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Protein

Epithelial cell-transforming sequence 2 oncogene-like

Gene

ECT2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell-transforming sequence 2 oncogene-like
Alternative name(s):
Lung-specific F-box and DH domain-containing protein
Putative guanine nucleotide exchange factor LFDH
Gene namesi
Name:ECT2L
Synonyms:C6orf91, LFDH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21118. ECT2L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893289.

Polymorphism and mutation databases

BioMutaiECT2L.
DMDMi189046616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Epithelial cell-transforming sequence 2 oncogene-likePRO_0000336075Add
BLAST

Proteomic databases

EPDiQ008S8.
PaxDbiQ008S8.
PRIDEiQ008S8.

PTM databases

iPTMnetiQ008S8.
PhosphoSiteiQ008S8.

Expressioni

Gene expression databases

BgeeiQ008S8.
ExpressionAtlasiQ008S8. baseline and differential.

Organism-specific databases

HPAiHPA035488.

Interactioni

Protein-protein interaction databases

BioGridi131369. 1 interaction.
STRINGi9606.ENSP00000356655.

Structurei

3D structure databases

ProteinModelPortaliQ008S8.
SMRiQ008S8. Positions 76-126, 548-894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 12147F-boxAdd
BLAST
Domaini566 – 754189DHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiENOG410IRSS. Eukaryota.
ENOG4110R79. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000067954.
InParanoidiQ008S8.
OMAiPFERTSK.
OrthoDBiEOG7R832J.
PhylomeDBiQ008S8.
TreeFamiTF343796.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR025592. DUF4347.
IPR001810. F-box_dom.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF14252. DUF4347. 1 hit.
PF12937. F-box-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q008S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFHTRFSA WTPFSNKSLN RQLFQERVAL ISHWFDLWTN KQRQEFLFAI
60 70 80 90 100
FLRCTKSQLR FVQDWFSERM QVAKVDFSTV LPRFISLYIF SFLSPKDLCA
110 120 130 140 150
AAQVSWPWKF LTEQDCLWMP KCVKFGWFLP YTPTDNEYGA WKRHYIACVS
160 170 180 190 200
HLDWLTPREA AATYGTLNEP KTEDEELLER QREKCLRKRI WEKIALRKKE
210 220 230 240 250
LFKVRPPWVS GTCCSSVLKP RCQPRLSQTV RERVGLHEAL EKQLVLTSLE
260 270 280 290 300
TLPKRSNISG SHSYPLLSKK NWHGVHKNDD RSSYALRPHF MLISSRIPAY
310 320 330 340 350
EMVMESVKAG VVSVVYEHSV TLESLLYLIE KALDGQKAQS IGIFSDGDSR
360 370 380 390 400
EINLLQGYKI GVKNLLRPEV RDFWEKLGSY VATEEEGGHV DFFVPLGASE
410 420 430 440 450
AGIEVLSQLS QLTGTFFTAP TGIATGSYQH ILSDWLGSQW GKAPSSIYFC
460 470 480 490 500
ESKLQTWSSF TDFLEETLKT VRKQLYPFFK ELQKSISGRM IGQFMFDTMG
510 520 530 540 550
MTNILNNQDT AQALADGLME LSKEDSERNV VEDNSWDTKS RLSKNDLNFE
560 570 580 590 600
ALINLERILQ KDSAEKRARV VRELLQSERK YVQILEIVRD VYVAPLKAAL
610 620 630 640 650
SSNRAILSAA NIQIIFCDIL QILSLNRQFL DNLRDRLQEW GPAHCVGEIV
660 670 680 690 700
TKFGSQLNTY TNFFNNYPVI LKTIEKCREM IPAFRTFLKR HDKTIVTKML
710 720 730 740 750
SLPELLLYPS RRFEEYLNLL YAVRLHTPAE HVDRGDLTTA IDQIKKYKGY
760 770 780 790 800
IDQMKQNITM KDHLSDIQRI IWGCPTLSEV NRYLIRVQDV AQLHCCDEEI
810 820 830 840 850
SFSLRLYEHI HDLSLFLFND ALLVSSRGTS HTPFERTSKT TYQFIASVAL
860 870 880 890 900
HRLLIENIPD SKYVKNAFIL QGPKYKWICA TEIEDDKFLW LSVLRNAIKS

SMEK
Length:904
Mass (Da):104,880
Last modified:May 20, 2008 - v2
Checksum:iCF4AD8C84D94E983
GO

Sequence cautioni

The sequence ABI98401.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601R → S in ABI98401 (Ref. 3) Curated
Sequence conflicti64 – 641D → E in ABI98401 (Ref. 3) Curated
Sequence conflicti472 – 4721R → K in ABI98401 (Ref. 3) Curated
Sequence conflicti641 – 6411G → D in ABI98401 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831Q → H.
Corresponds to variant rs12198781 [ dbSNP | Ensembl ].
VAR_051984
Natural varianti527 – 5271E → K.
Corresponds to variant rs1529151 [ dbSNP | Ensembl ].
VAR_043482
Natural varianti594 – 5941A → T.
Corresponds to variant rs11968285 [ dbSNP | Ensembl ].
VAR_043483

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121834 Genomic DNA. Translation: CAI42871.2.
BC146884 mRNA. Translation: AAI46885.1.
DQ904331 mRNA. Translation: ABI98401.1. Different initiation.
CCDSiCCDS43508.1.
RefSeqiNP_001071174.1. NM_001077706.2.
NP_001181966.1. NM_001195037.2.
UniGeneiHs.660603.

Genome annotation databases

EnsembliENST00000367682; ENSP00000356655; ENSG00000203734.
ENST00000423192; ENSP00000387388; ENSG00000203734.
ENST00000541398; ENSP00000442307; ENSG00000203734.
GeneIDi345930.
KEGGihsa:345930.
UCSCiuc003qif.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121834 Genomic DNA. Translation: CAI42871.2.
BC146884 mRNA. Translation: AAI46885.1.
DQ904331 mRNA. Translation: ABI98401.1. Different initiation.
CCDSiCCDS43508.1.
RefSeqiNP_001071174.1. NM_001077706.2.
NP_001181966.1. NM_001195037.2.
UniGeneiHs.660603.

3D structure databases

ProteinModelPortaliQ008S8.
SMRiQ008S8. Positions 76-126, 548-894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131369. 1 interaction.
STRINGi9606.ENSP00000356655.

PTM databases

iPTMnetiQ008S8.
PhosphoSiteiQ008S8.

Polymorphism and mutation databases

BioMutaiECT2L.
DMDMi189046616.

Proteomic databases

EPDiQ008S8.
PaxDbiQ008S8.
PRIDEiQ008S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367682; ENSP00000356655; ENSG00000203734.
ENST00000423192; ENSP00000387388; ENSG00000203734.
ENST00000541398; ENSP00000442307; ENSG00000203734.
GeneIDi345930.
KEGGihsa:345930.
UCSCiuc003qif.2. human.

Organism-specific databases

CTDi345930.
GeneCardsiECT2L.
HGNCiHGNC:21118. ECT2L.
HPAiHPA035488.
neXtProtiNX_Q008S8.
PharmGKBiPA134893289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRSS. Eukaryota.
ENOG4110R79. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000067954.
InParanoidiQ008S8.
OMAiPFERTSK.
OrthoDBiEOG7R832J.
PhylomeDBiQ008S8.
TreeFamiTF343796.

Miscellaneous databases

ChiTaRSiECT2L. human.
GeneWikiiECT2L.
GenomeRNAii345930.
PROiQ008S8.

Gene expression databases

BgeeiQ008S8.
ExpressionAtlasiQ008S8. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR025592. DUF4347.
IPR001810. F-box_dom.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF14252. DUF4347. 1 hit.
PF12937. F-box-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Identification and characterization of the gene for human lung specific F-box and DH domain containing protein (LFDH)."
    Corcoran M.M., Cepeda D., Akhondi S., Spruck C., Sangfelt O.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-904.

Entry informationi

Entry nameiECT2L_HUMAN
AccessioniPrimary (citable) accession number: Q008S8
Secondary accession number(s): B2RUV6
, Q5JWK2, Q5JWK3, Q5JWK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.