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Protein

Forkhead box protein G1

Gene

Foxg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi171 – 262Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • brain development Source: RGD
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein G1
Short name:
FoxG1
Alternative name(s):
Brain factor 1
Short name:
BF-1
Short name:
BF1
Forkhead-related protein FKHL1
Gene namesi
Name:Foxg1
Synonyms:Fkhl1, Foxg1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi2619. Foxg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918381 – 480Forkhead box protein G1Add BLAST480

Proteomic databases

PaxDbiQ00939.
PRIDEiQ00939.

PTM databases

iPTMnetiQ00939.
PhosphoSitePlusiQ00939.

Expressioni

Tissue specificityi

Is expressed in the cortex, olfactory bulb, hippocampus, and caudate putamen.

Developmental stagei

More abundant in fetal brain compared with the adult brain.

Gene expression databases

BgeeiENSRNOG00000047891.
GenevisibleiQ00939. RN.

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

BioGridi246542. 1 interactor.
STRINGi10116.ENSRNOP00000067118.

Structurei

3D structure databases

ProteinModelPortaliQ00939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 397Interaction with KDM5BBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 56His-richAdd BLAST24
Compositional biasi57 – 82Pro-richAdd BLAST26
Compositional biasi70 – 74Poly-Gln5

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOVERGENiHBG051645.
InParanoidiQ00939.
KOiK09385.
OMAiQSSTSMT.
OrthoDBiEOG091G0JF7.
PhylomeDBiQ00939.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH
60 70 80 90 100
HHHHHHPPPP APQPPPPPPQ QQQQPPPAPQ PPQARGAPAA DDDKGPQPLL
110 120 130 140 150
LPPSAALDGA KADALGAKGE PGGGPAELAP VGPDEKEKGA GAGGEEKKGA
160 170 180 190 200
GEGGKDGEGG KEGDKKNGKY EKPPFSYNAL IMMAIRQSPE KRLTLNGIYE
210 220 230 240 250
FIMKNFPYYR ENKQGWQNSI RHNLSLNKCF VKVPRHYDDP GKGNYWMLDP
260 270 280 290 300
SSDDVFIGGT TGKLRRRSTT SRAKLAFKRG ARLTSTGLTF MDRAGSLYWP
310 320 330 340 350
MSPFLSLHHP RASSTLSYNG TTSAYPSHPM PYSSVLTQNS LGNNHSFSTA
360 370 380 390 400
NGLSVDRLVN GEIPYATHHL TAAALAASVP CGLSVPCSGT YSLNPCSVNL
410 420 430 440 450
LAGQTSYFFP HVPHPSMTSQ TSTSMSARAA SSSTSPQAPS TLPCESLRPS
460 470 480
LPSFTTGLSG GLSDYFTHQN QGSSSNPLIH
Length:480
Mass (Da):51,466
Last modified:July 1, 1993 - v1
Checksum:i00425B2F5298F444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87634 mRNA. Translation: AAA40812.1.
PIRiJH0672.
RefSeqiNP_036692.1. NM_012560.2.
UniGeneiRn.9864.

Genome annotation databases

EnsembliENSRNOT00000075349; ENSRNOP00000067118; ENSRNOG00000047891.
GeneIDi24370.
KEGGirno:24370.
UCSCiRGD:2619. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87634 mRNA. Translation: AAA40812.1.
PIRiJH0672.
RefSeqiNP_036692.1. NM_012560.2.
UniGeneiRn.9864.

3D structure databases

ProteinModelPortaliQ00939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246542. 1 interactor.
STRINGi10116.ENSRNOP00000067118.

PTM databases

iPTMnetiQ00939.
PhosphoSitePlusiQ00939.

Proteomic databases

PaxDbiQ00939.
PRIDEiQ00939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075349; ENSRNOP00000067118; ENSRNOG00000047891.
GeneIDi24370.
KEGGirno:24370.
UCSCiRGD:2619. rat.

Organism-specific databases

CTDi2290.
RGDi2619. Foxg1.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOVERGENiHBG051645.
InParanoidiQ00939.
KOiK09385.
OMAiQSSTSMT.
OrthoDBiEOG091G0JF7.
PhylomeDBiQ00939.

Miscellaneous databases

PROiQ00939.

Gene expression databases

BgeeiENSRNOG00000047891.
GenevisibleiQ00939. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXG1_RAT
AccessioniPrimary (citable) accession number: Q00939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.