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Q00954

- SCN1B_RAT

UniProt

Q00954 - SCN1B_RAT

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Protein
Sodium channel subunit beta-1
Gene
Scn1b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sodium channel inhibitor activity Source: Ensembl
  3. sodium channel regulator activity Source: RGD
  4. voltage-gated sodium channel activity involved in Purkinje myocyte action potential Source: Ensembl

GO - Biological processi

  1. cardiac muscle cell action potential involved in contraction Source: Ensembl
  2. cardiac muscle contraction Source: Ensembl
  3. corticospinal neuron axon guidance Source: Ensembl
  4. neuronal action potential propagation Source: Ensembl
  5. positive regulation of neuron projection development Source: Ensembl
  6. positive regulation of sodium ion transport Source: Ensembl
  7. regulation of atrial cardiac muscle cell membrane depolarization Source: Ensembl
  8. regulation of heart rate by cardiac conduction Source: Ensembl
  9. regulation of sodium ion transmembrane transporter activity Source: Ensembl
  10. regulation of sodium ion transport Source: RGD
  11. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  12. response to pyrethroid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-1
Gene namesi
Name:Scn1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3631. Scn1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 160142Extracellular Reviewed prediction
Add
BLAST
Transmembranei161 – 18222Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 21836Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. T-tubule Source: Ensembl
  2. intercalated disc Source: Ensembl
  3. node of Ranvier Source: Ensembl
  4. plasma membrane Source: Reactome
  5. voltage-gated sodium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818
Add
BLAST
Chaini19 – 218200Sodium channel subunit beta-1
PRO_0000014929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 1211 Publication
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00954.
PRIDEiQ00954.

PTM databases

PhosphoSiteiQ00954.

Expressioni

Tissue specificityi

Expressed in brain, heart, skeletal muscle and spinal cord.

Developmental stagei

In developing nodes of Ranvier, it is localized in the sciatic nerve at postnantal days 3 and 10, during the process of myelination and maturation of the nodes.

Gene expression databases

ArrayExpressiQ00954.
GenevestigatoriQ00954.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Syt1P217072EBI-2619363,EBI-458098

Protein-protein interaction databases

IntActiQ00954. 2 interactions.
MINTiMINT-205402.

Structurei

3D structure databases

ProteinModelPortaliQ00954.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 150129Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45207.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ00954.
KOiK04845.
OMAiISCKKRS.
OrthoDBiEOG7M3J19.
PhylomeDBiQ00954.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR027098. Na_channel_b1/b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00954-1 [UniParc]FASTAAdd to Basket

« Hide

MGTLLALVVG AVLVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT    50
AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD 100
LQDLSIFITN VTYNHSGDYE CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA 150
NRDMASIVSE IMMYVLIVVL TIWLVAEMVY CYKKIAAATE AAAQENASEY 200
LAITSESKEN CTGVQVAE 218
Length:218
Mass (Da):24,692
Last modified:July 1, 1993 - v1
Checksum:i0BA84FC44FF2306B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91808 mRNA. Translation: AAA88513.1.
BC094523 mRNA. Translation: AAH94523.1.
PIRiA42737.
RefSeqiNP_001257974.1. NM_001271045.1.
NP_058984.1. NM_017288.2.
UniGeneiRn.4958.

Genome annotation databases

EnsembliENSRNOT00000028653; ENSRNOP00000028653; ENSRNOG00000021102.
GeneIDi29686.
KEGGirno:29686.
UCSCiRGD:3631. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91808 mRNA. Translation: AAA88513.1 .
BC094523 mRNA. Translation: AAH94523.1 .
PIRi A42737.
RefSeqi NP_001257974.1. NM_001271045.1.
NP_058984.1. NM_017288.2.
UniGenei Rn.4958.

3D structure databases

ProteinModelPortali Q00954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q00954. 2 interactions.
MINTi MINT-205402.

PTM databases

PhosphoSitei Q00954.

Proteomic databases

PaxDbi Q00954.
PRIDEi Q00954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028653 ; ENSRNOP00000028653 ; ENSRNOG00000021102 .
GeneIDi 29686.
KEGGi rno:29686.
UCSCi RGD:3631. rat.

Organism-specific databases

CTDi 6324.
RGDi 3631. Scn1b.

Phylogenomic databases

eggNOGi NOG45207.
GeneTreei ENSGT00390000018560.
HOGENOMi HOG000276881.
HOVERGENi HBG056582.
InParanoidi Q00954.
KOi K04845.
OMAi ISCKKRS.
OrthoDBi EOG7M3J19.
PhylomeDBi Q00954.
TreeFami TF332097.

Miscellaneous databases

NextBioi 610057.
PROi Q00954.

Gene expression databases

ArrayExpressi Q00954.
Genevestigatori Q00954.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR027098. Na_channel_b1/b3.
[Graphical view ]
PANTHERi PTHR10546. PTHR10546. 1 hit.
Pfami PF00047. ig. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel."
    Isom L.L., De Jongh K.S., Patton D.E., Reber B.F.X., Offord J., Charbonneau H., Walsh K., Goldin A.L., Catterall W.A.
    Science 256:839-842(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain."
    Ratcliffe C.F., Westenbroek R.E., Curtis R., Catterall W.A.
    J. Cell Biol. 154:427-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH NEUROFASCIN.
  4. "Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel."
    Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M.
    Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH SCN10A.
  5. "Identification of an intra-molecular disulfide bond in the sodium channel beta1-subunit."
    Barbieri R., Baroni D., Moran O.
    Biochem. Biophys. Res. Commun. 420:364-367(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.

Entry informationi

Entry nameiSCN1B_RAT
AccessioniPrimary (citable) accession number: Q00954
Secondary accession number(s): Q505J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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