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Q00975

- CAC1B_HUMAN

UniProt

Q00975 - CAC1B_HUMAN

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Protein

Voltage-dependent N-type calcium channel subunit alpha-1B

Gene

CACNA1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei314 – 3141Calcium ion selectivity and permeabilityBy similarity
Sitei663 – 6631Calcium ion selectivity and permeabilityBy similarity
Sitei1365 – 13651Calcium ion selectivity and permeabilityBy similarity
Sitei1655 – 16551Calcium ion selectivity and permeabilityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi451 – 4588ATPSequence Analysis
Calcium bindingi1737 – 174812PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. high voltage-gated calcium channel activity Source: RefGenome
  4. protein C-terminus binding Source: UniProtKB
  5. voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

  1. calcium ion import Source: RefGenome
  2. locomotory behavior Source: Ensembl
  3. membrane depolarization Source: Reactome
  4. membrane depolarization during action potential Source: RefGenome
  5. neurotransmitter secretion Source: Ensembl
  6. regulation of blood pressure Source: Ensembl
  7. regulation of calcium ion transport Source: Ensembl
  8. regulation of heart contraction Source: Ensembl
  9. response to pain Source: Ensembl
  10. synaptic transmission Source: RefGenome
  11. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alpha-1B
Alternative name(s):
Brain calcium channel III
Short name:
BIII
Calcium channel, L type, alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2
Gene namesi
Name:CACNA1B
Synonyms:CACH5, CACNL1A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1389. CACNA1B.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. plasma membrane Source: RefGenome
  4. voltage-gated calcium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23392339Voltage-dependent N-type calcium channel subunit alpha-1BPRO_0000053921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Modified residuei783 – 7831PhosphoserineBy similarity
Glycosylationi1563 – 15631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1675 – 16751N-linked (GlcNAc...)Sequence Analysis
Modified residuei1719 – 17191Phosphoserine; by PKASequence Analysis

Post-translational modificationi

Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ00975.
PRIDEiQ00975.

PTM databases

PhosphoSiteiQ00975.

Expressioni

Tissue specificityi

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Gene expression databases

BgeeiQ00975.
CleanExiHS_CACNA1B.
ExpressionAtlasiQ00975. baseline and differential.
GenevestigatoriQ00975.

Organism-specific databases

HPAiHPA044347.

Interactioni

Subunit structurei

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ppm1aP206503EBI-1055161,EBI-7491743From a different organism.
RXRBP287023EBI-1055161,EBI-748576

Protein-protein interaction databases

BioGridi107228. 7 interactions.
IntActiQ00975. 6 interactions.
MINTiMINT-102376.
STRINGi9606.ENSP00000277549.

Structurei

Secondary structure

1
2339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1244 – 126320
Turni1264 – 12663

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LCMNMR-A1242-1269[»]
ProteinModelPortaliQ00975.
SMRiQ00975. Positions 97-407, 475-710, 1146-1417, 1473-1709.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini115 – 13218ExtracellularSequence AnalysisAdd
BLAST
Topological domaini153 – 16311CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini184 – 1874ExtracellularSequence Analysis
Topological domaini207 – 22519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini246 – 33186ExtracellularSequence AnalysisAdd
BLAST
Topological domaini357 – 482126CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini502 – 51615ExtracellularSequence AnalysisAdd
BLAST
Topological domaini537 – 5448CytoplasmicSequence Analysis
Topological domaini563 – 57311ExtracellularSequence AnalysisAdd
BLAST
Topological domaini593 – 61119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini632 – 68453ExtracellularSequence AnalysisAdd
BLAST
Topological domaini710 – 1151442CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1170 – 118516ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1206 – 121712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1237 – 124610ExtracellularSequence Analysis
Topological domaini1266 – 128419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1305 – 139187ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1417 – 147155CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1491 – 150515ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1526 – 15338CytoplasmicSequence Analysis
Topological domaini1553 – 156311ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1583 – 160119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1622 – 168362ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1709 – 2339631CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11419Helical; Name=S1 of repeat ISequence AnalysisAdd
BLAST
Transmembranei133 – 15220Helical; Name=S2 of repeat ISequence AnalysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=S3 of repeat ISequence AnalysisAdd
BLAST
Transmembranei188 – 20619Helical; Name=S4 of repeat ISequence AnalysisAdd
BLAST
Transmembranei226 – 24520Helical; Name=S5 of repeat ISequence AnalysisAdd
BLAST
Transmembranei332 – 35625Helical; Name=S6 of repeat ISequence AnalysisAdd
BLAST
Transmembranei483 – 50119Helical; Name=S1 of repeat IISequence AnalysisAdd
BLAST
Transmembranei517 – 53620Helical; Name=S2 of repeat IISequence AnalysisAdd
BLAST
Transmembranei545 – 56218Helical; Name=S3 of repeat IISequence AnalysisAdd
BLAST
Transmembranei574 – 59219Helical; Name=S4 of repeat IISequence AnalysisAdd
BLAST
Transmembranei612 – 63120Helical; Name=S5 of repeat IISequence AnalysisAdd
BLAST
Transmembranei685 – 70925Helical; Name=S6 of repeat IISequence AnalysisAdd
BLAST
Transmembranei1152 – 116918Helical; Name=S1 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1186 – 120520Helical; Name=S2 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1218 – 123619Helical; Name=S3 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1247 – 126519Helical; Name=S4 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1285 – 130420Helical; Name=S5 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1392 – 141625Helical; Name=S6 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1472 – 149019Helical; Name=S1 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1506 – 152520Helical; Name=S2 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1534 – 155219Helical; Name=S3 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1564 – 158219Helical; Name=S4 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1602 – 162120Helical; Name=S5 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1684 – 170825Helical; Name=S6 of repeat IVSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 359278IAdd
BLAST
Repeati468 – 712245IIAdd
BLAST
Repeati1137 – 1419283IIIAdd
BLAST
Repeati1456 – 1711256IVAdd
BLAST
Domaini1724 – 175936EF-handPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 39618Binding to the beta subunitBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2050 – 20545Poly-His
Compositional biasi2118 – 21225Poly-Ser

