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Reviewed, UniProtKB/Swiss-Prot Q00961 (NMDE3_RAT)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutamate [NMDA] receptor subunit epsilon-3
Alternative name(s):
    N-methyl D-aspartate receptor subtype 2C
      Short name=NMDAR2C
      Short name=NR2C
Gene names
Name: Grin2c
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length1237 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subunit structure

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts with PDZ domains of INADL and DLG4.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification]

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dlg4P310162EBI-631045,EBI-375655

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 12371218Glutamate [NMDA] receptor subunit epsilon-3
PRO_0000011582

Regions

Topological domain20 – 553534Extracellular Potential
Transmembrane554 – 57421 Potential
Topological domain575 – 62652Cytoplasmic Potential
Transmembrane627 – 64721 Potential
Topological domain648 – 814167Extracellular Potential
Transmembrane815 – 83521 Potential
Topological domain836 – 1237402Cytoplasmic Potential
Motif1235 – 12373PDZ-binding

Sites

Site6121Functional determinant of NMDA receptors By similarity

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation5391N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q00961-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: B175993804B337A4

FASTA1,237135,271
        10         20         30         40         50         60 
MGGALGPALL LTSLLGAWAR LGAGQGEQAV TVAVVFGSSG PLQTQARTRL TSQNFLDLPL 

        70         80         90        100        110        120 
EIQPLTVGVN NTNPSSILTQ ICGLLGAARV HGIVFEDNVD TEAVAQLLDF VSSQTHVPIL 

       130        140        150        160        170        180 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 

       190        200        210        220        230        240 
GVRAVADASY LSWRLLDVLT LELGPGGPRA RTQRLLRQVD APVLVAYCSR EEAEVLFAEA 

       250        260        270        280        290        300 
AQAGLVGPGH VWLVPNLALG STDAPPAAFP VGLISVVTES WRLSLRQKVR DGVAILALGA 

       310        320        330        340        350        360 
HSYRRQYGTL PAPAGDCRSH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVRPTMVV 

       370        380        390        400        410        420 
IALNRHRLWE MVGRWDHGVL YMKYPVWPRY STSLQPVVDS RHLTVATLEE RPFVIVESPD 

       430        440        450        460        470        480 
PGTGGCVPNT VPCRRQSNHT FSSGDLTPYT KLCCKGFCID ILKKLAKVVK FSYDLYLVTN 

       490        500        510        520        530        540 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEII DFSVPFVETG ISVMVSRSNG 

       550        560        570        580        590        600 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTKGK KPGGPSFTIG 

       610        620        630        640        650        660 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 

       670        680        690        700        710        720 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 

       730        740        750        760        770        780 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQL 

       790        800        810        820        830        840 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 

       850        860        870        880        890        900 
WKLRHSVPNS SQLDFLLAFS RGIYSCFNGV QSLPSPARPP SPDLTADSAQ ANVLKMLQAA 

       910        920        930        940        950        960 
RDMVNTADVS SSLDRATRTI ENWGNNRRVP APTASGPRSS TPGPPGQPSP SGWGPPGGGR 

       970        980        990       1000       1010       1020 
TPLARRAPQP PARPATCGPP LPDVSRPSCR HASDARWPVR VGHQGPHVSA SERRALPERS 

      1030       1040       1050       1060       1070       1080 
LLPAHCHYSS FPRAERSGRP YLPLFPEPPE PDDLPLLGPE QLARREAMLR AAWARGPRPR 

      1090       1100       1110       1120       1130       1140 
HASLPSSVAE AFTRSNPLPA RCTGHACACP CPQSRPSCRH LAQAQSLRLP SYPEACVEGV 

      1150       1160       1170       1180       1190       1200 
PAGVATWQPR QHVCLHAHTR LPFCWGTVCR HPPPCTSHSP WLIGTWEPPA HRVRTLGLGT 

      1210       1220       1230 
GYRDSGVLEE VSREACGTQG FPRSCTWRRV SSLESEV

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References

[1]"Heteromeric NMDA receptors: molecular and functional distinction of subtypes."
Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., Seeburg P.H.
Science 256:1217-1221(1992) [PubMed: 1350383] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits."
Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., Nakanishi S.
J. Biol. Chem. 268:2836-2843(1993) [PubMed: 8428958] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95."
Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.
Science 269:1737-1740(1995) [PubMed: 7569905] [Abstract]
Cited for: INTERACTION WITH DLG4.
[4]"CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
Mol. Cell. Neurosci. 11:161-172(1998) [PubMed: 9647694] [Abstract]
Cited for: INTERACTION WITH INADL.

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Cross-references

Sequence databases

M91563 mRNA. Translation: AAA41713.1.
D13212 mRNA. Translation: BAA02499.1. Different initiation.
RefSeqNP_036707.3.
UniGeneRn.9709

3D structure databases

HSSPHSSP built from PDB template 1FTK based on UniProtKB P19491.
SMRQ00961. Positions 660-799.
ModBaseSearch...

Protein-protein interaction databases

IntActQ00961.

PTM databases

PhosphoSiteQ00961.

Genome annotation databases

EnsemblENSRNOG00000003280. Rattus norvegicus. [Contig view]
GeneID24411.
KEGGrno:24411.

Organism-specific databases

RGD2739. Grin2c.

Phylogenomic databases

HOVERGENQ00961.

Gene expression databases

ArrayExpressQ00961.
GermOnlineENSRNOG00000003280. Rattus norvegicus.

Family and domain databases

InterProIPR015683. Glutamate_receptor-rel.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
[Graphical view]
PANTHERPTHR18966. Glut_Rec_Related. 1 hit.
PfamPF00060. Lig_chan. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00079. PBPe. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio603235.

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Entry information

Entry nameNMDE3_RAT
AccessionPrimary (citable) accession number: Q00961
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 25, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents