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Q00917

- SUS2_ARATH

UniProt

Q00917 - SUS2_ARATH

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Protein

Sucrose synthase 2

Gene

SUS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and direct carbon towards starch synthesis in developing seeds.2 Publications

Catalytic activityi

NDP-glucose + D-fructose = NDP + sucrose.

GO - Molecular functioni

  1. sucrose synthase activity Source: TAIR

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. response to hypoxia Source: TAIR
  3. seed maturation Source: TAIR
  4. starch metabolic process Source: TAIR
  5. sucrose metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Stress response

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Sucrose synthase 2 (EC:2.4.1.13)
Short name:
AtSUS2
Alternative name(s):
Sucrose-UDP glucosyltransferase 2
Gene namesi
Name:SUS2
Synonyms:SSA
Ordered Locus Names:At5g49190
ORF Names:K21P3.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G49190.

Subcellular locationi

Cytoplasm 1 Publication. Plastid membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Associated with plastid membranes during the maturation phase of the seed.

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. membrane Source: TAIR
  3. plant-type cell wall Source: TAIR
  4. plastid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Plastid

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Diminution of the starch content of developing seeds and increased lipid accumulation early during seed development.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Sucrose synthase 2PRO_0000204645Add
BLAST

Proteomic databases

PaxDbiQ00917.
PRIDEiQ00917.

Expressioni

Tissue specificityi

Detected in the whole plant but at lower levels. Predominantly expressed in developing siliques. Also detected in the root tip. Detected in the embryo, endosperm and seed coat (at the protein level).4 Publications

Developmental stagei

Specifically and highly expressed during seed maturation at 12 days after flowering (at the protein level).2 Publications

Inductioni

By anaerobic stress and by glucose. Positively regulated by the NF-Y/HAP transcription factor complex at least composed of NFYB9/LEC1 or NFYB6/L1L and NFYC2/HAP5B in association with DPBF2/BZIP67. Positively regulated by LEC2.3 Publications

Gene expression databases

GenevestigatoriQ00917.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G49190.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ00917.
SMRiQ00917. Positions 22-805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 752479GT-B glycosyltransferaseBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000240125.
InParanoidiQ00917.
KOiK00695.
OMAiIAGSKNN.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR000368. Sucrose_synth.
IPR012820. Sucrose_synthase_pln/cyn.
[Graphical view]
PANTHERiPTHR12526:SF27. PTHR12526:SF27. 1 hit.
PfamiPF00534. Glycos_transf_1. 1 hit.
PF00862. Sucrose_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02470. sucr_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTGRFETMR EWVYDAISAQ RNELLSLFSR YVAQGKGILQ SHQLIDEFLK
60 70 80 90 100
TVKVDGTLED LNKSPFMKVL QSAEEAIVLP PFVALAIRPR PGVREYVRVN
110 120 130 140 150
VYELSVDHLT VSEYLRFKEE LVNGHANGDY LLELDFEPFN ATLPRPTRSS
160 170 180 190 200
SIGNGVQFLN RHLSSIMFRN KESMEPLLEF LRTHKHDGRP MMLNDRIQNI
210 220 230 240 250
PILQGALARA EEFLSKLPLA TPYSEFEFEL QGMGFERGWG DTAQKVSEMV
260 270 280 290 300
HLLLDILQAP DPSVLETFLG RIPMVFNVVI LSPHGYFGQA NVLGLPDTGG
310 320 330 340 350
QVVYILDQVR ALENEMLLRI QKQGLEVIPK ILIVTRLLPE AKGTTCNQRL
360 370 380 390 400
ERVSGTEHAH ILRIPFRTEK GILRKWISRF DVWPYLETFA EDASNEISAE
410 420 430 440 450
LQGVPNLIIG NYSDGNLVAS LLASKLGVIQ CNIAHALEKT KYPESDIYWR
460 470 480 490 500
NHEDKYHFSS QFTADLIAMN NADFIITSTY QEIAGSKNNV GQYESHTAFT
510 520 530 540 550
MPGLYRVVHG IDVFDPKFNI VSPGADMTIY FPYSDKERRL TALHESIEEL
560 570 580 590 600
LFSAEQNDEH VGLLSDQSKP IIFSMARLDR VKNLTGLVEC YAKNSKLREL
610 620 630 640 650
ANLVIVGGYI DENQSRDREE MAEIQKMHSL IEQYDLHGEF RWIAAQMNRA
660 670 680 690 700
RNGELYRYIA DTKGVFVQPA FYEAFGLTVV ESMTCALPTF ATCHGGPAEI
710 720 730 740 750
IENGVSGFHI DPYHPDQVAA TLVSFFETCN TNPNHWVKIS EGGLKRIYER
760 770 780 790 800
YTWKKYSERL LTLAGVYAFW KHVSKLERRE TRRYLEMFYS LKFRDLANSI

