Q00915 (RET1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol-binding protein 1

Alternative name(s):
Cellular retinol-binding protein
Short name=CRBP
Cellular retinol-binding protein I
Short name=CRBP-I
Short name=mCRBPI

Gene names

Name:	Rbp1
Synonyms:	Crbpi, Rbp-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Intracellular transport of retinol.
Subcellular location	Cytoplasm.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Retinol-binding Vitamin A
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of granulocyte differentiation Inferred from mutant phenotype PubMed 11222375. Source: MGI response to vitamin A Inferred from mutant phenotype PubMed 11222375. Source: MGI retinoic acid biosynthetic process Inferred from electronic annotation. Source: Compara retinoic acid metabolic process Inferred from mutant phenotype PubMed 15193143. Source: MGI retinol metabolic process Inferred from mutant phenotype PubMed 15193143PubMed 15765518. Source: MGI
Cellular_component	cell body Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinoid binding Traceable author statement PubMed 11022035. Source: MGI retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 135	134	Retinol-binding protein 1		PRO_0000067393
Sites
	Binding site	109	1	Retinoic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q00915 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 6816E73284BD28B7	FASTA	135	15,846
	10 20 30 40 50 60 MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN 70 80 90 100 110 120 YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM 130 RAEGVICKQV FKKVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter." Smith W.C., Nakshatri H., Leroy P., Rees J., Chambon P. EMBO J. 10:2223-2230(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X60367 mRNA. Translation: CAA42919.1. BC018254 mRNA. Translation: AAH18254.1.
IPI	IPI00225337.
PIR	S16355.
RefSeq	NP_035384.1. NM_011254.5.
UniGene	Mm.279741.
3D structure databases
ProteinModelPortal	Q00915.
SMR	Q00915. Positions 2-135.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000059749.
2D gel databases
REPRODUCTION-2DPAGE	Q00915.
Proteomic databases
PaxDb	Q00915.
PRIDE	Q00915.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneID	19659.
KEGG	mmu:19659.
Organism-specific databases
CTD	5947.
MGI	MGI:97876. Rbp1.
Phylogenomic databases
eggNOG	NOG306453.
HOGENOM	HOG000004831.
HOVERGEN	HBG005633.
InParanoid	Q00915.
OMA	HLEMRVE.
OrthoDB	EOG4G4GRR.
Gene expression databases
ArrayExpress	Q00915.
Bgee	Q00915.
CleanEx	MM_RBP1.
Genevestigator	Q00915.
GermOnline	ENSMUSG00000046402. Mus musculus.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296942.
SOURCE	Search...

Entry information

Entry name

RET1_MOUSE

Accession

Primary (citable) accession number: Q00915

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program