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Q00977

- CXB2_MOUSE

UniProt

Q00977 - CXB2_MOUSE

Protein

Gap junction beta-2 protein

Gene

Gjb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: MGI
    2. male genitalia development Source: Ensembl
    3. sensory perception of sound Source: UniProtKB-KW
    4. transmembrane transport Source: GOC

    Keywords - Biological processi

    Hearing

    Enzyme and pathway databases

    ReactomeiREACT_208406. Transport of connexons to the plasma membrane.
    REACT_216289. Oligomerization of connexins into connexons.
    REACT_226013. Transport of connexins along the secretory pathway.
    REACT_227366. Gap junction assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction beta-2 protein
    Alternative name(s):
    Connexin-26
    Short name:
    Cx26
    Gene namesi
    Name:Gjb2
    Synonyms:Cxn-26
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:95720. Gjb2.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. gap junction Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. lateral plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226Gap junction beta-2 proteinPRO_0000057858Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 180By similarity
    Disulfide bondi60 ↔ 174By similarity
    Disulfide bondi64 ↔ 169By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ00977.
    PaxDbiQ00977.
    PRIDEiQ00977.

    PTM databases

    PhosphoSiteiQ00977.

    Expressioni

    Tissue specificityi

    Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

    Gene expression databases

    ArrayExpressiQ00977.
    BgeeiQ00977.
    CleanExiMM_GJB2.
    GenevestigatoriQ00977.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

    Protein-protein interaction databases

    IntActiQ00977. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00977.
    SMRiQ00977. Positions 2-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 13941CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 22611CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39645.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiQ00977.
    KOiK07621.
    OMAiMYVFYIM.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiQ00977.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002268. Connexin26.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01139. CONNEXINB2.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD    50
    FVCNTLQPGC KNVCYDHHFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH 100
    EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF 150
    MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG 200
    ICILLNITEL CYLFVRYCSG KSKRPV 226
    Length:226
    Mass (Da):26,411
    Last modified:April 1, 1993 - v1
    Checksum:i0D8178F7A339E0B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81445 Genomic DNA. Translation: AAA37495.1.
    M63803 mRNA. Translation: AAA37276.1.
    BC013634 mRNA. Translation: AAH13634.1.
    BC051437 mRNA. Translation: AAH51437.1.
    CCDSiCCDS27153.1.
    RefSeqiNP_032151.1. NM_008125.3.
    UniGeneiMm.390683.

    Genome annotation databases

    EnsembliENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352.
    GeneIDi14619.
    KEGGimmu:14619.
    UCSCiuc007ucx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81445 Genomic DNA. Translation: AAA37495.1 .
    M63803 mRNA. Translation: AAA37276.1 .
    BC013634 mRNA. Translation: AAH13634.1 .
    BC051437 mRNA. Translation: AAH51437.1 .
    CCDSi CCDS27153.1.
    RefSeqi NP_032151.1. NM_008125.3.
    UniGenei Mm.390683.

    3D structure databases

    ProteinModelPortali Q00977.
    SMRi Q00977. Positions 2-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q00977. 1 interaction.

    PTM databases

    PhosphoSitei Q00977.

    Proteomic databases

    MaxQBi Q00977.
    PaxDbi Q00977.
    PRIDEi Q00977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055698 ; ENSMUSP00000054343 ; ENSMUSG00000046352 .
    GeneIDi 14619.
    KEGGi mmu:14619.
    UCSCi uc007ucx.2. mouse.

    Organism-specific databases

    CTDi 2706.
    MGIi MGI:95720. Gjb2.

    Phylogenomic databases

    eggNOGi NOG39645.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi Q00977.
    KOi K07621.
    OMAi MYVFYIM.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi Q00977.
    TreeFami TF329606.

    Enzyme and pathway databases

    Reactomei REACT_208406. Transport of connexons to the plasma membrane.
    REACT_216289. Oligomerization of connexins into connexons.
    REACT_226013. Transport of connexins along the secretory pathway.
    REACT_227366. Gap junction assembly.

    Miscellaneous databases

    NextBioi 286440.
    PROi Q00977.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00977.
    Bgeei Q00977.
    CleanExi MM_GJB2.
    Genevestigatori Q00977.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002268. Connexin26.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01139. CONNEXINB2.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes."
      Willecke K., Nicholson B.J., Dahl E., Kozjek G., Hennemann H.
      Eur. J. Cell Biol. 58:81-89(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Developmental regulation of gap junction gene expression during mouse embryonic development."
      Nishi M., Kumar N.M., Gilula N.B.
      Dev. Biol. 146:117-130(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver and Olfactory epithelium.
    4. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
      Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNST.

    Entry informationi

    Entry nameiCXB2_MOUSE
    AccessioniPrimary (citable) accession number: Q00977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3