ID   CSF2R_MOUSE             Reviewed;         388 AA.
AC   Q00941; E9QJX0;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   27-MAR-2024, entry version 178.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;
DE            Short=GM-CSF-R-alpha;
DE            Short=GMCSFR-alpha;
DE            Short=GMR-alpha;
DE   AltName: CD_antigen=CD116;
DE   Flags: Precursor;
GN   Name=Csf2ra; Synonyms=Csfgmra;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neonatal spleen;
RX   PubMed=1533931; DOI=10.1073/pnas.89.10.4295;
RA   Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D.,
RA   Larsen A.;
RT   "Cloning of the low-affinity murine granulocyte-macrophage colony-
RT   stimulating factor receptor and reconstitution of a high-affinity receptor
RT   complex.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Low affinity receptor for granulocyte-macrophage colony-
CC       stimulating factor. Transduces a signal that results in the
CC       proliferation, differentiation, and functional activation of
CC       hematopoietic cells.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit
CC       is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF
CC       receptor complex is a dodecamer of two head-to-head hexamers of two
CC       alpha, two beta, and two ligand subunits (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC       folding and thereby efficient intracellular transport and cell-surface
CC       receptor binding.
CC   -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC       activation.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M85078; AAA37421.1; -; mRNA.
DR   EMBL; AC165327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS29946.1; -.
DR   PIR; A45304; A45304.
DR   RefSeq; NP_034100.2; NM_009970.2.
DR   AlphaFoldDB; Q00941; -.
DR   SMR; Q00941; -.
DR   BioGRID; 198931; 1.
DR   STRING; 10090.ENSMUSP00000075423; -.
DR   GlyCosmos; Q00941; 6 sites, No reported glycans.
DR   GlyGen; Q00941; 6 sites.
DR   PhosphoSitePlus; Q00941; -.
DR   SwissPalm; Q00941; -.
DR   PaxDb; 10090-ENSMUSP00000075423; -.
DR   ProteomicsDB; 285346; -.
DR   Antibodypedia; 4251; 854 antibodies from 42 providers.
DR   DNASU; 12982; -.
DR   Ensembl; ENSMUST00000076046.7; ENSMUSP00000075423.7; ENSMUSG00000059326.8.
DR   Ensembl; ENSMUST00000237386.2; ENSMUSP00000158457.2; ENSMUSG00000059326.8.
DR   GeneID; 12982; -.
DR   KEGG; mmu:12982; -.
DR   UCSC; uc008icj.2; mouse.
DR   AGR; MGI:1339754; -.
DR   CTD; 1438; -.
DR   MGI; MGI:1339754; Csf2ra.
DR   VEuPathDB; HostDB:ENSMUSG00000059326; -.
DR   eggNOG; ENOG502RZVR; Eukaryota.
DR   GeneTree; ENSGT00520000055993; -.
DR   HOGENOM; CLU_039627_2_0_1; -.
DR   InParanoid; Q00941; -.
DR   OMA; DIQTEYV; -.
DR   OrthoDB; 5353959at2759; -.
DR   PhylomeDB; Q00941; -.
DR   TreeFam; TF331549; -.
DR   BioGRID-ORCS; 12982; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Csf2ra; mouse.
DR   PRO; PR:Q00941; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q00941; Protein.
DR   Bgee; ENSMUSG00000059326; Expressed in granulocyte and 242 other cell types or tissues.
DR   GO; GO:0030526; C:granulocyte macrophage colony-stimulating factor receptor complex; ISO:MGI.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   GO; GO:0038157; P:granulocyte-macrophage colony-stimulating factor signaling pathway; ISO:MGI.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; ISO:MGI.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:MGI.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040907; IL3Ra_N.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF35; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF18611; IL3Ra_N; 1.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
DR   Genevisible; Q00941; MM.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..388
FT                   /note="Granulocyte-macrophage colony-stimulating factor
FT                   receptor subunit alpha"
FT                   /id="PRO_0000010873"
FT   TOPO_DOM        30..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        349..388
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          228..324
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   MOTIF           310..314
FT                   /note="WSXWS motif"
FT   MOTIF           359..367
FT                   /note="Box 1 motif"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        237
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        124
FT                   /note="G -> S (in Ref. 1; AAA37421)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   388 AA;  41769 MW;  8877B0743D99B0FE CRC64;
     MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT RTLTWACDTA
     AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG VTLDVNGTVG GAAAHWRLSF
     VNEGAAGSGA ENLTCEIRAA RFLSCAWREG PAAPADVRYS LRVLNSTGHD VARCMADPGD
     DVITQCIAND LSLLGSEAYL VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH
     CTVSWAPPST WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV
     RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC RRFEVTRRLF
     PPIPGIRDKV SDDVRVNPET LRKDLLQP
//