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Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41RetinolBy similarity1
Binding sitei63RetinolBy similarity1
Binding sitei109RetinolBy similarity1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

  • regulation of granulocyte differentiation Source: MGI
  • response to vitamin A Source: MGI
  • retinoic acid biosynthetic process Source: Ensembl
  • retinoic acid metabolic process Source: MGI
  • retinol metabolic process Source: MGI
  • vitamin A metabolic process Source: InterPro

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Short name:
mCRBPI
Gene namesi
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97876. Rbp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

Pathology & Biotechi

Disruption phenotypei

No visible phenotype when mice are kept on a vitamin A-enriched diet. Still, mutant mice have impaired vitamin A homeostasis. Four week old mice have reduced levels of retinoids in the liver, due to more rapid vitamin A turnover. When mice are kept on a vitamin A-deficient diet after weaning, they gain weight normally during the first 5 weeks, and then stop gaining weight. Their hepatic retinyl palmitate stores begin to decrease from the moment they are fed a vitamin A-deficient diet and become undetectable after 14 weeks, After this, serum retinol levels decrease rapidly and approach undetectable levels after 24 weeks on a vitamin A-deficient diet. After 23 weeks on a vitamin A-deficient diet, electroretinograms show dramatically decreased amplitudes of the a and b waves in response to light. At the same time, their eyes show impaired contact between the retinal pigment epithelium and the outer segment photoreceptors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673931 – 135Retinol-binding protein 1Add BLAST135

Proteomic databases

PaxDbiQ00915.
PeptideAtlasiQ00915.
PRIDEiQ00915.

2D gel databases

REPRODUCTION-2DPAGEiQ00915.

PTM databases

iPTMnetiQ00915.
PhosphoSitePlusiQ00915.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046402.
CleanExiMM_RBP1.
ExpressionAtlasiQ00915. baseline and differential.
GenevisibleiQ00915. MM.

Interactioni

Subunit structurei

Interacts (only as retinol-free apoprotein) with STRA6.By similarity

Protein-protein interaction databases

BioGridi202827. 1 interactor.
IntActiQ00915. 1 interactor.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

Structurei

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 32Important for interaction with STRA6By similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG091G0QSV.
PhylomeDBiQ00915.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR031264. CRBP1.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF56. PTHR11955:SF56. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM
60 70 80 90 100
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG
110 120 130
EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH
Length:135
Mass (Da):15,846
Last modified:January 23, 2007 - v2
Checksum:i6816E73284BD28B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRET1_MOUSE
AccessioniPrimary (citable) accession number: Q00915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families