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Protein

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Gene

Csf2ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

GO - Molecular functioni

  • granulocyte colony-stimulating factor binding Source: MGI
  • granulocyte colony-stimulating factor receptor activity Source: MGI

GO - Biological processi

  • cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: MGI
  • granulocyte colony-stimulating factor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_294984. Interleukin-3, 5 and GM-CSF signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Short name:
GM-CSF-R-alpha
Short name:
GMCSFR-alpha
Short name:
GMR-alpha
Alternative name(s):
CD_antigen: CD116
Gene namesi
Name:Csf2ra
Synonyms:Csfgmra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1339754. Csf2ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 327298ExtracellularSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Topological domaini349 – 38840CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 388359Granulocyte-macrophage colony-stimulating factor receptor subunit alphaPRO_0000010873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ00941.

PTM databases

PhosphoSiteiQ00941.

Expressioni

Gene expression databases

BgeeiQ00941.
GenevisibleiQ00941. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075423.

Structurei

3D structure databases

ProteinModelPortaliQ00941.
SMRiQ00941. Positions 128-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 32497Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3145WSXWS motif
Motifi359 – 3679Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74889.
GeneTreeiENSGT00520000055993.
HOVERGENiHBG051129.
InParanoidiQ00941.
KOiK05066.
OMAiFEYEINI.
OrthoDBiEOG73BVCJ.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT
60 70 80 90 100
RTLTWACDTA AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG
110 120 130 140 150
VTLDVNGTVG GAAAHWRLSF VNEGAAGSGA ENLTCEIRAA RFLSCAWREG
160 170 180 190 200
PAAPADVRYS LRVLNSTGHD VARCMADPGD DVITQCIAND LSLLGSEAYL
210 220 230 240 250
VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH CTVSWAPPST
260 270 280 290 300
WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV
310 320 330 340 350
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC
360 370 380
RRFEVTRRLF PPIPGIRDKV SDDVRVNPET LRKDLLQP
Length:388
Mass (Da):41,769
Last modified:July 27, 2011 - v2
Checksum:i8877B0743D99B0FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241G → S in AAA37421 (PubMed:1533931).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85078 mRNA. Translation: AAA37421.1.
AC165327 Genomic DNA. No translation available.
CCDSiCCDS29946.1.
PIRiA45304.
RefSeqiNP_034100.2. NM_009970.2.
UniGeneiMm.287228.

Genome annotation databases

EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
GeneIDi12982.
KEGGimmu:12982.
UCSCiuc008icj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85078 mRNA. Translation: AAA37421.1.
AC165327 Genomic DNA. No translation available.
CCDSiCCDS29946.1.
PIRiA45304.
RefSeqiNP_034100.2. NM_009970.2.
UniGeneiMm.287228.

3D structure databases

ProteinModelPortaliQ00941.
SMRiQ00941. Positions 128-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075423.

PTM databases

PhosphoSiteiQ00941.

Proteomic databases

PRIDEiQ00941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
GeneIDi12982.
KEGGimmu:12982.
UCSCiuc008icj.2. mouse.

Organism-specific databases

CTDi1438.
MGIiMGI:1339754. Csf2ra.

Phylogenomic databases

eggNOGiNOG74889.
GeneTreeiENSGT00520000055993.
HOVERGENiHBG051129.
InParanoidiQ00941.
KOiK05066.
OMAiFEYEINI.
OrthoDBiEOG73BVCJ.
TreeFamiTF331549.

Enzyme and pathway databases

ReactomeiREACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_294984. Interleukin-3, 5 and GM-CSF signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Miscellaneous databases

NextBioi282760.
PROiQ00941.
SOURCEiSearch...

Gene expression databases

BgeeiQ00941.
GenevisibleiQ00941. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex."
    Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D., Larsen A.
    Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neonatal spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCSF2R_MOUSE
AccessioniPrimary (citable) accession number: Q00941
Secondary accession number(s): E9QJX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.