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Q00941

- CSF2R_MOUSE

UniProt

Q00941 - CSF2R_MOUSE

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Protein
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Gene
Csf2ra, Csfgmra
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. response to ethanol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Short name:
GM-CSF-R-alpha
Short name:
GMCSFR-alpha
Short name:
GMR-alpha
Alternative name(s):
CD_antigen: CD116
Gene namesi
Name:Csf2ra
Synonyms:Csfgmra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1339754. Csf2ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 327298Extracellular Reviewed prediction
Add
BLAST
Transmembranei328 – 34821Helical; Reviewed prediction
Add
BLAST
Topological domaini349 – 38840Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 388359Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
PRO_0000010873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi165 – 1651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ00941.

PTM databases

PhosphoSiteiQ00941.

Expressioni

Gene expression databases

BgeeiQ00941.
GenevestigatoriQ00941.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ00941.
SMRiQ00941. Positions 228-316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 32497Fibronectin type-III
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3145WSXWS motif
Motifi359 – 3679Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74889.
GeneTreeiENSGT00520000055993.
HOVERGENiHBG051129.
InParanoidiQ00941.
KOiK05066.
OMAiFEYEINI.
OrthoDBiEOG73BVCJ.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00941-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT    50
RTLTWACDTA AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG 100
VTLDVNGTVG GAAAHWRLSF VNEGAAGSGA ENLTCEIRAA RFLSCAWREG 150
PAAPADVRYS LRVLNSTGHD VARCMADPGD DVITQCIAND LSLLGSEAYL 200
VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH CTVSWAPPST 250
WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV 300
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC 350
RRFEVTRRLF PPIPGIRDKV SDDVRVNPET LRKDLLQP 388
Length:388
Mass (Da):41,769
Last modified:July 27, 2011 - v2
Checksum:i8877B0743D99B0FE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241G → S in AAA37421. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85078 mRNA. Translation: AAA37421.1.
AC165327 Genomic DNA. No translation available.
CCDSiCCDS29946.1.
PIRiA45304.
RefSeqiNP_034100.2. NM_009970.2.
UniGeneiMm.287228.

Genome annotation databases

EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
GeneIDi12982.
KEGGimmu:12982.
UCSCiuc008icj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85078 mRNA. Translation: AAA37421.1 .
AC165327 Genomic DNA. No translation available.
CCDSi CCDS29946.1.
PIRi A45304.
RefSeqi NP_034100.2. NM_009970.2.
UniGenei Mm.287228.

3D structure databases

ProteinModelPortali Q00941.
SMRi Q00941. Positions 228-316.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q00941.

Proteomic databases

PRIDEi Q00941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076046 ; ENSMUSP00000075423 ; ENSMUSG00000059326 .
GeneIDi 12982.
KEGGi mmu:12982.
UCSCi uc008icj.2. mouse.

Organism-specific databases

CTDi 1438.
MGIi MGI:1339754. Csf2ra.

Phylogenomic databases

eggNOGi NOG74889.
GeneTreei ENSGT00520000055993.
HOVERGENi HBG051129.
InParanoidi Q00941.
KOi K05066.
OMAi FEYEINI.
OrthoDBi EOG73BVCJ.
TreeFami TF331549.

Enzyme and pathway databases

Reactomei REACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Miscellaneous databases

NextBioi 282760.
PROi Q00941.
SOURCEi Search...

Gene expression databases

Bgeei Q00941.
Genevestigatori Q00941.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view ]
Pfami PF09240. IL6Ra-bind. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex."
    Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D., Larsen A.
    Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neonatal spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCSF2R_MOUSE
AccessioniPrimary (citable) accession number: Q00941
Secondary accession number(s): E9QJX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi