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Protein

Alcohol oxidase

Gene

AOD1

Organism
Candida boidinii (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of methanol to formaldehyde and hydrogen peroxide, the first step in the methanol utilization pathway of methylotrophic yeasts.1 Publication

Catalytic activityi

A primary alcohol + O2 = an aldehyde + H2O2.

Cofactori

Pathwayi: methane degradation

This protein is involved in the pathway methane degradation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway methane degradation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei567Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 39FADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processMethanol utilization
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13165
BRENDAi1.1.3.13 1100
UniPathwayiUPA00147

Protein family/group databases

CAZyiAA3 Auxiliary Activities 3

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol oxidase (EC:1.1.3.13)
Short name:
AO
Short name:
AOX
Alternative name(s):
Methanol oxidase
Short name:
MOX
Gene namesi
Name:AOD1
OrganismiCandida boidinii (Yeast)
Taxonomic identifieri5477 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataeaOgataea/Candida clade

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002055802 – 663Alcohol oxidaseAdd BLAST662

Proteomic databases

PRIDEiQ00922

Expressioni

Inductioni

Induced by methanol. Subject to strong carbon catabolite repression (By similarity).By similarity

Interactioni

Subunit structurei

Homooctamer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ00922
SMRiQ00922
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi661 – 663Microbody targeting signalSequence analysis3

Domaini

The C-terminal peroxisomal targeting signal (PTS) is essential for the efficient targeting and import of AOX into peroxisomes via the PTS1 pathway.By similarity

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.Curated

Family and domain databases

Gene3Di3.50.50.60, 5 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPEEFDVI VCGGGSTGCV IAGRLANVDE NLKVLLIENG ENNLNNPWVY
60 70 80 90 100
LPGIYPRNMR LDSKTATFYN SRPSKHLNGR RAIVPQANIL GGGSSINFMM
110 120 130 140 150
YTRASASDYD DWESEGWTTD ELLPLMKKFE TYQRPCNNRD VHGFDGPIKV
160 170 180 190 200
SFGNYTYPQC QDFLRACETQ GIPYVDDLED LKTSHGAEQW LKWINRDFGR
210 220 230 240 250
RSDTAHAFIH STMRNKENLF LMTNTKVDKV IIEDGRAVAV RTVPSKPIGD
260 270 280 290 300
SKVSRTFKAR KQIVVSCGTV SSPMVLQRSG IGEPSKLRAA GVKPIVELPG
310 320 330 340 350
VGRNFQDHFC YFVPYRIKQD SESFDAFVSG DKEAQKSAFD QWYATGAGPL
360 370 380 390 400
ATNGIEAGVK IRPTEAELAT ADKAFQQGWE SYFENKPDKP LMHYSVISGF
410 420 430 440 450
FGDHTRLPPG KYMTMFHFLE YPFSRGWLHI SSDDPYAAPD FDPGFMNDDR
460 470 480 490 500
DMWPMVWAFK KSRETARRME CFAGEPTAFH PHYKVDSPAR ALEQSAEDTK
510 520 530 540 550
KVAGPLHLTA NLYHGSWSTP IGEADKHDPN HVTSSHINVY SKDIQYTKED
560 570 580 590 600
DEAIENYIKE HAETTWHCLG TNSMAPREGN KNAPEGGVLD PRLNVHGVKG
610 620 630 640 650
LKVADLSVCP DNVGCNTFST ALTIGEKAAV LVAEDLGYSG SELDMEVPQH
660
KLKTYEQTGA ARY
Length:663
Mass (Da):74,082
Last modified:April 1, 1993 - v1
Checksum:iBC2E2F595B326AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81702 Genomic DNA Translation: AAA34321.1
PIRiJC1117

Similar proteinsi

Entry informationi

Entry nameiALOX_CANBO
AccessioniPrimary (citable) accession number: Q00922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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