37495.1.
M63803 mRNA. Translation: AAA37276.1.
BC013634 mRNA. Translation: AAH13634.1.
BC051437 mRNA. Translation: AAH51437.1.
CCDSiCCDS27153.1.
RefSeqiNP_032151.1. NM_008125.3.
UniGeneiMm.390683.

Genome annotation databases

EnsembliENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352.
GeneIDi14619.
KEGGimmu:14619.
UCSCiuc007ucx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81445 Genomic DNA. Translation: AAA37495.1.
M63803 mRNA. Translation: AAA37276.1.
BC013634 mRNA. Translation: AAH13634.1.
BC051437 mRNA. Translation: AAH51437.1.
CCDSiCCDS27153.1.
RefSeqiNP_032151.1. NM_008125.3.
UniGeneiMm.390683.

3D structure databases

ProteinModelPortaliQ00977.
SMRiQ00977. Positions 2-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00977. 1 interaction.
STRINGi10090.ENSMUSP00000054343.

PTM databases

PhosphoSiteiQ00977.

Proteomic databases

MaxQBiQ00977.
PaxDbiQ00977.
PRIDEiQ00977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352.
GeneIDi14619.
KEGGimmu:14619.
UCSCiuc007ucx.2. mouse.

Organism-specific databases

CTDi2706.
MGIiMGI:95720. Gjb2.

Phylogenomic databases

eggNOGiNOG39645.
GeneTreeiENSGT00800000124042.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ00977.
KOiK07621.
OMAiVMYDGFA.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ00977.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiREACT_278834. Transport of connexins along the secretory pathway.
REACT_284891. Oligomerization of connexins into connexons.
REACT_295993. Gap junction assembly.
REACT_352700. Transport of connexons to the plasma membrane.

Miscellaneous databases

NextBioi286440.
PROiQ00977.
SOURCEiSearch...

Gene expression databases

BgeeiQ00977.
CleanExiMM_GJB2.
ExpressionAtlasiQ00977. baseline and differential.
GenevisibleiQ00977. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002268. Connexin26.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01139. CONNEXINB2.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes."
    Willecke K., Nicholson B.J., Dahl E., Kozjek G., Hennemann H.
    Eur. J. Cell Biol. 58:81-89(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Developmental regulation of gap junction gene expression during mouse embryonic development."
    Nishi M., Kumar N.M., Gilula N.B.
    Dev. Biol. 146:117-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Olfactory epithelium.
  4. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNST.

Entry informationi

Entry nameiCXB2_MOUSE
AccessioniPrimary (citable) accession number: Q00977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 22, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.