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Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Retinoic acidBy similarity

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

  • regulation of granulocyte differentiation Source: MGI
  • response to vitamin A Source: MGI
  • retinoic acid biosynthetic process Source: Ensembl
  • retinoic acid metabolic process Source: MGI
  • retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiREACT_280597. The canonical retinoid cycle in rods (twilight vision).
REACT_295031. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Short name:
mCRBPI
Gene namesi
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97876. Rbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 135134Retinol-binding protein 1PRO_0000067393Add
BLAST

Proteomic databases

MaxQBiQ00915.
PaxDbiQ00915.
PRIDEiQ00915.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

Expressioni

Gene expression databases

BgeeiQ00915.
CleanExiMM_RBP1.
ExpressionAtlasiQ00915. baseline and differential.
GenevisibleiQ00915. MM.

Interactioni

Protein-protein interaction databases

BioGridi202827. 1 interaction.
IntActiQ00915. 1 interaction.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

Structurei

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915. Positions 2-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG306453.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ00915.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031264. CRBP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF56. PTHR11955:SF56. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM
60 70 80 90 100
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG
110 120 130
EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH
Length:135
Mass (Da):15,846
Last modified:January 23, 2007 - v2
Checksum:i6816E73284BD28B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSiCCDS23424.1.
PIRiS16355.
RefSeqiNP_035384.1. NM_011254.5.
UniGeneiMm.279741.

3D structure databases

ProteinModelPortaliQ00915.
SMRiQ00915. Positions 2-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202827. 1 interaction.
IntActiQ00915. 1 interaction.
MINTiMINT-4132243.
STRINGi10090.ENSMUSP00000059749.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

Proteomic databases

MaxQBiQ00915.
PaxDbiQ00915.
PRIDEiQ00915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneIDi19659.
KEGGimmu:19659.
UCSCiuc009rdj.1. mouse.

Organism-specific databases

CTDi5947.
MGIiMGI:97876. Rbp1.

Phylogenomic databases

eggNOGiNOG306453.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiQ00915.
OMAiGDEMHLE.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ00915.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiREACT_280597. The canonical retinoid cycle in rods (twilight vision).
REACT_295031. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi296942.
PROiQ00915.
SOURCEiSearch...

Gene expression databases

BgeeiQ00915.
CleanExiMM_RBP1.
ExpressionAtlasiQ00915. baseline and differential.
GenevisibleiQ00915. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031264. CRBP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF56. PTHR11955:SF56. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter."
    Smith W.C., Nakshatri H., Leroy P., Rees J., Chambon P.
    EMBO J. 10:2223-2230(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRET1_MOUSE
AccessioniPrimary (citable) accession number: Q00915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.