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Protein

Sodium channel subunit beta-1

Gene

Scn1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_340167. Interaction between L1 and Ankyrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-1
Gene namesi
Name:Scn1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3631. Scn1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 160142ExtracellularSequence AnalysisAdd
BLAST
Transmembranei161 – 18222HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 21836CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 218200Sodium channel subunit beta-1PRO_0000014929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 1211 Publication
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00954.
PRIDEiQ00954.

PTM databases

PhosphoSiteiQ00954.

Expressioni

Tissue specificityi

Expressed in brain, heart, skeletal muscle and spinal cord.

Developmental stagei

In developing nodes of Ranvier, it is localized in the sciatic nerve at postnantal days 3 and 10, during the process of myelination and maturation of the nodes.

Gene expression databases

ExpressionAtlasiQ00954. baseline and differential.
GenevisibleiQ00954. RN.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Syt1P217072EBI-2619363,EBI-458098

Protein-protein interaction databases

IntActiQ00954. 2 interactions.
MINTiMINT-205402.
STRINGi10116.ENSRNOP00000028653.

Structurei

3D structure databases

ProteinModelPortaliQ00954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 150129Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45207.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ00954.
KOiK04845.
OMAiISCKKRS.
OrthoDBiEOG7M3J19.
PhylomeDBiQ00954.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR027098. Na_channel_b1/b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLLALVVG AVLVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT
60 70 80 90 100
AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD
110 120 130 140 150
LQDLSIFITN VTYNHSGDYE CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA
160 170 180 190 200
NRDMASIVSE IMMYVLIVVL TIWLVAEMVY CYKKIAAATE AAAQENASEY
210
LAITSESKEN CTGVQVAE
Length:218
Mass (Da):24,692
Last modified:July 1, 1993 - v1
Checksum:i0BA84FC44FF2306B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91808 mRNA. Translation: AAA88513.1.
BC094523 mRNA. Translation: AAH94523.1.
PIRiA42737.
RefSeqiNP_001257974.1. NM_001271045.1.
NP_058984.1. NM_017288.2.
UniGeneiRn.4958.

Genome annotation databases

EnsembliENSRNOT00000028653; ENSRNOP00000028653; ENSRNOG00000021102.
GeneIDi29686.
KEGGirno:29686.
UCSCiRGD:3631. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91808 mRNA. Translation: AAA88513.1.
BC094523 mRNA. Translation: AAH94523.1.
PIRiA42737.
RefSeqiNP_001257974.1. NM_001271045.1.
NP_058984.1. NM_017288.2.
UniGeneiRn.4958.

3D structure databases

ProteinModelPortaliQ00954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00954. 2 interactions.
MINTiMINT-205402.
STRINGi10116.ENSRNOP00000028653.

PTM databases

PhosphoSiteiQ00954.

Proteomic databases

PaxDbiQ00954.
PRIDEiQ00954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028653; ENSRNOP00000028653; ENSRNOG00000021102.
GeneIDi29686.
KEGGirno:29686.
UCSCiRGD:3631. rat.

Organism-specific databases

CTDi6324.
RGDi3631. Scn1b.

Phylogenomic databases

eggNOGiNOG45207.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ00954.
KOiK04845.
OMAiISCKKRS.
OrthoDBiEOG7M3J19.
PhylomeDBiQ00954.
TreeFamiTF332097.

Enzyme and pathway databases

ReactomeiREACT_340167. Interaction between L1 and Ankyrins.

Miscellaneous databases

NextBioi610057.
PROiQ00954.

Gene expression databases

ExpressionAtlasiQ00954. baseline and differential.
GenevisibleiQ00954. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR027098. Na_channel_b1/b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel."
    Isom L.L., De Jongh K.S., Patton D.E., Reber B.F.X., Offord J., Charbonneau H., Walsh K., Goldin A.L., Catterall W.A.
    Science 256:839-842(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain."
    Ratcliffe C.F., Westenbroek R.E., Curtis R., Catterall W.A.
    J. Cell Biol. 154:427-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH NEUROFASCIN.
  4. "Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel."
    Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M.
    Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH SCN10A.
  5. "Identification of an intra-molecular disulfide bond in the sodium channel beta1-subunit."
    Barbieri R., Baroni D., Moran O.
    Biochem. Biophys. Res. Commun. 420:364-367(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.

Entry informationi

Entry nameiSCN1B_RAT
AccessioniPrimary (citable) accession number: Q00954
Secondary accession number(s): Q505J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 24, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.