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Q00917

- SUS2_ARATH

UniProt

Q00917 - SUS2_ARATH

Protein

Sucrose synthase 2

Gene

SUS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and direct carbon towards starch synthesis in developing seeds.2 Publications

    Catalytic activityi

    NDP-glucose + D-fructose = NDP + sucrose.

    GO - Molecular functioni

    1. sucrose synthase activity Source: TAIR

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. response to hypoxia Source: TAIR
    3. seed maturation Source: TAIR
    4. starch metabolic process Source: TAIR
    5. sucrose metabolic process Source: TAIR

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Stress response

    Protein family/group databases

    CAZyiGT4. Glycosyltransferase Family 4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sucrose synthase 2 (EC:2.4.1.13)
    Short name:
    AtSUS2
    Alternative name(s):
    Sucrose-UDP glucosyltransferase 2
    Gene namesi
    Name:SUS2
    Synonyms:SSA
    Ordered Locus Names:At5g49190
    ORF Names:K21P3.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G49190.

    Subcellular locationi

    Cytoplasm 1 Publication. Plastid membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Associated with plastid membranes during the maturation phase of the seed.

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. membrane Source: TAIR
    3. plant-type cell wall Source: TAIR
    4. plastid membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Plastid

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Diminution of the starch content of developing seeds and increased lipid accumulation early during seed development.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 807807Sucrose synthase 2PRO_0000204645Add
    BLAST

    Proteomic databases

    PaxDbiQ00917.
    PRIDEiQ00917.

    Expressioni

    Tissue specificityi

    Detected in the whole plant but at lower levels. Predominantly expressed in developing siliques. Also detected in the root tip. Detected in the embryo, endosperm and seed coat (at the protein level).4 Publications

    Developmental stagei

    Specifically and highly expressed during seed maturation at 12 days after flowering (at the protein level).2 Publications

    Inductioni

    By anaerobic stress and by glucose. Positively regulated by the NF-Y/HAP transcription factor complex at least composed of NFYB9/LEC1 or NFYB6/L1L and NFYC2/HAP5B in association with DPBF2/BZIP67. Positively regulated by LEC2.3 Publications

    Gene expression databases

    GenevestigatoriQ00917.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G49190.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00917.
    SMRiQ00917. Positions 22-805.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni274 – 752479GT-B glycosyltransferaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000240125.
    InParanoidiQ00917.
    KOiK00695.
    OMAiIAGSKNN.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    IPR000368. Sucrose_synth.
    IPR012820. Sucrose_synthase_pln/cyn.
    [Graphical view]
    PANTHERiPTHR12526:SF27. PTHR12526:SF27. 1 hit.
    PfamiPF00534. Glycos_transf_1. 1 hit.
    PF00862. Sucrose_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02470. sucr_synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q00917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTGRFETMR EWVYDAISAQ RNELLSLFSR YVAQGKGILQ SHQLIDEFLK    50
    TVKVDGTLED LNKSPFMKVL QSAEEAIVLP PFVALAIRPR PGVREYVRVN 100
    VYELSVDHLT VSEYLRFKEE LVNGHANGDY LLELDFEPFN ATLPRPTRSS 150
    SIGNGVQFLN RHLSSIMFRN KESMEPLLEF LRTHKHDGRP MMLNDRIQNI 200
    PILQGALARA EEFLSKLPLA TPYSEFEFEL QGMGFERGWG DTAQKVSEMV 250
    HLLLDILQAP DPSVLETFLG RIPMVFNVVI LSPHGYFGQA NVLGLPDTGG 300
    QVVYILDQVR ALENEMLLRI QKQGLEVIPK ILIVTRLLPE AKGTTCNQRL 350
    ERVSGTEHAH ILRIPFRTEK GILRKWISRF DVWPYLETFA EDASNEISAE 400
    LQGVPNLIIG NYSDGNLVAS LLASKLGVIQ CNIAHALEKT KYPESDIYWR 450
    NHEDKYHFSS QFTADLIAMN NADFIITSTY QEIAGSKNNV GQYESHTAFT 500
    MPGLYRVVHG IDVFDPKFNI VSPGADMTIY FPYSDKERRL TALHESIEEL 550
    LFSAEQNDEH VGLLSDQSKP IIFSMARLDR VKNLTGLVEC YAKNSKLREL 600
    ANLVIVGGYI DENQSRDREE MAEIQKMHSL IEQYDLHGEF RWIAAQMNRA 650
    RNGELYRYIA DTKGVFVQPA FYEAFGLTVV ESMTCALPTF ATCHGGPAEI 700
    IENGVSGFHI DPYHPDQVAA TLVSFFETCN TNPNHWVKIS EGGLKRIYER 750
    YTWKKYSERL LTLAGVYAFW KHVSKLERRE TRRYLEMFYS LKFRDLANSI 800
    PLATDEN 807
    Length:807
    Mass (Da):92,064
    Last modified:January 25, 2012 - v3
    Checksum:i48391FF65C4584DB
    GO

