Q00975 (CAC1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent N-type calcium channel subunit alpha-1B

Alternative name(s):
Brain calcium channel III
Short name=BIII
Calcium channel, L type, alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2

Gene names

Name:	CACNA1B
Synonyms:	CACH5, CACNL1A5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2339 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Subunit structure	Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
Domain	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Post-translational modification	Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK By similarity.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. [View classification] Contains 1 EF-hand domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Metal-binding Nucleotide-binding
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	membrane depolarization Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated calcium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: InterPro voltage-gated calcium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RXRB	P28702	3	EBI-1055161,EBI-748576

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha-1B-1 (identifier: Q00975-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Alpha-1B-2 (identifier: Q00975-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2164-2339: GSGSVNGSPL...YHHPDQDHWC → AGSAVGFPNT...APPGLPTCPP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2339

2339

Voltage-dependent N-type calcium channel subunit alpha-1B

PRO_0000053921

Regions

Topological domain

1 – 95

95

Cytoplasmic Potential

Transmembrane

96 – 114

19

Helical; Name=S1 of repeat I; Potential

Topological domain

115 – 132

18

Extracellular Potential

Transmembrane

133 – 152

20

Helical; Name=S2 of repeat I; Potential

Topological domain

153 – 163

11

Cytoplasmic Potential

Transmembrane

164 – 183

20

Helical; Name=S3 of repeat I; Potential

Topological domain

184 – 187

4

Extracellular Potential

Transmembrane

188 – 206

19

Helical; Name=S4 of repeat I; Potential

Topological domain

207 – 225

19

Cytoplasmic Potential

Transmembrane

226 – 245

20

Helical; Name=S5 of repeat I; Potential

Topological domain

246 – 331

86

Extracellular Potential

Transmembrane

332 – 356

25

Helical; Name=S6 of repeat I; Potential

Topological domain

357 – 482

126

Cytoplasmic Potential

Transmembrane

483 – 501

19

Helical; Name=S1 of repeat II; Potential

Topological domain

502 – 516

15

Extracellular Potential

Transmembrane

517 – 536

20

Helical; Name=S2 of repeat II; Potential

Topological domain

537 – 544

8

Cytoplasmic Potential

Transmembrane

545 – 562

18

Helical; Name=S3 of repeat II; Potential

Topological domain

563 – 573

11

Extracellular Potential

Transmembrane

574 – 592

19

Helical; Name=S4 of repeat II; Potential

Topological domain

593 – 611

19

Cytoplasmic Potential

Transmembrane

612 – 631

20

Helical; Name=S5 of repeat II; Potential

Topological domain

632 – 684

53

Extracellular Potential

Transmembrane

685 – 709

25

Helical; Name=S6 of repeat II; Potential

Topological domain

710 – 1151

442

Cytoplasmic Potential

Transmembrane

1152 – 1169

18

Helical; Name=S1 of repeat III; Potential

Topological domain

1170 – 1185

16

Extracellular Potential

Transmembrane

1186 – 1205

20

Helical; Name=S2 of repeat III; Potential

Topological domain

1206 – 1217

12

Cytoplasmic Potential

Transmembrane

1218 – 1236

19

Helical; Name=S3 of repeat III; Potential

Topological domain

1237 – 1246

10

Extracellular Potential

Transmembrane

1247 – 1265

19

Helical; Name=S4 of repeat III; Potential

Topological domain

1266 – 1284

19

Cytoplasmic Potential

Transmembrane

1285 – 1304

20

Helical; Name=S5 of repeat III; Potential

Topological domain

1305 – 1391

87

Extracellular Potential

Transmembrane

1392 – 1416

25

Helical; Name=S6 of repeat III; Potential

Topological domain

1417 – 1471

55

Cytoplasmic Potential

Transmembrane

1472 – 1490

19

Helical; Name=S1 of repeat IV; Potential

Topological domain

1491 – 1505

15

Extracellular Potential

Transmembrane

1506 – 1525

20

Helical; Name=S2 of repeat IV; Potential

Topological domain

1526 – 1533

8

Cytoplasmic Potential

Transmembrane

1534 – 1552

19

Helical; Name=S3 of repeat IV; Potential

Topological domain

1553 – 1563

11

Extracellular Potential

Transmembrane

1564 – 1582

19

Helical; Name=S4 of repeat IV; Potential

Topological domain

1583 – 1601

19

Cytoplasmic Potential

Transmembrane

1602 – 1621

20

Helical; Name=S5 of repeat IV; Potential

Topological domain

1622 – 1683

62

Extracellular Potential

Transmembrane

1684 – 1708

25

Helical; Name=S6 of repeat IV; Potential

Topological domain

1709 – 2339

631

Cytoplasmic Potential

Repeat

82 – 359

278

I

Repeat

468 – 712

245

II

Repeat

1137 – 1419

283

III

Repeat

1456 – 1711

256

IV

Domain

1724 – 1759

36

EF-hand

Nucleotide binding

451 – 458

8

ATP Potential

Calcium binding

1737 – 1748

12

By similarity

Region

379 – 396

18

Binding to the beta subunit By similarity

Compositional bias

2050 – 2054

5

Poly-His

Compositional bias

2118 – 2122

5

Poly-Ser

Sites

Site

314

1

Calcium ion selectivity and permeability By similarity

Site

663

1

Calcium ion selectivity and permeability By similarity

Site

1365

1

Calcium ion selectivity and permeability By similarity

Site

1655

1

Calcium ion selectivity and permeability By similarity

Amino acid modifications

Modified residue

745

1

Phosphoserine By similarity

Modified residue

783

1

Phosphoserine By similarity

Modified residue

1719

1

Phosphoserine; by PKA Potential

Modified residue

2256

1

Phosphoserine By similarity

Glycosylation

256

1

N-linked (GlcNAc...) Potential

Glycosylation

1563

1

N-linked (GlcNAc...) Potential

Glycosylation

1675

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

2164 – 2339

176

GSGSV…QDHWC → AGSAVGFPNTTPCCRETPSA SPWPLALELALTLTWGSVWT VRPLSTPCLRTRSLSRRLWP PTRAAPPGLPTCPP in isoform Alpha-1B-2.

VSP_000882

Natural variant

167

1

N → K.
Corresponds to variant rs4422842 [ dbSNP | Ensembl ].

VAR_048741

Natural variant

862

1

A → S.
Corresponds to variant rs7873074 [ dbSNP | Ensembl ].

VAR_061100

Natural variant

996

1

T → A.
Corresponds to variant rs11137342 [ dbSNP | Ensembl ].

VAR_061101

Natural variant

1436

1

E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].

VAR_048742

Natural variant

1500

1

E → K.
Corresponds to variant rs12377346 [ dbSNP | Ensembl ].

VAR_048743

Secondary structure

1

.

.

.

.

2339

Helix Strand Turn

Details...

