Reviewed,
UniProtKB/Swiss-Prot Q00958 (LFY_ARATH)
Last modified
November 25, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein LEAFY | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 424 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1. Is required subsequently for the transition of an inflorescence meristem into a floral meristem, by an immediate upstream regulation of the ABC classes of floral homeotic genes. Activates directly APETALA1, CAULIFLOWER and AGAMOUS, and indirectly APETALA3 and PISTILLATA with the cooperation of UFO. |
| Subcellular location | NucleusProbable. |
| Tissue specificity | Expressed uniformly throughout the young floral primordia. |
| Developmental stage | Expressed at an early stage of floral initiation. |
| Induction | Positively regulated by CAULIFLOWER and APETALA1. Down-regulated by TFL1. |
| Miscellaneous | Mutations in the LEAFY gene result in the complete transformation of the first few flowers into leaves with associated shoots. |
| Sequence similarities | Belongs to the FLO/LFY family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Differentiation Flowering Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Ligand | DNA-binding |
| Molecular function | Activator Developmental protein |
| Technical term | 3D-structure Complete proteome |
Gene Ontology (GO) | |
| Biological process | cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW flower developmentInferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 424 | 424 | Protein LEAFY | PRO_0000129147 | |||||
Regions | |||||||||
| Coiled coil | 108 – 133 | 26 | Potential | ||||||
| Compositional bias | 23 – 29 | 7 | Poly-Pro | ||||||
| Compositional bias | 114 – 130 | 17 | Arg/Glu-rich | ||||||
| Compositional bias | 208 – 220 | 13 | Asp/Glu-rich (acidic) | ||||||
Natural variations | |||||||||
| Natural variant | 8 | 1 | S → R in strain: cv. Jl-1. | ||||||
| Natural variant | 78 | 1 | G → D in strain: cv. Ita-0. | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "LEAFY controls floral meristem identity in Arabidopsis." Weigel D., Alvarez J., Smyth D.R., Yanofsky M.F., Meyerowitz E.M. Cell 69:843-859(1992) [PubMed: 1350515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Contrasting evolutionary forces in the Arabidopsis thaliana floral developmental pathway." Olsen K.M., Womack A., Garrett A.R., Suddith J.I., Purugganan M.D. Genetics 160:1641-1650(2002) [PubMed: 11973317] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS. Strain: cv. Bla-1, cv. Bretagny, cv. Bs-1, cv. Bu-0, cv. Bu-2, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0, cv. Gr-3, cv. Ita-0, cv. Jl-1, cv. Kas-1, cv. Kent, cv. Landsberg erecta, cv. Li-3, cv. Li-8, cv. Lisse and cv. Wassilewskija. |
| [3] | "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S. DNA Res. 5:41-54(1998) [PubMed: 9628582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Control of flower development in Arabidopsis thaliana by APETALA1 and interacting genes." Bowman J.L., Alvarez J., Weigel D., Meyerowitz E.M., Smyth D.R. Development 119:721-743(1993) Cited for: FUNCTION. |
| [5] | "The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function." Krizek B.A., Meyerowitz E.M. Development 122:11-22(1996) [PubMed: 8565821] [Abstract] Cited for: FUNCTION. |
| [6] | "A genetic framework for floral patterning." Parcy F., Nilsson O., Busch M.A., Lee I., Weigel D. Nature 395:561-566(1998) [PubMed: 9783581] [Abstract] Cited for: FUNCTION. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M91208 Genomic DNA. Translation: AAA32826.1. AF466787 Genomic DNA. Translation: AAM27927.1. AF466788 Genomic DNA. Translation: AAM27928.1. AF466789 Genomic DNA. Translation: AAM27929.1. AF466790 Genomic DNA. Translation: AAM27930.1. AF466791 Genomic DNA. Translation: AAM27931.1. AF466792 Genomic DNA. Translation: AAM27932.1. AF466793 Genomic DNA. Translation: AAM27933.1. AF466794 Genomic DNA. Translation: AAM27934.1. AF466795 Genomic DNA. Translation: AAM27935.1. AF466796 Genomic DNA. Translation: AAM27936.1. AF466797 Genomic DNA. Translation: AAM27937.1. AF466798 Genomic DNA. Translation: AAM27938.1. AF466799 Genomic DNA. Translation: AAM27939.1. AF466800 Genomic DNA. Translation: AAM27940.1. AF466801 Genomic DNA. Translation: AAM27941.1. AB010069 Genomic DNA. Translation: BAB10085.1. | |||||||||||||||||||
| PIR | A38104. B38104. C38104. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | Q00958. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| GenomeReviews | Gene locus AT5G61850 in contig BA000015_GR. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| TAIR | At5g61850. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q00958. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR002910. FLO_LFY. [Graphical view] | ||||||||||||||||||
| Pfam | PF01698. FLO_LFY. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Entry information
| Entry name | LFY_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q00958 Secondary accession number(s): Q8LSH2, Q8LSH3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


