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Protein

U1 small nuclear ribonucleoprotein 70 kDa homolog

Gene

SNP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nuclear mRNA splicing.

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mRNA binding Source: SGD
  • U1 snRNA binding Source: SGD

GO - Biological processi

  • mRNA splicing, via spliceosome Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31329-MONOMER
ReactomeiR-SCE-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein 70 kDa homolog
Short name:
U1 70K
Short name:
U1 snRNP 70 kDa homolog
Short name:
U1-70K
Alternative name(s):
U1 small nuclear ribonucleoprotein SNP1
Short name:
U1 snRNP protein SNP1
Gene namesi
Name:SNP1
Ordered Locus Names:YIL061C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YIL061C
SGDiS000001323 SNP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18 – 98Missing : Severely temperature-sensitive. Defective in pre-mRNA splicing. 1 PublicationAdd BLAST81
Mutagenesisi18 – 93Missing : Fails to complement the growth and splicing defective, temperature-sensitive phenotype of the null allele at 30 degrees Celsius. No association with U1 snRNP. 1 PublicationAdd BLAST76
Mutagenesisi92 – 248Missing : Associates with U1 snRNP. 2 PublicationsAdd BLAST157
Mutagenesisi148K → L: No splicing defects. Associates with U1 snRNP; when associated with T-150 and L-152. 2 Publications1
Mutagenesisi150Y → T: No splicing defects. Associates with U1 snRNP; when associated with L-148 and L-152. 2 Publications1
Mutagenesisi152F → L: No splicing defects. Associates with U1 snRNP; when associated with L-148 and T-150. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818861 – 300U1 small nuclear ribonucleoprotein 70 kDa homologAdd BLAST300

Proteomic databases

MaxQBiQ00916
PaxDbiQ00916
PRIDEiQ00916

Interactioni

Subunit structurei

Component of the spliceosome, where it is associated with snRNP U1. Binds stem loop I of U1 snRNA. Interacts with mRNA.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34931, 84 interactors
DIPiDIP-663N
IntActiQ00916, 45 interactors
MINTiQ00916
STRINGi4932.YIL061C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UZ5electron microscopy3.56A1-300[»]
ProteinModelPortaliQ00916
SMRiQ00916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 198RRMPROSITE-ProRule annotationAdd BLAST92

Phylogenomic databases

GeneTreeiENSGT00530000063750
HOGENOMiHOG000000970
InParanoidiQ00916
KOiK11093
OMAiKYPPNIQ
OrthoDBiEOG092C3SCB

Family and domain databases

CDDicd12236 RRM_snRNP70, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034143 snRNP70_RRM
IPR022023 U1snRNP70_N
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF12220 U1snRNP70_N, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q00916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYNLSKYPD DVSRLFKPRP PLSYKRPTDY PYAKRQTNPN ITGVANLLST
60 70 80 90 100
SLKHYMEEFP EGSPNNHLQR YEDIKLSKIK NAQLLDRRLQ NWNPNVDPHI
110 120 130 140 150
KDTDPYRTIF IGRLPYDLDE IELQKYFVKF GEIEKIRIVK DKITQKSKGY
160 170 180 190 200
AFIVFKDPIS SKMAFKEIGV HRGIQIKDRI CIVDIERGRT VKYFKPRRLG
210 220 230 240 250
GGLGGRGYSN RDSRLPGRFA SASTSNPAER NYAPRLPRRE TSSSAYSADR
260 270 280 290 300
YGSSTLDARY RGNRPLLSAA TPTAAVTSVY KSRNSRTRES QPAPKEAPDY
Length:300
Mass (Da):34,447
Last modified:April 1, 1993 - v1
Checksum:i7D9E47BE66FE1EB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38060 Genomic DNA Translation: CAA86162.1
X59986 Genomic DNA Translation: CAA42602.1
AY558085 Genomic DNA Translation: AAS56411.1
BK006942 Genomic DNA Translation: DAA08489.1
PIRiS16815
RefSeqiNP_012203.1, NM_001179411.1

Genome annotation databases

EnsemblFungiiYIL061C; YIL061C; YIL061C
GeneIDi854749
KEGGisce:YIL061C

Similar proteinsi

Entry informationi

Entry nameiRU17_YEAST
AccessioniPrimary (citable) accession number: Q00916
Secondary accession number(s): D6VVM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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