Helix

1244 – 1263

20

Turn

1264 – 1266

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha-1B-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 17A45C6D1E76B39D	FASTA	2,339	262,496
	10 20 30 40 50 60 MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN 70 80 90 100 110 120 PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD 130 140 150 160 170 180 GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA 190 200 210 220 230 240 TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII 250 260 270 280 290 300 GLEFYMGKFH KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI 310 320 330 340 350 360 LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA 370 380 390 400 410 420 KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDRNAEEK SPLDVLKRAA 430 440 450 460 470 480 TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK 490 500 510 520 530 540 AQSFYWVVLC VVALNTLCVA MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS 550 560 570 580 590 600 YFRSSFNCFD FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV 610 620 630 640 650 660 SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL 670 680 690 700 710 720 TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK 730 740 750 760 770 780 DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL 790 800 810 820 830 840 RASCEALYSE MDPEERLRFA TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE 850 860 870 880 890 900 APEGVDPPRR HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP 910 920 930 940 950 960 EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA KGERRARHRG 970 980 990 1000 1010 1020 GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE ATEKEAEIVE ADKEKELRNH 1030 1040 1050 1060 1070 1080 QPREPHCDLE TSGTVTVGPM HTLPSTCLQK VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI 1090 1100 1110 1120 1130 1140 PVMLTGPLGE ATVVPSGNVD LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR 1150 1160 1170 1180 1190 1200 RFCHYIVTMR YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI 1210 1220 1230 1240 1250 1260 KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL RVLRVLRPLK 1270 1280 1290 1300 1310 1320 TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA VQLFKGKFFY CTDESKELER 1330 1340 1350 1360 1370 1380 DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN VLWALLTLFT VSTGEGWPMV LKHSVDATYE 1390 1400 1410 1420 1430 1440 EQGPSPGYRM ELSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI 1450 1460 1470 1480 1490 1500 DFAISAKPLT RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE 1510 1520 1530 1540 1550 1560 LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI LVTEIAETNN 1570 1580 1590 1600 1610 1620 FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV 1630 1640 1650 1660 1670 1680 FGNIALDDDT SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNQAC DEQANATECG 1690 1700 1710 1720 1730 1740 SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA 1750 1760 1770 1780 1790 1800 CGRISYNDMF EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR 1810 1820 1830 1840 1850 1860 TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT VGKVYAALMI 1870 1880 1890 1900 1910 1920 FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT QPAVLRGARV FLRQKSSTSL 1930 1940 1950 1960 1970 1980 SNGGAIQNQE SGIKESVSWG TQRTQDAPHE ARPPLERGHS TEIPVGRSGA LAVDVQMQSI 1990 2000 2010 2020 2030 2040 TRRGPDGEPQ PGLESQGRAA SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD 2050 2060 2070 2080 2090 2100 RPPPSQASSH HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR 2110 2120 2130 2140 2150 2160 ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT SPTAGQEPGP 2170 2180 2190 2200 2210 2220 HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS ITYKTANSSP IHFAGAQTSL 2230 2240 2250 2260 2270 2280 PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP GSRIGSDPYL GQRLDSEASV HALPEDTLTF 2290 2300 2310 2320 2330 EEAVATNSGR SSRTSYVSSL TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC
	Isoform Alpha-1B-2 [UniParc]. Checksum: C6804E510F1E60F0	FASTA	2,237	251,759
