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Q00915 (RET1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name=CRBP
Cellular retinol-binding protein I
Short name=CRBP-I
Short name=mCRBPI
Gene names
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Intracellular transport of retinol.

Subcellular location

Cytoplasm.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 135134Retinol-binding protein 1
PRO_0000067393

Sites

Binding site1091Retinoic acid By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00915 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6816E73284BD28B7

FASTA13515,846
        10         20         30         40         50         60 
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN 

        70         80         90        100        110        120 
YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM 

       130 
RAEGVICKQV FKKVH 

« Hide

References

« Hide 'large scale' references
[1]"A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter."
Smith W.C., Nakshatri H., Leroy P., Rees J., Chambon P.
EMBO J. 10:2223-2230(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60367 mRNA. Translation: CAA42919.1.
BC018254 mRNA. Translation: AAH18254.1.
CCDSCCDS23424.1.
PIRS16355.
RefSeqNP_035384.1. NM_011254.5.
UniGeneMm.279741.

3D structure databases

ProteinModelPortalQ00915.
SMRQ00915. Positions 2-135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202827. 1 interaction.
IntActQ00915. 1 interaction.
MINTMINT-4132243.
STRING10090.ENSMUSP00000059749.

2D gel databases

REPRODUCTION-2DPAGEQ00915.

Proteomic databases

MaxQBQ00915.
PaxDbQ00915.
PRIDEQ00915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402.
GeneID19659.
KEGGmmu:19659.
UCSCuc009rdj.1. mouse.

Organism-specific databases

CTD5947.
MGIMGI:97876. Rbp1.

Phylogenomic databases

eggNOGNOG306453.
HOGENOMHOG000004831.
HOVERGENHBG005633.
InParanoidQ00915.
OMAGDEMHLE.
OrthoDBEOG7NW6BZ.
PhylomeDBQ00915.
TreeFamTF316894.

Gene expression databases

ArrayExpressQ00915.
BgeeQ00915.
CleanExMM_RBP1.
GenevestigatorQ00915.

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
SUPFAMSSF50814. SSF50814. 1 hit.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296942.
PROQ00915.
SOURCESearch...

Entry information

Entry nameRET1_MOUSE
AccessionPrimary (citable) accession number: Q00915
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot