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Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Retinoic acidBy similarity1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

  • regulation of granulocyte differentiation Source: MGI
  • response to vitamin A Source: MGI
  • retinoic acid biosynthetic process Source: Ensembl
  • retinoic acid metabolic process Source: MGI
  • retinol metabolic process Source: MGI
  • vitamin A metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Short name:
mCRBPI
Gene namesi
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97876. Rbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673932 – 135Retinol-binding protein 1Add BLAST134

Proteomic databases

PaxDbiQ00915.
PeptideAtlasiQ00915.
PRIDEiQ00915.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

PTM databases

iPTMnetiQ00915.
PhosphoSitePlusiQ00915.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046402.
CleanExiMM_RBP1.
ExpressionAtlasiQ00915. baseline and differential.
GenevisibleiQ00915. MM.

Interactioni

Protein-protein interaction databases

BioGridi202827. 1 interactor.
IntActiQ00915. 1 interactor.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

Structurei

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG091G0QSV.
PhylomeDBiQ00915.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031264. CRBP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF56. PTHR11955:SF56. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM
60 70 80 90 100
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG
110 120 130
EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH
Length:135
Mass (Da):15,846
Last modified:January 23, 2007 - v2
Checksum:i6816E73284BD28B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202827. 1 interactor.
IntActiQ00915. 1 interactor.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

PTM databases

iPTMnetiQ00915.
PhosphoSitePlusiQ00915.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

Proteomic databases

PaxDbiQ00915.
PeptideAtlasiQ00915.
PRIDEiQ00915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Organism-specific databases

CTDi5947.
MGIiMGI:97876. Rbp1.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG091G0QSV.
PhylomeDBiQ00915.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiQ00915.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046402.
CleanExiMM_RBP1.
ExpressionAtlasiQ00915. baseline and differential.
GenevisibleiQ00915. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031264. CRBP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF56. PTHR11955:SF56. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRET1_MOUSE
AccessioniPrimary (citable) accession number: Q00915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.