Q00958 (LFY_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein LEAFY | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 420 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1. Is required subsequently for the transition of an inflorescence meristem into a floral meristem, by an immediate upstream regulation of the ABC classes of floral homeotic genes. Activates directly APETALA1, CAULIFLOWER and AGAMOUS, and indirectly APETALA3 and PISTILLATA with the cooperation of UFO. Ref.6 Ref.7 Ref.8 |
| Subcellular location | Nucleus Probable. |
| Tissue specificity | Expressed uniformly throughout the young floral primordia. |
| Developmental stage | Expressed at an early stage of floral initiation. |
| Induction | Positively regulated by CAULIFLOWER and APETALA1. Down-regulated by TFL1. |
| Miscellaneous | Mutations in the LEAFY gene result in the complete transformation of the first few flowers into leaves with associated shoots. |
| Sequence similarities | Belongs to the FLO/LFY family. |
| Sequence caution | The sequence AAA32826.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27927.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27928.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27929.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27930.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27931.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27932.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27933.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27934.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27935.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27936.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27937.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27938.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27939.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27940.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM27941.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence ABK28773.1 differs from that shown. Reason: Erroneous termination at position 421. Translated as stop. The sequence BAB10085.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| UFO | Q39090 | 6 | EBI-1644366,EBI-590758 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 420 | 420 | Protein LEAFY | PRO_0000129147 | |||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||
| Coiled coil | 108 – 133 | 26 | Potential | ||||||||||||||||||||||||||
| Compositional bias | 23 – 29 | 7 | Poly-Pro | ||||||||||||||||||||||||||
| Compositional bias | 114 – 130 | 17 | Arg/Glu-rich | ||||||||||||||||||||||||||
| Compositional bias | 204 – 216 | 13 | Asp/Glu-rich (acidic) | ||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||
| Natural variant | 8 | 1 | S → R in strain: cv. Jl-1. | ||||||||||||||||||||||||||
| Natural variant | 78 | 1 | G → D in strain: cv. Ita-0. | ||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||
| Helix | 254 – 276 | 23 | |||||||||||||||||||||||||||
| Helix | 287 – 295 | 9 | |||||||||||||||||||||||||||
| Helix | 303 – 308 | 6 | |||||||||||||||||||||||||||
| Helix | 310 – 318 | 9 | |||||||||||||||||||||||||||
| Helix | 320 – 332 | 13 | |||||||||||||||||||||||||||
| Helix | 340 – 343 | 4 | |||||||||||||||||||||||||||
| Helix | 345 – 353 | 9 | |||||||||||||||||||||||||||
| Helix | 359 – 365 | 7 | |||||||||||||||||||||||||||
| Helix | 369 – 371 | 3 | |||||||||||||||||||||||||||
| Helix | 376 – 392 | 17 | |||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "LEAFY controls floral meristem identity in Arabidopsis." Weigel D., Alvarez J., Smyth D.R., Yanofsky M.F., Meyerowitz E.M. Cell 69:843-859(1992) [PubMed: 1350515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Contrasting evolutionary forces in the Arabidopsis thaliana floral developmental pathway." Olsen K.M., Womack A., Garrett A.R., Suddith J.I., Purugganan M.D. Genetics 160:1641-1650(2002) [PubMed: 11973317] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS. Strain: cv. Bla-1, cv. Bretagny, cv. Bs-1, cv. Bu-0, cv. Bu-2, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0, cv. Gr-3, cv. Ita-0, cv. Jl-1, cv. Kas-1, cv. Kent, cv. Landsberg erecta, cv. Li-3, cv. Li-8, cv. Lisse and cv. Wassilewskija. |
| [3] | "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S. DNA Res. 5:41-54(1998) [PubMed: 9628582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [5] | "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P. Plant Biotechnol. J. 4:317-324(2006) [PubMed: 17147637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [6] | "Control of flower development in Arabidopsis thaliana by APETALA1 and interacting genes." Bowman J.L., Alvarez J., Weigel D., Meyerowitz E.M., Smyth D.R. Development 119:721-743(1993) Cited for: FUNCTION. |
| [7] | "The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function." Krizek B.A., Meyerowitz E.M. Development 122:11-22(1996) [PubMed: 8565821] [Abstract] Cited for: FUNCTION. |
| [8] | "A genetic framework for floral patterning." Parcy F., Nilsson O., Busch M.A., Lee I., Weigel D. Nature 395:561-566(1998) [PubMed: 9783581] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M91208 Genomic DNA. Translation: AAA32826.1. Sequence problems. AF466787 Genomic DNA. Translation: AAM27927.1. Sequence problems. AF466788 Genomic DNA. Translation: AAM27928.1. Sequence problems. AF466789 Genomic DNA. Translation: AAM27929.1. Sequence problems. AF466790 Genomic DNA. Translation: AAM27930.1. Sequence problems. AF466791 Genomic DNA. Translation: AAM27931.1. Sequence problems. AF466792 Genomic DNA. Translation: AAM27932.1. Sequence problems. AF466793 Genomic DNA. Translation: AAM27933.1. Sequence problems. AF466794 Genomic DNA. Translation: AAM27934.1. Sequence problems. AF466795 Genomic DNA. Translation: AAM27935.1. Sequence problems. AF466796 Genomic DNA. Translation: AAM27936.1. Sequence problems. AF466797 Genomic DNA. Translation: AAM27937.1. Sequence problems. AF466798 Genomic DNA. Translation: AAM27938.1. Sequence problems. AF466799 Genomic DNA. Translation: AAM27939.1. Sequence problems. AF466800 Genomic DNA. Translation: AAM27940.1. Sequence problems. AF466801 Genomic DNA. Translation: AAM27941.1. Sequence problems. AB010069 Genomic DNA. Translation: BAB10085.1. Sequence problems. CP002688 Genomic DNA. Translation: AED97525.1. DQ447103 mRNA. Translation: ABE66271.1. DQ653389 mRNA. Translation: ABK28773.1. Sequence problems. | ||||||||||||||||||
| IPI | IPI00522122. | ||||||||||||||||||
| PIR | A38104. B38104. C38104. | ||||||||||||||||||
| RefSeq | NP_200993.1. NM_125579.1. | ||||||||||||||||||
| UniGene | At.55671. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q00958. | ||||||||||||||||||
| SMR | Q00958. Positions 233-394. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | Q00958. 1 interaction. | ||||||||||||||||||
| STRING | Q00958. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q00958. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| EnsemblPlants | AT5G61850.1; AT5G61850.1; AT5G61850. | ||||||||||||||||||
| GeneID | 836307. | ||||||||||||||||||
| GenomeReviews | Gene locus AT5G61850 in contig BA000015_GR. | ||||||||||||||||||
| KEGG | ath:AT5G61850. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| TAIR | At5g61850. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | HBG596286. | ||||||||||||||||||
| InParanoid | Q00958. | ||||||||||||||||||
| OMA | HCLDEDA. | ||||||||||||||||||
| PhylomeDB | Q00958. | ||||||||||||||||||
| ProtClustDB | CLSN2686949. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q00958. | ||||||||||||||||||
| Genevestigator | Q00958. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR002910. FLO_LFY. [Graphical view] | ||||||||||||||||||
| Pfam | PF01698. FLO_LFY. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Entry information
| Entry name | LFY_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q00958 Secondary accession number(s): A0MFR2 Q8LSH3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with