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000119135.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
InParanoidiQ00975.
KOiK04849.
PhylomeDBiQ00975.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha-1B-1 (identifier: Q00975-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR
460 470 480 490 500
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA
510 520 530 540 550
MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
560 570 580 590 600
FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
610 620 630 640 650
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
660 670 680 690 700
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
760 770 780 790 800
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA
810 820 830 840 850
TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR
860 870 880 890 900
HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP
910 920 930 940 950
EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA
960 970 980 990 1000
KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE
1010 1020 1030 1040 1050
ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK
1060 1070 1080 1090 1100
VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD
1110 1120 1130 1140 1150
LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR
1160 1170 1180 1190 1200
YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI
1210 1220 1230 1240 1250
KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL
1260 1270 1280 1290 1300
RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA
1310 1320 1330 1340 1350
VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN
1360 1370 1380 1390 1400
VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF
1410 1420 1430 1440 1450
VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT
1460 1470 1480 1490 1500
RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE
1510 1520 1530 1540 1550
LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI
1560 1570 1580 1590 1600
LVTEIAETNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP
1610 1620 1630 1640 1650
YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR
1660 1670 1680 1690 1700
SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML
1710 1720 1730 1740 1750
NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF
1760 1770 1780 1790 1800
EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR
1810 1820 1830 1840 1850
TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT
1860 1870 1880 1890 1900
VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT
1910 1920 1930 1940 1950
QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE
1960 1970 1980 1990 2000
ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA
2010 2020 2030 2040 2050
SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH
2060 2070 2080 2090 2100
HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR
2110 2120 2130 2140 2150
ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT
2160 2170 2180 2190 2200
SPTAGQEPGP HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS
2210 2220 2230 2240 2250
ITYKTANSSP IHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP
2260 2270 2280 2290 2300
GSRIGSDPYL GQRLDSEASV HALPEDTLTF EEAVATNSGR SSRTSYVSSL
2310 2320 2330
TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC
Length:2,339
Mass (Da):262,496
Last modified:October 1, 1996 - v1
Checksum:i17A45C6D1E76B39D
GO
Isoform Alpha-1B-2 (identifier: Q00975-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2164-2339: GSGSVNGSPL...YHHPDQDHWC → AGSAVGFPNT...APPGLPTCPP

Show »
Length:2,237
Mass (Da):251,716
Checksum:i28804E510F1E7747
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform Alpha-1B-2 (identifier: Q00975-2)
Sequence conflicti2215 – 22151L → R in AAA51898. (PubMed:1321501)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671N → K.
Corresponds to variant rs4422842 [ dbSNP | Ensembl ].
VAR_048741
Natural varianti862 – 8621A → S.
Corresponds to variant rs7873074 [ dbSNP | Ensembl ].
VAR_061100
Natural varianti996 – 9961T → A.
Corresponds to variant rs11137342 [ dbSNP | Ensembl ].
VAR_061101
Natural varianti1436 – 14361E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].
VAR_048742
Natural varianti1500 – 15001E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].
VAR_048743

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2164 – 2339176GSGSV…QDHWC → AGSAVGFPNTTPCCRETPSA SPWPLALELALTLTWGSVWT VRPLSTPCLRTLSLSRRLWP PTRAAPPGLPTCPP in isoform Alpha-1B-2. 1 PublicationVSP_000882Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94172 mRNA. Translation: AAA51897.1.
M94173 mRNA. Translation: AAA51898.1.
AL591424, AL772363 Genomic DNA. Translation: CAI40687.1.
AL772363, AL591424 Genomic DNA. Translation: CAI17144.1.
U76666 Genomic DNA. Translation: AAC51138.1.
CCDSiCCDS59522.1. [Q00975-1]
CCDS59523.1. [Q00975-2]
PIRiA42566.
T45115.
RefSeqiNP_000709.1. NM_000718.3. [Q00975-1]
NP_001230741.1. NM_001243812.1. [Q00975-2]
UniGeneiHs.495522.

Genome annotation databases

EnsembliENST00000277551; ENSP00000277551; ENSG00000148408. [Q00975-2]
ENST00000371372; ENSP00000360423; ENSG00000148408. [Q00975-1]
GeneIDi774.
KEGGihsa:774.
UCSCiuc004cog.3. human. [Q00975-1]

Polymorphism databases

DMDMi1705854.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94172 mRNA. Translation: AAA51897.1 .
M94173 mRNA. Translation: AAA51898.1 .
AL591424 , AL772363 Genomic DNA. Translation: CAI40687.1 .
AL772363 , AL591424 Genomic DNA. Translation: CAI17144.1 .
U76666 Genomic DNA. Translation: AAC51138.1 .
CCDSi CCDS59522.1. [Q00975-1 ]
CCDS59523.1. [Q00975-2 ]
PIRi A42566.
T45115.
RefSeqi NP_000709.1. NM_000718.3. [Q00975-1 ]
NP_001230741.1. NM_001243812.1. [Q00975-2 ]
UniGenei Hs.495522.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LCM NMR - A 1242-1269 [» ]
ProteinModelPortali Q00975.
SMRi Q00975. Positions 97-407, 475-710, 1146-1417, 1473-1709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107228. 7 interactions.
IntActi Q00975. 6 interactions.
MINTi MINT-102376.
STRINGi 9606.ENSP00000277549.

Chemistry

BindingDBi Q00975.
ChEMBLi CHEMBL2097170.
DrugBanki DB00381. Amlodipine.
DB00996. Gabapentin.
DB01202. Levetiracetam.
DB00421. Spironolactone.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi 533.

PTM databases

PhosphoSitei Q00975.

Polymorphism databases

DMDMi 1705854.

Proteomic databases

PaxDbi Q00975.
PRIDEi Q00975.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277551 ; ENSP00000277551 ; ENSG00000148408 . [Q00975-2 ]
ENST00000371372 ; ENSP00000360423 ; ENSG00000148408 . [Q00975-1 ]
GeneIDi 774.
KEGGi hsa:774.
UCSCi uc004cog.3. human. [Q00975-1 ]

Organism-specific databases

CTDi 774.
GeneCardsi GC09P140772.
HGNCi HGNC:1389. CACNA1B.
HPAi HPA044347.
MIMi 601012. gene.
neXtProti NX_Q00975.
PharmGKBi PA26008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000119135.
HOGENOMi HOG000231530.
HOVERGENi HBG050763.
InParanoidi Q00975.
KOi K04849.
PhylomeDBi Q00975.

Enzyme and pathway databases

Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

GeneWikii N-type_calcium_channel.
GenomeRNAii 774.
NextBioi 3128.
PROi Q00975.
SOURCEi Search...

Gene expression databases

Bgeei Q00975.
CleanExi HS_CACNA1B.
ExpressionAtlasi Q00975. baseline and differential.
Genevestigatori Q00975.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
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Publicationsi

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  1. "Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel."
    Williams M.E., Brust P.F., Feldman D.H., Patthi S., Simerson S., Maroufi A., McCue A.F., Velicelebi G., Ellis S.B., Harpold M.M.
    Science 257:389-395(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1B-1 AND ALPHA-1B-2).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis."
    Kim D.S., Jung H.-H., Park S.-H., Chin H.
    J. Biol. Chem. 272:5098-5104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-94.
    Tissue: Lung fibroblast.

Entry informationi

Entry nameiCAC1B_HUMAN
AccessioniPrimary (citable) accession number: Q00975
Secondary accession number(s): B1AQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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