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Q00915

- RET1_MOUSE

UniProt

Q00915 - RET1_MOUSE

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Protein
Retinol-binding protein 1
Gene
Rbp1, Crbpi, Rbp-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Retinoic acid By similarity

GO - Molecular functioni

  1. retinal binding Source: UniProtKB-KW
  2. retinoid binding Source: MGI
  3. retinol binding Source: UniProtKB-KW
  4. transporter activity Source: InterPro

GO - Biological processi

  1. regulation of granulocyte differentiation Source: MGI
  2. response to vitamin A Source: MGI
  3. retinoic acid biosynthetic process Source: Ensembl
  4. retinoic acid metabolic process Source: MGI
  5. retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196615. Retinoid cycle disease events.
REACT_198569. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Short name:
mCRBPI
Gene namesi
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:97876. Rbp1.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 135134Retinol-binding protein 1
PRO_0000067393Add
BLAST

Proteomic databases

MaxQBiQ00915.
PaxDbiQ00915.
PRIDEiQ00915.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

Expressioni

Gene expression databases

ArrayExpressiQ00915.
BgeeiQ00915.
CleanExiMM_RBP1.
GenevestigatoriQ00915.

Interactioni

Protein-protein interaction databases

BioGridi202827. 1 interaction.
IntActiQ00915. 1 interaction.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

Structurei

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915. Positions 2-135.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG306453.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ00915.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00915-1 [UniParc]FASTAAdd to Basket

« Hide

MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM    50
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG 100
EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH 135
Length:135
Mass (Da):15,846
Last modified:January 23, 2007 - v2
Checksum:i6816E73284BD28B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60367 mRNA. Translation: CAA42919.1 .
BC018254 mRNA. Translation: AAH18254.1 .
CCDSi CCDS23424.1.
PIRi S16355.
RefSeqi NP_035384.1. NM_011254.5.
UniGenei Mm.279741.

3D structure databases

ProteinModelPortali Q00915.
SMRi Q00915. Positions 2-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202827. 1 interaction.
IntActi Q00915. 1 interaction.
MINTi MINT-4132243.
STRINGi 10090.ENSMUSP00000059749.

2D gel databases

REPRODUCTION-2DPAGE Q00915.

Proteomic databases

MaxQBi Q00915.
PaxDbi Q00915.
PRIDEi Q00915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052068 ; ENSMUSP00000059749 ; ENSMUSG00000046402 .
GeneIDi 19659.
KEGGi mmu:19659.
UCSCi uc009rdj.1. mouse.

Organism-specific databases

CTDi 5947.
MGIi MGI:97876. Rbp1.

Phylogenomic databases

eggNOGi NOG306453.
HOGENOMi HOG000004831.
HOVERGENi HBG005633.
InParanoidi Q00915.
OMAi GDEMHLE.
OrthoDBi EOG7NW6BZ.
PhylomeDBi Q00915.
TreeFami TF316894.

Enzyme and pathway databases

Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196615. Retinoid cycle disease events.
REACT_198569. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 296942.
PROi Q00915.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00915.
Bgeei Q00915.
CleanExi MM_RBP1.
Genevestigatori Q00915.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter."
    Smith W.C., Nakshatri H., Leroy P., Rees J., Chambon P.
    EMBO J. 10:2223-2230(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRET1_MOUSE
AccessioniPrimary (citable) accession number: Q00915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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