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Q00975

- CAC1B_HUMAN

UniProt

Q00975 - CAC1B_HUMAN

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Protein
Voltage-dependent N-type calcium channel subunit alpha-1B
Gene
CACNA1B, CACH5, CACNL1A5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei314 – 3141Calcium ion selectivity and permeability By similarity
Sitei663 – 6631Calcium ion selectivity and permeability By similarity
Sitei1365 – 13651Calcium ion selectivity and permeability By similarity
Sitei1655 – 16551Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi451 – 4588ATP Reviewed prediction
Calcium bindingi1737 – 174812 By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. high voltage-gated calcium channel activity Source: RefGenome
  4. protein C-terminus binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. voltage-gated calcium channel activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. calcium ion import Source: RefGenome
  2. locomotory behavior Source: Ensembl
  3. membrane depolarization Source: Reactome
  4. membrane depolarization during action potential Source: RefGenome
  5. neurotransmitter secretion Source: Ensembl
  6. regulation of blood pressure Source: Ensembl
  7. regulation of calcium ion transport Source: Ensembl
  8. regulation of heart contraction Source: Ensembl
  9. response to pain Source: Ensembl
  10. synaptic transmission Source: RefGenome
  11. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alpha-1B
Alternative name(s):
Brain calcium channel III
Short name:
BIII
Calcium channel, L type, alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2
Gene namesi
Name:CACNA1B
Synonyms:CACH5, CACNL1A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1389. CACNA1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei96 – 11419Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini115 – 13218Extracellular Reviewed prediction
Add
BLAST
Transmembranei133 – 15220Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini153 – 16311Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei164 – 18320Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini184 – 1874Extracellular Reviewed prediction
Transmembranei188 – 20619Helical; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini207 – 22519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei226 – 24520Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini246 – 33186Extracellular Reviewed prediction
Add
BLAST
Transmembranei332 – 35625Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini357 – 482126Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei483 – 50119Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini502 – 51615Extracellular Reviewed prediction
Add
BLAST
Transmembranei517 – 53620Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini537 – 5448Cytoplasmic Reviewed prediction
Transmembranei545 – 56218Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini563 – 57311Extracellular Reviewed prediction
Add
BLAST
Transmembranei574 – 59219Helical; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini593 – 61119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei612 – 63120Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini632 – 68453Extracellular Reviewed prediction
Add
BLAST
Transmembranei685 – 70925Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini710 – 1151442Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1152 – 116918Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1170 – 118516Extracellular Reviewed prediction
Add
BLAST
Transmembranei1186 – 120520Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1206 – 121712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1218 – 123619Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1237 – 124610Extracellular Reviewed prediction
Transmembranei1247 – 126519Helical; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1266 – 128419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1285 – 130420Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1305 – 139187Extracellular Reviewed prediction
Add
BLAST
Transmembranei1392 – 141625Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1417 – 147155Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1472 – 149019Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1491 – 150515Extracellular Reviewed prediction
Add
BLAST
Transmembranei1506 – 152520Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1526 – 15338Cytoplasmic Reviewed prediction
Transmembranei1534 – 155219Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1553 – 156311Extracellular Reviewed prediction
Add
BLAST
Transmembranei1564 – 158219Helical; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1583 – 160119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1602 – 162120Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1622 – 168362Extracellular Reviewed prediction
Add
BLAST
Transmembranei1684 – 170825Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1709 – 2339631Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. plasma membrane Source: RefGenome
  4. voltage-gated calcium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23392339Voltage-dependent N-type calcium channel subunit alpha-1B
PRO_0000053921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Modified residuei783 – 7831Phosphoserine By similarity
Glycosylationi1563 – 15631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1675 – 16751N-linked (GlcNAc...) Reviewed prediction
Modified residuei1719 – 17191Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ00975.
PRIDEiQ00975.

PTM databases

PhosphoSiteiQ00975.

Expressioni

Tissue specificityi

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Gene expression databases

ArrayExpressiQ00975.
BgeeiQ00975.
CleanExiHS_CACNA1B.
GenevestigatoriQ00975.

Organism-specific databases

HPAiHPA044347.

Interactioni

Subunit structurei

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Ppm1aP206503EBI-1055161,EBI-7491743From a different organism.
RXRBP287023EBI-1055161,EBI-748576

Protein-protein interaction databases

BioGridi107228. 7 interactions.
IntActiQ00975. 6 interactions.
MINTiMINT-102376.
STRINGi9606.ENSP00000277549.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1244 – 126320
Turni1264 – 12663

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LCMNMR-A1242-1269[»]
ProteinModelPortaliQ00975.
SMRiQ00975. Positions 97-407, 475-710, 1146-1417, 1473-1709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 359278I
Add
BLAST
Repeati468 – 712245II
Add
BLAST
Repeati1137 – 1419283III
Add
BLAST
Repeati1456 – 1711256IV
Add
BLAST
Domaini1724 – 175936EF-hand
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 39618Binding to the beta subunit By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2050 – 20545Poly-His
Compositional biasi2118 – 21225Poly-Ser

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 EF-hand domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
KOiK04849.
PhylomeDBiQ00975.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha-1B-1 (identifier: Q00975-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA     50
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM 100
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII 150
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL 200
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH 250
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI 300
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL 350
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML 400
AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR 450
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA 500
MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD 550
FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV 600
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP 650
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL 700
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA 750
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA 800
TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR 850
HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP 900
EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA 950
KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE 1000
ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK 1050
VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD 1100
LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR 1150
YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI 1200
KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL 1250
RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA 1300
VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN 1350
VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF 1400
VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT 1450
RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE 1500
LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI 1550
LVTEIAETNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP 1600
YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR 1650
SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML 1700
NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF 1750
EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR 1800
TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT 1850
VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT 1900
QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE 1950
ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA 2000
SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH 2050
HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR 2100
ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT 2150
SPTAGQEPGP HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS 2200
ITYKTANSSP IHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP 2250
GSRIGSDPYL GQRLDSEASV HALPEDTLTF EEAVATNSGR SSRTSYVSSL 2300
TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC 2339
Length:2,339
Mass (Da):262,496
Last modified:October 1, 1996 - v1
Checksum:i17A45C6D1E76B39D
GO
Isoform Alpha-1B-2 (identifier: Q00975-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2164-2339: GSGSVNGSPL...YHHPDQDHWC → AGSAVGFPNT...APPGLPTCPP

Show »
Length:2,237
Mass (Da):251,716
Checksum:i28804E510F1E7747
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671N → K.
Corresponds to variant rs4422842 [ dbSNP | Ensembl ].
VAR_048741
Natural varianti862 – 8621A → S.
Corresponds to variant rs7873074 [ dbSNP | Ensembl ].
VAR_061100
Natural varianti996 – 9961T → A.
Corresponds to variant rs11137342 [ dbSNP | Ensembl ].
VAR_061101
Natural varianti1436 – 14361E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].
VAR_048742
Natural varianti1500 – 15001E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].
VAR_048743

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2164 – 2339176GSGSV…QDHWC → AGSAVGFPNTTPCCRETPSA SPWPLALELALTLTWGSVWT VRPLSTPCLRTLSLSRRLWP PTRAAPPGLPTCPP in isoform Alpha-1B-2.
VSP_000882Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform Alpha-1B-2 (identifier: Q00975-2)
Sequence conflicti2215 – 22151L → R in AAA51898. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94172 mRNA. Translation: AAA51897.1.
M94173 mRNA. Translation: AAA51898.1.
AL591424, AL772363 Genomic DNA. Translation: CAI40687.1.
AL772363, AL591424 Genomic DNA. Translation: CAI17144.1.
U76666 Genomic DNA. Translation: AAC51138.1.
CCDSiCCDS59522.1. [Q00975-1]
CCDS59523.1. [Q00975-2]
PIRiA42566.
T45115.
RefSeqiNP_000709.1. NM_000718.3. [Q00975-1]
NP_001230741.1. NM_001243812.1.
UniGeneiHs.495522.

Genome annotation databases

EnsembliENST00000371372; ENSP00000360423; ENSG00000148408. [Q00975-1]
GeneIDi774.
KEGGihsa:774.
UCSCiuc004cog.3. human. [Q00975-1]

Polymorphism databases

DMDMi1705854.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94172 mRNA. Translation: AAA51897.1 .
M94173 mRNA. Translation: AAA51898.1 .
AL591424 , AL772363 Genomic DNA. Translation: CAI40687.1 .
AL772363 , AL591424 Genomic DNA. Translation: CAI17144.1 .
U76666 Genomic DNA. Translation: AAC51138.1 .
CCDSi CCDS59522.1. [Q00975-1 ]
CCDS59523.1. [Q00975-2 ]
PIRi A42566.
T45115.
RefSeqi NP_000709.1. NM_000718.3. [Q00975-1 ]
NP_001230741.1. NM_001243812.1.
UniGenei Hs.495522.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LCM NMR - A 1242-1269 [» ]
ProteinModelPortali Q00975.
SMRi Q00975. Positions 97-407, 475-710, 1146-1417, 1473-1709.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107228. 7 interactions.
IntActi Q00975. 6 interactions.
MINTi MINT-102376.
STRINGi 9606.ENSP00000277549.

Chemistry

BindingDBi Q00975.
ChEMBLi CHEMBL2363032.
DrugBanki DB00381. Amlodipine.
DB00996. Gabapentin.
GuidetoPHARMACOLOGYi 533.

PTM databases

PhosphoSitei Q00975.

Polymorphism databases

DMDMi 1705854.

Proteomic databases

PaxDbi Q00975.
PRIDEi Q00975.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371372 ; ENSP00000360423 ; ENSG00000148408 . [Q00975-1 ]
GeneIDi 774.
KEGGi hsa:774.
UCSCi uc004cog.3. human. [Q00975-1 ]

Organism-specific databases

CTDi 774.
GeneCardsi GC09P140772.
HGNCi HGNC:1389. CACNA1B.
HPAi HPA044347.
MIMi 601012. gene.
neXtProti NX_Q00975.
PharmGKBi PA26008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231530.
HOVERGENi HBG050763.
KOi K04849.
PhylomeDBi Q00975.

Enzyme and pathway databases

Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

GeneWikii N-type_calcium_channel.
GenomeRNAii 774.
NextBioi 3128.
PROi Q00975.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00975.
Bgeei Q00975.
CleanExi HS_CACNA1B.
Genevestigatori Q00975.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel."
    Williams M.E., Brust P.F., Feldman D.H., Patthi S., Simerson S., Maroufi A., McCue A.F., Velicelebi G., Ellis S.B., Harpold M.M.
    Science 257:389-395(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1B-1 AND ALPHA-1B-2).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis."
    Kim D.S., Jung H.-H., Park S.-H., Chin H.
    J. Biol. Chem. 272:5098-5104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-94.
    Tissue: Lung fibroblast.

Entry informationi

Entry nameiCAC1B_HUMAN
AccessioniPrimary (citable) accession number: Q00975
Secondary accession number(s): B1AQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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