	10 20 30 40 50 60 MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN 70 80 90 100 110 120 PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD 130 140 150 160 170 180 GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA 190 200 210 220 230 240 TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII 250 260 270 280 290 300 GLEFYMGKFH KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI 310 320 330 340 350 360 LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA 370 380 390 400 410 420 KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDRNAEEK SPLDVLKRAA 430 440 450 460 470 480 TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK 490 500 510 520 530 540 AQSFYWVVLC VVALNTLCVA MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS 550 560 570 580 590 600 YFRSSFNCFD FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV 610 620 630 640 650 660 SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL 670 680 690 700 710 720 TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK 730 740 750 760 770 780 DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL 790 800 810 820 830 840 RASCEALYSE MDPEERLRFA TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE 850 860 870 880 890 900 APEGVDPPRR HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP 910 920 930 940 950 960 EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA KGERRARHRG 970 980 990 1000 1010 1020 GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE ATEKEAEIVE ADKEKELRNH 1030 1040 1050 1060 1070 1080 QPREPHCDLE TSGTVTVGPM HTLPSTCLQK VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI 1090 1100 1110 1120 1130 1140 PVMLTGPLGE ATVVPSGNVD LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR 1150 1160 1170 1180 1190 1200 RFCHYIVTMR YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI 1210 1220 1230 1240 1250 1260 KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL RVLRVLRPLK 1270 1280 1290 1300 1310 1320 TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA VQLFKGKFFY CTDESKELER 1330 1340 1350 1360 1370 1380 DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN VLWALLTLFT VSTGEGWPMV LKHSVDATYE 1390 1400 1410 1420 1430 1440 EQGPSPGYRM ELSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI 1450 1460 1470 1480 1490 1500 DFAISAKPLT RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE 1510 1520 1530 1540 1550 1560 LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI LVTEIAETNN 1570 1580 1590 1600 1610 1620 FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV 1630 1640 1650 1660 1670 1680 FGNIALDDDT SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNQAC DEQANATECG 1690 1700 1710 1720 1730 1740 SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA 1750 1760 1770 1780 1790 1800 CGRISYNDMF EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR 1810 1820 1830 1840 1850 1860 TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT VGKVYAALMI 1870 1880 1890 1900 1910 1920 FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT QPAVLRGARV FLRQKSSTSL 1930 1940 1950 1960 1970 1980 SNGGAIQNQE SGIKESVSWG TQRTQDAPHE ARPPLERGHS TEIPVGRSGA LAVDVQMQSI 1990 2000 2010 2020 2030 2040 TRRGPDGEPQ PGLESQGRAA SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD 2050 2060 2070 2080 2090 2100 RPPPSQASSH HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR 2110 2120 2130 2140 2150 2160 ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT SPTAGQEPGP 2170 2180 2190 2200 2210 2220 HPQAGSAVGF PNTTPCCRET PSASPWPLAL ELALTLTWGS VWTVRPLSTP CLRTRSLSRR 2230 LWPPTRAAPP GLPTCPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel." Williams M.E., Brust P.F., Feldman D.H., Patthi S., Simerson S., Maroufi A., McCue A.F., Velicelebi G., Ellis S.B., Harpold M.M. Science 257:389-395(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1B-1 AND ALPHA-1B-2). Tissue: Brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis." Kim D.S., Jung H.-H., Park S.-H., Chin H. J. Biol. Chem. 272:5098-5104(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-94. Tissue: Lung fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M94172 mRNA. Translation: AAA51897.1.
M94173 mRNA. Translation: AAA51898.1.
AL591424, AL772363 Genomic DNA. Translation: CAI40687.1.
AL772363, AL591424 Genomic DNA. Translation: CAI17144.1.
U76666 Genomic DNA. Translation: AAC51138.1.