PLATDEN
Length:807
Mass (Da):92,064
Last modified:January 25, 2012 - v3
Checksum:i48391FF65C4584DB
GO

Sequence cautioni

The sequence BAB10337.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA43303.1 differs from that shown. Reason: Sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60987 Genomic DNA. Translation: CAA43303.1. Sequence problems.
AB016872 Genomic DNA. Translation: BAB10337.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED95780.1.
PIRiS19125. YUMU.
RefSeqiNP_199730.1. NM_124296.2.
UniGeneiAt.8597.

Genome annotation databases

EnsemblPlantsiAT5G49190.1; AT5G49190.1; AT5G49190.
GeneIDi834978.
KEGGiath:AT5G49190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60987 Genomic DNA. Translation: CAA43303.1 . Sequence problems.
AB016872 Genomic DNA. Translation: BAB10337.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED95780.1 .
PIRi S19125. YUMU.
RefSeqi NP_199730.1. NM_124296.2.
UniGenei At.8597.

3D structure databases

ProteinModelPortali Q00917.
SMRi Q00917. Positions 22-805.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G49190.1-P.

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

Proteomic databases

PaxDbi Q00917.
PRIDEi Q00917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G49190.1 ; AT5G49190.1 ; AT5G49190 .
GeneIDi 834978.
KEGGi ath:AT5G49190.

Organism-specific databases

TAIRi AT5G49190.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000240125.
InParanoidi Q00917.
KOi K00695.
OMAi IAGSKNN.

Gene expression databases

Genevestigatori Q00917.

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
IPR000368. Sucrose_synth.
IPR012820. Sucrose_synthase_pln/cyn.
[Graphical view ]
PANTHERi PTHR12526:SF27. PTHR12526:SF27. 1 hit.
Pfami PF00534. Glycos_transf_1. 1 hit.
PF00862. Sucrose_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02470. sucr_synth. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sucrose synthase of Arabidopsis: genomic cloning and sequence characterization."
    Chopra S., Del-Favero J., Dolferus R., Jacobs M.
    Plant Mol. Biol. 18:131-134(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
    Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Sugar/osmoticum levels modulate differential abscisic acid-independent expression of two stress-responsive sucrose synthase genes in Arabidopsis."
    Dejardin A., Sokolov L.N., Kleczkowski L.A.
    Biochem. J. 344:503-509(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Structure and expression profile of the sucrose synthase multigene family in Arabidopsis."
    Baud S., Vaultier M.N., Rochat C.
    J. Exp. Bot. 55:397-409(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  6. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Localization of sucrose synthase in developing seed and siliques of Arabidopsis thaliana reveals diverse roles for SUS during development."
    Fallahi H., Scofield G.N., Badger M.R., Chow W.S., Furbank R.T., Ruan Y.L.
    J. Exp. Bot. 59:3283-3295(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Study of AtSUS2 localization in seeds reveals a strong association with plastids."
    Angeles-Nunez J.G., Kronenberger J., Wuilleme S., Lepiniec L., Rochat C.
    Plant Cell Physiol. 49:1621-1626(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Arabidopsis NF-YB subunits LEC1 and LEC1-LIKE activate transcription by interacting with seed-specific ABRE-binding factors."
    Yamamoto A., Kagaya Y., Toyoshima R., Kagaya M., Takeda S., Hattori T.
    Plant J. 58:843-856(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "Arabidopsis sucrose synthase 2 and 3 modulate metabolic homeostasis and direct carbon towards starch synthesis in developing seeds."
    Angeles-Nunez J.G., Tiessen A.
    Planta 232:701-718(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "Regulation of AtSUS2 and AtSUS3 by glucose and the transcription factor LEC2 in different tissues and at different stages of Arabidopsis seed development."
    Angeles-Nunez J.G., Tiessen A.
    Plant Mol. Biol. 78:377-392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY LEC2.

Entry informationi

Entry nameiSUS2_ARATH
AccessioniPrimary (citable) accession number: Q00917
Secondary accession number(s): F4K4S0, Q9FJ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 25, 2012
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3