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Q00941

- CSF2R_MOUSE

UniProt

Q00941 - CSF2R_MOUSE

Protein

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Gene

Csf2ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro

    GO - Biological processi

    1. response to ethanol Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
    Short name:
    GM-CSF-R-alpha
    Short name:
    GMCSFR-alpha
    Short name:
    GMR-alpha
    Alternative name(s):
    CD_antigen: CD116
    Gene namesi
    Name:Csf2ra
    Synonyms:Csfgmra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1339754. Csf2ra.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 388359Granulocyte-macrophage colony-stimulating factor receptor subunit alphaPRO_0000010873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ00941.

    PTM databases

    PhosphoSiteiQ00941.

    Expressioni

    Gene expression databases

    BgeeiQ00941.
    GenevestigatoriQ00941.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ00941.
    SMRiQ00941. Positions 228-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 327298ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini349 – 38840CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini228 – 32497Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi310 – 3145WSXWS motif
    Motifi359 – 3679Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74889.
    GeneTreeiENSGT00520000055993.
    HOVERGENiHBG051129.
    InParanoidiQ00941.
    KOiK05066.
    OMAiFEYEINI.
    OrthoDBiEOG73BVCJ.
    TreeFamiTF331549.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view]
    PfamiPF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT    50
    RTLTWACDTA AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG 100
    VTLDVNGTVG GAAAHWRLSF VNEGAAGSGA ENLTCEIRAA RFLSCAWREG 150
    PAAPADVRYS LRVLNSTGHD VARCMADPGD DVITQCIAND LSLLGSEAYL 200
    VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH CTVSWAPPST 250
    WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV 300
    RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC 350
    RRFEVTRRLF PPIPGIRDKV SDDVRVNPET LRKDLLQP 388
    Length:388
    Mass (Da):41,769
    Last modified:July 27, 2011 - v2
    Checksum:i8877B0743D99B0FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241G → S in AAA37421. (PubMed:1533931)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85078 mRNA. Translation: AAA37421.1.
    AC165327 Genomic DNA. No translation available.
    CCDSiCCDS29946.1.
    PIRiA45304.
    RefSeqiNP_034100.2. NM_009970.2.
    UniGeneiMm.287228.

    Genome annotation databases

    EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
    GeneIDi12982.
    KEGGimmu:12982.
    UCSCiuc008icj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85078 mRNA. Translation: AAA37421.1 .
    AC165327 Genomic DNA. No translation available.
    CCDSi CCDS29946.1.
    PIRi A45304.
    RefSeqi NP_034100.2. NM_009970.2.
    UniGenei Mm.287228.

    3D structure databases

    ProteinModelPortali Q00941.
    SMRi Q00941. Positions 228-316.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q00941.

    Proteomic databases

    PRIDEi Q00941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076046 ; ENSMUSP00000075423 ; ENSMUSG00000059326 .
    GeneIDi 12982.
    KEGGi mmu:12982.
    UCSCi uc008icj.2. mouse.

    Organism-specific databases

    CTDi 1438.
    MGIi MGI:1339754. Csf2ra.

    Phylogenomic databases

    eggNOGi NOG74889.
    GeneTreei ENSGT00520000055993.
    HOVERGENi HBG051129.
    InParanoidi Q00941.
    KOi K05066.
    OMAi FEYEINI.
    OrthoDBi EOG73BVCJ.
    TreeFami TF331549.

    Enzyme and pathway databases

    Reactomei REACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Miscellaneous databases

    NextBioi 282760.
    PROi Q00941.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q00941.
    Genevestigatori Q00941.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view ]
    Pfami PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex."
      Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D., Larsen A.
      Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Neonatal spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCSF2R_MOUSE
    AccessioniPrimary (citable) accession number: Q00941
    Secondary accession number(s): E9QJX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3