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Protein

Early growth response protein 4

Gene

Egr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to growth factor stimulus Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Alternative name(s):
Early response protein NGFI-C
Nerve growth factor-induced protein C
Short name:
NGFI-C
Gene namesi
Name:Egr4
Synonyms:Egr-4, Ngfic
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2546. Egr4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Early growth response protein 4PRO_0000047130Add
BLAST

Proteomic databases

PaxDbiQ00911.
PRIDEiQ00911.

Expressioni

Inductioni

By nerve growth factor.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021097.

Structurei

3D structure databases

ProteinModelPortaliQ00911.
SMRiQ00911. Positions 370-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ00911.
KOiK12498.
PhylomeDBiQ00911.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLSDFSGP DALLSKPTEG CAHTSPELPR LPARDAPSAA AYPGGDFLSW
60 70 80 90 100
ALSTCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF
110 120 130 140 150
NLMSGILGLA PFPSPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP
160 170 180 190 200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP
210 220 230 240 250
YAPWELLSAG APGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG
260 270 280 290 300
PASRLYPPGA YDAFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
310 320 330 340 350
VPQAQLSPLG LRGAATADFS KALVADLPGG SGVAAPSSPA TSFPAAKARR
360 370 380 390 400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RTFARSDELN RHLRIHTGHK
410 420 430 440 450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK
460 470
VHLKQKARAE ERLKGLGFYS LGLSFAAL
Length:478
Mass (Da):49,668
Last modified:October 1, 1993 - v1
Checksum:iF85C48E7B37040F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65008 mRNA. Translation: AAA41698.1.
M92433 Genomic DNA. Translation: AAA41699.1.
PIRiA45285.
RefSeqiNP_062010.1. NM_019137.1.
UniGeneiRn.31998.

Genome annotation databases

GeneIDi25129.
KEGGirno:25129.
UCSCiRGD:2546. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65008 mRNA. Translation: AAA41698.1.
M92433 Genomic DNA. Translation: AAA41699.1.
PIRiA45285.
RefSeqiNP_062010.1. NM_019137.1.
UniGeneiRn.31998.

3D structure databases

ProteinModelPortaliQ00911.
SMRiQ00911. Positions 370-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021097.

Proteomic databases

PaxDbiQ00911.
PRIDEiQ00911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25129.
KEGGirno:25129.
UCSCiRGD:2546. rat.

Organism-specific databases

CTDi1961.
RGDi2546. Egr4.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ00911.
KOiK12498.
PhylomeDBiQ00911.

Miscellaneous databases

PROiQ00911.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family."
    Crosby S.D., Puetz J.J., Simburger K.S., Fahrner T.J., Milbrandt J.
    Mol. Cell. Biol. 11:3835-3841(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
  2. "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C."
    Crosby S.D., Veile R.A., Donis-Keller H., Baraban J.M., Bhat R.V., Simburger K.S., Milbrandt J.
    Proc. Natl. Acad. Sci. U.S.A. 89:4739-4743(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiEGR4_RAT
AccessioniPrimary (citable) accession number: Q00911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.