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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.60.1.2. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Matrin F/G 1
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Matr1, Slc21a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3051. Slco2a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073680.
GuidetoPHARMACOLOGYi1223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910601 – 644Solute carrier organic anion transporter family member 2A1Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Glycosylationi639N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ00910.
PeptideAtlasiQ00910.
PRIDEiQ00910.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012162.

Chemistry databases

BindingDBiQ00910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 496Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ00910.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLKPGAR QGSGTSSVPD RRCPRSVFSN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NATLIIFISY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYTST TDGNRSSFQT DLCQKHFGAL
160 170 180 190 200
PPSKCHSTVP DTHKETSSLW GLMVVAQLLA GIGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV TAEETMQTEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYGATA AYANFLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIITISMIL CVPLFFMGCS TSAVAEVYPP STSSSIHPQQ PPACRRDCSC
460 470 480 490 500
PDSFFHPVCG DNGVEYVSPC HAGCSSTNTS SEASKEPIYL NCSCVSGGSA
510 520 530 540 550
SAKTGSCPTS CAQLLLPSIF LISFAALIAC ISHNPLYMMV LRVVNQDEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPAPS LYGLLIDSSC VRWNYLCSGR RGACAYYDND
610 620 630 640
ALRNRYLGLQ MVYKALGTLL LFFISWRMKK NREYSLQENT SGLI
Length:644
Mass (Da):70,387
Last modified:November 16, 2011 - v3
Checksum:i143841277CC95F85
GO

Sequence cautioni

The sequence AAA41574 differs from that shown. Reason: Frameshift at positions 502 and 513.Curated
The sequence AAA41574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64862 mRNA. Translation: AAA41574.1. Sequence problems.
PIRiA41120.
UniGeneiRn.9671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64862 mRNA. Translation: AAA41574.1. Sequence problems.
PIRiA41120.
UniGeneiRn.9671.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012162.

Chemistry databases

BindingDBiQ00910.
ChEMBLiCHEMBL2073680.
GuidetoPHARMACOLOGYi1223.

Protein family/group databases

TCDBi2.A.60.1.2. the organo anion transporter (oat) family.

Proteomic databases

PaxDbiQ00910.
PeptideAtlasiQ00910.
PRIDEiQ00910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3051. Slco2a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ00910.

Miscellaneous databases

PROiQ00910.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2A1_RAT
AccessioniPrimary (citable) accession number: Q00910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 16, 2011
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a nuclear DNA-binding protein.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.