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Protein

Human immunodeficiency virus type I enhancer-binding protein 2 homolog

Gene

Hivep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to DNA at the acute-phase response element of the angiotensinogen gene and related nuclear factor kappa-B binding sites through a zinc-finger motif.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1790 – 181223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1818 – 184225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Alternative name(s):
Angiotensinogen gene-inducible enhancer-binding protein 1
DNA-binding protein AGIE-BP1
Myc intron-binding protein 1
Short name:
MIBP-1
Gene namesi
Name:Hivep2
Synonyms:Agie-bp1, Mibp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61988. Hivep2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24372437Human immunodeficiency virus type I enhancer-binding protein 2 homologPRO_0000047373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei816 – 8161PhosphoserineCombined sources
Modified residuei947 – 9471PhosphoserineBy similarity
Modified residuei952 – 9521PhosphoserineBy similarity
Modified residuei1045 – 10451PhosphoserineBy similarity
Modified residuei1438 – 14381PhosphoserineCombined sources
Modified residuei1442 – 14421PhosphoserineBy similarity
Cross-linki2083 – 2083Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei2109 – 21091PhosphoserineBy similarity
Modified residuei2288 – 22881PhosphoserineBy similarity
Modified residuei2292 – 22921PhosphoserineBy similarity
Modified residuei2420 – 24201PhosphoserineBy similarity
Modified residuei2422 – 24221PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ00900.
PRIDEiQ00900.

PTM databases

iPTMnetiQ00900.
PhosphoSiteiQ00900.

Expressioni

Tissue specificityi

Expressed in brain, spleen, kidney, muscle and to a lower extent in liver.1 Publication

Interactioni

Subunit structurei

Interacts with TCF4.By similarity

Protein-protein interaction databases

IntActiQ00900. 1 interaction.
STRINGi10116.ENSRNOP00000015131.

Structurei

3D structure databases

ProteinModelPortaliQ00900.
SMRiQ00900. Positions 188-244, 1789-1845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2044 – 204741
Repeati2050 – 205342
Repeati2062 – 206543
Repeati2074 – 207744
Repeati2080 – 208345
Repeati2097 – 210046
Repeati2103 – 210647
Repeati2109 – 211248
Repeati2121 – 212449
Repeati2136 – 2139410

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2044 – 21399610 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi934 – 9407Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi947 – 97933Ser-richAdd
BLAST
Compositional biasi1503 – 157775Ser-richAdd
BLAST
Compositional biasi1890 – 191425Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi2064 – 213976Arg-richAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1790 – 181223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1818 – 184225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000155774.
HOVERGENiHBG007119.
InParanoidiQ00900.
KOiK09239.
PhylomeDBiQ00900.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGDTALGQ KATSRSGETD SVSGRWRQEQ SAGLKMSTFS SQEGQRQPQI
60 70 80 90 100
DPDQIGNVAS AQLFGSGKLA SPGEGVHQVT EKQYPPHRPS PYPCQHSLSF
110 120 130 140 150
PQHSLPQGMM HSNKPHQSLE GPPWLFSGPL PSVASEDLFP FPMHGHSSGY
160 170 180 190 200
PRKKISSLNP AYSQYSQKSI EQAEDAHKKE HKPKKPGKYI CPYCSRACAK
210 220 230 240 250
PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA HAIKAGLVPF
260 270 280 290 300
TESSVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKVSPGPP
310 320 330 340 350
IPLDIASRGG YPGSLEESLG GPMKVPILII PKSGIPLPNE GSQYLGPDML
360 370 380 390 400
PNPSLNAKAD DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY
410 420 430 440 450
FSRSESAEQQ ISPPNTNAKS YEEIIFGKYC RLSPRNTLSV TPTGQERTAM
460 470 480 490 500
GRRGLVEPLP HVNTRLEVKM FEDPITQLIP SKGEMDPSQV NMLKTTKFNS
510 520 530 540 550
ECRQPQAMAA SVRNEGKPYP GSFPGSNPIL LEAPVDSSPL IRSNSMPTSS
560 570 580 590 600
ATNLSIPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS
610 620 630 640 650
VQEGHMEFEH PARVPKILAG SSLKEKKLVP GDRSGYDYDA CRKPYKKWED
660 670 680 690 700
PETPKQSYRD ISCLSTFKHG GEYFMDPSVP LPGVPTMFGT TCENRKRRKE
710 720 730 740 750
KSVGDEEDTP MICGGMGSAP GSMMSSEYDS KLQDGGRSGF TMTGHESLPH
760 770 780 790 800
GYSDRLDLAR PQLPSRSPSL GSEDLPSAGD PDKMTDLGKK PPGNVISVIQ
810 820 830 840 850
HTNSLSRPNS FERSESTEMA VSTQDKTPSP SEMGDSEVLE GPVSPEWAPP
860 870 880 890 900
GDGAESGSRP TPSQQVPQHS YHGQPRLVRQ HNIQVPEIRV TEEPDKPEKE
910 920 930 940 950
KEAPTKEPEK PVEEFQWPQR SETLSQLPAE KLPPKKKRLR LADMEHSSGE
960 970 980 990 1000
SSFESTGTGL SRSPSQESNL SHSSSFSMSF DRDETVKLTA PPKQDESGKH
1010 1020 1030 1040 1050
SEFLTVPAGS YSLSVPGHHH QKEMRRCSSE QMPCPHPTEV PEIRSKSFDY
1060 1070 1080 1090 1100
GNLSHAPVAG ASPSTLSPSR ERKKCFLVRQ ASFSGSPEIA QGEAGMDPSV
1110 1120 1130 1140 1150
KQEQLEQLHA GLRAAWTTVL PPLPGDDPGK QVVGPCGQLS SGPPLHLAQQ
1160 1170 1180 1190 1200
QIMHMDSQES LRNPLIQPTS YMTGKHLPEQ PHLFPHQDAV PFSPIQNALF
1210 1220 1230 1240 1250
QFQYPTVCMV HLPAQQPPWW QAHFPHPFTP HPQNSYSKPP FQADIHSSYS
1260 1270 1280 1290 1300
LEHVAEHTGK KSADYPHAKE QTYPCYSGAS GLHSKNLPPK FPSDPGSKST
1310 1320 1330 1340 1350
EAPPTEQLLR EDFASENAGP LQSLPGTVVP VRIQTHVPSY GSVMYTSISQ
1360 1370 1380 1390 1400
ILGQNSPAIV ICKVDENMTQ RTLVTNAAMQ GIGFNIAQVL GQRTGLEKYP
1410 1420 1430 1440 1450
LWKVPQTLPL GLESSIPLCL PSTSDSAASL GGSKRMLSPA SSLELFMETK
1460 1470 1480 1490 1500
QQKRVKEEKM YGQIVEELSA VELTNSDIKK GLSRPQKPQL VRQGCASEPK
1510 1520 1530 1540 1550
DGSSQSRSSS FSSLSPSSSQ DHPAASGPFP PNREILSGSR APPRRKFSGP
1560 1570 1580 1590 1600
SESRESSDEL DIDETSSDMS MSPQSSSLPT GGSQQEDEGK ARKLPVSMLV
1610 1620 1630 1640 1650
HMASGPGGNV ANSTLLFTDV ADFQQILQFP SLRTTTTVSW CFLNYTKPNF
1660 1670 1680 1690 1700
VQQATFKSSV YASWCISSCN PNPSGLNTKT TLALLRSKQK ITAEIYTLAA
1710 1720 1730 1740 1750
MHRPGTGKLT SSSAWKQFAQ MKPDAPFLFG NKLERKLGGN VLKERGKGEI
1760 1770 1780 1790 1800
HGDKDLGSKQ TEPIRIKIFE GGYKSNEDYV YVRGRGRGKY ICEECGIRCK
1810 1820 1830 1840 1850
KPSMLKKHIR THTDVRPYVC KLCNFAFKTK GNLTKHMKSK AHMKKCLELG
1860 1870 1880 1890 1900
VSMTSVDETE TEEAENMEDL HKTSEKHSMS GISTDHQFSD AEESDGEDGD
1910 1920 1930 1940 1950
DNDEDDEDDD DFDDQGDLTP KTRSRSTSPQ PPRFSSLPVN VGAVAHGVPS
1960 1970 1980 1990 2000
DSSLGHSSLI SYLVTLPSIQ VTQLMTPSDS CEDTQMTEYQ RLFQSKSTDS
2010 2020 2030 2040 2050
EPDKDRLDIP SSMDEEAMLS SEPSSSPRDF SPSSYRSSPG YDSSPCRDNS
2060 2070 2080 2090 2100
PKRYLIPKGD LSPRRHLSPR RDLSPMRHLS PRKEAALRRE MSQGDASPRR
2110 2120 2130 2140 2150
HLSPRRPLSP GKDITTRRDL SPRRERRYMT TIRAPSPRRA LYHNPPLPMG
2160 2170 2180 2190 2200
QYLQTEPIVL GPPNLRRGLP QVPYFSLYGD QEGAYEHHGS SLFPEGPTDY
2210 2220 2230 2240 2250
VFSHLPLHSQ QQVRAPIPMV PVGGIQMVHS LPPAISGLHP PPTLPLPTEG
2260 2270 2280 2290 2300
SEEKKGAPGE ALTQDPYTLS RRHEKQAPHV LQSSGLPSSP SSPRLLMKQS
2310 2320 2330 2340 2350
TSEDSLNSTE REQEENIQTC TKAIASLRIA TEEAALLGAD QPTWVQESPQ
2360 2370 2380 2390 2400
KPLESAHISI RHFSGPEPGQ LCTSAAHPDL HDGEKDTFGT SQTAVAHPTF
2410 2420 2430
YSKGSVDEKQ VDFQSSKELS LSTEEGNEPS SEKNRLH
Length:2,437
Mass (Da):267,426
Last modified:December 6, 2005 - v2
Checksum:iBD5C21358D3A1F5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1522 – 15221H → I in AAA40698 (PubMed:2017183).Curated
Sequence conflicti2264 – 22641Q → K in AAA40698 (PubMed:2017183).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37951 mRNA. Translation: BAA07168.1.
M65251 mRNA. Translation: AAA40698.1.
PIRiS53611.
RefSeqiNP_077051.1. NM_024137.1.
UniGeneiRn.9802.

Genome annotation databases

GeneIDi29721.
KEGGirno:29721.
UCSCiRGD:61988. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37951 mRNA. Translation: BAA07168.1.
M65251 mRNA. Translation: AAA40698.1.
PIRiS53611.
RefSeqiNP_077051.1. NM_024137.1.
UniGeneiRn.9802.

3D structure databases

ProteinModelPortaliQ00900.
SMRiQ00900. Positions 188-244, 1789-1845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00900. 1 interaction.
STRINGi10116.ENSRNOP00000015131.

PTM databases

iPTMnetiQ00900.
PhosphoSiteiQ00900.

Proteomic databases

PaxDbiQ00900.
PRIDEiQ00900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29721.
KEGGirno:29721.
UCSCiRGD:61988. rat.

Organism-specific databases

CTDi3097.
RGDi61988. Hivep2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000155774.
HOVERGENiHBG007119.
InParanoidiQ00900.
KOiK09239.
PhylomeDBiQ00900.

Miscellaneous databases

PROiQ00900.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZEP2_RAT
AccessioniPrimary (citable) accession number: Q00900
Secondary accession number(s): Q63725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 6, 2005
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.