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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Caution

Was originally thought to be a nuclear DNA-binding protein.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.60.1.2 the organo anion transporter (oat) family

Chemistry databases

SwissLipidsiSLP:000001648

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Matrin F/G 1
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Matr1, Slc21a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3051 Slco2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073680
GuidetoPHARMACOLOGYi1223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910601 – 644Solute carrier organic anion transporter family member 2A1Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ00910
PeptideAtlasiQ00910
PRIDEiQ00910

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012162

Chemistry databases

BindingDBiQ00910

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 496Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiQ00910

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q00910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLKPGAR QGSGTSSVPD RRCPRSVFSN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NATLIIFISY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYTST TDGNRSSFQT DLCQKHFGAL
160 170 180 190 200
PPSKCHSTVP DTHKETSSLW GLMVVAQLLA GIGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV TAEETMQTEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYGATA AYANFLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIITISMIL CVPLFFMGCS TSAVAEVYPP STSSSIHPQQ PPACRRDCSC
460 470 480 490 500
PDSFFHPVCG DNGVEYVSPC HAGCSSTNTS SEASKEPIYL NCSCVSGGSA
510 520 530 540 550
SAKTGSCPTS CAQLLLPSIF LISFAALIAC ISHNPLYMMV LRVVNQDEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPAPS LYGLLIDSSC VRWNYLCSGR RGACAYYDND
610 620 630 640
ALRNRYLGLQ MVYKALGTLL LFFISWRMKK NREYSLQENT SGLI
Length:644
Mass (Da):70,387
Last modified:November 16, 2011 - v3
Checksum:i143841277CC95F85
GO

Sequence cautioni

The sequence AAA41574 differs from that shown. Reason: Frameshift at positions 502 and 513.Curated
The sequence AAA41574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64862 mRNA Translation: AAA41574.1 Sequence problems.
PIRiA41120
UniGeneiRn.9671

Similar proteinsi

Entry informationi

Entry nameiSO2A1_RAT
AccessioniPrimary (citable) accession number: Q00910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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