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Q00941 (CSF2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Short name=GM-CSF-R-alpha
Short name=GMCSFR-alpha
Short name=GMR-alpha
Alternative name(s):
CD_antigen=CD116
Gene names
Name:Csf2ra
Synonyms:Csfgmra
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Subunit structure

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Contains 1 fibronectin type-III domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to ethanol

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 388359Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
PRO_0000010873

Regions

Topological domain30 – 327298Extracellular Potential
Transmembrane328 – 34821Helical; Potential
Topological domain349 – 38840Cytoplasmic Potential
Domain228 – 32497Fibronectin type-III
Motif310 – 3145WSXWS motif
Motif359 – 3679Box 1 motif

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1321N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1241G → S in AAA37421. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q00941 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8877B0743D99B0FE

FASTA38841,769
        10         20         30         40         50         60 
MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT RTLTWACDTA 

        70         80         90        100        110        120 
AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG VTLDVNGTVG GAAAHWRLSF 

       130        140        150        160        170        180 
VNEGAAGSGA ENLTCEIRAA RFLSCAWREG PAAPADVRYS LRVLNSTGHD VARCMADPGD 

       190        200        210        220        230        240 
DVITQCIAND LSLLGSEAYL VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH 

       250        260        270        280        290        300 
CTVSWAPPST WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV 

       310        320        330        340        350        360 
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC RRFEVTRRLF 

       370        380 
PPIPGIRDKV SDDVRVNPET LRKDLLQP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex."
Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D., Larsen A.
Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Neonatal spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M85078 mRNA. Translation: AAA37421.1.
AC165327 Genomic DNA. No translation available.
PIRA45304.
RefSeqNP_034100.2. NM_009970.2.
UniGeneMm.287228.

3D structure databases

ProteinModelPortalQ00941.
SMRQ00941. Positions 124-322.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ00941.

Proteomic databases

PRIDEQ00941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
GeneID12982.
KEGGmmu:12982.
UCSCuc008icj.2. mouse.

Organism-specific databases

CTD1438.
MGIMGI:1339754. Csf2ra.

Phylogenomic databases

eggNOGNOG74889.
GeneTreeENSGT00520000055993.
HOVERGENHBG051129.
InParanoidQ00941.
KOK05066.
OMAFEYEINI.
OrthoDBEOG73BVCJ.
TreeFamTF331549.

Gene expression databases

BgeeQ00941.
GenevestigatorQ00941.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 1 hit.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282760.
PROQ00941.
SOURCESearch...

Entry information

Entry nameCSF2R_MOUSE
AccessionPrimary (citable) accession number: Q00941
Secondary accession number(s): E9QJX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot