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Q00915

- RET1_MOUSE

UniProt

Q00915 - RET1_MOUSE

Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Intracellular transport of retinol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091Retinoic acidBy similarity

    GO - Molecular functioni

    1. retinal binding Source: UniProtKB-KW
    2. retinoid binding Source: MGI
    3. retinol binding Source: UniProtKB-KW
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. regulation of granulocyte differentiation Source: MGI
    2. response to vitamin A Source: MGI
    3. retinoic acid biosynthetic process Source: Ensembl
    4. retinoic acid metabolic process Source: MGI
    5. retinol metabolic process Source: MGI

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Retinol-binding, Vitamin A

    Enzyme and pathway databases

    ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
    REACT_196615. Retinoid cycle disease events.
    REACT_198569. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinol-binding protein 1
    Alternative name(s):
    Cellular retinol-binding protein
    Short name:
    CRBP
    Cellular retinol-binding protein I
    Short name:
    CRBP-I
    Short name:
    mCRBPI
    Gene namesi
    Name:Rbp1
    Synonyms:Crbpi, Rbp-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:97876. Rbp1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 135134Retinol-binding protein 1PRO_0000067393Add
    BLAST

    Proteomic databases

    MaxQBiQ00915.
    PaxDbiQ00915.
    PRIDEiQ00915.

    2D gel databases

    REPRODUCTION-2DPAGEQ00915.

    Expressioni

    Gene expression databases

    ArrayExpressiQ00915.
    BgeeiQ00915.
    CleanExiMM_RBP1.
    GenevestigatoriQ00915.

    Interactioni

    Protein-protein interaction databases

    BioGridi202827. 1 interaction.
    IntActiQ00915. 1 interaction.
    MINTiMINT-4132243.
    STRINGi10090.ENSMUSP00000059749.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00915.
    SMRiQ00915. Positions 2-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG306453.
    HOGENOMiHOG000004831.
    HOVERGENiHBG005633.
    InParanoidiQ00915.
    OMAiGDEMHLE.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiQ00915.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM    50
    IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG 100
    EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH 135
    Length:135
    Mass (Da):15,846
    Last modified:January 23, 2007 - v2
    Checksum:i6816E73284BD28B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60367 mRNA. Translation: CAA42919.1.
    BC018254 mRNA. Translation: AAH18254.1.
    CCDSiCCDS23424.1.
    PIRiS16355.
    RefSeqiNP_035384.1. NM_011254.5.
    UniGeneiMm.279741.

    Genome annotation databases

    EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
    GeneIDi19659.
    KEGGimmu:19659.
    UCSCiuc009rdj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60367 mRNA. Translation: CAA42919.1 .
    BC018254 mRNA. Translation: AAH18254.1 .
    CCDSi CCDS23424.1.
    PIRi S16355.
    RefSeqi NP_035384.1. NM_011254.5.
    UniGenei Mm.279741.

    3D structure databases

    ProteinModelPortali Q00915.
    SMRi Q00915. Positions 2-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202827. 1 interaction.
    IntActi Q00915. 1 interaction.
    MINTi MINT-4132243.
    STRINGi 10090.ENSMUSP00000059749.

    2D gel databases

    REPRODUCTION-2DPAGE Q00915.

    Proteomic databases

    MaxQBi Q00915.
    PaxDbi Q00915.
    PRIDEi Q00915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052068 ; ENSMUSP00000059749 ; ENSMUSG00000046402 .
    GeneIDi 19659.
    KEGGi mmu:19659.
    UCSCi uc009rdj.1. mouse.

    Organism-specific databases

    CTDi 5947.
    MGIi MGI:97876. Rbp1.

    Phylogenomic databases

    eggNOGi NOG306453.
    HOGENOMi HOG000004831.
    HOVERGENi HBG005633.
    InParanoidi Q00915.
    OMAi GDEMHLE.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi Q00915.
    TreeFami TF316894.

    Enzyme and pathway databases

    Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).
    REACT_196615. Retinoid cycle disease events.
    REACT_198569. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 296942.
    PROi Q00915.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00915.
    Bgeei Q00915.
    CleanExi MM_RBP1.
    Genevestigatori Q00915.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter."
      Smith W.C., Nakshatri H., Leroy P., Rees J., Chambon P.
      EMBO J. 10:2223-2230(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiRET1_MOUSE
    AccessioniPrimary (citable) accession number: Q00915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3