    Sequence cautioni

    The sequence CAA43303.1 differs from that shown. Reason: Sequencing errors.
    The sequence BAB10337.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60987 Genomic DNA. Translation: CAA43303.1. Sequence problems.
    AB016872 Genomic DNA. Translation: BAB10337.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED95780.1.
    PIRiS19125. YUMU.
    RefSeqiNP_199730.1. NM_124296.2.
    UniGeneiAt.8597.

    Genome annotation databases

    EnsemblPlantsiAT5G49190.1; AT5G49190.1; AT5G49190.
    GeneIDi834978.
    KEGGiath:AT5G49190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60987 Genomic DNA. Translation: CAA43303.1 . Sequence problems.
    AB016872 Genomic DNA. Translation: BAB10337.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED95780.1 .
    PIRi S19125. YUMU.
    RefSeqi NP_199730.1. NM_124296.2.
    UniGenei At.8597.

    3D structure databases

    ProteinModelPortali Q00917.
    SMRi Q00917. Positions 22-805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G49190.1-P.

    Protein family/group databases

    CAZyi GT4. Glycosyltransferase Family 4.

    Proteomic databases

    PaxDbi Q00917.
    PRIDEi Q00917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G49190.1 ; AT5G49190.1 ; AT5G49190 .
    GeneIDi 834978.
    KEGGi ath:AT5G49190.

    Organism-specific databases

    TAIRi AT5G49190.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000240125.
    InParanoidi Q00917.
    KOi K00695.
    OMAi IAGSKNN.

    Gene expression databases

    Genevestigatori Q00917.

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    IPR000368. Sucrose_synth.
    IPR012820. Sucrose_synthase_pln/cyn.
    [Graphical view ]
    PANTHERi PTHR12526:SF27. PTHR12526:SF27. 1 hit.
    Pfami PF00534. Glycos_transf_1. 1 hit.
    PF00862. Sucrose_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02470. sucr_synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sucrose synthase of Arabidopsis: genomic cloning and sequence characterization."
      Chopra S., Del-Favero J., Dolferus R., Jacobs M.
      Plant Mol. Biol. 18:131-134(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
      Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
      DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Sugar/osmoticum levels modulate differential abscisic acid-independent expression of two stress-responsive sucrose synthase genes in Arabidopsis."
      Dejardin A., Sokolov L.N., Kleczkowski L.A.
      Biochem. J. 344:503-509(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Structure and expression profile of the sucrose synthase multigene family in Arabidopsis."
      Baud S., Vaultier M.N., Rochat C.
      J. Exp. Bot. 55:397-409(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    6. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    7. "Localization of sucrose synthase in developing seed and siliques of Arabidopsis thaliana reveals diverse roles for SUS during development."
      Fallahi H., Scofield G.N., Badger M.R., Chow W.S., Furbank R.T., Ruan Y.L.
      J. Exp. Bot. 59:3283-3295(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Study of AtSUS2 localization in seeds reveals a strong association with plastids."
      Angeles-Nunez J.G., Kronenberger J., Wuilleme S., Lepiniec L., Rochat C.
      Plant Cell Physiol. 49:1621-1626(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    9. "Arabidopsis NF-YB subunits LEC1 and LEC1-LIKE activate transcription by interacting with seed-specific ABRE-binding factors."
      Yamamoto A., Kagaya Y., Toyoshima R., Kagaya M., Takeda S., Hattori T.
      Plant J. 58:843-856(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    10. "Arabidopsis sucrose synthase 2 and 3 modulate metabolic homeostasis and direct carbon towards starch synthesis in developing seeds."
      Angeles-Nunez J.G., Tiessen A.
      Planta 232:701-718(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    11. "Regulation of AtSUS2 and AtSUS3 by glucose and the transcription factor LEC2 in different tissues and at different stages of Arabidopsis seed development."
      Angeles-Nunez J.G., Tiessen A.
      Plant Mol. Biol. 78:377-392(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY LEC2.

    Entry informationi

    Entry nameiSUS2_ARATH
    AccessioniPrimary (citable) accession number: Q00917
    Secondary accession number(s): F4K4S0, Q9FJ20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3