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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.60.1.2. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Matrin F/G 1
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Matr1, Slc21a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3051. Slco2a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Transmembranei551 – 57121HelicalSequence analysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073680.
GuidetoPHARMACOLOGYi1223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Solute carrier organic anion transporter family member 2A1PRO_0000191060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ00910.
PRIDEiQ00910.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012162.

Chemistry

BindingDBiQ00910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 49659Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ00910.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLKPGAR QGSGTSSVPD RRCPRSVFSN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NATLIIFISY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYTST TDGNRSSFQT DLCQKHFGAL
160 170 180 190 200
PPSKCHSTVP DTHKETSSLW GLMVVAQLLA GIGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV TAEETMQTEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYGATA AYANFLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIITISMIL CVPLFFMGCS TSAVAEVYPP STSSSIHPQQ PPACRRDCSC
460 470 480 490 500
PDSFFHPVCG DNGVEYVSPC HAGCSSTNTS SEASKEPIYL NCSCVSGGSA
510 520 530 540 550
SAKTGSCPTS CAQLLLPSIF LISFAALIAC ISHNPLYMMV LRVVNQDEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPAPS LYGLLIDSSC VRWNYLCSGR RGACAYYDND
610 620 630 640
ALRNRYLGLQ MVYKALGTLL LFFISWRMKK NREYSLQENT SGLI
Length:644
Mass (Da):70,387
Last modified:November 16, 2011 - v3
Checksum:i143841277CC95F85
GO

Sequence cautioni

The sequence AAA41574.1 differs from that shown. Reason: Frameshift at positions 502 and 513. Curated
The sequence AAA41574.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64862 mRNA. Translation: AAA41574.1. Sequence problems.
PIRiA41120.
UniGeneiRn.9671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64862 mRNA. Translation: AAA41574.1. Sequence problems.
PIRiA41120.
UniGeneiRn.9671.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012162.

Chemistry

BindingDBiQ00910.
ChEMBLiCHEMBL2073680.
GuidetoPHARMACOLOGYi1223.

Protein family/group databases

TCDBi2.A.60.1.2. the organo anion transporter (oat) family.

Proteomic databases

PaxDbiQ00910.
PRIDEiQ00910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3051. Slco2a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ00910.

Miscellaneous databases

PROiQ00910.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of matrin F/G: a DNA binding protein of the nuclear matrix that contains putative zinc finger motifs."
    Hakes D.J., Berezney R.
    Proc. Natl. Acad. Sci. U.S.A. 88:6186-6190(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Identification and characterization of a prostaglandin transporter."
    Kanai N., Lu R., Satriano J.A., Bao Y., Wolkoff A.W., Schuster V.L.
    Science 268:866-869(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiSO2A1_RAT
AccessioniPrimary (citable) accession number: Q00910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 16, 2011
Last modified: June 8, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a nuclear DNA-binding protein.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.