IPI

IPI00025477.
IPI00220431.

PIR

A42566.
T45115.

RefSeq

NP_000709.1. NM_000718.3.
NP_001230741.1. NM_001243812.1.

UniGene

Hs.495522.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LCM	NMR	-	A	1242-1269	[»]

ProteinModelPortal

Q00975.

ModBase

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Protein-protein interaction databases

IntAct

Q00975. 3 interactions.

MINT

MINT-102376.

STRING

9606.ENSP00000277549.

PTM databases

PhosphoSite

Q00975.

Polymorphism databases

DMDM

1705854.

Proteomic databases

PaxDb

Q00975.

PRIDE

Q00975.

Protocols and materials databases

StructuralBiologyKnowledgebase

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Genome annotation databases

Ensembl

ENST00000371372; ENSP00000360423; ENSG00000148408.

GeneID

774.

KEGG

hsa:774.

UCSC

uc004cog.3. human.

Organism-specific databases

CTD

774.

GeneCards

GC09P140772.

HGNC

HGNC:1389. CACNA1B.

HPA

HPA044347.

MIM

601012. gene.

neXtProt

NX_Q00975.

PharmGKB

PA26008.

GenAtlas

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Phylogenomic databases

eggNOG

COG1226.

HOGENOM

HOG000231530.

HOVERGEN

HBG050763.

KO

K04849.

OrthoDB

EOG48KR9C.

Enzyme and pathway databases

Reactome

REACT_13685. Neuronal System.

Gene expression databases

ArrayExpress

Q00975.

Bgee

Q00975.

CleanEx

HS_CACNA1B.

Genevestigator

Q00975.

GermOnline

ENSG00000148408. Homo sapiens.

Family and domain databases

Gene3D

1.20.120.350. 4 hits.

InterPro

IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR027359. K_channel_four-helix_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]

PANTHER

PTHR10037:SF131. PTHR10037:SF131. 1 hit.

Pfam

PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]

PRINTS

PR00167. CACHANNEL.
PR01631. NVDCCALPHA1.

SMART

SM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

PROSITE

PS50222. EF_HAND_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q00975.

ChEMBL

CHEMBL4478.

DrugBank

DB00381. Amlodipine.
DB00996. Gabapentin.

GenomeRNAi

774.

NextBio

3128.

SOURCE

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Entry information

Entry name

CAC1B_HUMAN

Accession

Primary (citable) accession number: Q00975
Secondary accession number(s): B1AQK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.